... they are important for catalysis [20,26–31] However, the mechanistic roles of several of these residues are not described well and there is no example of mutational analysis of all of these residues ... be interesting to see if other important residues are revealed by additional mutagenesis studies, for example of residues further down inthe core ofthe TIM barrel Catalysis infamily 18 chitinases ... highlighting the residues discussed in this report Inthe free enzyme, Asp142 is inthe ÔdownÕ position, interacting with Asp140 Upon substrate-binding, Asp142 moves into the ÔupÕ position and interacts...
... lacks the arginine patch Therefore the BNIP-2 interactome discovered from these early studies hinted at BNIP-2’s involvement in a variety of pathways such as tyrosine kinase receptor signalling, ... ofthe enveloping layer (EVL) from the deep cells, abnormal morphology of EVL marginal cells and a widened actin band inthe yolk syncytial layer were observed Overexpression of a constitutively ... classifications of BCH-domain containing proteins Proteins containing the BCH domains can be subdivided into three groups: Group members are defined by the presence of a single BCH domain that has the high...
... Similarities between the groups were found in many areas of functioning However, sex differences were reported inthe following areas: girls were found to have greater verbal ability than boys, whereas ... Jacklin, 1974) It is interesting to note that the results of this review were widely reported as a finding of ‘‘no differences’’ inthe behaviour of adults However, more recent research into ... Despite this prediction, the increases of women in senior or executive roles over the past decade have been less than impressive We must, therefore, ask the question: can leadership research and subsequent...
... of Institution Building inthe Financial Sector A Main driving forces of institution building A review ofthe developments of China’s financial sector over the past 20 years reveals that reform ... years, foreign financial institutions, mainly foreign banks have played an important roleinthe opening up of Chinese financial industry Intheearly days of their operation in China, foreign banks’ ... summary, the deepening process ofthe financial markets has rendered the dominance ofthe banking sector inthe financial system At the same time, opening of markets and reforms have contributed to the...
... Control and Prevention Theroleof BCG vaccine inthe prevention and control of tuberculosis inthe United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis andthe ... resurgence inthe incidence of TB occurred inthe United States and included increases inthe number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving ... children and adults who are at high risk for TB and, if indicated, administering preventive therapy to those persons who have positive tuberculin skin-test results The preferred method of skin...
... decline 30 FEDERAL RESERVE BANK OF KANSAS CITY further but remain inthe thousands The section then points out that community banks as a group have performed well relative to large banks over the ... more profitable than the large size group at the beginning ofthe 1990s, when large banks were still recovering from heavy losses on commercial real estate and business loans The gap in profitability ... lower average ROA than large banks during each ofthe last four years However, the difference in ROA between the two size groups has remained small, less than ten basis points in three out of the...
... Nter are the C-terminal and N-terminal structural regions, respectively, ofthe two A and B monomers ofthe dimeric RNase The black circle between the monomers indicates the mass center ofthe ... conformation were prepared using the 7RSA structure andthe structure of nonexchanging BS-RNase (1R3M) as template Briefly, two molecules of RNase A were superimposed to the subunits of BS-RNase using the ... the method ofthe grid energy differences [42] through the equation: EIE ¼ DGbindingR=M ¼ GR=M À GR À GM where GR ⁄ M, GR and GM are the grid energies ofthe complex, ofthe RNase alone and of...
... of each immunoprecipitate were treated either with Endo H or PNGase F The resulting mixture andthe other aliquots ofthe immunoprecipitate were analyzed by SDS ⁄ PAGE (7.5%) and immunoblotting ... side-chains are important for the GABA transport activity 1-Deoxymannojirimycin inhibits the GABA-uptake of GAT1 In order to gain further insight into theroleofthe terminal structures ofthe N-glycans ... Solid lines represent the exponential fit with half-lives of 22 and 23 h for wild type GAT1 inthe absence and presence of dMM, respectively, andof 12 and 5.5 h for the DDN and DDQ mutants, respectively...
... Because ofthe import of articles in language processing, as b r i e f l y mentioned, how they are represented is of great interest when one wants to In explaining the representation issues for French, ... Example"lesions" are changes in memory decay, elimination of a knowledge type, and slowing of processing relative to on-line word recognition Studying the results of such "lesions" and their occurrence or ... is defined 4.1 The processes are independent ofthe knowledge representations defined and are blindly applied across a l l of them This often produces unexpected but humanly interpretable results...
