why water is essential for fat loss how much you need and what else you should and shouldn t drink
Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... augmented PTB expression Taken together, these data suggest that PTB is a key factor in switching of cell identity through mitotic phase modulation PTB is a multifunctional protein that is involved ... identity is of the target protein regulated by PTB in the mitotic phase and how this target protein modulates mitosis and cell proliferation The answers to these questions will provide novel insights ... from the block and fixed them at the time points indicated in Fig 5C, and then analyzed the DNA contents of the cells by flow cytometry Up until h after the release, the DNA content patterns were essentially...
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Báo cáo khoa học: Replacement of two invariant serine residues in chorismate synthase provides evidence that a proton relay system is essential for intermediate formation and catalytic activity docx
... catalytic activity, indicating that replacement of both serine residues produces a synergistic effect This result is consistent with the inability of the double-mutant protein to form the transient ... experiments (Fig 4) For the Ser16AlaSer127Ala doublemutant protein we were not able to detect the intermediate This demonstrates that the Ser16AlaSer127Ala double-mutant protein, in contrast to the ... were able to initiate a structure-based mutagenesis study to test mechanistic proposals In our first study we demonstrated that the invariant histidine residues (His17 and His106) function as general...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... AAAAGGATCCAAATGGCCAAAGCCGCGGCG TCGGGTACCGGATCTACCTCCTCAATGGTG CTGATGGGGGACTCCTACGCCTTCAACATGAAGAGC GAAGGCGTAGGAGTCCCCCATCAGGATGGCCGCCTG AAAAGGATCCAAAGTCCGAGAACTGGCAGGAC TCGGGTACCGGATCTACCTCCTCAATGGTG ... [23] However, the results obtained in the present study suggest that the inhibitory effect of HSP70 on the release of Smac and H2O2-mediated and Smac-promoted apoptosis is not attributable to a ... either kept untreated or treated with 0.5 mM of H2O2 for h, then harvested, lysed under conditions that kept mitochondria intact, and centrifuged to obtain a supernatant (Cyto) and a pellet fraction...
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Báo cáo khoa học: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre doc
... 5¢-GGTGGTA GATGATCGGCAAGGTTTGC-3¢), C130S (forward 5¢CCAATTGGTGTGCTAAAGACTTTG-3¢/reverse 5¢-AA GGATAAATATGTGAGAAGATATTC-3¢), C133 (forward 5¢-CTTTGAAAAATATATCAGAGAAAATG-3¢/ reverse 5¢-TCTTTAGCAGACCAGTTGTAAGG-3¢), ... 5¢-TCTTTAGCAGACCAGTTGTAAGG-3¢), C159S (forward 5¢-GCCCACAATAAAGTCAATAAG AAAT-3¢/reverse 5¢-CTCAGACATCCACCTCCCAAG TTCTT-3¢), C176S (forward 5¢-CTCCAATTTCTGG GAAAAAAGATGGAAG- 3¢/reverse 5¢-TCAAATTTGG GCTTCCTCAATTTC-3¢) ... N- and the C-terminal parts of the proteins [8,10] The hatched area marks the part of Erv2p whose structure has been solved [11] GTTTGCCATCTTCG-3¢), C33 (forward 5¢-CTACTT GACTTTCAGTACGTGACC-3¢/reverse...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... dimer formation [24] Fourthly, the C-terminal domain of HSP90 contains a client-binding site with characteristics distinct from those of the site located at the N-terminal domain [14–17] This C-terminal ... settle this issue, we reinvestigated the domain–domain interaction of human GRP94 by use of the bacterial two-hybrid system Table shows that the dimerization was mediated via the interaction between ... is truly indispensable for client binding or simply present adjacent to the client-binding site with the result of being affinity-labeled with the client peptide This issue is now under investigation...
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Báo cáo khoa học: The mitochondrial protein frataxin is essential for heme biosynthesis in plants potx
... fact that the decrease in catalase activity correlates with the deficiency in heme content, and the observation that the normal enzymatic activity is recovered after addition of hemin, but not the ... Cornah et al [30] and Masuda et al [42] reported that most FC activity was associated with plastids Lister et al [43] found that either of the two FC isoforms from A thaliana were imported into chloroplasts ... frataxin-deficient plants constitute a good model to study the biogenesis of cellular hemeproteins Alteration of heme pathway transcripts in plants with AtFH deficiency To better understand the...
