role in haemostasis and venous thromboembolism
the auditors’ role in detecting and preventing fraud
... implementation and maintenance of effective internal controls by: - Developing and maintaining an internal control system that is adequate and effective in managing risk - Improving the efficiency and effectiveness ... auditors’ role 2.2.1.2 Internal auditor’s role 2.2.2 Role of auditor in preventing fraud 2.3 The company applies internal control to detecting and preventing fraudulent activities 2.3.1 How internal ... auditors in detecting fraud in financial statements SAS No.99 request independent auditors to obtain information to determine the risk of financial statement fraud, risk assessment by participating in...
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Interest Rate Policy in Egypt - Its Role in Stabilization and Adjustment pdf
... discounted A Interest Rate and Business Investment The first step in examining how higher interestrates may influence business investmentdecisions and performances is the understandingof firms' ... Government plays a dominantrole in the financialmarket and its interventiinstake many forms, not only in terms of deficit financing,but also equity participationand management control in virtually all ... and domestic demand including public coneumption,the poor performance in export earnings brought about by a combinationof fallingoil prices, rising interestpaymentson external debt, and declining...
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Lipoproteins – Role in Health and Diseases by Saša Frank and Gerhard Kostner doc
... the protein chain According to this model, epitopes in the LDL receptor binding domain are located on one side of LDL, whereas epitopes located in the N-terminal and Cterminal domains are in close ... lipoprotein structure, the assembly and kinetics of apoB containing lipoproteins, and the role of Lp(a) in kidney patients Section reviews clinical chemical methods for diagnosing patients at increased ... Insights into the Assembly and Metabolism of ApoB-Containing Lipoproteins from in vivo Kinetic Studies: Results on Healthy Subjects and Patients with Chronic Kidney Disease 21 Benjamin Dieplinger and...
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Immunosuppression – Role in Health and Diseases Edited by Suman Kapur and Maristela Barbosa Portela ppt
... inflammatory molecules, such as chemokines and chemokine receptors, in leukocytes Chemokines induce cellular migration and are crucial players in initiating both innate and adaptive immune response (Figure ... Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF J Clin Invest., 101, 4, ... – Role in Health and Diseases inflammatory genes during ET are also available For example, binding of high-mobility group box proteins (HMGB1) and histone H1 linker at the promoters of TNFα and...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... upregulation of inflammation in this setting [181] Another RAGE ligand, AGE-CML, is present in endoneurial and epineurial mononuclear cells in chronic inflammatory demyelinating polyneuropathy and vasculitic ... dominant-negative phenotype and blocks signaling Soluble RAGE can act as an extracellular "decoy receptor", antagonizing flRAGE and other receptors by binding DAMPs and other ligands and inhibiting...
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IMMUNOSUPPRESSION – ROLE IN HEALTH AND DISEASES pdf
... inflammatory molecules, such as chemokines and chemokine receptors, in leukocytes Chemokines induce cellular migration and are crucial players in initiating both innate and adaptive immune response (Figure ... Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF J Clin Invest., 101, 4, ... – Role in Health and Diseases inflammatory genes during ET are also available For example, binding of high-mobility group box proteins (HMGB1) and histone H1 linker at the promoters of TNFα and...
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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx
... important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are ... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the...
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báo cáo khoa học: "Left sided inferior vena cava duplication and venous thromboembolism: case report and review of literature" ppsx
... findings in the case report Duplication of the IVC, the prominent manifestation in our case report, occurs because the left supracardinal vein fails to regress early in gestation resulting in ... following an extensive PubMed literature search encompassing the following keywords: inferior vena cava, congenital, deep venous thrombosis, and pulmonary embolism From an anatomical standpoint in ... wall-stent draining into the left renal vein with a non-occlusive thrombus within it The orthotopic IVC remained patent The patient was kept on heparin for 24-hours and then started on Coumadin Discussion...
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báo cáo khoa học: " Inversion variants in the human genome: role in disease and genome architecture" ppsx
... remain to be explored in further detail include inversion formation mechanisms, characterization of breakpoints, and development of maps and strategies for inclusion of inversion variants in genome-wide ... breakinduced replication (MMBIR) [33] Other specific mechanisms that have been suggested to be involved in creation of inversions include fork stalling and template switching (FoSTeS) [34] and ... sequencing, the number of inversions reported has increased dramatically and the inversion breakpoints will be pinpointed at much higher resolution Over the next year or two, the true extent of inversion...
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Báo cáo y học: " Etanercept and venous thromboembolism: a case series" docx
... baseline data on aPLs prior to the initiation of etanercept therapy in two of the three patients In addition, this clinical observation is insufficient to explain if there is, indeed, an increased ... deficiencies and confirm phospholipid dependency; protein C; protein S; antithrombin III, Factor V Leiden; homocysteine; and prothrombin gene mutation (Table 1) All three patients had prolonged aPTT and ... details Internal Medicine, Michigan State University, East Lansing, MI, USA 2Internal Medicine and Rheumatology, Michigan State University, East Lansing, MI, USA 3Department of Medicine, Special...
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Báo cáo khoa học: "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions" ppt
... main HECT E3 protein families They are characterized by a unique domain architecture, with an amino-terminal C2 domain, two to four proteinprotein interacting WW domains and a carboxyl terminal ... network in HSV-2 infected cells We further investigated detailed intracellular localization of UL56 in infected cells using immunostaining Infected cells contain abundant viral proteins which are incorpo- ... suggests that the interaction of the two proteins is dynamic and transient Given that Nedd4 participates in many cellular trafficking activities including protein sorting and viral budding, UL56 can...
