Tài liệu Báo cáo khoa học: Allosteric modulation of myristat

Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx

... Myristate and Mn(III)heme binding to HSA–heme FEBS Journal 272 (2005) 4672–4683 ª 2005 FEBS 4683 Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy ... albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to hu...

Ngày tải lên : 20/02/2014, 02:22

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Tài liệu Báo cáo khoa học: Identiﬁcation of Ewing’s sarcoma protein as a G-quadruplex DNA- and RNA-binding protein ppt

... Afﬁnity of RGG3 for binding to a G-quadruplex DNA and RNA. Fig. S2. CD spectra of DNAs and RNAs. Fig. S3. Binding afﬁnity of EWS and RBD to Htelo. Fig. S4. In vitro arginine methylation of RGG3 ... transcriptional activator. Cancer Res 61, 2690–2695. 51 Ishii S, Imamoto F, Yamanashi Y, Toyoshima K & Yamamoto T (1987) Characterization of the promoter region of...

Ngày tải lên : 15/02/2014, 01:20

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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf

... Philip A. Marsden 3 and Gary A. Levy 1 1 Multi Organ Transplant Program, Toronto General Hospital and The University of Toronto, Canada; 2 Department of Pathology and Laboratory Medicine, Texas ... The adding of extracts and cold probe are indicated in the top of the panel. Supershift, ss-Sp1 and ss-Sp3, were shown in presence of anti-Sp1 and anti-Sp3 Ig. Cold and muta...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Specific targeting of a DNA-alkylating reagent to mitochondria Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide doc

... electrode was used to measure the uptake of mitoDC-81 into rat liver mitochondria. To calibrate the electrode ﬁve stepwise addi- tions of 1 l M mitoDC-81 were made to a suspension of mitochondria in ... concentration of mitoDC-81 within mitochondria on incubation of cells with high nanomolar to micromolar concentrations of mitoDC-81. This high local concentration of mito...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt

... (a component of the NuRD complex containing HDAC1 and HDAC2) proteins and to binding of HSF1 to MTA1 [78]. The complex is recruited to the promoters of estrogen-responsive genes and participates ... (SWI ⁄ SNF, ISW1 and RSC) and histone chaperones (Asf1, Spt6 and Spt16), are involved in histone acetylation and eviction [52–55]. Stress-inducible or constitutive bin...

Ngày tải lên : 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters pdf

... ester). Results and Discussion Action of reversible effectors on AAA activity of BuChE The investigation of the effects of the ligands (tyramine, serotonin and benzalkonium) on the AAA and esterase ... site concentration of wild-type BuChE was 0.16 ± 0.01 lm, and that of the D70G mutant was 0.196 ± 0.02 lm. Effects of ligands on steady-state kinetics The effects of the...

Ngày tải lên : 18/02/2014, 17:20

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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... hydrogen bond ThepH-activityproﬁlesweresuggestiveofacloserelation- ship of the ionization states in both His57 and His210. To explore this possibility,we attempted to titrate the His57 Nd1 and Ne2 protons by means of 1 H -NMR (Fig. 4). A sharp proton signal ... interchange rate of the proton between His57 Nd1- Asp113 Oc2 may be too fast to monitor as the split signals, while...

Ngày tải lên : 21/02/2014, 03:20

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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc

... ones; and (b) progressive optimization for glyphosate activity is accompanied by improved binding to longer ligands (up to ﬁve atoms in the main chain) and retained binding to shorter ligands ... some of the key ﬁndings that have led to our current under- standing of the molecular mode of action of glyphosate and the molecular basis for glyphosate resistance. Struc...

Ngày tải lên : 14/02/2014, 14:20

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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt

... in Ab-induced excitotoxicity [11]. Furthermore, Fyn sensitizes mice to the toxic effects of Ab [15,16], and tau is required for the Fyn-mediated and Ab-mediated synaptic deﬁcits and network impairments ... fusion proteins of Fyn-SH2 and Fyn- SH3 to further investigate the mechanisms by which tau and Fyn interact. We determined that tau binds to both Fyn-SH2 and Fyn-SH3,...

Ngày tải lên : 14/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt

... molecules A and B (and C and D) of the asymmetric unit form a weak dimer (Fig . 6). On the basis of calculations performed Fig. 6. (A) Cartoon representation of dimers of TaLcc1 (blue) and rMaL ... Kruus 2 , Juha Rouvinen 1 and Nina Hakulinen 1 1 Department of Chemistry, University of Eastern Finland, Joensuu, Finland 2 VTT Technical Research Centre of Finland, Espoo,...

Ngày tải lên : 14/02/2014, 18:20

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