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Báo cáo khoa học: ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature potx
... at only 0.8–1% of the 25 °C activity (data not shown) This is surprising, considering the fact that the protein displayed approximately 30% ATPase activity at °C This suggests that the DNA strand ... molecule for the hydrolytic reaction, and their alteration causes reduction in the ATPase and DNA-unwinding activities [17,18] Consistent with this, the present study demonstrates that D323N and E324Q ... substrates [32,33] Importantly, however, T2 59A is active in supporting growth of CS1 at °C Retention of the biological activity suggests that the uncoupled ATPase activity in the mutant protein...
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Báo cáo sinh học: "Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance" ppt
... did not rescue either chico or PI3K mutant phenotypes (data not shown) are consistent with the hypothesis that Imp-L2 acts upstream of the intracellular IIS cascade at the level of the ligands ... nutritional conditions, fat body cells with increased IIS activity continue stockpiling nutrients, thereby limiting the amount of circulating nutrients, which induces hypersensitivity to starvation ... point mutation that resulted in a truncation (Trp232Stop) In order to generate additional Imp-L2 mutants, the Pelement GE24013 (marked with white+) inserted 102 bp upstream of the first exon of the...
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Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... data on taking home replacement therapy (HRT) suggests that the loss of estrogen inactivation may be an important mechanism in the pathogenesis of colonic cancer [41] Studies suggest that estrogen ... tumour tissues than normal tissues [26] uPA upregulated in colon tumor tissue enhances colorectal cancer invasion and metastasis, and this upregulation in uPA is correlated with Dukes’s staging and ... culture with drug dose test YML and WWK performed Immunoblotting assay LMC and WKC performed cell motility assay JMH and FJT performed integrity of the data and the accuracy of the data analysis CJL...
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báo cáo khoa học: " Glutathione synthesis is essential for pollen germination in vitro" ppt
... out the electron and light microscopical work and drafted the manuscript BK participated in electron and light microscopical studies, and performed quantitative and statistical analysis of the ... Results of this study demonstrated that the application of BSO together with IAA diminished the deleterious effects of BSO and led to pollen germination rates similar to that of control pollen The ... or post stained with uranyl-acetate (2% dissolved in double distilled water) for 15 s Post staining with uranyl acetate was applied to facilitate the distinction of different cell structures...
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báo cáo khoa học: " Novel genes for QTc interval. How much heritability is explained, and how much is left to find?" pdf
... architecture of this complex trait Future and existing QT GWA study results have and will continue to identify important and potentially novel biochemical pathways for patho hysio p logy and therapeutics ... more weight to SNPs with larger effect and is standardized in such a way that the risk score lies between and 22, that is, the maximum number of risk alleles This model was then validated in an ... identified risk genes can therefore potentially advance drug development by highlighting novel thera peutic targets, or refocusing existing efforts for drug development to target, for example, the...
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báo cáo khoa học: " Sgt1, but not Rar1, is essential for the RB-mediated broad-spectrum resistance to potato late blight" pptx
... resistance, but the same plants still held the Mi-1-mediated root-knot nematode resistance These results support the hypothesis that plant R proteins differ in the amounts of SGT1 needed to trigger ... essential for the RB-mediated broad-spectrum resistance to potato late blight Results Identification of the potato Rar1 and Sgt1 genes A search of the Institute for Genomic Research (TIGR) potato database ... Rar1silenced plants and other resistant controls but revealed significant differences with the susceptible control, Katahdin These results show that the RB-mediated resistance was not affected in the Rar1...
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báo cáo khoa học: " Ornithine-δ-aminotransferase is essential for Arginine Catabolism but not for Proline Biosynthesis" ppsx
... of the TDNA flanking sequences Gene specific primers were: Oatf: 5'agtcttggattaacttaggagag, Oat-r: 5'gtcccatatagttgagccattc for oat1 and oat2; Oat-f2: 5'gctttcatggacgtacattag, Oat-r2: 5'caagtatcaccatgtcaggac ... 5'ctggatccgactctaatggcagccaccac and 5'ctggatccgcatagaggtttcttccac The resulting PCR product was cloned via the introduced BamHI sites into the vector pEZT-NL (Dave Erhardt, [46]) Agrobacterium tumefaciens ... confirmation of the predicted localisation of δOAT in mitochondria using a δOAT-GFP fusion protein With the use of loss- of-function T- DNA insertion mutants we demonstrate that δOAT is essential for...
