Tài liệu Báo cáo khoa học: Epidermal growth factor receptor

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt

... of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 98, 1817–1824. 13 ... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor ty...

Ngày tải lên : 16/02/2014, 09:20

8
684
0

Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc

... of EGFR (EGFR- TKIs), geﬁti- nib and erlotinib, compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling ... MINIREVIEW Epidermal growth factor receptor in relation to tumor development: EGFR- targeted anticancer therapy Isamu Okamoto Department of Medical Oncology, Kinki...

Ngày tải lên : 16/02/2014, 09:20

7
511
0

Tài liệu Báo cáo khoa học: Human intrinsic factor expressed in the plant Arabidopsis thaliana doc

... trans- porting proteins and several receptors which together ensure its efﬁcient uptake [2–4]. Intrinsic factor (IF) is responsible for intestinal absorption of vitamin B 12 facilitating its internalization ... ligand 30 l M (dash-dotted line) is given for a comparison. Fig. 3. Binding of Cbl and Cbi to recombinant and gastric IFs. Radio- active ligand Cbl* was prevented from bindin...

Ngày tải lên : 21/02/2014, 00:20

6
492
0

Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx

... listed in Table 1, we blocked EGFR signaling with gefitinib. Gefitinib is an inhibitor of tyrosine kinase that competes with ATP for binding to the intracellular kinase domain, preventing receptor ... expression in a subset of human lung cancers To gain further insights into the role of miR-125a-5p in lung carcinogenesis and to examine the clinical rele- vance of our findings,...

Ngày tải lên : 07/03/2014, 00:20

8
536
0

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): a unique metalloprotein ppt

Ngày tải lên : 16/02/2014, 15:20

1
363
0

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): structure–function relationships docx

... growth- inhibitory factor; hGIF, human neuronal growth- inhibitory factor; MT, metallothionein; NO, nitric oxide; pDB, protein data bank; rlMT2, rat liver MT2; sGIF, sheep neuronal growth- inhibitory factor; ... important role in modulating the stability of the metal–thiolate cluster and conformation of the b-domain by domain–domain interactions, thus altering zinc homeostasis in...

Ngày tải lên : 16/02/2014, 15:20

9
552
0

**Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal–thiolate clusters* doc**

... [M(II) 3 - Cys 9 ], including three bridging and six terminal cysteines. The C-terminal a-domain (amino acids 31-61) binds four divalent metal ions by 11 deprotonated cysteines in an adamantane-like ... growth- inhibitory factor (GIF) [1] because of the discovery that it is a factor in brain extract with the ability to inhibit neuronal outgrowth. Moreover, MT3 or GIF was report...

Ngày tải lên : 16/02/2014, 15:20

10
569
0

Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf

... MINIREVIEW Neuronal growth- inhibitory factor (metallothionein-3): evaluation of the biological function of growth- inhibitory factor in the injured and neurodegenerative brain Claire ... distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth- inhibi- tory factor within the brain, particularly in response...

Ngày tải lên : 16/02/2014, 15:20

9
664
0

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... protein expression were prevented by GdCl 3 . In addition, elevated serum con- centrations of tumor necrosis factor- a and interleukin-6, and increased hepatic mRNA...

Ngày tải lên : 14/02/2014, 18:20

11
769
0

Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... corre- spond to the ﬂexible importin-b binding domain. The importin-b binding domain is known to have an autoinhibitory function, whereby an internal NLS-like sequence competes for the importin-a binding ... the binding pocket. In total, the CLIC4 NLS main chain and side chains make 174 atom -to- atom van der Waals’ contacts with importin-a and 13 hydrogen bonds, including one salt...

Ngày tải lên : 14/02/2014, 19:20

14
741
0