... activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell cyclearresting action of CY inthe stomach in this study was due to the activation of p53 and therefore ... was therefore not surprising that CY administration resulted in a decrease inthe proliferating cell number in both the gastric and duodenal tissues Indeed the decrease in cell proliferation in ... therefore leading to the suppression ofthe c-Myc/ODC pathway All these findings could explain the mechanism of CY on repression of cell proliferation inthe gastroduodenal mucosae In general,...
... fora at national level At the same time, the Platform can create input for integrating the responses to the obesity challenge into a wide range of EU policies The Commission regards the Platform ... consensus-building exercise The Global Strategy underlines the importance of achieving a balanced diet reducing the consumption of fats, free sugars and salt, of increasing the intake of fruits, ... food chain operators and the general public on the impact ofnutrition on health) with scientific advice and assistance (on theroleof EFSA inthe establishment of food- based dietary guidelines,...
... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia Similarly, hyperleptinemia is a consequence ofthe development of insulin resistance ... The expression ofin ammatory cytokines (tumor necrosis factor-a, interleukin-6 and interleukin-1b) was increased inthe adipose tissue of ANGPTL2 transgenic mice compared with that of wild-type ... overexpression of ANGPTL6 ⁄ AGF inthe liver of diet-induced obese mice results in elevated ANGPTL6 ⁄ AGF serum levels and amelioration of diet-induced obesity and insulin resistance [14] Taken together, these...
... because the latter depends on (a) the structural integrity ofthe vascular bed ofthe penis; (b) the endothelium lining the cavernosal arteries and the helicine arterioles, as well as the endothelium ... and increases blood flow to the corpus cavernosum The increased blood flow stimulates the endothelium lining the lacunar spaces ofthe corpus cavernosum to release endothelial NO from the endothelium ... hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52, 355–361 Wannamethee SG, Shaper AG, Morris RW & Whincup PH (2005) Measures of adiposity inthe identification...
... for 68% ofthe decrease in Jo, 68% ofthe decrease in Jp, 56% ofthe increase inthe QH2 ⁄ Q ratio, 70% ofthe increase in Dw, 72% ofthe increase inthe ATPin ⁄ ADPin ratio, and 59% ofthe decrease ... reduction in Jo, 76% ofthe reduction in Jp, 68% ofthe increase in Dw, 88% ofthe increase inthe ATPin ⁄ ADPin ratio, and 69% ofthe reduction inthe ATPout ⁄ ADPout ratio The exception was the QH2 ... malate instead of succinate, control ofthe fluxes shifts from the respiratory chain to ATP synthesis Furthermore, the distribution ofthe control within the respiratory chain shifts from the part...
... flavonoids, tannin, catechin and alkaloid were found principally in ethanol, n-hexan and chloroform fractions Especially, there is no alkaloid inthe ethylacetate fraction To determine relatively the composition ... designed the process of natural product extraction from Fortunella japonica peels [7] The scheme of extraction process was reprented inthe Fig.1 § Mandarine (Fortunella japonica (Thunb) Swingle ... complications to drug therapy usually were exhibited [1,3] One ofthe novel strategies for anti-obesity is to exploit the natural products from traditional medicinal plants in form of plant extracts...
... flavonoids, tannin, catechin were found principally inthe ethyl acetate and ethanol fractions In order to determine relatively the composition of natural compounds we used the technique of thin layer ... concentrates /kg) The experimental schema was presented inthe following: The results obtained from the model of experimentally obese mice inthe figure show that the body weights of experimentally ... countries The fact that the obesity explosion significantly increases the risk of developing various livethreatening diseases, including type II diabetes, hypertension, coronary heart diseases...
... two instrumental variables: the average monthly rainfall in millileters inthe basin and output upstream ofthe basin containing the DSP site The F statistic forthe joint significance ofthe ... shown forthe DSP sites which were inthe 19 provinces included inthe CHIS (1995), which includes 102 ofthe 145 DSP sites Information on diet is shown for DSP sites located inthe provinces included ... reflecting more particulates inthe air, and is reported as the average reading inthe river basin containing the DSP site The rainfall measure is the average monthly rainfall in millileters in the...
... advertising efforts The proliferation of electronic media, the deregulation of and declining support for public service advertising, and the booming economy ofthe 1990s all contributed to the transformation ... create a strong body of evidence indicating that advertising influences underage drinking These methods may be useful for studying the effects of marketing and advertising offood and beverages ... children and youth would begin drinking or increase the amount of alcohol they drank before the age of 21 That research points to three important findings: ß Advertising has both immediate and...
... associated with an increased risk of a variety of other health problems, including the following: Several types of cancer, including cancers ofthe endometrium (lining ofthe uterus), colon and ... (Council for Biotechnology Information) It was created by inserting an inactive form of a gene for NAD-dependent malic enzyme into the potatoes that increases the conversion of sugar into starch These ... because of their long history of safe use for other purposes, not require approval from the FDA before being used Like applesauce, they are already part ofthefood supply They’re just being used for...
