Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Báo cáo khoa học: Adipocyte hyperplasia and RMI1 in the treatment of obesity doc

Báo cáo khoa học: Adipocyte hyperplasia and RMI1 in the treatment of obesity doc

... December 2010) doi:10.1111/j.1742-4658.2010.07980.x The escalating prevalence of obesity is one of the most pressing health concerns of the modern era, yet existing medicines to combat this global pandemic are disappointingly limited in terms ... a deficiency in Skp2, the substrate-binding subunit of the SCF Skp2 complex, contributes to the degradation of p27 Kip1 ,...
Ngày tải lên : 06/03/2014, 01:20
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Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

Tài liệu Báo cáo khoa học: Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases pptx

... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia. Similarly, hyperleptinemia is a consequence of the development of insulin resistance in ... overexpression of ANG- PTL6 ⁄ AGF in the liver of diet-induced obese mice results in elevated ANGPTL6 ⁄ AGF serum levels and amelioration of diet-...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

Tài liệu Báo cáo khoa học: Domain deletions and substitutions in the modular protein evolution doc

... domain deletions are more com- mon at either of the protein termini, and that their occurrence is slightly higher at one of the termini, depending on the number of domains in the protein and the ... combinations are the P-loop nucleotide triphosphate hydrolase domain, the epider- mal growth factor (EGF) domain, the SH3 domain, the P-kinase domain and the doma...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... MINIREVIEW Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity Michael J. Wolfgang and M. Daniel Lane Department of Biological Chemistry, The Johns Hopkins University School of Medicine, ... nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The major challenge to understand...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

Tài liệu Báo cáo khoa học: A systems biology approach for the analysis of carbohydrate dynamics during acclimation to low temperature in Arabidopsis thaliana doc

... metabolism in the cold. Mathemati- cal modelling and simulation of cold-induced metabolic reprogramming indicated major differences in the rates of interconversion between the pools of hexoses and sucrose, ... assessment of the trajec- tory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various int...
Ngày tải lên : 14/02/2014, 22:20
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... 3665 (ruling out the possibility of an autocrine, paracrine or endocrine mechanism of regulation in the ob ⁄ ob model), and given that the majority of leptin receptors exist in the arcuate nucleus of ... Y5 and y6) that vary in their binding profiles and in their distribution in the central nervous system and periphery. Y1, Y2 and Y5 are the best charact...
Ngày tải lên : 18/02/2014, 04:20
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf

Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf

... higher than for the THF:A ligand. The presence of Mg 2+ had little effect on the binding of Fpg to the THF:C ligand and slightly improved binding to the THF:A ligand, making it comparable with binding to ... decrease in binding at 0 and 500 mm KCl [32]. Thus, to address the in uence of the reaction conditions on the binding of Fpg and OGG1 to damaged DNA, we d...
Ngày tải lên : 18/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

... kinetically in uential ionizations were identified in plots of k lim ⁄ K d of pK a values 7.1 and 9.3, again with the maximum value realized in the alkaline region. The poten- tial origin of these kinetically ... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-r...
Ngày tải lên : 19/02/2014, 07:20
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc

... argues against a role for a3inthe formation of native MII binding sites, but may reflect the scarcity of these sites in the investigated brain tissues and/ or the formation of low affinity binding sites ... studies. The high selectivity of the a-conotoxins, together with the possibility of obtaining detailed information on their three dimen- sional structures and the...
Ngày tải lên : 19/02/2014, 12:20
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Tài liệu Báo cáo khoa học: "Hidden Markov Tree Model in Dependency-based Machine Translation∗" pptx

Tài liệu Báo cáo khoa học: "Hidden Markov Tree Model in Dependency-based Machine Translation∗" pptx

... states 1 in the tree nodes, given another (observable) labeling of the nodes of the same tree. The second novel claim is that HMTMs are suitable for modeling the transfer phase in Ma- chine Translation ... unexploited in the field of Computational Linguistics, in spite of highly successful Hidden Markov (Chain) Models. In dependency trees, the independence assum...
Ngày tải lên : 20/02/2014, 09:20
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