rate gene age and gene expression in cortical vs sub cortical regions
Báo cáo y học: "Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas" ppsx
... neuroblastoma cell lines according to the MYCN/cMYC-binding pattern clearly separated MYCN- and c-MYCexpressing neuroblastoma cell lines Differentiation between MYCN and c-MYC binding was mainly achieved ... target genes in relation to MYCN and c-MYC expression in different clinical neuroblastoma subtypes In addition, the association of MYCN/c-MYC target gene expression with overall survival independent ... average gene expression profiles, we grouped the clusters into two subgroups, I and II Subgroup I genes (clusters 140, 168, and 195) were expressed at equal levels in SH-EPMYCN cells expressing...
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báo cáo khoa học: "Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties" pot
... apoptosis involving p73 and UHRF1 deregulation in Jurkat cells and in an in vivo colorectal cancer model A Schematic representation of RWPs-induced apoptosis involving p73 and UHRF1 deregulation in ... structural domains, some facing DNA and others facing histones (Figure 1) Among them, one of the most amazing domain is undoubtedly the SRA domain (Set and Ring Associated) which, in vertebrates, is ... S, Orpianesi C, Cresci A: Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats Mutat Res 2005, 591:237-46...
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Báo cáo y học: "Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units"
... cell count and noninfection and infectionC-reactive protein level for discrimination of noninfection and infection Receiver operating characteristic (ROC) curve of eosinophil cell count and C-reactive ... report testing the value of eosinopenia in the diagnosis of sepsis on admission to the ICU Eosinopenia is a good diagnostic marker in distinguishing between noninfection and infection in newly ... evaluated their age, gender, principal diagnosis, and vital signs (body temperature, heart rate, respiratory rate, systolic and diastolic arterial pressure, and urine rate) The Mc Cabe index [20],...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... chloroform and purified using QIAGEN RNeasy Mini Kit (QIAgen, Inc., Valencia, CA) cDNA was prepared from μg total RNA using the Invitrogen SuperScript Double-Stranded cDNA Synthesis Kit (Invitrogen, Inc, ... DNA content was divided into regions, sub- 2N DNA, 2N DNA, 2N to 4N DNA, 4N DNA and >4N DNA and the percentage of cellular events in each of the five regions quantified Defining Cell Sensitivity ... sensitive and resistant is defined in the Methods) Discordant values between proliferation and cell death were identified for 32 cell lines and subsequently excluded, leaving 59 cell lines in the...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
... chloroform and purified using QIAGEN RNeasy Mini Kit (QIAgen, Inc., Valencia, CA) cDNA was prepared from μg total RNA using the Invitrogen SuperScript Double-Stranded cDNA Synthesis Kit (Invitrogen, Inc, ... DNA content was divided into regions, sub- 2N DNA, 2N DNA, 2N to 4N DNA, 4N DNA and >4N DNA and the percentage of cellular events in each of the five regions quantified Defining Cell Sensitivity ... sensitive and resistant is defined in the Methods) Discordant values between proliferation and cell death were identified for 32 cell lines and subsequently excluded, leaving 59 cell lines in the...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... B-lymphocyte-induced maturation protein-1 (Blimp1), also called PR domain zinc finger protein (PRDM1), contains a PR-SET domain near the amino terminus (N-terminus) and five C2H2 Zinc finger domains near ... a sequence specific DNA binding domain, named the BED-type zinc finger domain (Aravind, 2000) The likely human BED-3 ortholog Zinc finger BED domain-containing protein (ZBED4) was reported to ... Soluble BLMP-1 conserved Zinc finger domain fusion protein was detected and purified in pGEX-KG vector 53 Figure 10: BLMP-1 zinc finger domain binds to motifs A and B in EMSA assays…………...
