... instead ofthe six sites ofthe wild-type protein[31]. However, only three ofthe six sites were requiredfor reproducible deactivation. The findings of thisarticle are consistent with an unordered ... isstrongly affected by the two groups of parameters thatdetermine the protein–protein interactions: the concen-trations ofthe enzymes relative to the target protein,and the respective dissociation ... the global response coefficient R is the ratio ofthe concentration of active kinase K0.9atwhich there is 90% fully phosphorylated target to the kinase concentration K0.1at which 10% of the...
... way, the problem of finding the order best supported by the evidence can be statedas a general shortest path problem: tofind the pre-ferred order for {a, b}, find the sum ofthe weights of the ... corpora the constraintson theorderof prenominal adjectives in English.2 Word bigram model The problem of generating ordered sequences of adjectives is an instance ofthe more general prob-lem of ... subset ofthe in-stance base which has value vifor feature f. The information gain of a feature then is simply the difference between the total entropy ofthe in-stance base and the entropy of...
... procedure. The translator just has to do two things: (1) firstly identify the divisions between theelements in thegroup and (2) then convert the position oftheelements from English word order ... importance ofthe readership to the choice of lexical word is undeniable, 22TABLE OF CONTENTSPART A: INTRODUCTION 11. Rationale 12. Scope ofthe study 23. Aims ofthe study 24. Methods ofthe ... HI terms of equivalence group. It may be concluded that amateur 32Strategies: translated with the deletion or omission ofthe preposition OF 2. The terms of non-equivalence group Group 4:...
... turns of the DNA double helix yields binding ofthe two orthree NF-Y complexes on the same side ofthe DNA.Conservation of spacing is required for optimal pro-moter activity because changing the ... notsimply adopt the timing of expression from the otherpromoter as a result of replacing the cell cycle-regula-tory elements. Thus, it is likely that cell cycle-dependenttiming of expression ... located upstream ofthe CDE-like site [46].These observations and the fact that activation doesnot rely on CCAAT-boxes, NF-Y or Sp1 proteins,leave open the question of whether the BUB1B pro-moter...
... mandate, theGroup also expects the on-going fundamental review of the trading book by the Basel Committee to improve the control of market risk within the banking system. The Group sees the Commission's ... maintaining the integrity ofthe single market. Finally, Chapter 5 draws together the analysis ofthe previous chapters. It reiterates the importance of banks in the EU economy, summarises the key ... predictability ofthe use ofthe bail-in instrument. Specifically, theGroup is ofthe opinion that the bail-in requirement ought to be applied explicitly to a certain category of debt instruments, the requirement...
... the question arisesconcerning the mechanisms underlying the orchestratedexpression of these enzymes by the oxygen tension. The findings that the effect of hypoxia on the geneexpression ofthe ... hydroxylases. With the exception of PDI, whichis known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR,supporting the assumption that they are more ... clear twofold increase of PDI mRNA,a more moderate increase ofthe mRNAs for prolylhydroxylases, and did not increase the mRNA abundance of the other enzymes.DiscussionOur data show that the...
... bond, linkage ofthe activesite Ser ofthe protease to the carboxyl groupof P1by anester bond and insertion ofthe N-terminal part ofthe RCLas strand 4 in b-sheet A (s4A) ofthe serpin. ... cognateproteases is fuelled by the thermodynamic properties of the serpin. Accordingly, insertion ofthe RCL as s4A and the ensuing structural rearrangements ofthe serpin stabilizes the molecule in a so-called ... close to the point of initialinsertion ofthe RCL [36] represents an obstacle for the localstructural rearrangements required for the movements of the RCL during latency transition. N152 is often...
... they, undesignedly of course, keep our Church in ignorance, not only ofthe absolute unity of the Churches in the region of Amoy, but also ofthe real progress ofthe cause of Christ and ofthe ... upon thousands ofthe saints ofthe Most High, is made to lie at the basis ofthe action ofthe lastSynod!History and Ecclesiastical Relations ofthe Churches ofthe Presbyterial Order at Amoy, ... according to the newplan, the Missionaries form themselves into the kind of Classis now required of them; what will be the relation ofthe Classis of Amoy to the Board of Foreign Missions? Is the Classis,...
... in the provision of microcredit. The Commission sees the role ofthe savings banks as a complementary to non-banking financial institutions, since they often target different segments ofthe ... of serving such clients render them unattractive to the traditional banking sector. Some ofthe challenges in the sector are developing a common definition ofthe terms used in the microfinance ... of €27 million. The development of microfinance in Europe requires a mix of both funding and technical assistance in order to adequately serve the market. In Europe, there are two types of...
... moratorium on the death penalty by Council of Europe member states" f. Adoption oftheorderof business g. Adoption ofthe minutes ofthe meeting ofthe Standing Committee (17 November ... in the Chair: Mr Miguel Barceló Pérez (Spain, EPP/CD)) a. Examination of credentials (Doc. 11124) b. Election ofthe President ofthe Assembly c. Election ofthe Vice-Presidents ofthe ... 7.30 p.m. End ofthe sitting - 2 - Monday 22 January 2007 8 a.m. Bureau ofthe Assembly 9.30 a.m. Political groups 11.30 a.m. 1. Opening ofthe first part ofthe 2007 Ordinary...
... structure. The two groups of peaks at 6.85 and7.15 p.p.m. correspond to the aromatic resonances of the seven tyrosines in the protein, and the inset 2D expansion of the 1H-1H COSY shows that the ... tyrosine by assaying the transfer of 32P by recombinant Lck on to each of the peptides. The rates of phosphorylation were found todepend on the location ofthe tyrosine, leading to the pro-posal ... to their location in the TCR, with the ITAM closest to the N-terminus/membrane referred to as 1, the next closest as 2, and the farthest as 3. The two tyrosineswithin each ITAM are then further...
... fillers for the descriptor slots ofthe temp]ate in question, and a third argument which re- presents the output ofthe procedure, i.e., the in- stantiated slots. The body ofthe "construct" ... message boundaries, but often are ofthe kind that have no explicit re- ferent in the previous discourse. Of the two languages studied thus far, the discourse structure ofthe missile and satellite ... and (2), a model ofthe analyst-user's conceptualization ofthe world (i.e., a model ofthe entities and relations characteristic of his world). THE SUBLANGUAGE The two sublanguage...
... parasites ofthe genus Giardia are one of the earliest lineages of eukaryotic cells, and the Giardia proteaseis the earliest known branch ofthe cathepsin B family [23].Its phylogeny confirms that the ... regions surrounding the active sites of the proteinases and their expansin counterparts [4], andtheir comparable location enhances the significance of the sequence similarities. Other functional ... concentra-ting the allergen according to the isoelectric point (pI) of the molecule. A pH gradient from 2 to 11 was established for the characterization of Phl p 1. After completion ofthe run, the individual...