Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... antiapoptotic
activity of epidermal growth factor by promoting the
ubiquitylation and degradation of the truncated C-terminal
portion of Bid
Bilal A. Azakir, Guillaume Desrochers and Annie Angers
De
´
partement ... tBid levels and the ubiquitin ligase activity of Itch.
In this study, we first examined the ability of Itch to
interact w...
... product by isoform 2
mRNA (Fig. 4B). The product by isoform 1 mRNA
was smaller than the isoform 2 product. The multiple
bands may be explained by incomplete translation
from truncated mRNA synthesized ... RT-PCR to study the tissue-specific use of
each promoter. We show the translation initiation site
of isoform 2 and different intracellular distribution of
isoforms 1...
... the scale of the Bard’s genera-
tivity, and the quality of its insights.
5 Empirical Evaluation
The vastness of the web, captured in the large-
scale sample that is the Google ngrams, means the
Jigsaw ... instances of the patterns
“as ADJ and * as” and “as * and ADJ as” from
Google, noting the combinations that are found and
their frequencies. These frequ...
... proliferation and cell death [27]. The functional
roles of the activation of these kinases are often con-
troversially discussed. The ERK1 ⁄ 2 cascade is
regarded to be the main method of transmission ... translocation and
cytochrome c release are suppressed by NAC
To investigate the effects of ROS on Bax translocation
and cytochrome c release, the levels of Bax...
... Effect of MAFP on the growth of U937 cells. (A) Dose–
response curve for the effect of MAFP on the Ca
2+
-independent
PLA
2
activity of U937 cell homogenates. The substrate was pre-
sented in the ... better with the kinetics of its catabolism rather
than synthesis [23,33,35], and the involvement of
iPLA
2
-VIA in the homeostatic regulation of mem-
brane pho...
... carried out a total of 572 conversa-
tions with the system. Because of the variety of pos-
sible exercise barriers known by the system (52 in
total) and the fact that some of these barriers are
more ... (composed of the values of the features listed
in Table 2). For instance, in the p
a
policy, the deci-
sion in the last row of the table (give a joke or n...
... an unit and any other domains, domainj
seems to be the domain of unit~. The system se-
lects the domain which is the largest of all sim-
ilarities in N of domains as the domain of the
unit ... firstly, the system divides radio news into
segments according to the length of pauses. We
call the segments units. The domain which has
the largest similarity be...
... than the conviction on the part of the terminal
operators that they are in control of the system and
not the system in control of them. Equally, nothing
can be more damaging to satisfactory ...
regardless of how well all other aspects of the imple-
mentatlon have been handled, than the operator's con-
viction that the terminal and thus ~he @~t.e~ ~re i...
... 4). Both the heterogeneous bands at 80 kDa
and the group of bands at 65 kDa were recognized
by the anti-HA serum (Fig. 4B, lanes 4 and 5). As
these proteins are also recognized by the anti-FLAG
serum, ... suggesting
that the N-terminal portion of the protein containing
the HA epitope was lost from these proteins by pro-
teolysis.
To determine which of the...
... stress
conditions.
Degradation pathway of Egd2 ubiquitinated by
Rsp5
To explore the pathway involved in degradation of the
ubiquitinated Egd2, we first examined the protein lev-
els of Egd2 by western ... regulate the expression of many proteins at the
transcriptional and post-translational level, because
Rsp5 is known to regulate the activity of the RNA
pol...