the nature of strength enhancement and weakening by pentagonu2013heptagon defects in graphene
Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... for the majority of cells to contain sub2N DNA. Furthermore, the Ymin (minimum response of the dose response curve) and the T = 0 values (the number of cells at Time zero)were determined from the ... GSK1070916. Ymin values represent the bottom of theresponsecurveanddefinethelargesteffectofthecompound. These Ymin values are evaluated relative to the number of cells at time zero using a Ymin/T0 ratio.Response ... treatmentwith Aurora inhibitors. These findings warrant furtherinvestigation about the relationship of chromosome num-ber in primary and secondary populations of the tumorduring and after treatment...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
... for the majority of cells to contain sub2N DNA. Furthermore, the Ymin (minimum response of the dose response curve) and the T = 0 values (the number of cells at Time zero)were determined from the ... GSK1070916. Ymin values represent the bottom of theresponsecurveanddefinethelargesteffectofthecompound. These Ymin values are evaluated relative to the number of cells at time zero using a Ymin/T0 ratio.Response ... wereperformed by the Upstate Group http://www.upstate.com using the KinaseProfiler to determine activityacross a range of kinases including the ABL kinaseoncogene.Results In Vitro Response...
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Báo cáo khoa học: Dissecting the role of protein–protein and protein–nucleic acid interactions in MS2 bacteriophage stability potx
... unsure of the mechanism of DNA-induced stabilization of the protein, and whe-ther it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect. The increased ... another, webelieve that they maintain additional interactionswithin the dimer, and that these interactions are affec-ted negatively by the presence of the probe duringdenaturation by guanidine, ... leaving behind an intact capsid. The dlFG version of coat protein is dimeric and therefore lacks both the protein–protein and protein–nucleic acid interactions that normally occur withinthe...
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Báo cáo hóa học: " ON THE BOUNDEDNESS OF MAXIMAL OPERATORS AND SINGULAR OPERATORS WITH KERNELS IN L(logL)α (Sn−1 )" doc
... of our main results.3. Proofs of Theorems 1.3 and 1.6Since the proof of Theorem 1.3 will rely heavily on Theorem 1.6 as well as on its proof,we start by proving Theorem 1.6.Proof of Theorem ... (2.32) By using the operator interpolation theorem between (2.31 )and( 2.32) and since γ∈[1,2], we get (2.25) which concludes the proof of the lemma. We are now ready to present the proofs of ... whichinturnimplies(3.5)for1<γ<2. The proof of Theorem 1.6 iscomplete.Proof of Theorem 1.3. We divide the proof of Theorem 1.3 into three separate cases.Case 1 (1 <γ≤ 2). As we pointed...
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Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... cataloging the structure to class I. As the bulky NH2group on guanine was believedto prevent binding of the drug in the minor groove, the detailed nature of several of the amidinium and guanidinium ... calculations The netropsin amidinium end The contact area of the Nt amidinium end (NAE) wasinvestigated by evaluating the interaction energies and hydrogen positions of the end fragment and the bases of ... complex. The NH amide atoms of the drug in particular form H-bonds with thymine O2 and adenine N3 atoms in the AATT-rich sequence of the decamer. Part of the spine of hydration is substituted by the...
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Báo cáo khoa học: Monitoring the prevention of amyloid fibril formation by a-crystallin Temperature dependence and the nature of the aggregating species pdf
... in greaterdetail the kinetics of a-synuclein aggregation in both the absence and presence of aB-crystallin, therebyrevealing the stage at which aB-crystallin interacts witha-synuclein to inhibit ... [37–39,43]. In this study, the rate of fibril formation of bothj-casein and a-synuclein increased with temperature,as monitored by TFT binding. In the presence of a-crystallin, the initial lag ... decreased by 0.0167 gặcm)3, from the start of the experiment. By the end of the measurement, the thickness had increased by 0.342 nm, the mass hadincreased by 0.10 ngặmm)2 and the density...
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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"
... Institutional Review Boards of all institutes involved in the study. Dietary intake and other exposure information Dietary intake was assessed through an in- person interview using a validated food ... disease between the baseline and follow-up FFQs, only dietary data from the baseline FFQ were included in this analysis. For other participants the average of the baseline and follow-up FFQ ... during the previous 5 years and provided information on daily activity such as walking, stair climbing, cycling, household activities and daily commuting to and from work (walking and cycling)....
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... and Fig. 5. Arrows indicate the bands that are interacting with theseprobes. All the lanes have labelled probes. The adding of extracts and cold probe are indicated in the top of the panel. Supershift, ... activity of the Sp1/Sp3 interaction or the Sp1/Sp3/Ets-1 interaction by approximately 90% and 80%, respectively. Mutation of the Ets-1 binding site (mut5) also blocked the effect of Ets-1 in the ... important role in the regulation of many consti-tutively expressed genes [45]. Sp1 might be initially recruitedto the fgl2 promoter and then facilitate the furtherrecruitment and binding of other positive...
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Open Cultures and The Nature of Networks doc
... movements. In particular he made audible the resonances between the blast of Dada at the end of WWI in Zurich and Berlin, the gust of the Situationists on the Rive Gauche in Paris in the 1960s, and the ... that process the information and by doing so maintain themselves and the continuity of the flows. These two elements, flows and nodes, are mutually constitutive, one builds upon the other. Flows ... microelectronics in the last quarter of the century, the control over the means of distribution increased during the same period of time. The cultural markets became dominated by an ever dwindling number of...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... shape of the response curve isstrongly affected by the two groups of parameters thatdetermine the protein–protein interactions: the concen-trations of the enzymes relative to the target protein, and ... dephosphorylation by the kinase) due to competi-tion of the two enzymes for the target. Indeed, there isexperimental evidence for kinases and phosphatasescompeting for binding to their targets [39].Assuming ... of phosphataseboundtarget protein3ịThese account for both enzyme–target binding and the catalysis. K and P denote the free concentrations of kinase and phosphatase, respectively, and Ln and Qnare the respective...
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THE FACTORS AFFECTING THE USE OF ELDERLY CARE AND THE NEED FOR RESOURCES BY 2030 IN FINLAND pot
... Simulations30 The growth in operating costs is of the same order of magnitude as the rise in the number of care personnel. The € 508 million operating cost of the domicileelderly care in the year 1999 ... IntroductionDuring the next decades the demographic composition of the Finnish populationwill change dramatically. Due to the combined effects of increased longevity and ageing of the large post-war baby ... 10). Finally, the change in probability to have a certain dependency statusat a certain age group was calculated linearly by multiplying the marginal value by the assumed number of years, the...
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