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báo cáo khoa học: " Co-expression and promoter content analyses assign a role in biotic and abiotic stress responses to plant natriuretic peptides" pptx
... protein Wall-associated kinase (WAK1) Hin1 – role in hypersensitive response Mitochondrial protein of unknown function Zinc finger (C3HC4-type RING) family Calmodulin binding protein SigA-binding ... a number of Ca2+ sensing/binding proteins including, the above mentioned CNGC20, calreticulin (At1g08450; r = 0.60), two calmodulin-binding proteins (At1g73800; r = 0.63 and At1g73805; r = 0.588) ... Protein kinase family protein Phosphohistidine phosphatase activity Disease resistance, leucine rich-repeats Similar to YGL010w-like protein NPR1/NIM1-interacting prot (NIMIN1) Protein kinase...
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Characterization of rab22b, an astroglia enriched rab GTPase, and its role in golgi and post golgi membrane traffic
... act in a more indirect manner Thus, Rab11, besides playing important roles in retinal development of the eye and embryogenesis, also appears to have a specific role in neuronal and neuroendocrine ... form myelin sheaths (Simons and Trajkovic, 2006) The microglia is the equivalence of 24 Introduction immune cells in the CNS, playing roles in CNS inflammatory responses and serving in phagocytotic ... and the ability to disrupt a specific marker seemed to indicate that it may be involved in trafficking in and/ or out of the TGN Further investigations illustrate that Rab22B is not involved in...
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Tài liệu Pathophysiology and Clinical Aspects of Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients Edited by Mohammed A. Abdelaal ppt
... promising and exciting new area for researchers and clinicians working in this area Microparticles: Role in Haemostasis and Venous Thromboembolism 13 Microparticles have therefore emerged as key role ... Microparticles: Role in Haemostasis and Venous Thromboembolism Anoop K Enjeti and Michael Seldon Chapter Hyperhomocysteinemia: Relation to Cardiovascular Disease and Venous Thromboembolism 17 Nadja Plazar and ... 2.2 Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins may result in misincorporation...
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PATHOPHYSIOLOGY AND CLINICAL ASPECTS OF VENOUS THROMBOEMBOLISM IN NEONATES, RENAL DISEASE AND CANCER PATIENTS pdf
... promising and exciting new area for researchers and clinicians working in this area Microparticles: Role in Haemostasis and Venous Thromboembolism 13 Microparticles have therefore emerged as key role ... Microparticles: Role in Haemostasis and Venous Thromboembolism Anoop K Enjeti and Michael Seldon Chapter Hyperhomocysteinemia: Relation to Cardiovascular Disease and Venous Thromboembolism 17 Nadja Plazar and ... 2.2 Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins may result in misincorporation...
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Báo cáo y học: "Prevention and diagnosis of venous thromboembolism in critically ill patients: a Canadian survey" ppt
... particularly in pulmonary medicine [31] and VTE [32], could better inform clinical decisions and minimize the dissemination of nondiscriminating and unnecessary tests Pressing investigations in this ... projects, industry-initiated projects, or funding agency directives An alternative approach to set intensive care research priorities in the United Kingdom and Ireland incorporated a survey, then nominal ... Topics to address included the test properties and risk:benefit ratio of noninvasive VTE investigations in the ICU setting, accurate profiling of both the thrombotic and bleeding risk among critically...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... ethanol-induced expression and activation of cytokines and chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal ... NM_014393 ▲ 1.52 regulation of transcription protein binding double-stranded RNA binding DNA binding ▼ 5.02 protein binding NM_001149 NM_004242 ▲- increased ▼- decreased Validation of microarray ... Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular carcinoma derived...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... very-KIND-MAP2 interaction v-KIND KIND2 KIND2-1 KIND2-2 KIND2-3 KIND2-4 KIND2-5 A 620 521 555 488 589 EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 ... the structural and functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding core module in MAP2) across ... deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain anchors v-KIND to dendrites Flag-tagged v-KIND, DKIND1, DKIND2, DKIND1 + 2, DRasN, DGEF, KIND1 or KIND2 together with...
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Tài liệu LIVESTOCK''''S ROLE IN CLIMATE CHANGE AND AIR POLLUTION ppt
... acidity, integrated pest management, double-cropping, and crop Livestock’s role in climate change and air pollution rotations including green manure and cover crops Increasing crop yields result in ... Burning is common in establishing and managing burning represented some 85 percent of the area of pastures, tropical rain forests and savannah burned in Latin American fires 2000, 60 percent in ... conversion to appropriate land uses, and adoption of recommended management practices on cropland and grazing land.” Taking just the grasslands in Africa, if the gains in soil carbon stocks, technologically...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... PDZ proteins: Mint-3, AMPA binding protein and glutamate receptor interacting protein (GRIP) It would therefore be interesting to determine whether this motif is also involved in the interaction ... binding domain We therefore cannot rule out an interaction between MT1-MMP ICD and the GRASP55 PDZ1 domain GRASP55 binds to furin, PC5/6B and PC7 intracellular domains The pro-convertase furin ... UK) were maintained in DMEM containing 10% (v/v) fetal bovine serum (Hyclone Laboratories Inc., UT, USA), mm l-glutamine, 100 UÆmL)1 penicillin and 100 lgÆmL)1 streptomycin at 37 °C in 5% CO2...
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