pdk 2 and 4 are increased in the fasted state to inactivate the pyruvate dehydrogenase complex pdc by phosphorylation to conserve substrates for glucose production to assess the importance of pdk2
Báo cáo y học: " Tenascin-C and alpha-smooth muscle actin positive cells are increased in the large airways in patients with COPD" pot
... in consecutive sections Staining for desmin was done in 44 of the most representative cases for phenotyping the a-SMA positive cells In addition, vimentin was evaluated in 22 cases in which the ... in 83% of the COPD patients, in 46 % of the smokers and in 41 % of the nonsmokers When data are presented as cumulative number and proportion of individuals with increasing number of cells stained ... compared to smokers and nonsmokers (P < 0.001) Of the three ex-smokers in the COPD group, two were in the lowest staining category (a), and one in the intermediate (b) Page of 11 available stainings...
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Báo cáo y học: " Hemoglobin a and b are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD" potx
... M, Kinnula VL: Peroxiredoxin II expression and its association with oxidative Page 12 of 13 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 stress and cell proliferation in ... monomers Interestingly the larger molecular masses of spot (27 kDa) and (26 kDa) indicated the presence of Hba complexes Since exclusively Hba was detected in these complexes, they are likely to represent ... system (GE Healthcare) at 1 -2 W per gel and 12 C The total protein in the gel was visualized by silver staining The protein pattern was analyzed with the 2- D PAGE image analysis software Melanie 3.0...
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Báo cáo y học: "Markers of collagen synthesis and degradation are increased in serum in severe sepsis: a longitudinal study of 44 patients" pdf
... 0 .44 (0 .29 to 1) 0 . 24 (0. 12 to 1. 14) 0.3 0. 42 ( 0.19 to 1) Adrenaline 0 .4 (2% ) Vasopressin and analogues 3 1.0 ( 14% ) Activated protein C 0 .4 ( 14% ) Length of stay at the intensive care unit (4 to ... (4 to 12) (4 to 12) 0.7 (4 to 12) APACHE II 24 (23 to 29 ) 26 (22 to 30) 0.7 26 (22 to 30) Age, years Body mass index, kg/m2 Male sex Chronic diseases Focus of infection Organ failure 18 12 0.5 ... patients (25 ) Medical patients (19) P value All (n = 44 ) 63 (57 to 68) 63 (56 to 74) 0.9 63 (56 to 71) 26 ( 24 to 32) 26 ( 24 to 30) 0.8 26 ( 24 to 32) 15 14 0.3 29 (66%) - Ischaemic heart disease (20 %)...
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Báo cáo y học: "Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status" pps
... CC: Phosphorylation of CBP 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 Volume 9, Issue 3, Article R53 Yan et al R53 .20 by IKKalpha promotes cell growth by switching the binding preference of ... Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res 20 04, 10 ( 24 ): 820 4- 821 3 ... and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1 ,2, 11 , 24 -26 ] Furthermore, there is potential for cross-talk between IKK/NF-κB and other major...
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Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... E1aF266A E1aR267A E1aD276A E1aY281A E1aR282A E1aS283C E1aY281A/R282A/S283A E1aY281A/R282A E1aY281S/R282S 0. 128 0.133 0. 325 0.319 0 .26 8 0 .23 0 0.156 0 .4 52 0 .27 9 0 .41 ± ± ± ± ± ± ± ± ± ± 0.0 04 0.001 ... inactivated Binding of E1 to the peripheral subunit-binding domain of E2 The E1 component of the PDH complex of B stearothermophilus is bound to the E2 core mainly by interaction of its Table Kinetic ... 0 .46 0.35 1 .25 0.91 0.97 0. 62 0 .45 1.39 0.98 1.30 23 21 0.56 21 5.5 5 .2 13 2. 9 3.0 2. 7 20 17 22 32 42 177 121 33 48 1 326 47 5 ± ± ± ± ± ± ± ± ± ± 0.01 0.01 0. 02 0.01 0.01 0.01 0.01 0. 02 0.01 0.02...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... 1. 42 ) 1.51 ) 1 .43 ND ) 2. 17 ) 1.70 2. 60 3.09 3.17 3. 12 3.57 2. 71 2. 28 2. 04 1.86 1.01 2. 19 2. 51 2. 89 2. 78 2. 99 2. 38 1.99 ND 1.08 0. 74 0.07 0. 14 0. 04 0. 04 0.06 0. 14 0.07 0.17 0. 04 0.07 ... stabilizing the proteinprotein interface [31] All of the interactions reported in Fig in the range between and 6.0 A are identical in the major and minor fractions of the holoprotein in solution In ... group is linked to the protein by the Ser37 O-c atom Only residues 3138 of the protein make extensive contacts with the cofactor For the sake of better understanding of the interactions, the entire...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
... SSIII-CD 22 1 025 D1 D2 D3 40 5 CD-D 123 CD CD-St2.1 D3 344 CD D3 316 CD CD-St2 .2 D3 CD 22 CD-St2.3 575 576 D1 D2 29 0 D3 D2 D3 45 6 29 0 22 (Fig 2) After incubation of the CD extract with the Ni2+ resin ... was observed for CD 23 and CD–St2.1, but not for the CD–St2 .2 protein, showing the importance of the interacting region in the D2 domain and the linker region connecting CD and SBDs for full SSIII ... pVAL21, pVAL25, pVAL29 and pVAL31– pVAL38 (corresponding to D 123 , D23, D3, D2, D1, D 123 W366A, D 123 Y394A, D 123 W366AY394A, St2.1, St2 .2, St2.3, St3.3 and St3 .2 His6-tag-containing proteins cloned in...