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C elegans PRDM1 blimp1 homolog BLMP 1 is a positive regulator of bed 3 transcription
... B-lymphocyte-induced maturation protein-1 (Blimp1), also called PR domain zinc finger protein (PRDM1), contains a PR-SET domain near the amino terminus (N-terminus) and five C2H2 Zinc finger domains near ... a sequence specific DNA binding domain, named the BED-type zinc finger domain (Aravind, 2000) The likely human BED-3 ortholog Zinc finger BED domain-containing protein (ZBED4) was reported to ... Soluble BLMP-1 conserved Zinc finger domain fusion protein was detected and purified in pGEX-KG vector 53 Figure 10: BLMP-1 zinc finger domain binds to motifs A and B in EMSA assays…………...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... Ang-1/Tie-2 signalling by reducing Ang-1 and inducing Ang-2 expression [39] In line with these results, admission levels of Ang-1 were markedly decreased in our patients This finding is in apparent ... 112:2139-2148 35 Mandriota SJ, Pyke C, Di Sanza C, Quinodoz P, Pittet B, Pepper MS: Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response ... various factors, including complement, cytokines, fibrin, activated platelets and leucocytes, and changes in oxygenation or blood flow [8,15] Orfanos and colleagues [25] and Ganter and colleagues...
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Tài liệu .An ARCO Book ARCO is a registered trademark of Thomson Learning, Inc., and is used herein under pptx
... describing a phenomenon and explaining its causes (B) outlining a position and supporting it with statistics (C) isolating an ambiguity and clarifying it by definition (D) presenting a problem and ... features, be sure to look in the margins of the book for extra information and advice, including: Bonus Information Note Notes highlight critical information pertaining to the GMAT Tip Tips draw ... market (C) is incorrect since this is not the main point of the selection You can infer that the author would approve of such a demand, but issuing the demand is not the main point of the selection...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
... (DNA-directed), delta interacting protein (POLDIP3) gene as a binding partner of the human ER PDIP46 ⁄ SKAR had been reported to be an interacting partner of the p50 subunit of DNA polymerase d and S6K1 that ... phenotype, whereas the YL7 strains expressing either the LexA DNA binding domain alone or this domain fused to lamin, were not able to grow on a medium lacking histidine and did not show the b-galactosidase ... C-terminus of both isoforms of PDIP46 ⁄ SKAR, including the amino acids of the RNA recognition motif (RRM) also known as the RNA binding domain (Fig 2) [26] Interaction of the human proteins ER and...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western blot analysis of PKCa in control VSMC, VSMC treated ... participating in cell survival signaling pathways and TS effects In this study, we found for the first time that TS enhanced LPS/IFN-induced NO production in VSMC, and that the TS effect would be induced ... with LPS, we examined the effects of inhibitors of PKA and PKC on TS-enhanced NO production As shown in Fig 5A, the PKA inhibitors KT-5720 and H8 and the PKC inhibitors Ro31-2880 and GF109203X did...
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Báo cáo khoa học: Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex pptx
... Drosophila and worm [21,22] A2BP1 and Rbm9 are involved in the regulation of alternative splicing in muscle and the nervous system, and operate through their binding to an intronic splicing enhancer in ... S1) In addition, the ORF contains two arginine ⁄ glycine-rich (RGG) motifs that are characteristic of RNA-binding proteins, and an alanine-rich carboxy-terminal sequence that could be involved in ... CPE-containing mRNAs via its interaction with other partners, including Maskin, the RNA helicase Xp54 and Pumilio [3–5] Maskin interacts simultaneously with both CPEB and the eukaryotic initiation...
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Báo cáo khoa học: "Creative Language Retrieval: A Robust Hybrid of Information Retrieval and Linguistic Creativity" pot
... Intent in Creative Comparisons In Proc of ECAI’2010, the 19th European Conference on Artificial Intelligence Veale, T and Butnariu, C (2010) Harvesting and Understanding On-line Neologisms In: ... a generic level, as in “priests and imams” or “mosques and synagogues” More generally, consider the pattern “X and Y”, where X and Y are proper-names (e.g., “Zeus and Hera”), or X and Y are inflected ... the ranking of Xij in ??X is a function of the ranking of Xi in ?X and the ranking of Xij in ?Xi Thus, ??artist matches far more terms than ?artist, yielding more diversity, more noise, and more...
