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the secretariat of the icc international court of arbitration

Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

Báo cáo khoa học

... described in the Materials and methods. Completion of the hydrolysis wasconfirmed by the disappearance of the (Met1)-ONC(M23L) signal in the MALDI-TOF mass spectra 1 h after the addition of AAP. The ... calculating the slope of the curves of Pyr-ONC (M23L) vs. time. From the rates of cyclizationshowninTable1,itcanbeinferredthattheformation of the N-terminal pyroglutamyl is not dependenton pH in the ... hydrogen bonded to the e-amino group of the Lys9 side-chain, which simultaneouslyinteracts with the main phosphate of the substrate [32]. The closer positioning of the N-terminus to the mainprotein...
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Tài liệu Euphorion Being Studies of the Antique and the Mediaeval in the Renaissance - Vol. II pot

Tài liệu Euphorion Being Studies of the Antique and the Mediaeval in the Renaissance - Vol. II pot

Khoa học xã hội

... imagine the old knight, onlyhalf aware of the sunshine of the evening, the noise of the streets, the looks of the crowd, the great minsterrising half-finished in the midst of the town by the Rhine, ... Boiardo, of the Ferrarese court to which he belonged, and of the school of poetry (including the more notable but less original work of Ariosto) which the genius of the man and the character of the court ... this: on the extreme pinnacle, high on the roof, they might indeed place against the russet brick or the blue sky, amid the hum of life and the movement of the air, the living man, like the Scaligers,...
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Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx

Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx

Báo cáo khoa học

... arboxylateoxygen of Asp273 (Asp366), the carbonyl oxygen of the P1residue with the side-chain amine of Lys262 (Lys354), and the backbone amino group of the P 1Â residue with the backbone carbonyl oxygen of ... identified the residues important for LAP catalysis and coordination of the two zinc io ns in the a ctive site. The i mpact of the mutations on the tomato LAP enzyme must be viewed in the context o f these ... waters and the bihydroxide ion in the general base mechanism of blLAP [21,24]. The recentidentification of bicarbonate in the active site of the nativeE. coli PepA and blLAP and the influence of bicarbonateon...
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Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Sinh học

... fold, while the S15 contactsabove the internal loop of helix 22 and to the tetraloop of helix 23a stabilize the tertiary fold of the upper three-helix junction. The tertiarystructure of the upper ... regions of the central domainRNA are not involved in directing assembly of the domain but rather are displayed on the sur-face of a preassembled RNP core. Hence, for-mation of the core of the ... and S18. The structure of the complexdemonstrates the central role of S15-induced reorganization of central domainRNA for the subsequent steps of ribosome assembly. The recent explosion of structural...
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Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt

Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt

Báo cáo khoa học

... loop in the primed side of the binding sitegroove. Although the prodomains of cathepsins F andW share the same degree of similarity to the prodo-main of cruzipain, the similarity of the mature ... RGVDLQPS-LIS at the C-terminus, which resulted from the fusion of the propeptide with a small stretch of coding sequencewithin the multiple cloning site of the pQE30 plasmidbefore the stop codon. The predicted ... cross-inhibition of brucipain by PCZ. The pro-domain of cruzipain shares the highest identity with the C-terminal portion (residues Pro147–Leu251) of the prodomain of cathepsin F (32%) and that of cath-epsin...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

Báo cáo khoa học

... interaction in the presence of agonist R5020, but not in the presence of antagonistRU486 [54]. LxxLL motifs in the PR-B form were mostprobably not involved, because the shorter PR-A form,lacking these ... sequence of protein interaction events, includingN/C interaction, in regulation of AR function. Detailedknowledge on the role of the AR N/C interaction wouldrequire the elucidation of its function ... AR3)13deletion,whereas in the mammalian assay almost all reporter geneactivity was lost. The most obvious difference betweenboth assays is the coupling of AR.NTD to GalAD in the yeast assay, and the absence of a...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc

Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc

Báo cáo khoa học

... FAD/NADPH domain(% 16-fold) (29). However, the domain mixture still recon-stituted only % 2% of the activity of the full length CPR. InthecaseofNR1,thekcatfor the full length enzyme is low(1.3 s)1) ... enzymes, the potentials for the FAD/NADPHdomains are rather more negative than those for the FMNdomain, reflecting the direction of electron transfer fromNADPH through FAD, then FMN and on to the ... BM3 [28]. Aggregation of the NR1FAD/NADPH domain was much less extensive in the absence of cofactor reduction.Stopped-flow kinetic studiesReduction of the FAD/NADPH domain of NR1 wasinvestigated...
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Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