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Báo cáo y học: " PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line" ppsx
... candidates to mediate Tax1 activity in HTLV-1-infected T- cells We recently showed that Tax2, through the activation of transcription factor NFAT, constitutively induces the expression of IL-2, and the ... Binding Motif Tax351A EAEV Tax353A ETEA Figure Structure of Tax1, Tax2B and their mutant proteins Structure of Tax1, Tax2B and their mutant proteins The amino acid sequence of PBM and its mutants are ... after transfection (Figure 3A) These results indicate that Tax∆C still has IL-2-independent growth inducing activity in CTLL-2 cells, but the activity is much less than that of Tax1 Both Tax2B and...
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Báo cáo y học: " Number of active transcription factor binding sites is essential for the Hes7 oscillator" pptx
... intermediate synthesis steps such as transport, elongation and splicing to be subsumed in the delays Thus, only two equations are needed, one for the mRNA and one for the protein, in contrast to ... differential equations The system reads dp (t ) = am (t − Tp ) − bp (t ), dt dm = k ⋅ fh ( p (t − Tm ) ) − cm (t ), dt ( 3) where p (t) and m (t) denote the amounts of Hes7 mRNA and Hes7 proteins at time t ... sensitive to changes in the Hill coefficient Is this inherent in the Hes7 oscillator or is it just an artefact of the model? http://www.tbiomed.com/content/3/1/11 References 10 11 12 Therefore, it...
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LUẬN MẪU LỚP 12 Discuss the view that tolerance is essential for peace and harmony in any community or country
... fight or concealment whenever there is a threat to personal security It is in moments of desperation that courage asserts itself and enables one to meet all threats; and it is in such moments that ... protection of his master Thus, courage is the most important quality in man He needs it for his own advancement and to meet all the challenges of his existence New words: obstacle (n): cản trở, ... who is devoted to his family fights tooth and nail to protect his family from destruction or extinction, whatever the consequences to himself Similarly, a loyal servant may give his life for the...
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Mypt1 mediated spatial positioning of bmp2 producing cells is essential for liver organogenesis
... epiblasts (Wells and Melton, 1999) The visceral endoderm is an extraembryonic tissue to nourish the early embryo and does not give rise to embryonic tissue but to the yolk sac To distinguish with the ... intrinsic transcriptional factors and interaction with other tissues There are two phases: first the proliferative hepatoblasts invade the STM to form a distinct liver organ by E9.5; then hepatoblasts ... covering the bottom surface of the developing embryo (Wells and Melton, 1999) The sheet then forms a gut tube with invaginations at the anterior and posterior ends of the tube to generate the foregut...
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Genetic approaches to study liver development in zebrafish core component sec13 in COPII complex is essential for liver development in zebrafish
... with a relatively small numbers of differentiated cell types This characteristic has made the liver an attractive system for scientists to investigate organogenesis and tissue development for ... acquire hepatic competency This is consistent with morphogenic pattern during this stage, which results in the invagination of the foregut and juxtaposing of the ventral endoderm with the developing ... endoderm tissue They found that although gata6 is not necessary for hepatic specification, it is essential for hepatoblast proliferation and differentiation (Zhao et al., 2005) Interestingly,...
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Tài liệu Crack the Fat-Loss Code: Outsmart Your Metabolism and Conquer the Diet Plateau ppt
... popular protein-heavy, low-carb diets But what is fact, and what is fiction? What is myth, and what is reality? To cut through the fat, so to speak, and better understand the role of protein in the body, ... lost weight and kept it off That’s because Wendy’s program is more than a diet; it’s a lifestyle It teaches you how to eat what works for you rather than tell you what you must eat and when It’s ... to think of fat in the diet We need it, just not so much of it Unsaturated Fats: Polyunsaturated and Monounsaturated Like proteins, not all fats are created equal The more natural a fat is, the...
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