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Báo cáo khoa học: Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle pptx
... cloned into pET32a (Novagen, San Diego, CA, USA) and expressed as a recombinant protein in Escherichia coli, BL21(DE3) Production of the protein containing histidine-tag residues was induced ... Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun N-terminal kinaseactivated EGR-1 signaling pathway in tumor necrosis factor-ƒ and lipopolysaccharide-induced ... DDC sense probe Actin Fig TH protein and mRNA expression in vertical sections of integument (A) Immunohistochemical staining of TH protein with the P separata anti-TH IgG (B) In situ hybridization...
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Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx
... in the same assay system In addition, T20 activated transcription in an EBVori-containing episome and, most interestingly, in the genome of all stable transformants established in the study In ... construct and subsequent sequencing of this DNA (Fig 7A) In the cell lines HLB8 ⁄ T20, HLB10 ⁄ T20, HLB15 ⁄ T20 and HLB13n5 ⁄ T20, each reporter was found to be integrated into an intergenic ... in Experimental procedures The corresponding regions in normal human chromosomes are shown The loci of integration are indicated with arrowheads (B) Luciferase gene expression in each cell line...
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Báo cáo khoa học: Ets-1/ Elk-1 is a critical mediator of dipeptidyl-peptidase III transcription in human glioblastoma cells pdf
... N-terminal domain of Ets-1 is involved in the formation of a complex with other proteins, whereas its C-terminal domain is involved in DNA binding [38] By contrast, the DNA-binding domain of ... binding a heterodimer of Ets-1 and Elk-1 to the probe, and the N-terminus of Ets-1 and the C-terminus of Elk-1 were involved in the formation of the heterodimer Preincubation of nuclear proteins ... rule out the inadvertent induction of mutation(s) by PCR Site-directed mutagenesis Oligonucleotide-mediated mutagenesis was employed to introduce mutations into the Ets-1- and Elk-1-binding motifs...
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Báo cáo khoa học: Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein potx
... important role in the regulation of MSP/RON signaling involved in inflammation, wound healing and cancer progression Further experiments of tissue injury and in ammation using genetically engineered ... MSP gene was subcloned into the pcDNA3.1/myc-HisA expression plasmid (Invitrogen, Carlsbad, CA, USA) and transfected into Chinese hamster ovary (CHO) cells using Lipofectamine 2000 reagent (Invitrogen) ... wild-type mice and HGFA)/) mice We generated a small mechanical wound in the dorsal skin of mice and examined the in ltration of macrophages by measuring the CD68 mRNA level One day after injury, the...
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Báo cáo khoa học: Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours pot
... Hippel–Lindau tumour suppressor protein acts as the substrate recognition protein of the E3 ubiquitin ligase complex [43], and induces the ubiquitination of HIF-1a on its N-terminal and C-terminal ... Toffoli and C Michiels Hypoxia-inducible factor-1 (HIF) a-subunit stabilization and HIF-1 activation under intermittent hypoxia Hypoxia induces numerous changes in gene expression in normal and tumour ... The use of these techniques and their combination allow a better understanding of spatial and temporal changes in hypoxia in solid tumours, and also allow the linkage of these changes with other...
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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
... VWF–collagen binding and to inhibit a2b1–collagen interactions Inhibition of a2 integrin subunit I domain binding to collagen by saratin In an attempt to determine whether the binding site on collagen ... that saratin interferes with integrin a2b1 binding to collagen, in addition to inhibiting VWF–collagen binding, presumably by binding to an overlapping epitope on collagen This has significant implications ... inhibiting VWF binding to collagen [8–11] Depraetere et al [12] then went on to demonstrate that both LAPP and calin block the binding site on collagen for the platelet integrin a2b1 The saratin-binding...
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Báo cáo khoa học: Myocyte enhancer factor 2 (MEF2) is a key modulator of the expression of the prothoracicotropic hormone gene in the silkworm, Bombyx mori ppt
... target gene in B mori as well as MADS box-containing genes in various other organisms Furthermore, the BmMEF2 gene is expressed in various tissues containing muscle and neural tissues in Bombyx ... tissues In this study, we demonstrated that the MEF2 binding sequences in the PTTH promoter enhance expression of the EGFP reporter gene in PTPCs and are important for binding of the BmMEF2 protein ... protein in Bombyx brain bound to the MEF2 consensus binding sequence, and its binding was prevented by an antiserum that recognizes the MADS box of BmMEF2 We examined this further using recombinant...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25