their role in health and disease in man and birds
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... case in point, formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing ... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency ... paralysis, and the proteins colocalize intracellularly, suggesting a role for molecular chaperones in Ab toxicity and metabolism Human recombinant aB-crystallin also interacts with Ab in vitro, and...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... Phytochemicals A Global Perspective of Their Role in Nutrition and Health entire world and currently is being integrated into mainstream medicine Different catalogues including De Materia Medica, Historia ... important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are...
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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx
... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... morphogenetic protein signaling in joint homeostasis and disease Cytokine Growth Factor Rev 2005, 16:287-298 Sancho E, Batlle E, Clevers H: Signaling pathways in intestinal development and cancer Annu ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... rats with hypoxia-induced pulmonary hypertension J Clin Invest 1995, 96:1823–1833 23 Morrell NW, Morris KG, Stenmark KR: Role of angiotensin-converting enzyme and angiotensin II in development of ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins...
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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... Recycling (code 370), Manufacture of coke, refined petroleum and nuclear fuel (code 230), Mining of metal ores (code 130), Tanning and dressing of leather (code 190), Manufacture of office machinery ... decreasing demand and then contributes again to loan losses for banks Commercial property index is mainly connected to lending to the industries related to rental business and property management...
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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... overlapping ligand-binding pockets The difference of the binding pocket is easy to understand by looking at the superimposition between PonA and BYI06830 shown in Fig Ligand-binding affinity Typically, ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... that have distinct and often unapparent RAGEactivating properties S100 Proteins as RAGE ligands and their role in Inflammation A recent review on S100 proteins has been published, and provides ... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected...
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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx
... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... on insulin signaling and coronary heart disease Insulin and zinc ions have potent stimulatory effects on lipogenesis and glucose uptake Zinc-deficient animals are less sensitive to insulin Zinc ... zinc The other is MT 1A, a member of a protein family that links zinc and redox metabolism Changes in the availability of zinc ions modulate insulin signaling and redox processes Both zinc and...
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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... suppressor by inhibiting tumor cell motility, invasion, metastasis and angiogenesis [12] Maspin expression is aberrantly silenced in many human cancers including breast, prostate, and thyroid cancer ... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical...
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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising ... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie...
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báo cáo khoa học: " Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism" pdf
... recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of male and ... position -30 in the 5'UTR, (ACAAAAAAGG) position 1083 in the second intron, and (TCAAAAAAGG) position 3052 in intron We detected a single potential LEAFY binding site (CCATTGT) in the second intron ... genes in their native context SpAGAMOUS retains floral organ identity and meristem determinacy functions in spinach A single C class gene has been previously described in Spinacia oleracea and...
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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... 1) are found in many plants and in vertebrate and invertebrate animal species Those members with known function share the feature of being involved in host responses to injury and infection [8] ... sections) Understanding the regulation of TLR expression will provide further insight into their tissue distribution and their role in combating infection There has been an initial report of...
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Báo cáo y học: "Psychosocial factors and their role in chronic pain: A brief review of development and current stat" ppsx
... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals ... the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing into a ... central and dominant influencing psychological factors in the assessment for identification and intervention strategies Competing interests The author(s) declare that they have no competing interests...
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Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products
... from training in how to harvest, render and market beeswax BEE–MAINTAINING Harvesting of a bee colony nesting in a tree would be described as honey hunting The piece of tree cut and, containing the ... other pollinators like bats and birds play a greater role in plant pollination In farmed areas, bees are needed for the pollination of many cultivated crops (see Chapter 7), and for maintaining biodiversity ... projects introducing beekeeping technology that cannot be sustained Yet, there are many ways of managing bees and obtaining a crop from them: a hive is just a container for bees to live inside and...
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HCV functional genomic protein interactions with NS3 and their role in viral replication
... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing ... implicating its involvement in oncogenesis Taken together, most of the viral proteins interact and may affect the activities of host proteins in the long-term The understanding of the interplay ... activity (Levin and Patel, 1999), helicase mutants defective in self-interaction may be inactive for their unwinding activity because of their inability to from dimers or oligomers To investigate...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia 1
... display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point of 9.6, without ... examine the expression of muscarinic receptors Human SF were cultured on slides and mAchR were stained using Anti human m1-m5 receptor rabbit IgG-fluorescein conjugates Positive immunostaining ... carried out in triplicates and the results indicate independent experiments FGF-2 (0.1-10 ng/ml) caused a increase in DNA synthesis in a dose dependent manner in both SF from myopic and control...
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Effect of muscarinic agents on sclera fibroblast and their role in myopia
... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract Sepcific bands did ... chick sclera protein extract and SF cell lysate using anti human MMP-9 antibody Lane 1: chick sclera fibroblast cell lysate Lane 2: chick sclera protein extract Land 3: MMP-9 standard Diagram Mechanism...
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Tài liệu Health and Safety in the Child Care Setting: Prevention of Infectious Disease pdf
... in their child care setting Assist providers in establishing, developing and promoting written policies regarding health and safety in their child care setting Help providers to understand and ... require 15 hours of health and safety training—eight hours for CPR and First Aid and seven for prevention of infectious disease and injuries The training in prevention of infectious disease is estimated ... on Infectious Disease 25th Ed Elk Grove Village, Il The California Department of Education and The Center for Health Training Keeping Kids Healthy—Preventing and Managing Communicable Disease in...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... lymphoproliferative disease Arginine 335 is found in the ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain Thus, these ... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red Bottom left: SH2 domain Right: kinase domain The mutated residues are indicated in yellow, a-helices are in cyan,...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc
... Defects in SAC lead inevitably to high chromosome missegregation levels both in vitro and in vivo and thus to aneuploidy Besides mutations in spindle assembly checkpoint and in mitotic spindle ... other factors influencing the DNA strand breaks The increasingly detailed map of human DNA will certainly bring new insight into the possible links between DNA secondary structure and sites of ... with diseases affecting the brain [65] In particular, the percentage of aneuploid cells is higher in brains from patients 16 Aneuploidy in Health and Disease with Alzheimer disease (AD) than in...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25