... CtCBM11
FEBS Journal 275 (2008) 252 4–2 535 ª 2008 The Authors Journal compilation ª 2008 FEBS 2535
Molecular determinants of ligand specificity in family 11
carbohydrate binding modules – an NMR, X-ray
crystallography ... NMR and computational chemistry
approaches to identify the molecular determinants of
ligand specificity of CtCBM11. By m...
... leucine degradation and the
sku mutant accumulates branched-chain amino acids in haemolymph, this
mutant may be useful in the investigation of unique branched-chain amino
acid catabolism in insects.
Abbreviations
ACAD, ... +
sku
) and the skunk mutant (sku ⁄ sku)
at (A) day 2 of fifth instar and (B) 10 days
after spinning. Until spinning, the skunk
mutant larva develops normall...
... chemokines
Interleukin-8 ⁄ CXCL8 (a ligand of CXCR1 and
CXCR2) was the first chemokine identified to be
involved in leukocyte chemotaxis [29]. Interleukin-8 ⁄
CXCL8 is present in high quantities in ... of
mediators of in ammation, cell proliferation and
angiogenesis. To date, several animal studies and
human studies have shown the biological efficacy of
specific antagonism...
... dinucleo-
tide -binding sequence motifs (Rossmann-fold motifs) –
GxGxxG – which are involved in binding of the ADP
moieties of FAD and NADPH [27]. This distinguishes
them from another class of flavin-containing ... 2004
Identifying determinants of NADPH specificity in Baeyer–Villiger
monooxygenases
Nanne M. Kamerbeek, Marco W. Fraaije and Dick B. Janssen
Laborator...
... activity is accompanied by improved bind-
ing to longer ligands (up to five atoms in the main
chain) and retained binding to shorter ligands [55].
Of the 21 changes in the evolution of R7 from
native ... deamination of
primary and secondary amines (sarcosine, N-ethylgly-
cine, and glycine) and d-amino acids (d-alanine and d-
proline), yielding the corresponding a-keto aci...
... 545 6–5 470 ª 2009 The Authors Journal compilation ª 2009 FEBS
Molecular characterization of Arabidopsis thaliana PUF
proteins – binding specificity and target candidates
Carlos W. Francischini and ... These proteins
must bind to transcripts in the plant and regulate their
translation and ⁄ or turnover.
A large number of APUM target candidates: is
this plausible?
RNA...
... demonstrated both in studies of
twins and families, as well as in genome-wide linkage scans, and it is esti-
mated that genetic factors are responsible for 5 0–6 0% of the risk of devel-
oping RA. Thus, ... levels of
B19 DNA are similar in RA and control synovial
membranes [11] . Thus, the contribution of B19 infec-
tion in RA remains controversial.
Epstein–Barr viru...
... different intracellular proteins, namely FK506-
binding protein (FKBP) and cyclophilin, and the
drug–protein complex then binds to the interface of the
calcineurin A ⁄ B complex and blocks its phosphatase
activity ... expression of genes such as IL-2,
IL-3, GM-CSF, IL-4, IL-5, IL-13, IFN-c, TNF-a,
CD40 ligand and Fas ligand, etc. (Fig. 3). Ligand bind-
ing of various rece...
... Kobayashi
4
and Koichiro Kishi
3
1
Division of Medical Genetics and Biochemistry and
2
Division of Legal Medicine, Faculty of Medical Sciences, University of Fukui,
Japan;
3
Department of Legal Medicine, ... by
carrying out comprehensive comparisons of the enzymes
from lower and higher vertebrates: the biochemical
and molecular characterizations of mammalian [ 11 16...
... metal -binding site
at the interface of the two domains, which consists
of four side chains: two (His31 and His79) from the
N-terminal domain and two (Asp165 and His169) from
the C-terminal domain ... Suzuki
5
and Yasushi Kawata
3,4
1 National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan
2 Department of Food Science and Nutrition, Faculty...