Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx

... Journal compilation ª 2010 FEBS X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate Kalyan Sundar Chakrabarti*, ... basis for the homotropic inhibition of pantothenate synthe- tase by the substrate pantoate was investigated by X-ray crystallography an...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

... mediated by other mammalian difla- vin reductases and also subdomains of MSR; (b) the extent of reductive remethylation of hMS catalysed by the different redox states of MSR; and (c) the ability of ... cob(II)alamin. Reduction of the Co centre promotes the dissociation of the lower dimethylbenz- imidazole base of the cofactor. Consistent with this, the c...
Ngày tải lên : 18/02/2014, 08:20
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Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc

Tài liệu Báo cáo khoa học: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory doc

... FTHF to the Gly binary complex. The results highlight the role of E53 in bind- ing of THF ⁄ FTHF and in the proper positioning of l-Ser for direct attack by N5 of THF. The structure of E53QbsSHMT ... held by hydrogen bonding interaction with the phenolate oxygen of Y51, N of G257 and NE2 of Q53 of the symmetry related subunit. Another oxygen atom is hel...
Ngày tải lên : 18/02/2014, 16:20
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Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... that the data were described best by a two-binding site model. The IC 50 (the concentration of the competing ligand that inhib- its 50% of the specific binding of [ 125 I]TC-PCSK9) val- ues for the ... are assumed, then about 70% of the high-affinity sites and about 12% of the low-affinity sites are expected to be occupied at the concen- trations of unlabeled li...
Ngày tải lên : 14/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... membrane, although the nature of the cellular signal required and the mecha- nism of its transduction are still a matter of debate [14,15]. The third, major part of the T3SS is the ‘translo- con’, ... mem- brane-associated and faces the bacterial cytoplasm, and is suggested to be involved in facilitating the entry of export substrates into the secretion sys...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx

Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx

... expression of T-bet has been seen within a wide variety of tissues and cells in the Ginbuna crucian carp [27] and, in mammals, in the lung tissue of mouse and spleen and thymus of human and mouse ... CD4 + CD25 + Foxp3 + T reg or whether they induce the production of these cytokines from another population of cells [20]. To date, our knowledge about the different...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... without fat, of WT and H-PGDS TG mice (n = 6). Continuous dissections of mouse fat and bone in the whole body were quantified by use of a micro-CT scanner and LATHETA software (Aloka). Open and closed ... obesity. Experimental procedures Generation of H-PGDS TG mice The coding region of human H-PGDS was cloned into the downstream sites of the chicken b-actin pro...
Ngày tải lên : 16/02/2014, 09:20
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... Y5 and y6) that vary in their binding profiles and in their distribution in the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of ... stromal cells and osteoblasts [40,46–48], despite the absence of the other Y receptors (Y2, Y4, Y5 and y6) [40,46]. In addition to the presence of NPY-immunoreactive...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf

Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf

... organelle and membrane proteins are synthe- sized and folded with the assistance of molecular chap- erones and other folding factors in the endoplasmic reticulum (ER). In many cases, the process of ... synthesis of storage proteins was initiated. These results suggest that GmPDIL-3a and GmPDIL-3b may play important roles in the maturation of the cotyledon by mechan...
Ngày tải lên : 18/02/2014, 11:20
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

... [20]. The role of SREBP-1a in the regulation of cell growth and the cell cycle might be biphasic and complex, and needs to be further investigated. SREBP is evolutionarily conserved; however, the key ... inhibit lipogenesis and lower tissue and plasma triglyceride levels through inhibition of SREBP-1c. The molecular mechanisms by which PUFAs inhibit SREBP-1c are...
Ngày tải lên : 18/02/2014, 13:20
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