Báo cáo khoa học

... with the Substance P receptor [25]. Detachment of the cells from the surface of the culture dish could r eflectdisassembly of the actin cytoskeleton in the me mbraneregions as a consequence of ... both the cAMP and the PLC pathway [22], the second messengerproduct of either or both of these pathways couldbe invo lved in agonist-stimulated internalization of thisreceptor. The effect of ... f125I-labelled sauvagine could be observedin the presence of any of these inhibitors. These findingsindicate that neither the activation of PKA nor the activation of PKC is necessary for agonist-induced...
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Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot

Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot

Báo cáo khoa học

... determinant of the hydrophobic SÂ2 bindingpocket of trypsins is the side-chain of Tyr151 [18]. The importance of this residue is underlined by the fact that in the case of the second Kunitz-domain of ... raising the possibility that the inability of WFIKKN-KU2 to inhibitthese proteases is partly due to the lack of such a favorableinteraction of the PÂ2 Trp with the target enzymes. The factthat the ... (JASCO).Fig. 3. Alignment of the sequences of the second Kunitz-modules of the human and fugu WFIKKN proteins (wfikkn_hu_2; wfikkn_fugu_2) with the second Kunitz-domains of the human and the two fugu WFIKKNRP...
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The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf

The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf

Khoa học xã hội

... abuse their office andinfluence to the injury of the laws and peace of the country. The elimination of the Christian teachers of the Negro race, and the prevention of the immigration of workers ... as their peculiar needs demanded. In the agricultural sections the first duty of the teacher of the blacks was to show them how to get their living from the soil. This was the final test of their ... resulting from the proximity of the communities, and to the coöperation of the Canadians. The previous experience of most of theseadventurers as sojourners in the free States developed in them such...
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Báo cáo hóa học:

Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

Hóa học - Dầu khí

... Child-OIDP. The self-administered ver-sion of the Child-OIDP performed similarly to the inter-viewer-administered original version of the instrument.Despite the demonstrated appropriateness of the ... Child-OIDP and some of the asso-ciations between the Child-OIDP and proxy measureswere not significant. While the low value of alpha isaffected by the nature of the Child-OIDP index and the fact that ... self-administration of the index. Furtherstudies are needed on the comprehensive psychometricevaluation of the self-administered Child-OIDP.Declaration of competing interests The authors declare that they...
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báo cáo hóa học:

báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf

Hóa học - Dầu khí

... osteoar-thritis of 1 grade in 52% of the patients, 35% of the patients had an increase of 2 grades and 3% of the patientshad an increase of 3 grades. (Table 4, 5 and 6) 10 % of the patients had ... per-formance, the score may appear too high, and will reflect the actual function of the knee as well as the satisfaction of the patient. The Lysholm score has never been validatedfor the purpose of following ... test). Thesepatients were considered at high risk of further knee injurydue to the degree of laxity and the desired level of activity[27]. In order to minimise the development of arthrofi-brosis,...
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báo cáo hóa học:

báo cáo hóa học:" Revision hip replacement for recurrent Hydatid disease of the pelvis: a case report and review of the literature" doc

Hóa học - Dầu khí

... flexiondeformityofthehipof40degreesandfurtherflexionand rotations were painful. X-ray showed lytic lesion of the ilium and 2 centimetre proximal migration of the femoral head into the infected ... organs. Due to their physiologic role as capillaryfilters and their vast capillary volume, the liver and lungare most often affected. The brain, the muscle s or the bones are the more frequently ... recur-renceofthecystsdespitetheongoingAlbendazoletreatment. She returned again on 8/7/08, with increasingpain in the right hip. X-ray has shown that loosening of the acetabular component of the total...
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báo cáo hóa học:

báo cáo hóa học:" Repositioning and stabilization of the radial styloid process in comminuted fractures of the distal radius using a single approach: the radio-volar double plating technique" pot

Hóa học - Dầu khí

... possible difficulty in intra-articular fracture of the distal radius is the displacement tendency of the radial styloid process due to the tension of the brachioradialis tendon.Methods: Ten patients ... drafting of the manuscript.GK participated in the design of the study and coordination and helped todraft the manuscript. All authors read and approved the final manuscript.Competing interestsThere ... in the interval between the flexor carpi radialis tendon and the radial artery. The distal part of the pronator quadratus muscle wasreleased from the radius. Care was taken to release onlythe...
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