regulation of viral gene expression and the discovery of runx family genes
Báo cáo y học: "Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren’s syndrome" pdf
... specific VH genes for the variable regions Despite the apparent increase in the use of these specific genes, the generalized higher frequency of somatic hypermutation, abnormal patterns of targeted ... similar in the peripheral blood and in the parotid gland These results suggest an important role for VL chain gene usage in the immune activation of B cells within the parotid gland of the pSS patient ... CD5, further supporting the hypothesis of homing and activation of specific B cells in the glands B cell malignancies and Sjögren’s syndrome In contrast to the focal sialadenitis of the minor...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
... rule out the possibility that the connection between age and expression is spurious due to the misclassification of rapidly evolving genes and the connection between tissue expression and recent ... recent rate of evolution, Subramanian and Kumar [3] showed that the connection still exists in a slowly evolving set of data However, the assumption that the slow rate of evolution of the genes assumes ... chromosome-encoded genes The absence of those two enzymes during the inactivation of the X chromosome in postmeiotic spermatogenic cells is compensated for by the expression of their autosomal testis-specific...
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Báo cáo y học: "Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep" pdf
... Altogether, our findings strongly support the hypothesis that switching-off viral gene expression, including Tax, the essential contributor to the oncogenic potential of BLV, is critical, if not mandatory, ... this antigen is the major transforming protein The demonstration in S2531 of a link between the interruption of the long clinical latency and the complete suppression of viral expression suggests ... Whatever the mechanism – genetic or epigenetic – it is critical for achieving complete silencing of all viral genes Cellular changes that have occurred during the process of leukemogenesis are...
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Báo cáo y học: "Genome-wide patterns of carbon and nitrogen regulation of gene expression validate the combined carbon and nitrogen (CN)-signaling hypothesis in plants" pptx
... list, n was the number of genes in Model CN-enhanced (the child list), k was the number of genes in the pathway being analyzed and in the child list, and p was the number of genes in the pathway ... examine the regulation of these funcats in all of the sub-models This analysis enabled us to determine into which sub-models the genes from these funcats fell and to determine whether the genes in these ... was the number of genes assigned to Model CNenhanced and the funcat being analyzed divided by the number of genes assigned to Model CN-enhanced and a funcat; k was the number of genes in the...
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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx
... Src- and Shc-dependent and resulted in enhanced expression of the uPA gene and, to a lesser extent, of the MMP-9 gene (data not shown) Disruption of cell–cell adhesion by calcium chelation Loss of ... increased expression of uPA is directly related to higher tumor growth and metastasis [1] Several analyses have already made it clear that the expression of E-cadherin and the expression of MMPs ... disruption of E-cadherin-dependent cell–cell-adhesion and the expression of uPA are causally involved in tumor progression, the understanding of these underlying intracellular events is of importance...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... bromide stained gels of the reaction products obtained using lL of the RT products after 30 cycles of PCR amplification The lower part of panel A, and panels B, C report the expression of c-myc mRNA ... Interestingly, both the inhibition of MEK/ERK pathway and the exposure of ECV304 cells to NAMI-A resulted in down regulation of c-myc gene expression with superimposable magnitudes and kinetics profiles ... corresponding to the immunoreactivity of ERK1/2 and phospho ERK1/2 (A,B), and MEK1/2 and phospho MEK1/2 (C,D) The lower part of each panel reports the quantitative analysis of phospho ERK1/2 (A,B), and phospho...
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... activity of PEPCK, G6Pase and F1,6bpase, and the targeted overexpression or knockouts of these enzymes play a major regulatory role in glucose homeostasis [40,41] As far as the regulation of these genes ... least in part, the expression of gluconeogenic genes [17,31], we studied its status within the cell in the given experimental conditions Foxo1, another member of the forkhead family of transcription ... a series of events beginning with the TNFa-mediated prevention of the effect of insulin on Foxa2 localization and leading to the abrogation of insulin inhibition of gluconeogenesis and glucose...
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Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... respond to the presence of IPTG, and such clones were indeed found at a frequency of 22% of the second cross over event Southern blot analysis and DNA sequencing of one of these clones in the topA ... due to regulation at the activity level and 28% (2.2 of 7.8) is due to regulation at the gene expression level Of the latter 28%, 7% is accounted for by regulation through topoisomerase I expression ... at D540 0.2, 0.3 and 0.4) The error bars denote the standard error of the mean Precise growth conditions are given in Materials and methods Modulation of the expression of topoisomerase I by...
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Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt
... the rest of the cell cycle (10 and 20 h), correlating with the expression of the gene (Fig 6C,D) The correlation of promoter occupancy of MLL1, H3K4 trimethylation and RNAP II with Hox gene expression ... Hox gene regulation during the cell cycle In order to understand the molecular mechanism of the differential regulation of Hox gene expression, we analyzed the changes in H3K4 methylation and ... indicates the critical roles of MLL1 and H3K4 trimethylation in differential Hox gene expression during the cell cycle To further confirm the importance of MLL1 in the regulation of HoxA5, HoxA7 and...
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Báo cáo khoa học: Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes docx
... increased, but then the mRNA levels of both SREBPs and their target genes became significantly elevated at and 12 h (Fig 4) Based on the fact that the increase in the mRNA of these genes was nearly ... imply the involvement of the O-glycosylation of Sp1 in the induction of SREBP-1a transcription by glutamine The gene expression of SREBP-1c, which represented less than 20% of the SREBP-1a gene expression ... for the constituent of membrane, we examined whether glutamine regulates the expression of genes involved in cholesterol homeostasis To investigate the effect of glutamine on the transcription of...
