... December
2010)
doi:10.1111/j.1742-4658.2010.07980.x
The escalating prevalence of obesity is one of the most pressing health
concerns of the modern era, yet existing medicines to combat this global
pandemic are disappointingly limited in terms ... a
deficiency in Skp2, the substrate-binding subunit of the
SCF
Skp2
complex, contributes to the degradation of
p27
Kip1
,...
... in ammation induces a state of ‘leptin resistance’
in obese animals and humans resulting in development
of hyperleptinemia. Similarly, hyperleptinemia is a
consequence of the development of insulin resistance
in ... overexpression of ANG-
PTL6 ⁄ AGF in the liver of diet-induced obese mice
results in elevated ANGPTL6 ⁄ AGF serum levels and
amelioration of diet-...
... domain deletions are more com-
mon at either of the protein termini, and that their
occurrence is slightly higher at one of the termini,
depending on the number of domains in the protein
and the ... combinations are the P-loop
nucleotide triphosphate hydrolase domain, the epider-
mal growth factor (EGF) domain, the SH3 domain,
the P-kinase domain and the doma...
... MINIREVIEW
Hypothalamic malonyl-CoA and CPT1c in the treatment
of obesity
Michael J. Wolfgang and M. Daniel Lane
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, ... nutrient sensing in the
brain and is an example of an enzyme that can sense
and respond to the nutritional environment. The major
challenge to understand...
... metabolism in the cold. Mathemati-
cal modelling and simulation of cold-induced metabolic reprogramming
indicated major differences in the rates of interconversion between the
pools of hexoses and sucrose, ... assessment of the trajec-
tory of interconversion rates as a function of time of
cold exposure, (b) comparison of the magnitudes of
the various int...
... 3665
(ruling out the possibility of an autocrine, paracrine or
endocrine mechanism of regulation in the ob ⁄ ob
model), and given that the majority of leptin receptors
exist in the arcuate nucleus of ... Y5 and y6) that
vary in their binding profiles and in their distribution
in the central nervous system and periphery. Y1, Y2
and Y5 are the best charact...
... higher
than for the THF:A ligand. The presence of Mg
2+
had
little effect on the binding of Fpg to the THF:C ligand
and slightly improved binding to the THF:A ligand,
making it comparable with binding to ... decrease in binding at 0 and
500 mm KCl [32]. Thus, to address the in uence of the
reaction conditions on the binding of Fpg and OGG1
to damaged DNA, we d...
... kinetically in uential
ionizations were identified in plots of k
lim
⁄ K
d
of pK
a
values 7.1 and 9.3,
again with the maximum value realized in the alkaline region. The poten-
tial origin of these kinetically ... substrate carbinolamine intermediate;
III, iminoquinone intermediate; IV, product Schiff base intermediate;
V, aminoquinol intermediate. In the oxidative half-r...
... argues against a role for a3inthe
formation of native MII binding sites, but may reflect the
scarcity of these sites in the investigated brain tissues and/ or
the formation of low affinity binding sites ... studies. The high
selectivity of the a-conotoxins, together with the possibility
of obtaining detailed information on their three dimen-
sional structures and the...
... states
1
in the
tree nodes, given another (observable) labeling of
the nodes of the same tree.
The second novel claim is that HMTMs are
suitable for modeling the transfer phase in Ma-
chine Translation ... unexploited in
the field of Computational Linguistics, in
spite of highly successful Hidden Markov
(Chain) Models. In dependency trees,
the independence assum...