... lipoprotein receptor is the major receptor involved inthe clearance of ApoE-containing lipoproteins from the circulation [41] Therefore, one mechanistic explanation fortheroleof ApoE inthe development ... forthe catabolism of atherogenic lipoproteins [32,35–37] In this study, we sought to determine theroleof ApoE inthe development of diet-induced obesity, glucose intolerance and insulin resistance ... remained normal forthe duration ofthe experiment This is not surprising, because inthe absence ofthe LDLr, reduced clearance of ApoE-containing lipoproteins from the circulation results in elevated...
... metastatic disease (spread to other parts ofthe body).21 Approximately 90% of oral cancers are squamous cell carcinomas, arising from the lining ofthe mouth, most often the tongue and the floor ofthe ... skills training They should be involved in co-ordinating care for individual patients, but should not be expected to take on the administrative burden of co-ordinating MDT meetings 69 44 Inthe text ... surface ofthe soft palate, the base ofthe tongue and the tonsils, the hypopharynx (bottom part ofthe throat) and the nasopharynx (behind the nose) The most common site of cancer within the pharynx...
... noteworthy that in many cases, the excess weight of children in developing countries is because of their stunting (15, 20, 21) These findings highlight the need for determining the barriers to ... later, the expression of inducible nitric oxide synthase (iNOS) mRNA increased inthe liver Injection of DEP did not induce inflammation or oxidative damage to DNA inthe lungs and aorta Therefore, ... given to the effects of environmental factors on liver diseases, including NAFLD Many recent studies have also documented the association of smoking with the incidence of and acceleration of disease...
... ApoE3 isoform are taken up more avidly by adipose tissue than the lipoproteins containing mouse ApoE There has been much discussion inthe medical community concerning theroleofin ammation in obesity ... expression reduces food intake in rats Specifically, the intrecerebroventricular injection of ApoE in rats decreased their food intake, whereas intrecerebroventricular infusion of ApoE anti-serum ... Diet-induced obesity b) Insulin resistance c) Glucose intolerance Fat cells Fig Model fortheroleof ApoE inthe development of diet-induced obesity in mice Dietary lipids are packaged into...
... facilitates the expression of multiple proteins regulating insulin sensitivity, including the insulin-dependent glucose transporter GLUT4 and the insulin-sensitizing hormone, adiponectin [13] Indeed, ... the mice after the expression ofthe PPARc-Cre gene, then the marked cells continued to produce LacZ because ofthe indelible nature ofthe system (ROSA26-flox-stop-flox-lacZ) Inthe other GFP mouse, ... pathways might have a rolein directing the formation of WAT and BAT during development The most notable of these adipogenic effectors are members ofthe BMP family of transform- FEBS Journal 276...
... the circulatory demands ofthe invading lesion The adipokine leptin is strongly angiogenic [26] and may increase tumor angiogenesis either by directly acting on the endothelium or by increasing ... In what has become increasingly indicative ofthe metabolic disease potential, the expansion of WAT results in hypoxia and increased levels of HIF-1a that, in turn, lead to an up-regulation of ... propagated by intestinal in ammation, such as in inflammatory boweldisease and Crohn’s disease [40] In these instances, flux of dietary lipids into lymphatics, downstream lymphatic vessel drainage and...
... is often viewed as the least harmful of these compounds In fact, nicotine exhibits anti -inflammatory properties in many systems [15,16,21,22] Among the earliest findings in support ofthe antiinflammatory ... element binding protein that promotes the degradation of a number ofinflammatory mediators including TNF-a Nicotine-activated STAT3 signaling induces the expression of TTP in macrophages and, in turn, ... a key rolein nicotine-induced anti -inflammatory effect through destabilization of TNF-a transcripts Since an excess of TNF-a is involved in many inflammatory diseases, the inhibition of TNF-a...
... index) and the peak of knee flexion (KMSw index) during swing; - the values of peak of ankle plantarflexion in stance (AmSt index) and of knee extension (KmSt index) during the gait cycle; - the hip ... in cm [32] All the details ofthe three groups are reported in Table The clinical examination included palpation ofthe paravertebral muscles, straight leg raising test for sciatic nerve impingement, ... worsen the gait pattern of obese subjects Bearing in mind that walking is a key component of comprehensive rehabilitation in obesity, verifying our hypothesis would reinforce the need for specific...
... play a roleinthe onset of cLBP in obese patients A rehabilitative spin-off of our study is that targeted exercises forthe thoracic spine could prevent the onset of cLBP in obese patients In lateral ... used kinematic analysis ofthe spine inhealthy subjects Our study suggests that kinematics ofthe spine can represent a non-invasive clinically useful technique for functional investigation in various ... gave Page of final approval to the version ofthe manuscript to be submitted All the authors approved the final version ofthe manuscript Competing interests The authors declare that they have...
... is often viewed as the least harmful of these compounds In fact, nicotine exhibits anti -inflammatory properties in many systems [15,16,21,22] Among the earliest findings in support ofthe antiinflammatory ... element binding protein that promotes the degradation of a number ofinflammatory mediators including TNF-a Nicotine-activated STAT3 signaling induces the expression of TTP in macrophages and, in turn, ... a key rolein nicotine-induced anti -inflammatory effect through destabilization of TNF-a transcripts Since an excess of TNF-a is involved in many inflammatory diseases, the inhibition of TNF-a...