serial changes in expression of proteins in response to neoadjuvant chemotherapy in breast cance
báo cáo hóa học:" Optical imaging of the peri-tumoral inflammatory response in breast cancer" docx
... [32,33] Jin et al demonstrated a role for integrin alpha beta in the homing of monocytes to tumors Specifically, the group noted that blocking this integrin in a mouse model of implanted lung cancer ... mouse after intravenous injection of DiD-labeled monocytes (a) In vivo optical imaging of a MMTV-PymT mouse after intravenous injection of DiD-labeled monocytes Top row, left to right: pre-injection, ... FDA approval In conclusion, tracking monocytes non-invasively will lead to a better temporal and pathophysiological understanding of the in vivo inflammatory response around breast cancers Moreover,...
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Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx
... reported to be an indicator of poor prognosis in AML [3] In the present study, we evaluated the cytotoxicity of curcumin in DNR-insensitive CD34+ AML cell lines (KG1a and Kasumi-1) and in CD34+ ... the cytotoxic effect of DNR in DNR-insensitive KG1a and Kasumi-1 cells, associated with down-regulation of Bcl-2 To determine if curcumin could enhance the cytotoxic activity of DNR, DNR-insensitive ... Curcumin inhibits proliferation in a variety of cancer cells through targeting multiple cellular signaling pathways [21], including the mitogen-activated protein kinase [22], nuclear factor kappaB...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... (IL)-4 staining Multiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants (b) An excess of Th1 over Th2 cytokines was detected PE, phycoerythrin; TNF, ... T-cell lines was determined by intracellular (IC) staining of lines PMA (phorbol 12-myristate 13-acetate)/ionomycin activated T cells (a) We detected interferon (IFN)-γ staining but no interleukin ... proliferative response to CI was defined as a greater-than-twofold increase in proliferating T cells (CFSElow) in response to antigen Flow cytometry Surface markers of proliferating cells were...
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Báo cáo khoa học: "Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer" ppt
... start of CRT, and serial- step sections of the biopsy samples were cut with μm width, fixed in 10% formalin solution, then embedded in paraffin, stained with hematoxylin-eosin, and the grade of tumor ... lymphocytes into the irradiated tumor during CRT, which may lead to improvement of the clinical efficacy of RT in rectal cancer Taken together, our results indicate that the quantitative measurement of ... the circulating lymphocyte count is correlated with tumor response to CRT [13] This finding is in line with the data in this study, and suggested that the maintenance of circulating lymphocytes...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
... Ras-GAP binding proteins (G3BP) Oncogene 2007, 26(29):4209-4215 27 French J, Stirling R, Walsh M, Kennedy HD: The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in ... Cell Death inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression Breast Cancer Res Treat 2009, 114(2):203-209 37 Frankel LB, Christoffersen NR, ... verification Haematoxylin and eosin (H&E) staining and immunohistochemical staining are shown on pathology sections of tumors implanted in NOD/SCID mice In a, b and c, the staining showed a single cell...
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báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx
... molecule mechanism of MTA1 restraining ER alpha expression in breast cancer cells was that MTA1 interacted with MTA1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulated ... deacetylation of histone made chromatin structure become compacting, and restrain transcription Acetyl was linked to N-terminal of histone by histone acetylase (HAT) catalyzing, then the histone acetyl in ... cyclinD1, and on cancer cells invasion, proliferation and cell cycle cell in two cell lines were investigated Page of 11 Construction of shRNA expression vector for MTA1 According to principle of...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... immunoglobulins isotypes, other cytokines of importance in mucosal immune responses as well as responses to purified secreted proteins Competing interests The kinetics of lymphoproliferative response ... production of this cytokine was observed over the study period (data not shown) Discussion Use of intradermal BCG vaccination results in a greater number of individuals capable of responding to skin ... Levels of expression differed between individuals, but kinetics were maintained All subjects were capable of IL-4 production in response to secreted proteins although no peak was observed; instead...
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Báo cáo y học: " Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma" pdf
... examine reproducibility of the airway response to exercise in the type of individual most likely to be referred for exercise testing for EIB Exercise testing to identify EIB in the laboratory ... prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination Eur Respir J 1990, 3:540-547 Dahlén B, Roquet A, Inman MD, ... fall in FEV on both challenges) was 10.7% and similar to that reported for groups of normal adults or children, without a history of symptoms of asthma, exercising in ambient air in a laboratory...