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báo cáo hóa học: " Indoors illumination and seasonal changes in mood and behavior are associated with the health-related quality of life" pdf
... 0. 14 2. 56 -0. 82 -1 .46 1.30 -0.0030 0.70 -2. 51 -0. 74 -1.19 -0. 62 -1.09 0.69 1. 14 2. 22 8. 94 2. 37 -2. 45 -2. 62 -1.86 -3 .46 0.010 0 .41 0. 14 0 .20 1.00 0 .49 0.0 12 0 .46 0 .23 0. 54 0 .28 0 .49 0 .25 0. 027 ... 0.0 028 0.0 026 0.0 027 0.0051 0.0 023 0.0 026 0.0038 0.0 0 24 0.0 029 0.0 026 0.0 028 0.0 029 0.0 0 24 0.0 025 -0 .29 -7.68 -4. 31 -1.50 1 . 24 1 .22 1. 12 -0.77 2. 54 4.08 1. 84 2. 14 1.010 -0.59 -8.70 -23 .63 -4. 10 ... indicators of the HRQoL and mental well-being Our study was supported in part by the grants #20 1097 and #21 026 2 from the Academy of Finland and a grant from The Finnish Medical Foundation (to Dr Partonen)...
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Báo cáo hóa học: " MAC Security and Security Overhead Analysis in the IEEE 802.15.4 Wireless Sensor Networks" potx
... up the role of a coordinator and a router 2. 2 Network topology The RFDs and FFDs combine together to form the two types of network topologies: star topology and peer -to- peer topology, shown in ... Figure In the star topology, the PAN coordinator acts as the initiation point for the network and other FFDs and RFDs connect to it Communications are performed between RFDs/FFDs and the PAN coordinator, ... parameters to select: M, the size of the authentication field, and L, the size of the length field M (3 bits) can be 4, 6, 8, 10, 12, 14, and 16 octets, has an encoding field of (M − 2) /2, and involves...
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Báo cáo y học: " MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppt
... (5 to 85) 65 (10 to 90) 0.39 ESR (mm/hour) 14 (1 to 43 ) 13 (2 to 86) 0.61 CRP (mg/litre) (n = 25 ) 11.6 (3 to 59) 4. 9 (< to 46 ) 0 .26 DAS28-CRP (n = 23 ) 3.91 (2. 6 to 5.7) 4 .2 (2. 3 to 6 .2) 0. 64 DAS28-ESR ... 53.0* (28 to 125 ) 15.0 (3 to 22 ) 0.0 04 1.8 (0 .4 to 16.3) 1.0 (0 to 4) 0. 045 PIPs bone erosion 2. 8 (0 to 20 ) 0 .4 (0 to 3 .4) 0.036 DIPs bone erosion 1.3 (0 to 8.8) 0.0 (0 to 3 .4) 0.018 14. 7 (8.3 to ... joint count 17 (1 to 40 ) 11 (4 to 51) 0.98 Swollen joint count (0 to 33) (0 to 9) 0 .20 Pain score 35 (16 to 78) 45 (6 to 82) 0 .47 HAQ score (n = 27 ) 1.1 (0 to 3.5) 0.7 (0 to 3) 0 .26 PF-SF-36 52. 5...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... crucial for the induction of Foxp3+CD4+CD25+ T cells and for the suppression of CIIreactive T-cell function in induction of oral tolerance to CII These results demonstrate that the induction of IDO+ ... cells induces the expression of IDO on DCs [40 ] Considering these findings, we next sought to determine whether IDO+ DCs increase the proportion of antigen-specific CD4+CD25+ regulatory T cells in ... for CD4+CD25+ regulatory T cells Foxp3 may be necessary for the induction of CD4+CD25+ regulatory T cells by conversion of CD4+CD25T cells after antigen stimulation [41 ] We found that CD4+CD25+...
