... to their study are considered to be valid if
performed carefully.
Isolation of lipid rafts ⁄ caveolae is very often the first
step inthe biochemical analysis oftheroleof these
domains in cellular ... Considering the exquisite specificity of
different purinergic receptors for different purinergic
compounds [6], this extracellular processing of nucleo-
tides is crucial in determining the final ... (glycero-)sphingolipids. In addition the
fatty acid chains ofthe phospholipids composing
these rigid domains are generally more saturated than
those inthe lipids ofthe surrounding membrane. In
fact, this fatty...
... Leiden, the Netherlands
Lactoferrin (LF) is an iron-binding glycoprotein of the
innate host defence system. To elucidate theroleof N-linked
glycosylation in protection of LF against proteolysis, ... Properties ofthe iron-binding site ofthe N-terminal lobe of
human and bovine lactotransferrins. Importance ofthe glycan
moiety and ofthe non–covalent interactions between the N- and
C-terminal ... considering oral application of lactoferrin where the
protein has to survive the harsh environment ofthe gastro-
intestinal tract. Thus, on the basis of this study, rhLF may
be preferred over bLF in...
... teaching methods Thereby, the
author offers the following solutions: clearly aware ofthe importance of building,
developing and improving the quality of human resources; continue promoting
innovation ... HR isthe
working ability ofthe society, including the population groups at working ages
likely to participate in working - production, ie all individuals can participate inthe
working process, ... A synthesis of physical and mentality
capacity existing in all people who will join the social labor force and capable of
fulfilling the objectives and tasks ofthe process, in which the growth...
... The tumor invades the
cervical stroma (arrowhead). c DWI with b = 1,000 s/mm
2
shows a
well-defined hyperintensity mass inthe cervical area. The shape of
the uterine cervix is distorted inthe ... of peritoneal dissemination is
rendered difficult by the poor contrast resolution vis-a-vis
surrounding organs. DWI clearly discriminates the abnor-
mal signal intensity of peritoneal dissemination ... controls).
Further study using larger numbers of patients is needed
to establish the accuracy of ADC measurement in
monitoring the effect of therapy for uterine cervical cancer.
For the diagnosis, McVeigh et...
... normalization.
7
Following
Pang et al. (2002), we use frequency as presence.
In other words, the ith element ofthe document
vector is 1 if the corresponding unigram is present
in the document and 0 otherwise. The ... natural language processing systems.
We will focus on an important linguistic aspect
of polarity classification: examining theroleof a
variety of simple, yet under-investigated, linguis-
tic knowledge ... re-
moving them from the reviews is not effective in
terms of improving performance. To determine the
reason, we examine the n-grams and the depen-
dency relations that are extracted from the non-
reviews....
... ⁄ ))]. These results indicate
that a functional deletion of Synoviolin causes a change
in the intracellular trafficking of NCT.
Effect of Synoviolin on the production of Ab
NCT is one ofthe essential ... expansion ofthe recognized roles
for ubiquitin in processes other than proteasome-
dependent proteolysis, which includes intracellular
trafficking (reviewed in [13]). In this regard, it is note-
worthy ... Further study of the
mechanism underlying NCT degradation mediated by
Synoviolin, including an in vitro study, is needed.
It was also noted that the overexpression of Syno-
violin increased the...
... outlines some ofthe basic IdM processes. The
range of conceptions of identity is very broad. The examination ofthe following concepts is for the
purposes of this Primer only and recognises ... within the organisation. The organisation isin some sense
wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same
information.
Nonetheless, there ... managing and protecting digital identities, with
a view to strengthening confidence inthe online activities crucial to the growth ofthe Internet Economy.
The primer is a product ofthe Working...
... used to describe the binding
isotherms obtained previously for the b-casein 1–25 phos-
phopeptide in this pH range, and the same model was
adapted to fit the binding isotherm of OPN 1–149 mea-
sured ... that
their ratio is unchanged.
Notwithstanding the difference in hydration in the
core, it is most probable that the core is amorphous,
similar to CaP in casein micelles and the core CaP of
casein ... on the assumption that all the peptides
in the OPNmix sample had the same binding isotherm
as OPN 1–149. The complete model of ionic equilibria
was then used to calculate the composition of an...
... (2007), they are set taking into account the performance
sensitivity of funds’ clienteles. This is especially relevant inthe context ofthe recent debate
in the literature regarding the sensitivity ... feature of our sample is that it is free of survivorship bias, since the
CRSP dataset contains information on all funds operating during the entire sample period
and since we obtained historical lists ... tracking thein ows
of new money into mutual funds) does not differ from that of a “smart-money” portfolio of
conventional funds.
5 Concluding Remarks
In this paper, we revisit the question of whether...
... least in this cell line.
Although we failed to see an increase inthe shedding of
APP upon incubation ofthe cells with APMA, the
shedding of ACE was increased several-fold. The soluble
form of ... shedding of ACE
indicating that this ADAM is not involved. ASO knock-
down also revealed that ADAM10 was not involved in
the APMA induced shedding of ACE. It remains to be
determined whether the ... metalloproteases
are involved inthe shedding of individual membrane
proteins and that further work is required to elucidate
the physiological role played by each enzyme in the
increasingly complicated process of...
... denatured
heavy chains [38], and W6/32 that binds to the combined
epitope contributed by the α2 and α3 domains of the
heavy chain and β2m, dependent on the presence of pep-
tides inthe peptide-binding groove ... participated inthe generation
of the tissue array and performed analysis of IHC. BR per-
formed flow cytometry analysis. EJR performed analysis of
IHC and participated inthe writing ofthe manuscript.
MRC ... advan-
tage of this study is that MHC class I processing machinery
was analyzed in greater detail, by examining expression of
HLA heavy and light chains and TAP2 subunit. In addi-
tion, other molecules,...