oxidative stress and microglial cells in parkinsons disease
Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... depletioninduced no major changes in cell cycle and in mito-chondria aspect and network, and suggest that ADF cells possess alternative mechanisms for providingmitochondria with ATP and maintaining ... reported that ANT1 levels are increased in reactive astrocytes [28] and that ANT2 levels areincreased in glial cells and neurons during hypertonic-ity in the brain [29]. In the present study, we ... 1. Analysis of ANT1 and ANT2 expres-sion in nontransfected ADF cells and in ANT1- and ANT2-silenced ADF cells. (A)Number of ANT1 and ANT2 transcripts in nontransfected ADF cells. (B) Number ofANT1...
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Tài liệu OXIDATIVE STRESS AND DISEASES pptx
... researchers in the field of basic investigations interested in the involvement of reactive oxygen species and oxidative stress in diverse pathologies, medical scientists and practical physicians wishing ... States, Oxidative Stress and Cellular Damage 413 Cano-Europa, Blas-Valdivia Vanessa, Franco-Colin Margarita and Ortiz-Butron Rocio Chapter 19 Oxidative Stress in Human Autoimmune Joint Diseases ... ROS role and potential benefits of glutathione in maintaining of cell functions, which can be used to understand fundamental pathogenic mechanisms in the mammalian brain during normal aging, as...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... erable interest in “brown-like adi pose cells in WAT.These so c alled “brite” cells are present in WAT as evi-denced by the presence of UCP1 expressing cells in WAT. Studies in cell culture indicate ... PM2.5exposureinduced a marked increase in macroph age (F4/80+ cells) infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM2.5exposure. As shown in Figure ... PM2.5onWATandBATspecificgenesindifferent adipose depots. There are several major find-ings in this study. First, exposure to PM2.5resulted in oxidative stress in BAT. Second, exposure to PM2.5induced...
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Báo cáo khoa học: CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells pdf
... producing in ammatory cytokines in mouse models, although theresponse is apparently dependent on the prion strainused for infection [33,34]. Microglial cells can containinfectivity in vivo and ... slight increase in CpG-ODN-stimulated cells. PrPScaccumulates intracellularly in macrophages and microglial cells before degradationTo ascertain that J774 and BV-2 cells effectively inter-nalize ... obvious in uence of stimulation. By contrast, onRML infection, an increase was observed in PrPSc in LPS-stimulated cells ( 1.4-fold) after 24 h incubationwithout brain homogenate, and a slight increase...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... radicalformation in diabetic rats induced by streptozotocin.Life Sci 56, 1789–1798.4 Hodges NJ, Green RM, Chipman JK & Graham M(2007) Induction of DNA strand breaks and oxidative stress in HeLa cells ... compounds, includ-ing acetaminophen, benzene, carbon tetrachloride,ethanol and N-nitrosodimethylamine. CYP2E1 is alsoinvolved in the metabolism of endogenous aldehydes and ketones and plays ... longitudinal sections are shown in (A) (magnifi-cation ·20; scale bars = 1 mm). The hemotoxylin and eosin-stained sections of the left ventricle are shown in (B) and Masson’s trichromestained sections...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative stress- induced ... confirming PARP activation in D. discoideum under oxidative stress. PARP inhibition during oxidative stress- inducedgrowth changes in D. discoideumPARP inhibition conferred protection against ... the effect ofPARP inhibition under oxidative stress on two genera-tions by reviving the spores and monitoring growth and doubling time. It was found that in normal cells, PARP inhibition (1 mm...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... under-standing of the mechanisms involved in coral bleachingevents in host cells of symbiotic cnidarians. Gastroder-mal cells appear to be the predominant location ofthermal stress impact. In the ... equations for determining chlorophylls a, b, c1 and c2 in higher plants, algae and natural phytoplank-ton. Biochem Physiol Pflanzen 167, 191–194.Apoptosis and oxidative stress in bleaching S. Richier ... capacity in the host and symbiont cells [12,13,15,16]. The first hypothesis of oxidative stress involvement in the bleaching event was proposed,Keywordsapoptosis; bleaching; caspase; cnidarian;oxidative...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... orunfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies ... M & Vierling E (2001) Theexpanding family of Arabidopsis thaliana small heat stress proteins and a new family of proteins containinga-crystallin domains (Acd proteins). Cell Stress Chap-erones ... aA-crystallin requires this domain [66]. Attachment ofR116C aA-crystallin to Hsp27 and aB-crystallinincreases in comparison to wild type, while binding tocC-crystallin and bB2-crystallin decreases....
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Báo cáo khoa học: Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae potx
... Ca2+sensor protein calmodulin, which can bind and activate calcineurin; this inhibits, at the post-tran-scriptional level, the function of Vcx1p [11,15,16] and induces the expression of PMC1 and PMR1 ... cell lines for studying theeffect of oxidative stress on the eukaryotic cells and also an interesting model for studying antioxidants in vivo [21–28]. Living in an oxidant-rich mediumunder natural ... coelenterazine, cells wereexposed to H2O2shock directly in the luminometertube. The cells responded promptly, as H2O2initiatedimmediate and transient luminescence peaks, indicatingsudden...
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Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
... detected in patients with PTB in this study may therefore indicate the contribution of NK cells in the host immune response against MTB infection. The immune response after MTB infection and disease ... B cells in the optimal host response against MTB by increasing the infection inoculum (Vordermeier et al., 1996; Maglione et al., 2007). In addition the protection of mice against MTB infection ... B cells in defending against the infection. B cells and antibodies are thought to offer no significant contribution towards protection against MTB (Kumararatne, 1997). However experiments in...
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