... Qualitative Survey In 1996, the credit has overall been decreasing for 53% ofthe sample, it has been increasing for 36%, and has been stable for the remaining 11% An increase in indebtedness (of 80% ... strong inthe lower half ofthe Graph where indebted enterprises represent a much larger proportion ofthe total than inthe other half ofthe pool Table 6C shows that the demand for credit is here ... have also shown more perverse patterns: access to soft finance have regularly played a strong rolein sustaining firms with low actual level of demand Here inventory reflects changes over the...
... pioneers inthe Latin American microfinance industry As of today, out of 15 Latin American members are active in microfinance These members are involved in different ways inthe microfinance sector ... 17.27% 1.3.2 Savings WSBI members are first and foremost savings institutions Historically they were created with the main purpose of mobilizing domestic resources and investing them in their communities.17 ... their microfinance activities are at the core of their retail business They are heavily involved inthe mobilization of savings and their clients are typically households, microenterprises and SMEs,...
... clarify the narrative structure ofthe film There are instances in which the narrative structure andthe formal structure ofthe music coalesce to create the resulting sense of order The narrative in ... (including music), taking into account the director’s – and, therefore, the composer’s – intentions, the narrative content ofthe film, andthe overall strategy ofthe director in constructing the ... by the performers involved in recording the score cannot be separated from theroleofthe sound editor who is eventually responsible for the manner in which the sound and image are combined and...
... with the average Results of our runs are shown in Table We report values for the baseline relevance score with the max and avg aggregation functions, as well as the regression relevance scores ... (without blind relevance feedback) yielded the highest P OURPRE scores However, none ofthe differences observed were statistically significant These numbers point to an interesting interaction between ... work in anaphora resolution and discourse modeling The current setup ofthe task, where answers consist of unordered strings, does not place any value on coherence and readability ofthe responses,...
... skills are developed at home, in schools, or elsewhere, they are included inthe growth analyses As inthe analyses underlying Figure 3.1, the source ofthe income data is version 6.1 ofthe Penn ... above 45 The result remains the same when the measure of years of schooling refers to the average between 1960 and 2000, rather than the initial 1960 value The coefficient estimate on years of ... literature, however, contrasts with much ofthe policy discussion that, even inthe poorest areas, involves elements of “quality” of schooling Most countries are involved in policy debates about the...
... of a catchment area and a receiving area for the capture of runoff, and are generally small both in size andin level of investment Water harvesting activities occur near the location wherethe ... crop yields in rainfed areas, even inthe more marginal rainfed environments The continued application of conventional breeding andthe recent developments in non-conventional breeding offer considerable ... tons in developing countries as a whole in 2021-25 relative to the baseline These reductions can be offset by an increase in rainfed area and yield, but the required increase in yields would be very...
... by e-mail, fax, and other new technologies Governments inthe African region are therefore increasingly rethinking the rationale of maintaining and operating postal networks The challenge for ... On the other hand, inthe course ofthe desk research in 2004, other countries that were not included inthe list of 24 countries were found to have postal networks with an active rolein financial ... portion of total postal revenues In Pakistan and India, they amount to nearly 50 percent of total revenues For postal savings, the revenues stem from the interest margin between the customer interest...
... (At and Nt , respectively) not react significantly to the shock’s impact The adjustments in leverage are therefore driven by sizeable reductions in bank lending and aggregate investment Figure ... reserved for bank investors To keep the contract incentive-compatible, banks and entrepreneurs must invest more of their own net worth in financing projects, that is they must reduce their leverage ... aggregate investment It , which declines significantly Declines in aggregate investment depress earnings and thus lead to lower levels of bank and entrepreneurial net worth in future periods Lower levels...
... Stereo figures ofthe model ofthe bound substrate inthe AD2 E526A mutant (A) and D524A mutant (B) The structures of bound sugars andthe side-chains of three acidic residues inthe conserved ... alignment of three family 18 chitinases The side-chains of three residues (Asp522, Asp524 and Glu526) inthe DXDXE motif were mutated into the corresponding amide (Asn or Gln) and Ala All the AD2 mutants ... statistics are summarized in Table For the final model, the structures ofthe two independent monomers inthe asymmetric unit were almost identical (Table 2) Inthe interest of simplicity, the structures...
... throughout the 1990s showed that increasing salinity inthe Basin is threatening the further success ofthe Strategy Therefore, a new Basin Salinity Management Strategy 2001-2015 has been developed ... are presented from the US including the Tar-Pamlico Basin in North Carolina (case of point-point source trading also allowing for point-non-point trade), the case of Lake Dillon andthe case of ... contribute to joint or individual works that will reduce the salinity ofthe shared rivers, thus earning salinity credits Any work within a State that further reduces salinity inthe shared rivers will...