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Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt
... of human autoimmune conditions, including SLE [ 24 ,25 ,40 ], scleroderma [ 24 ,40 ,41 ], Sjögren's syndrome [ 24 ,40 ], rheumatoid arthritis [ 24 ,40 , 42 ] , multiple sclerosis [ 24 ,40 ,43 ], and type DM [33 ,44 ] ... ± 0 .20 *** (0.013) 0.11 ± 0.17 CD4+CD25+ Treg cells 6. 62 ± 4. 30 6.39 ± 3 .41 6 .46 ± 2. 98 31. 62 ± 14. 41 25 .06 ± 13.13** 29 .05 ± 12. 69 CD4+CD45RA+CD45RO- Naive CD4+ cells CD4+CD45RA-CD45RO+ CD4+ cells ... College of Rheumatology criteria for the classification of SLE and had two living parents who agreed to participate in the study In total 144 patients, 28 8 parents, and 79 siblings were investigated...
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Báo cáo y học: "MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage" ppsx
... (5 to 85) 65 (10 to 90) 0.39 ESR (mm/hour) 14 (1 to 43 ) 13 (2 to 86) 0.61 CRP (mg/litre) (n = 25 ) 11.6 (3 to 59) 4. 9 (< to 46 ) 0 .26 DAS28-CRP (n = 23 ) 3.91 (2. 6 to 5.7) 4 .2 (2. 3 to 6 .2) 0. 64 DAS28-ESR ... 53.0* (28 to 125 ) 15.0 (3 to 22 ) 0.0 04 1.8 (0 .4 to 16.3) 1.0 (0 to 4) 0. 045 PIPs bone erosion 2. 8 (0 to 20 ) 0 .4 (0 to 3 .4) 0.036 DIPs bone erosion 1.3 (0 to 8.8) 0.0 (0 to 3 .4) 0.018 14. 7 (8.3 to ... joint count 17 (1 to 40 ) 11 (4 to 51) 0.98 Swollen joint count (0 to 33) (0 to 9) 0 .20 Pain score 35 (16 to 78) 45 (6 to 82) 0 .47 HAQ score (n = 27 ) 1.1 (0 to 3.5) 0.7 (0 to 3) 0 .26 PF-SF-36 52. 5...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... action of Page 14 of 14 30 31 32 33 34 35 36 37 38 39 40 41 42 43 transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus J Immunol 20 04, 173:3 5 24 -35 34 ... production of these proteins may influence the proportion of A2 B and AB2 heterotrimers that are endogenously formed Furthermore, BLyS and APRIL appear to be differentially regulated [16 ,23 -25 ], and their ... determined from the kinetic rate constants (ka and kd) The binding curves were processed by double referencing and were globally fitted to a 1:1 binding model The stoichiometry of binding was...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... screening of candidate genes [21 ,22 ] This locus includes the genes for the TH2 cytokines IL -4, IL-5, IL-9, and IL-13 Aberrant production of IL -4 or hyperresponsiveness to this cytokine owing to inherited ... death of activated T cells Of these, IL -4 and IL-15 are the most effective [11] Inhibition of apoptosis by IL -4 might be mediated partly by the ability of this cytokine to maintain levels of the ... either the common γ chain or the IL-13 receptor α chain Binding of IL -4 results in the tyrosine phosphorylation of signal transduction molecules including motifs similar to those involved in insulin...
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Role of multidrug resistance associated protein 4 (MRP4 ABCC4) in the resistance and toxicity of oxazaphosphorines
... aim of this study was to investigate the resistance profiles of MRP4/ABCC4 to oxazaphosphorines including CP and IF in the absence and presence of various MRP4/ABCC4 inhibitors or MRP4/ABCC4 inducers ... delavirdine, efavirenz, emtricitabine [16 -22 , 24 , 25 , 29 34, 42 , 65] MRP2(ABCC2) Cisplatin, etoposide (VP16) , epirubicin, vincristine, vinblastine, doxorubicin, daunorubicin, methotrexate, camptothecins, ... TXB2 are high-affinity inhibitors of MRP4/ABCC4 -mediated transport of PGE1 and PGE2 [75] Various NSAIDs including indomethacin, indoprofen, ketoprofen, and flurbiprofen inhibited MRP4/ABCC4 mediated...
