topics in nonlinear functional analysis
ercises in Functional Analysis
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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt
... N-terminal region of DEC1, including thebHLH domain, interacted with the C-terminal r egion o fBMAL1 in a mammalian two-hybrid assay. Accordingly, aFig. 5. Analysis of DEC1 mutants for bindingto ... by DEC1 coincidedwith that for interaction with BMAL1 and binding to theE-boxes, indicating the importance of t his region in DEC1for its suppressive activity against CLOCK/BMAL1-induced transcription.Materials ... Arg65, is responsible for t heE-box binding.Determination of the region in BMAL1 for bindingto DEC1To identify the region in BMAL1 required for the binding toDEC1, w e constructed e xpression...
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Báo cáo khoa học: Functional analysis of mutations in UDP-galactose-4epimerase (GALE) associated with galactosemia in Korean patients using mammalian GALE-null cells pdf
... transfected individually or in combination into ldlD cells and immunoprecipitation was carried out withmyc antibody using detergent-soluble cell lysates containing the amount of protein indicated. ... protein. Tubulin serves as a loading control. The relative amountof mutant protein was calculated based on the ratio of the band intensities of myc-GALE to tubulin in the western blot and indicated ... measuring theintensity of the individual GALE and tubulin bands in the western blot using Scion Image (Scion Corporation,Frederick, MD, USA).Generation of stable cell lines and BrdUincorporation...
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Báo cáo khoa học: Functional analysis of disease-causing mutations in human galactokinase potx
... alsoaffects the binding of galactose at some point in thereaction. Modest changes in Km,ATPare seen in H44Y andR68C. That H44 in uences the binding of both substratessuggests that the binding sites ... change in the enzyme, which creates a functional binding site for galactose. Identifying the natureof this change and the residues involved in transmittinginformation through the protein will ... 2003homoserine kinase, proton transfer is unlikely to play amajor role in the rate-determining step of catalysis.Several of the disease-causing mutationsare not soluble following induction in E....
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Báo cáo Y học: Monoterpene biosynthesis in lemon (Citrus limon) cDNA isolation and functional analysis of four monoterpene synthases pot
... terpenesare produced in resin ducts [2,3]. Their biosynthesis isinduced upon wounding [4–6], indicating their role in thedefence against bark beetle infestation. For angiospermsmany investigations ... afterdrying dissolved in 5 mMTris, pH 6.8, 0.2% (w/v) SDS and1% glycerol. Protein concentration was determined usingthe BCA Protein assay kit using BSA as protein standardreference, according ... to 200 °Cat5°CÆmin)1with He gasflow at 3 mLÆmin)1. The compounds of interest weretransferred from GC1 to GC2 from 6.6 min to 7.1 min(a-pinene) and 10.2 min to 10.4 min (b-pinene). The fusedsilica...
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Báo cáo khoa học: Functional analysis of two divalent metal-dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants ppt
... DNA-binding proteinof the ferritin family563 nt20 052 DaContains domains typical of the ferritin-likesuperfamily, such as: DNA-binding ferritin-like protein, ferritins and bacterioferritinsPutative ... shows anincreased level in the dmdR1 mutant, is a DNA-bindingprotein with domains typical of the ferritin superfamily.This protein might be involved in a cascade of iron regu-lation in response ... availableregarding ferritin regulation in Streptomyces species. In addition to the 11 proteins listed in Tables 1 and2, minor changes in other proteins were observed.These proteins may be involved in other...
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Báo cáo khoa học: Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase pot
... °Cor22 °C), by using an alternative expression host{BL21(DE3)[pLysS]} or by including protease inhibi-tors in the solutions used during purification.Kinetic analysis of disease-causing mutationsThe ... theseenzymes and inserted into the corresponding sites in theexpression vector pET-21d (Merck, Nottingham, UK). Theentire GALE coding sequence was verified by DNA sequen-cing.The recombinant plasmid ... stained withCoomassie blue. C, control lanes containing 50 lM GALE; P, GALEdigested with 90 nM thermolysin for 30 min at 37 °C; U, GALEdigested with 90 nM thermolysin for 30 min at 37 °C in...
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Báo cáo khoa học: Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans docx
... similarity to human uridine kinase, UMPK, andUDPK. Uridine kinases are downstream of UP in thepyrimidine salvage pathway. Homology searchesrevealed that several uridine kinases exist in the C. ele-gans ... is expressed in the hypo-dermis and intestine, both UP ⁄ UMPK in the hypo-dermis and OPRT ⁄ UMPK in the intestine are essentialfor mediating 5-FU function in C. elegans. It is alsopossible ... acontrol. In vitro enzymatic assaysTo induce the MBP–UPP1 fusion protein, 0.3 lm IPTGwas added to the culture. Induced fusion proteins werepurified using amylose resin (New England Biolabs),according...
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nonlinear and mixed integer optimization fundamentals and applications topics in chemical engineering
... and there exist nonlinear terms in theobjective function and constraints, then (1.1) is a mixed-integer nonlinear programming MINLPproblem. The fundamentals of MINLP optimization ... multipliers in a constrained nonlinear optimization problem have a similar inter-pretation to the dual variables or shadow prices in linear programming. To provide such aninterpretation, ... stationary points of the Lagrangefunction correspond to the minimum of (3.3).Illustration 3.2.2 Consider the following two-variable constrained nonlinear programming prob-lem in the...
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Báo cáo hóa học: " Some new nonlinear integral inequalities and their applications in the qualitative analysis of differential equations" potx
... ∞)and∞t01ψ(φ−1(s))ds =∞, a(t), a(t) are defined as in Theorem 2.1, and a(0) >t0>0. If x Î C(R+, R+) satisfies the following integral inequality containing multipleintegralsφ(x(t)) ≤ a(t)+α1(t)0f ... R+), and a, j, ψ , ω, a,b, J, Y are defined as in Theorem 2.3. If u Î C(R+× R+, R+) satisfies the following inte-gral inequality containing multiple integralsφ(u(x, y)) ≤a(x, y)+β(y)0α(x)0[f ... R+), i =1,2,anda, j, ψ, ω, J, Yare defined as in Theorem 2.3. If u Î C(R+× R+, R+) satisfies the following integralinequality containing multiple integralsφ(u(x, y)) ≤ a(x, y)+β(y)0α(x)0[f1(s,...
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Báo cáo toán học: "Some inequalities in functional analysis, combinatorics, and probability theory" pdf
... 11T99AbstractThe main purpose of this paper is to show that many inequalities in functional analysis, probability theory and combinatorics are immediate corollaries of the bestapproximation theorem in inner ... of combinatorics 17 (2010), #R58 4Proof. Since the total number s of (n − 1)-dimensional hyperplanes passing through theorigin equals the total number of lines passing through the origin,s ... electronic journal of combinatorics 17 (2010), #R58 3The main purpose of this paper is to show that many inequalities in functional analysis, probability theory and combinatorics are immediate...
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Further Topics in JavaScript
... and retuo appear in the string following the number. use parseInt( ) and parseFloat( )ber at the beginningn-numbers. parseInt( ) parsers and floating-point numbers. If ) interprets it as ... behavior inherited from Perl: if the specified separator character is a single space, it discards any leading and trailing whitespace in the string before splitting the remainder of the string.being ... "NaN"As is falseNumber objectInfinity "Infinity"As is trueNumber objectNegativeinfinity "-Infinity"As is trueNumber objectAny other String value of trueNumber...
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