Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx

Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt

Tài liệu Báo cáo khoa học: Casein kinase 2 specifically binds to and phosphorylates the carboxy termini of ENaC subunits ppt

... between the C tails of b and c and the ubiquitin ligase Nedd4. The WW domains of Nedd4 bind to the proline-rich PY motifs of b and cENaC, leading to channel ubiquitination, internalization and degradation ... donor (Fig. 8A), the inhibitory effects of heparin and DPG (Fig. 8B), the fact that purified CK2 can phosphorylate bS631 and cT599 (Fig. 7A), the presenc...
Ngày tải lên : 21/02/2014, 03:20
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Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt

Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt

... pyruvate, and meth- ylamine are bound to the enzyme in this order, and N-methyl-l-alanine and then NADP + are released from the enzyme. Therefore, the kinetic mechanism of the enzyme is the same ... amino-acid sequences of the gene showed high identities (97.9% and 99.1%, respectively) with those of the PP3591 gene of P. putida KT2440. Purification and subunit s...
Ngày tải lên : 19/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx

... hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remains unclear and it is uncertain whether it has the capacity to ... II. The hood domain is mainly built up by residues from the C-terminus and consists of a two-stranded anti-parallel b-sheet composed of b2 and b9 and an a-h...
Ngày tải lên : 15/02/2014, 01:20
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Tài liệu Báo cáo khoa học: Structural features of proinsulin C-peptide oligomeric and amyloid states pptx

Tài liệu Báo cáo khoa học: Structural features of proinsulin C-peptide oligomeric and amyloid states pptx

... distribu- tion of 100 l M proinsulin C-peptide in the presence of divalent Ca 2+ and Mg 2+ ions under native conditions (B), and of 100 l M C-peptide in the presence of insulin (C) and of 100 l M ... SDS to structurally character- ize the oligomerization process of C-peptide and ana- lyzed the formation of oligomers and their secondary structure by complementar...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf

... hinge domains The composition of the two hinges that connect the FMN subdomain in NOS enzymes (H1 and H2 in Fig. 5) defines the allowable movements of the FMN subdomain and thus controls the FMN–NOSoxy ... further test the validity, kinetics and thermodynam- ics of the through-heme pathway in NOS enzymes. Conclusions Although the NOS flavoprotein domain has fundame...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: probes of hydrogen tunnelling pptx

... Klinman and cowork- ers to study the viscosity dependence of the rate of hydride transfer in GO [70,71]. These authors studied various glycoforms of the enzyme (varying in the extent of glycosylation) ... Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: photosynthetic electron transfer from photosystem I to NADP+ doc

... orientation of the N5 of the flavin, the hydride to be transferred, and C4 of the nicotinamide. In FNR, displacement of the C-terminal Tyr appears to be required for the interaction to occur [117,118]. The ... because the semiquinone H-bond with the CO of Asn is weaker than the bond formed with the sma- ller Gly, and because of the presence in the oxid...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... N10 and E97 of the second subunit. The backbone NH group of R98 forms a hydrogen bond with the backbone CO of F102. Fur- thermore, the orientation of the side chain of the two residues brings the ... nature. The growing body of sequence and structural data on these well-studied enzymes affords an opportunity to evaluate the conse- quences of mutations. In...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt

Tài liệu Báo cáo khoa học: Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium ppt

... indicate the starting and ending residues of the secondary structural elements. (C) The domain-swapped dimer of St SurE. The A and B subunits are shown in green and blue, respectively. The darker and ... as in archaic and thermophilic homo- logues. The St SurE monomer consists of 13 b-strands, six a-helices and three 3 10 -helices. The core of the pro- te...
Ngày tải lên : 18/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt

Tài liệu Báo cáo khoa học: Structural and functional investigations of Ureaplasma parvum UMP kinase – a potential antibacterial drug target ppt

... to the side chain of Asp70, and one from the backbone N of Gly63, and the phosphate group forming hydrogen bonds from O1 to Arg55, from O2 to the backbone N and the side chain of Thr138, and ... to the three lysines (Fig. 3E). There is no water molecule fix- ing the three lysines from the B, C and F subunits, and there is no direct interaction between subunits...
Ngày tải lên : 18/02/2014, 16:20
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