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Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I docx
... 4.3 and 7.3 mgÆdL)1) This indicates that the genetic basis of APA is complex and other genetic and/ or biological factors are involved in the occurrence of APA The structural organization of the ... 3) than the CC genotype (lanes 1, and 4) Effect of the )1CfiA mutation on reporter gene expression To further confirm that the )1CfiA mutation is associated with low expression of the b2GPI gene, ... disequilibrium with the Trp316Ser mutation and is associated with significantly lower b2GPI plasma and mRNA levels and the low occurrence of APA Furthermore, this mutation reduces the expression of the luciferase...
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Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... molecules of the target gene to the number of molecules of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene The primer efficiencies for the test genes were the same as those for the GAPDH gene ... with licofelone at both concentrations reduced the levels of mRNA expression and protein synthesis of cathepsin K The effect was similar at both of the tested dosages for gene expression and more ... for the resorption of the calcified cartilage and subchondral bone in the early phase of the disease [18] Licofelone treatment was shown to reduce the level of synthesis of cathepsin K in both of...
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Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats potx
... measure of the total number of receptors present in the tissue and the equilibrium dissociation constant is the measure of the affinity of the receptors for the radioligand The Kd is inversely related ... plotting the specific binding of the radioligand on X-axis and bound/free on Y-axis using Sigma plot software (version 2.0, Jandel GmbH, Erkrath, Germany) The maximal binding is a measure of the total ... Scatchard analysis of [3H] dopamine binding against dopamine in the cerebral cortex and cerebellum of control and experimental rats The Scatchard analysis showed that the Bmax and Kd of the [3H] dopamine...
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Báo cáo y học: "JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin" ppsx
... components of NF-κB (data not shown) One of the consequences of inhibition of NF-κB is the inhibition of the nuclear translocation of p50 and p65 through the blockage of IκB release To study the result ... stimulating the cells with LPS or SNP in the + + - the treatment of JNK inhibitor on the translocation of p50 and p65 into the nucleus, we determined the appearance of the p50 and p65 in the nucleus ... effects of melittin and bee venom on iNOS and COX-2 expression, and on NO and PGE2 generation To investigate whether the suppressed effect of SP600125 on the inhibitory effect of bee venom and melittin...
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Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
... to increase the efficacy of the EGSs in vivo These studies will facilitate the Table 1: Inhibiting rates of the mRNA and protein expression of different viral genes in cells Viral genes HFFs EGS324 ... in the expression of IE2, UL44, pp28, and gB (Table 1) The observed level of inhibition of UL49 expression was consistent with the extent of the reduction of viral growth HCMV is a member of the ... cleavage of the target mRNA, but is due to other effects of the EGS on viral lytic replication, such as blocking the expression of viral immediate-early genes To exclude these possibilities and further...
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Báo cáo y học: "Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver" pdf
... unknown whether the chronic effect of AG28262 will result in morphologic changes or if the compound will independently alter the intrinsic regulation of ALT gene expression and synthesis Further investigation ... from the right and left branches of the portal vein [7] Insight on the potential distribution of drugs and toxins may help in understanding the potential localization of hepatic diseases and carcinomas ... amplification run to generate a standard curve off of which samples were quantified and expressed as a relative value Values were then normalized to the reference gene to generate gene expression results...
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Báo cáo y học: "Comment on and reply to "Analysis of variation of amplitudes in cell cycle gene expression" by Liu, Gaido and Wolfinger: On the analysis of gene expression during the normal, eukaryotic, cell cycle" docx
... wishes to look at the response of genes to perturbation, then it is a good experiment The problem is whether the methods of Whitfield et al lead to an understanding of what happens in the normal, unperturbed ... synchrony The data should speak for themselves 7) The DNA distribution of cells should be narrow in the synchronized cells and these distributions should then reflect the movement of cells through the ... synchronization and analysis of gene expression 8) The size distribution of newly synchronized cells should be narrower than the size distribution of the original population, cell size should increase as the...
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Báo cáo y học: " Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia col" ppt
... to HGT genes We found that HGT genes tend to be under more complex regulation than native genes, and the global regulator CRP regulates a higher proportion of HGT genes than of native genes We ... selection However, because these studies compared orthologous genes in E coli and its relatives, they did not examine the regulation of recently acquired genes As most of the genes in E coli K12 were ... TFs and putative, as yet uncharacterized regulators We analyzed the history of each of the global regulators, and of a sample of each of the other types of regulators (see Figure and Materials and...
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Báo cáo y học: "The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation" potx
... one-third of the predicted number of release4 genes were detected in the proteome of the tachyzoite, although it is important to remember that these predicted genes will include stage-specific genes ... confirmation of the correct prediction of ORFs and positioning of exon-intron boundaries, including a large number of hitherto 'hypothetical proteins' The further significance and importance of this ... reading frame and the large number of peptide hits to one region only indicates that the gene is likely to comprise a single exon For the majority of annotated genes, integration of the expressed...
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DEVELOPMENTAL DIFFERENCES AND ALTERED GENE EXPRESSION IN THE TS65DN MOUSE MODEL OF DOWN SYNDROME
... on the expression of these genes and molecules, but the dysregulation of other genes may also indirectly affect mandibular development 10 1.5 Sox9 Affects Endochondral Bone Development One gene ... interest, there were 11 down regulated Hox genes in the skeletal development group, six of which were in the top 20 most dysregulated genes (Figure 3.6.9) Further examination of these genes and their ... alter the development of the Ts65Dn mandible Interestingly, 155 genes were differentially expressed in the Ts65Dn mandibular precursor at E13.5, but none of these genes were triplicated in the...
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