Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf

Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf

Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf

... siRNAs versus siRNA 396 was significant at P < 0.05. A B Fig. 5. Effect of terminal and internal mismatches on siRNA TRBP and siRNA Dicer complexes. (A) EMSA of siRNA TRBP and siRNA Dicer complexes ... function of TRBP in RNAi. Here, we have characterized the interactions of siRNAs that contain terminal mismatches with TRBP and Dicer, and determi...
Ngày tải lên : 18/02/2014, 06:20
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... mm enhanced the binding of InsP 6 to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength on catalytic activity ... absence of ligand, the WPD loop of PTP1B and RPTPa adopts an open (inactive) conformation, and upon ligand bind- ing, it adopts a closed (active) conformation (Fig. 3A)...
Ngày tải lên : 18/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx

... role of this region in the transcription of the Ig-b gene. Deletion of region III decreased the expres- sion of Ig-b mRNA to 40% of the expression in prede- letion cells (Fig. 4A). Region III ... hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns are shown as in Fig. 2A. Positions of the DT4...
Ngày tải lên : 19/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx

Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx

... cation binding site has been des- cribed so far. As the regulatory effect of the trans calcium concentration was voltage-dependent and changed as the function of the cis EGTA concentra- tion, ... several cytoplasmic ligands. It is activa- ted by millimolar concentrations of ATP and micromo- lar Ca 2+ , and inhibited by higher concentrations (> 100 lm)ofCa 2+ and by millim...
Ngày tải lên : 19/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf

Tài liệu Báo cáo khoa học: Effect of sequence polymorphism and drug resistance on two HIV-1 Gag processing sites pdf

... analyzer. Stock solutions and dilutions were made in distilled water and the peptide concentrations were determined by amino-acid analysis. Construction and purification of HIV-1 PR mutants HIV-1 ... the substrate binding site of the PR, and these mutations have considerable impact on PR activity and specificity. Other resistant mutations alter residues outside of the substr...
Ngày tải lên : 21/02/2014, 03:20
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Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot

Tài liệu Báo cáo khoa học: "Effect of Cross-Language IR in Bilingual Lexicon Acquisition from Comparable Corpora" pot

... term correspondences are estimated, in terms of both computational complexity and the performance of precise estimation of bilingual term correspondences. 1 Introduction Translation knowledge acquisition ... situ- ation. One limitation of the corpus-based trans- lation knowledge acquisition approach is that the techniques of translation knowledge acquisition heavily rely on avai...
Ngày tải lên : 22/02/2014, 02:20
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Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 fi 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf

Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 fi 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf

... a function of dextran concentration, the activity of GSGB was highly dependent on dextran (filled circles in Fig. 2B); however, that of GS was nearly zero, inde- pendently of dextran concentration ... reciprocal plot of nigerotriose accep- tor reaction of GS. Fig. S4. Separation of nigerooligosaccharides by acti- vated carbon chromatography. Doc. S1. Simulation of the glucan...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

Tài liệu Báo cáo khoa học: Degradation of tropoelastin by matrix metalloproteinases – cleavage site specificities and release of matrikines pptx

... The formation of pyroglutamic acid moieties from Glu and Gln were considered as variable modifications. Moreover, automated de novo sequencing of the nano- ESI–qTOF and MALDI-TOF ⁄ TOF MS data ... com- ponents of the extracellular matrix (ECM). MMPs play a central role in connective tissue remodeling pro- cesses and regulation of cell matrix composition through their effects on...
Ngày tải lên : 16/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx

Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx

... demonstrate strong modulation of expression after stimulation with LPS and LP. LP and LPS mediate immunomodulating functions, at least in part, through regulation of RGS1 and RGS2 expression. Results RGS1 ... RGS1 and RGS2 mRNA and modu- late expression after stimulation with LP and LPS. Expression patterns of RGS1 and RGS2 after activation of TLR3 and TLR9 To investig...
Ngày tải lên : 18/02/2014, 13:20
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx

Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx

... this, UV-irradiation of the cells (2.4 JÆm )2 ), although inducing a strong activation of JNK1/2 and only a very weak phosphorylation of p38, had no effects on C TGF expression, which ruled out ... expression occurs via increased transcription and/ or by stabilization of the CTGF transcripts and t he role of RhoA GTPase and p38 signaling in such a regulation, nuclear run -o...
Ngày tải lên : 19/02/2014, 16:20
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