Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

Tài liệu Báo cáo khoa học: Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate docx

... Author Journal compilation ª 2009 FEBS Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate Jody M. Mason Department of Biological ... 2009) doi:10.1111/j.1742-4658.2009.07440.x The hypothesis is tested that Jun–Fos activator protein-1 coiled coil inter- actions are dominated du...
Ngày tải lên : 18/02/2014, 13:20
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf

... the luminal membrane of endothelial cells via interactions between selectins, chemokines and integrins. After docking to the vessel wall, leukocytes extend their processes toward interen- dothelial ... and differences in the luminal–abluminal polarity of the endothelium. To bridge the gap between in vitro condi- tions and the actual environment, experiments should incorporate...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf

... with increasing solvent-accessibility of the His210 side-chain. In the protein interior, the dielectrostatic constant is lower than on the protein surface, while the dielectrostatic constant in water ... depending on NaCl concentration were determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210....
Ngày tải lên : 21/02/2014, 03:20
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

... lacking p15 INK4b are resistant to the growth-inhibitory effects of gefitinib. As the level of p15 INK4b is increased by MEK inhibi- tors, but not by Akt inhibitors, the induction of Fig. 3. The ... cyclin-dependent kinases (CDKs), in asso- ciation with each other, play key roles in promoting the G 1 -to-S phase transition of the cell-cycle by phos- phorylating the reti...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

Tài liệu Báo cáo khoa học: Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy in living cells doc

... that induction of FRET does not sim- ply depend on the length of linkers. In the linker con- taining seven amino acids, a Pro-Pro sequence that is not contained in other linkers is incorporated. ... decreased the lifetimes of cerulean–GAPDH in the cytoplasm, con- firming the results shown in Fig. 2B,D. The lifetimes analyzed by the two-exponential fitting are summarized...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx

Tài liệu Báo cáo khoa học: How disorder influences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx

... B, Finet S & Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct ... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy....
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions – contribution and expression from motor neurons doc

Tài liệu Báo cáo khoa học: Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions – contribution and expression from motor neurons doc

... plateau in the spinal cord about 10 days after birth (Fig. 5E). To determine the origin of AChE in the spinal cord, the lumbar region of the spinal cord was sectioned and stained with the PRiMA ... be analyzed by real-time PCR. The PRiMA I pro- tein level in the spinal cord, determined in western blots with the PRiMA antibody (recognizing the cytoplasmic domain o...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx

... lacks other aromatic rings in the vicinity. In comparing the three structures, it should be noted that the residue numbering is the same for the yeast enzyme and Pf TIM, but is increased by 1 in ... is not regained even upon dimerization. Thus, position 74 is not only critical for the stability of the dimer, it may also be involved in maintaining the integrity of...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor doc

... the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch sys- tems, and the Wnt pathway. Furthermore, the blood ... clinical outcomes by developing new strategies with combination therapy using known anti- angiogenic drugs or by developing unique medicines specifically targeting the blood ve...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke docx

... angiogenesis in the brain. Is it possible that some of the acute neurovascular events in the brain after stroke represent an endogenous attempt by the brain to prepare the substrates necessary ... signaling actions involving the platelet-derived growth factor and low-density lipo- protein receptors [32,33]. These experimental findings are now beginning to be supported by cl...
Ngày tải lên : 18/02/2014, 11:20
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