primary prevention of hepatitis c
Báo cáo y học: "Epidemiology of Hepatitis C Virus (HCV) Infection"
... Hepatitis C virus all need to be elucidated. Conflict of interest The authors have declared that no conflict of interest exists. References 1. WHO. Global surveillance and control of hepatitis C. ... world. Incidence rates across the world fluctuate and are difficult to calculate given the asymptomatic, often latent nature of the disease prior to clinical presentation. Prevalence rates across ... HCV transmission to others. The physician should also offer counseling on treatment, reducing alcohol usage and immunization with hepatitis A, hepatitis B, pneumococcal and influenza vaccines....
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Báo cáo y học: "The Natural History of Hepatitis C Virus (HCV) Infection"
... cirrhosis, hepatocellular carcinoma, HCV, HCC 1. Introduction Chronic hepatitis C is the most common cause of chronic liver disease and cirrhosis, and the most common indication for liver transplantation ... immunodeficient patients. The anti-HCV assay detects greater than 90% of HCV infections after the initial 3 months. 4. Chronic Hepatitis C Chronic hepatitis C is marked by the persistence of HCV ... development of complications, among different racial and ethnic groups with HCV infection. For unclear reasons, African Americans appear to have a higher rate of chronic HCV infection than Caucasians...
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Báo cáo y học: "Molecular Virology of Hepatitis C Virus (HCV): 2006 Update"
... Comparison of different replicon systems. A selection of different bicistronic and monocistronic replicon constructs including subgenomic and full-length HCV sequences is depicted schematically. ... Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science 2000; 290: 1972-4. 10. Bartosch B, Dubuisson J and Cosset FL. Infectious hepatitis C virus pseudo-particles containing ... research focus includes molecular biology and immunology of viral hepatitis B and C as well as basic and clinical aspects of gastrointestinal malignancies, especially hepatocellular and colorectal...
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Báo cáo y học: "Epidemiology and Prevention of Hepatitis B Virus Infection"
... adolescent vaccinatin programmes in Italy. Vaccine 2000;18:S31-S34. 77. Chang MH, Chen CJ,cLai MS. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. ... genotype C in China [34]. Accumulated data suggest the importance of genotype, subgroup and recombination that may influence the biological characteristics of virus and clinical outcome of HBV infection. ... Characteristics of endemic patterns of hepatitis B virus infection. Source: adapted from Ref.[7]. Characteristic Endemicity of infection Low (%) Intermediate (%) High (%) Chronic infection...
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Báo cáo y học: "Primary prevention of Down’s syndrome"
... successes with so-called ‘secondary’ prevention have not been matched with progress in primary prevention. Despite considerable research over many decades the principle cause of DS is unclear. ... decreased frequency of coitus in older women [73]. Such behaviour would reduce the chance of fertilisation before the ovum became over-ripe. There is epidemiological evidence which indicates ... Antenatal screening has the capacity to detect more than 90% of Down’s syndrome pregnancies leading to therapeutic abortion. Successes in recent years with such so-called ‘secondary’ prevention...
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Báo cáo y học: "The primary prevention of birth defects: Multivitamins or folic acid"
... termination of pregnancies. These cases comprised 77% of the HCAR [17]. Cases of isolated CAs and multiple CAs were included in the data set of the HCCSCA. However, three mild CAs (such as congenital ... Abnormalities (HCCSCA) [17] can provide a chance for the estimation of effectiveness of high dose of folic acid supplementation during the periconceptional period for the prevention of CAs. Here ... found in the occurrence of nonsyndromic omphalocele in a US population-based case-control study [13]. These CAs are considered as candidate CAs for the primary prevention by folic acid containing...
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Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx
... Pasteur, Paris,France). The primers used were VB1: 5¢-AAACATATGAGCATGAGCTACCACCTGGACC-3¢ and VB3: 5¢-CTCGAGCTTCACAAGAAACTTCTGC-3¢. The PCR fragmentwas cleaved by the restriction enzymes Nde1 ... used were NS5Bj4s2:5¢-GATATCATGTCAATGTCCTATACGTGGAC-3¢ andNS5Bj4r 5¢-AAACTCGAGGCGGGGTCGGGCACGAGACAGG-3¢. The PCR fragment was cleaved with restrictionenzymes EcoRV and Xho1 and inserted between ... discus-sions and critical reading of the manuscript. This workwas supported by the Agence Nationale de Recherchecontre le Sida (ANRS), the Centre National de laRecherche Scientifique (CNRS),...
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Báo cáo khoa học: Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses ppt
... proteintruncated 159 aa from the amino terminus, was amplifiedby PCR using the following primers: forward, 5¢-CATGCCATGGCGCCATTTTTCTTGAGACATGCC-3¢; reverse,5¢-CTGGGATCCGTCCGAATCAGGTTCCTTC-3¢(purchased ... benzimidazoles/benzotriazoles. Hepatitis C virus (HCV) infection, which results in chronicor acute hepatitis, and may lead to liver cirrhosis andhepatocellular carcinoma, is currently known to affect morethan 3% of the population ... underconditions described above.Effect of preincubation of compounds with enzymeon unwinding and hydrolysis efficacyThe selected enzyme was preincubated with a givencompound at 30 °Cin20lL of...
