... substantialcontribution in analysing and interpreting the patient’sdata during the ICU admission and has been involved in drafting the manuscript for the part concerning the ICUadmission. He gave final approval ... journal.Competing interestsThe authors declare that they have no competing interests.Authors’ contributionsCB was the major contributor in collecting the patient’sdata and writing the manuscript. ... gave final approvalof the version to be published. VL made a substantialcontribution in the data-analysis and interpretation, andhas been involved in drafting the manuscript. She gavefinal...
... a benefitto prone positioning. CommentaryPro/con clinical debate: The use of pronepositioningin themanagement of patients with acuterespiratory distress syndrome John J Marini* and Gordon ... complications, such as ocular injury,jugular vein compression, and skin ulceration at points ofincreased pressure (for instance, the nose, chin, or knees).Maintaining a supine position may also be ... withholding effective life-saving therapy from apatient with ARDS by deciding not to put the patient in the prone position. Clinicians who choose ventilation in the prone position are applying experimental...
... concentration in pulmonaryepithelial lining fluid is a useful prognostic indicator in patients with acute respiratorydistress syndrome. Respiratory Research 2011 12:32.Kondo et al. Respiratory ... intense inflammatory and profibrotic reactions in the early phaseof acuterespiratorydistress syndrome. Crit Care Med 1999, 27:304-312.2. Ware LB, Matthay MA: Medical progress: the acuterespiratory ... Nakamura M, Fang X, Martin TR, Matthay MA,Hashimoto S: Elevation of KL-6, a lung epithelial cell marker, in plasmaand epithelial lining fluid inacuterespiratorydistress syndrome. Am JPhysiol...
... written,informed consent was obtained. After intubation with acuffed tube, all patients received into the trachea 20 ml ofnormal saline containing 7.5 mg of 13C-dipalmitoyl-phosphatidylcholine ... number not for citation purposes) Respiratory ResearchOpen AccessResearchSurfactant disaturated-phosphatidylcholine kinetics inacute respiratory distresssyndrome by stable isotopes and a ... therapeutic options. IntensiveCare Med 2001, 27:1699-1717.5. Haitsma JJ, Papadakos PJ, Lachmann B: Surfactant therapy for acute lung injury /acute respiratorydistress syndrome. CurrOpin Crit Care...
... implicated in thecourse of inflammatory lung diseases such as the Acute RespiratoryDistressSyndrome (ARDS). Indeed, in clinicalstudies focusing on ARDS [3-6] and, more recently, on severe pneumonia ... volumes as comparedwith traditional tidal volumes for acute lung injury and the acute respiratorydistress syndrome. The Acute Respiratory DistressSyndrome Network. N Engl J Med 2000, 342:1301-1308.15. ... regimen, may indeed promote better outcome in ARDS. In this line of reasoning, multiple surfactant dos-ing with persistent improvement in gas exchange mayultimately improve outcome in ARDS.ConclusionWe...
... resistance index (∆PVRI) induced by increasing inspiratory intratracheal concentrations of inhaled NO (Insp IT NO) in the presence (n = 8, ●) or absence (n = 8, ❍) of septic shock in 16 patients ... oxide in patients with adult respiratorydistress syndrome. Anesthesiol-ogy 1994, 80:761-770.7. Young JD, Brampton WJ, Knighton JD, Finfer SR: Inhaled nitricoxide inacuterespiratory failure in ... decrease in MPAPand an increase in PaO2/FiO2 in the range of 0.15 to 150ppm inhaled NO.Toxic effects of increasing concentrations of inhaled NOAs shown in Table 3, methemoglobin and NO2...
... cGMP increased significantly during NOinhalation. EVLWI did not change either during ANP infu-sion or during NO inhalation. In patients who responded toNO inhalation with an increase in PaO2/FiO2> ... only a modest increase in the arterialconcentration during the infusion of ANP. Since ANP wasinfused on the venous side of the circulation, these find-ings suggest that most of the infused ANP ... researchPrimary researchAtrial natriuretic peptide infusion and nitric oxide inhalation in patients with acuterespiratorydistress syndrome Alexander JGH Bindels*Đ, Johannes G van der Hoeven*ả,...
... adequatemechanical ventilation inacute lung injury and acuterespiratorydistresssyndrome (ARDS). In the presentstudy we tested the effect on gastric intramucosal pH of incremental increases in PEEP level ... http://ccforum.com/content/7/3/R17ResearchGastric intramucosal pH is stable during titration of positiveend-expiratory pressure to improve oxygenation in acute respiratorydistress syndrome Ibrahim Ozkan Akinci1, Nahit ầakar2, ... of acute lung injury(ALI) and acuterespiratorydistresssyndrome (ARDS). PEEPimproves oxygenation by redistributing the alveolar fluid andrestores functional residual capacity by keeping...
... and theirinteractions [1]. The common increase in the elastance(decrease in compliance) of the whole respiratory system in acute lung injury (ALI) and inacuterespiratory distress syndrome ... importance of chest wall elastance in characterizing acute lung injury /acute respiratory distress syndrome patients and in setting mechanical ventilation is increasingly recognized. Nearly 30% ofpatients ... the intra-abdominal pressureis altered. We in fact found that chest wall elastanceincreases linearly with the intra-abdominal pressureaccording to the following equation: Ecw= 0.47 ì intra-abdominal...
... in the acuterespiratory distress syndrome. N Engl J Med 1998, 338:347-354.3. Gutierrez G, Palizas F, Doglio G, Wainsztein N, Gallesio A, PacinJ, Dubin A, Schiavi E, Jorge M, Pusajo J, Klein ... NSAPACHE, Acute Physiology and Chronic Health Evaluation; Crs, Respiratory system compliance; Dbt, dobutamine; Dp, dopamine; LIP, lower inflection point; NE, norepinephrine (noradrenaline); NL, ... applied in four consecutive 30 minperiods, respectively. Respiratory rate was modified to main-tain end tidal CO2 within ± 10 mmHg of basal. All patientswere receiving a constant infusion...
... [11,12], adequate replacement ofintravascular fluid volumes is required to maintain cardiacCommentaryPositive end-expiratory pressure inacuterespiratory distress syndrome – an old yet mysterious ... end-expiratory pressure (PEEP)into the practice of mechanical ventilation in patients with acute respiratorydistresssyndrome (ARDS) [1] was amongthe most important milestones in critical care therapy.However, ... ventilation forpatients with acute lung injury or ARDS [7] increasinglyrecommend fairly high levels of PEEP. In view of this, anydata that may improve our understanding of the benefits anddangers...
... was present only in one patient(no. 13). Clinical data are given in Table 1. Twenty healthy non-smoking students independent of the investigating institutionswere enrolled and interviewed to ... ventilation by a moderateincrease in PEEP. Accordingly, increasing PEEP from 0 to 15cmH2O has been shown in a study of pulmonary mechanics toincrease pulmonary compliance in some patients, which ... CT scanned in maintained apnoea. The rebreathing proce-dure was performed in duplicate before and after a single CTexposure.Before the supine measurements, the nose-clipped, supineand relaxed...
... mortality in the acuterespiratorydistress syn-drome. N Engl J Med 1998, 338:347–354.Figure 1Thoracic tomography of two different models of acute lung injury /acute respiratorydistresssyndrome ... be kept in the mind of the critical care physicianswhen treating a patient with ARDS in the intensive care unit.Competing interestsThe author(s) declare that they have no competing interests.References1. ... ventilation [1]. (b) CT scan of acuterespiratorydistresssyndrome patients beforeand after a recruitment maneuver with 60 cmH2O maximal inspiratory pressure maintaining PEEP values of 20 and 25...