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Single and dual task tests of gait speed are equivalent in the prediction of falls in older people a systematic review and meta analysis
... B4CJ B 4BY2 ASB4B&K2B4&&b J4kk SB4Bk2ASB4w&K2B4&8b &4wG B4&82AB4BBK2B4w_b w4&k B4&w2ASB4BwK2B4w_b &4GB SB4B&2ASB4&BK2B4BJb k4wG B4&G2AB4B8K2B48wb &4JB B4wB2AB4B_K2B48kb &4Jk B4B_2AB4BwK2B4&Bb &B4CB ... B4B_2ASB4B&K2B4&wb _4kk B4&&2ASB4&8K2B48kb B4_G SB4B_2ASB4wkK2B4&8b &4BC B4Bw2ASB4B8K2B4BJb J4 SB4Bw2ASB4w&K2B4&Gb &4BB B4&&2AB4BBK2B4wwb w4CY B4B&2ASB4&BK2B4&8b w4_8 SB4B&2ASB4BJK2B4B_b _4wJ B4&Y2AB4B&K2B48Bb ... B4&Y2AB4B&K2B48Bb &4J8 B4&J2AB4B_K2B4wGb w4GJ B4Bw2ASB4B&K2B4BYb &&4kJ B4Bk2AB4BwK2B4BJb Yw4BC Ac ce pt B4Bw2ASB4B8K2B4BJb G4&C B 4BY2 ASB4B&K2B4&Bb J48_ B4&J2ASB4kBK2B4Jkb B4&w SB4B82ASB4wwK2B4&Jb B4CJ...
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4 19 technology in the world (space and technology)
... all the kinds of technology he’s using In- line skates aren’t found in nature They are made using a combination of natural resources and technology Technology helps make other equipment too The ... Machines gather crops of grain This X ray of the head and neck clearly shows the bones of the skull and the backbone MRI scans show images of any part of the body from any direction You can see the ... photographs are the copyright © of Dorling Kindersley, a division of Pearson ISBN: 0- 328 -139 14- 9 Copyright © Pearson Education, Inc All Rights Reserved Printed in the United States of America...
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International Capital Flows and Boom-Bust Cycles in the Asia Pacific Region +
... Zealand 4. 41 3. 42 7 .44 4. 82 4. 55 3. 14 5.60 2. 32 2 .44 5. 84 4.71 3.57 4. 07 4. 47 4. 07 4. 19 4. 37 3. 42 2 . 24 2. 59 2. 92 4. 34 3. 64 3.55 5.01 3. 72 4. 08 4 .28 3. 84 3.16 2. 26 2. 70 2. 73 4 .25 3.85 3. 54 5.15 ... 3.51 3.71 2. 39 2. 98 1.99 2. 46 1.50 1 .28 3. 14 5 .49 3.38 0.98 3 . 24 3.61 2. 51 2. 87 1.87 2. 23 3. 52 6 .23 4. 94 2. 13 6.38 1.71 2. 82 3 .40 1.97 3.07 1. 84 1.89 1990 -20 01 (w/o crisis) 2. 52 5.38 4. 31 2. 05 6.30 ... standard deviation of investment Korea 4. 60 Indonesia 4. 17 Malaysia 4. 32 Philippines 4. 82 Thailand 3 .48 Japan 3.13 China 2. 22 Singapore 2. 76 Taiwan 4. 84 Hong Kong 3.99 Australia 4. 09 New Zealand...
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focuses on expressions of criticizing in American and Vietnamese e-newspapers in the light of Directness/Indirectness
... able to find out the subject and the main verb In this case, subject and main verb are together at the beginning of the sentence, but in other case, they are separated or the writer delays the ... analysis and findings Structure of the articles Each of the three main part of an article (the headline, the lead and the body) has its own distinctive style and content 16 4 .2. 1.1 The headline The ... articles of criticism in the US e-newspapers have a very clear style They give the main points and state the criticism at the top in the headline and the lead paragraph(s) The body of the articles then...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008