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Diagnosis, Management, and Treatment of Hepatitis C: An Update docx
... adjunct to treat-ment of HCV infection (Class IIa, Level C) .Treatment of Persons with PsychiatricIllnessesPatients with chronic HCV infection have a higherprevalence of psychiatric illness compared ... thepresence of HCV infection (Table 2) (Class I, level B).Counseling. Good clinical practice dictates that per-sons found to be HCV-infected are counseled regarding prevention of spread of the ... from child to child is rare. Therefore, theAmerican Academy of Pediatrics does not recommendrestricting children with chronic HCV infection fromschool attendance or participation in routine activities,including...
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Management of hepatitis C pot
... family, or close contacts, and sexual partners. Cohort studies of couples discordant for HCV indicated an HCV incidence of 0-2 per 1,000 years of sexual contact. Those with HIV co-infection, ... 5 Children and hepatitis C 106 Acute hepatitis C 127 Assessment of liver disease 138 Progression of untreated disease 159 Treatment of chronic hepatitis C 1810 Treatment of advanced infection ... Medical Association Scottish General Practice Committee Professor Hilary Capell Royal College of Physicians and Surgeons of Glasgow Ms Anne Marie Hawthorne Royal College of Nursing Professor...
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Báo cáo khoa học: Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle pdf
... replicationSerum-derived HCV Entire life cycle entry processreplication mechanismsintracellular host defencesantiviral screeningfew cell lines support infectiontechnical difficulties of primary ... of primary cell cultureHCV-LP Infection, morphogenesis cell attachmentvaccinationmorphogenesisno secretion of particlesindependence of CD81 for entryHCVpp Infection entry process no budding ... ERexogenous coreno association of particles with lipoproteinsHCVcc Entire life cycle entry processreplication mechanismsintracellular host defenceevasion mechanismsvirus productionantiviral screeningrestricted...
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Báo cáo sinh học: " Evolution of naturally occurring 5''''non-coding region variants of Hepatitis C virus in human populations of the South American region" doc
... indicated by a dot.A63TTCACGCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCTCCCGGGAGA TTCACGCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTACAGCCTCCAGGACCCCCCCTCCCGGGAGA GCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACCGGGTCCTTTCTTGGATCAACCCG ... GCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACCGGGTCCTTTCTTGGATCAACCCG GCCATAGTGGTCTGCGGAACCGGTGAGTACACCGGAATTGCCAGGACGACCGGGTCCTTTCTTGGATCAACCCG CTCAATGCCTGGAGATTTGGGCGTGCCCCCGCGAGACTGCTAGCCGAGTAGTGTTGGGTCGCGAAAGGCCTT ... CTCAATGCCTGGAGATTTGGGCGTGCCCCCGCGAGACTGCTAGCCGAGTAGTGTTGGGTCGCGAAAGGCCTT CTCAATGCCTGGAGATTTGGGCGTGCCCCCGCAAGATCGCTAGCCGAGTAGTGTTGGGTCGCGAAAGGCCTT 283 B Background1 TTCACGCAGAAAGCGTCTAGCCATGGCGTTAGTATGAGTGTCGTGCAGCCTCCAGGACCCCCCCTCCCGGGAGAGCCATAGTGGTCTGCG...
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Báo cáo hóa học: " Separation of Hepatitis C genotype 4a into IgG-depleted and IgG-enriched fractions reveals a unique quasispecies profile" docx
... Pure LC (RocheDiagnostics Ltd. UK,) according to the MagNA Pure LCTotal Nucleic Acid Isolation Kit protocol (Catalogue No:03038505001, Roche Diagnostics Ltd., UK) from 25 μl of an unfractionated ... AbstractBackground: Hepatitis C virus (HCV) circulates in an infected individual as a heterogeneousmixture of closely related viruses called quasispecies. The E1/E2 region of the HCV genome ... Neither of these latter events, whichare rare occurrences in genotype 4a, was identified in the IgG-enriched fraction.Conclusion: In conclusion, the homogeneity of the IgG-enriched species is...
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Báo cáo y học: " Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms" pps
... silencing,’’ the inhibition of distinct gene transcription. Oligonucleotide (ODN)decoys competitively inhibit binding of transcriptionfactors at the deoxyribonucleic acid (DNA) of specificpromoter ... moleculesInhibitors of ICOS-inducingprotein kinases3 Induction of Th1immune responsePattern recognitionreceptors on APCsActivation of TLR-2 Mycobacterial antigensActivation of TLR-9 CpG motifsActivation ... diseases.Subcutaneous applications of increasing doses of allergenover 3 to 5 years induce allergen-specific Foxp3+Tregs,which express surface molecules such as cytotoxic T-lymphocyte antigen (CTLA)-4...
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