Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... Cork, Ireland
(Received 16 February 2 010 , revised 19
March 2 010 , accepted 23 March 2 010 )
doi :10 .11 11/ j .17 42-4658.2 010 .076 61. x
Activation of the c-JUN N-terminal kinase (JNK) pathway is implicated ... c-JUN
N-terminal kinase (JNK) stimulatory phosphatase 1 is
necessary for its activation of JNK signaling and apoptosis
Ulla Sc...
... + 81 29 853 4490
Tel: + 81 29 853 5600 (5466)
E-mail: yokokawa@ims.tsukuba.ac.jp
(Received 9 March 2 011 , revised 24 May
2 011 , accepted 16 June 2 011 )
doi :10 .11 11/ j .17 42-4658.2 011 .08222.x
Studies of ... events, and k
1
is the rate
constant. The obtained rate constants (k
1
) were
0 .15 ms
)1
at 10 nm ATP and 0 .17 ms
)1
at 10 0 lm
Fig. 2. Histograms of...
... (2 011 ) 11 90 12 02 ª 2 011 The Authors Journal compilation ª 2 011 FEBS
VirB5 then forms a complex with VirB2, which is a
key step in the formation of the T4SS pilus assembly
subcomplex. A model for ... ª 2 011 FEBS 11 93
Type IV secretion in H. pylori pathogenesis N. Tegtmeyer et al.
11 94 FEBS Journal 278 (2 011 ) 11 90 12 02 ª 2 011 The Authors Journal compilation ª 2 0...
... Epac and
the small GTPase Rac [11 1 ,11 2]. This recently led to
synthesis and evaluation of novel 5-HT4-agonists; two
of them increased APPs-a production in the cortex
and hippocampus of mice and ... January 2 010 )
doi :10 .11 11/ j .17 42-4658.2 010 .07566.x
A decade ago, a disintegrin and metalloproteinase 10 (ADAM10) was iden-
tified as an a-secretase and as a key p...
... July
2 010 , accepted 11 August 2 010 )
doi :10 .11 11/ j .17 42-4658.2 010 .07828.x
Regulation of gene expression is fundamental in all living organisms and is
facilitated by transcription factors, the single ... activity of HSF1 and HSF2
is needed for normal spermatogenesis and male fertility
[11 5]. The finding that HSF1 and HSF2 physically
interact in lysates of...
... -2, -3, -10 , and -11
relative to the cleavage site. The leader sequence inter-
acts with the TOM receptor, responsible for the trans-
location of the preproteins to the translocase of the
inner ... ATP
concentration for 10 min at 30 °C with
0.5 l
M of purified protein. MDL1 (A) and
MDL1(60-695) (B) showed Michaelis–
Menten kinetics with a K
m ATP
of
12 0 ± 6 l...
... observed. The other two components of the nuage,
Nanos and Tudor, exhibit diffusion constants of 1. 7
0
0.2
0.4
0.6
0.8
1
1.2
0 10 203040
0
0.2
0.4
0.6
0.8
1
1.2
1. 4
A
B
1 10 10 0 10 00 10 000 10 0 000
Time ... together and apart in this time
scale. Arrowheads show the assembly and dissociation points.
0
0.2
0.4
0.6
0.8
1
1.2
0 5 10 15 20
0
0.4
0.8
1. 2
1....
... Bacterial 15 .00 3.60 1fdr [10 ]
a
Angle formed between the tyrosine and the re-face of isoalloxa-
zine, measured as shown in Fig. 2A.
b
Distance (d ) from the center
of the phenol ring to the center of ... coplanar to the re-face of
the isoalloxazine moiety and interacts extensively with
it (Fig. 1A) ( [1, 2 ,13 ] and references therein). This tyro-
sine has been...
... miR16
and miR105 have a 5¢-end of precursor form in the
mature form and miR142, miR17, miR302, miR373
and miR9 have both ends in mature forms
[7 ,16 ,17 ,24]. Even though the molecular mechanism of
miR ... dsl@plaza.snu.ac.kr
*These authors contributed equally to this
work
(Received 18 January 2008, revised 10
March 2008, accepted 17 March 2008)
doi :10 .11 11/ j .17 42-4658...