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Báo cáo y học: "Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions" doc
... applied in order to investigate the KLK5 expression association with the histological features of breast cancer patients, aiming to examine its clinical value for the discrimination of the cancerous ... factor binding proteins (IGFBPs), thus releasing, in this way, the mitogenic role of insulin-like growth factors (IGFs) [3] Furthermore, KLKs are able to stimulate protease-activated receptors ... aim of the current study was the expression analysis of KLK5 in cancerous and benign breast lesions, targeting the evaluation of the clinical use of KLK5 expression for the discrimination of the...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... binds to the hypoxiaresponsive element of target genes that encode proteins involved in various cellular processes, including inhibition of apoptosis Hypoxia has been reported to inhibit apoptosis ... apoptosis in HCT116 human colon carcinoma cells by inhibiting the translocation of Bax from the cytosol to the mitochondria, thereby preventing the release of cytochrome c and progression of apoptosis ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells...
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Báo cáo hóa học: " In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor" potx
... cytoplasmic expression Dif- Page of 13 ferently, using the anti-ErbB-2 antiserum cross reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane ... action of htid in human tumorigenesis is of biological relevance in view of the multiple molecular interactions of the proteins it encodes [715,25,26] The ability of the hTid proteins to interact ... central component of the Wingless/Wnt pathway and the E-Cadherin mediated signalling or the Inhibitor of IKB in the NFκB signalling [11], crucial for driving the expression of regulators of cell cycle...
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báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt
... quality -of- life measurement in randomized clinical trials in breast cancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life in breast ... Classifying patients into subgroups Change scores on global health of the EORTC QLQ-C30 were used to identify subgroups of patients In an analysis of the clinical significance of changes in HRQoL, ... and Treatment of Cancer QLQC30: a quality -of- life instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85(5):365-376 Bottomley A, Aaronson NK: International...
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Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
... study: this surprisingly positive finding may be explained in terms of perceived quality of care related to the offering of custom-made specialised exercise protocols Short duration interventions ... impact of exercise training on QOL in breast cancer survivors The aim of this study was to assess the association between physical exercise and quality of life in a population of female breast cancer ... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
... high [7] Cancer invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer ... prognosis of the patient unlike that of CRP Interleukin-6 (IL-6) is a multi-poietic cytokine that induces the growth and differentiation of immune cells, the production and expression of other cytokines, ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer,...
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Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
... at 65°C, deparaffinized in two 10-minute changes of xylene, transferred through two 3-minute changes of 100% ethanol, one 3-minute changes of 85% ethanol, one 3-minute changes of 70% ethanol and ... Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) ... concordance between IHC and FISH in 50 cases of invasive ductal carcinoma of breast Methods Study Design The study population consists of 50 cases of invasive ductal carcinoma of breast treated between...
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Báo cáo khoa học: "Reduction of radiation pneumonitis by V20-constraints in breast cancer" pps
... radiological and symptomatic RP was rare in this study when 3-D treatment planning, aiming at minimizing V20 to the ipsilateral lung to
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Báo cáo khoa học: "An ultrasonographic evaluation of skin thickness in breast cancer patients after postmastectomy radiation therapy" docx
... measurements of each of the nine points of irradiated skin were compared with corresponding points of non-irradiated skin by using a t-test This test determined the significance of differences ... variation in skin thickness in the conservatively managed breast This finding suggests a need to use the same examination point when performing serial and comparative examinations The results of this ... non-irradiated breast This finding might be helpful to predict late skin reactions In spite of just using two grades of RTOG scoring in this study, a statistically significant predisposition to chronic...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
... truncating, giving rise to shorter versions of the protein where the C-terminal domain of the protein often is deleted [4] Individuals who are AT- heterozygous have been reported to have intermediate ... PI3K domain, substrate binding domains and ATPbinding domains, is illustrated in Figure Single marker associations Risk for developing breast cancer The association between any variant in the ATM ... variation in the ATM gene where combined into one group The level of adverse side effects in the Norwegian breast cancer patients or risk of IBTR in the American breast cancer cases were then Page of...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25