... 2008)
doi:10.1111/j.1742-4658.2008.06347.x
Strategies for the chemical construction of synthetic proteins with precisely
positioned post-translational modifications or their mimics offer a powerful
method for dissecting the complexity of functional ... consequence of the lack of direct genetic control of
their biosynthesis, natural PTMs vary in site and level
of incorpo...
... Future Work
The abundance of knowledge allows us to widen
the application of NLP tools, developed in a
research environment. The tailor made voting
system maximizes the use of the different ...
platform. The platform enriches the
content of these websites with revealing
details and reduces the manual work of
classification editors by automatically
categorisi...
... denaturant). The problem is
that there is another limitation to library approaches: one
must be able to identify the functional proteins at the end of
the experiment.
Identification of selectants
There ... the absence of polar sidechains (oil-droplet behavior).
Further libraries have been created to explore these issues,
and we will also expand the scope of these stu...
... [4,5]).
Most of the work has been performed on the muscle
subtype, thanks to the large amount of the receptor
obtained from the electric organ of the Torpedo marmorata
ray and availability of selective ... increasing use of computational tools in the field
of nicotinic receptors has led to the publication of several
models of ligand–receptor interactions. Th...
... of the
CD95 from inside the hepatocyte to the plasma mem-
brane [39], which depends on a ROS-mediated tyrosine
phosphorylation of the epidermal growth factor
(EGF)-receptor, the association of ... trafficking of the
CD95 to the plasma membrane surface, and death
inducing signaling complex formation, leading to the
execution of apoptosis in this case [38]. Althou...
... a
pair of coupled motors, a chemically driven motor (F
1
)
and a membrane-embedded, ion gradient-driven motor
(F
0
) [3]. The membrane-embedded motor comprises a
stator and a rotor. The stator is ... that the c rings
contain both types of c subunits. The stoichiometry for c
2
⁄ c
3
: c
1
was
9 : 1. Furthermore, this stoichiometry was independent of the carbon
source of the...
... has to approach the ste-
roidal substrate for both abstraction of a hydrogen
atom and insertion of the hydroxyl group. Thus,
C17 must be able to come close to the heme iron,
presumably due to the ... purifying them and determining the
substrates from which they arose by the action of
P450scc, as well as the products that they gave rise to.
This revealed both the...
... confined to certain motor nuclei of the central
nervous system (CNS). From the very beginning, these
findings pointed to a possible neuromodulatory role
for UII.
The aim of this review is to provide ... Phylogenetic
analysis of the receptor’s primary sequence shows stri-
king similarities to the somatostatin receptor family,
most notably in the transmembrane domains....
... original. For the
purposes of this experiment, the question of the fidelity
of a translation was converted into the complementary
question of whether the original could be found to con-
tain ... was to be
judged in terms of the “informativeness” of the original
relative to the translation. In this way, the translation
is being evaluated—not the orig...
... applications,
e.g. the MediaWiki software
5
, integrated within a
Linux, Apache, MySQL and PHP (LAMP) software
bundle. The architecture of the API consists of the
following modules:
1. RDBMS: at the lowest ... ency-
clopedia entries to the MediaWiki software (which
in turn queries the database) and efficiently parsing
the text responses into structured objects.
5 Using t...