oxidative stress and antioxidant therapy in parkinson disease
Tài liệu OXIDATIVE STRESS AND DISEASES pptx
... biology and oxidative stress in Parkinson disease pathogenesis, Nature Clinical Practice. Neurology, Vol. 4, No. 11, pp. 600-609. Hermes-Lima, M. (2004a) Oxidative stress and medical sciences, In: ... researchers in the field of basic investigations interested in the involvement of reactive oxygen species and oxidative stress in diverse pathologies, medical scientists and practical physicians wishing ... if oxidative stress was primary event, possible oxidative modifications of antioxidant enzymes may exacerbate diseases and define cell destiny. Finally, it is worth mentioning advantages and...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... PM2.5onWATandBATspecificgenesindifferent adipose depots. There are several major find-ings in this study. First, exposure to PM2.5resulted in oxidative stress in BAT. Second, exposure to PM2.5induced ... analyzed.Finally, mitochondrial number was reduced in botheWAT and iBAT in response to PM2.5exposure.Recent studies have implicated PM2.5 in in creased adi-pose inflammation and insulin resistance ... PM2.5exposureinduced a marked increase in macroph age (F4/80+cells)infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM2.5exposure. As shown in Figure...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
... radicalformation in diabetic rats induced by streptozotocin.Life Sci 56, 1789–1798.4 Hodges NJ, Green RM, Chipman JK & Graham M(2007) Induction of DNA strand breaks and oxidative stress in HeLa ... compounds, includ-ing acetaminophen, benzene, carbon tetrachloride,ethanol and N-nitrosodimethylamine. CYP2E1 is alsoinvolved in the metabolism of endogenous aldehydes and ketones and plays ... longitudinal sections are shown in (A) (magnifi-cation ·20; scale bars = 1 mm). The hemotoxylin and eosin-stained sections of the left ventricle are shown in (B) and Masson’s trichromestained sections...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative stress- induced ... confirming PARP activation in D. discoideum under oxidative stress. PARP inhibition during oxidative stress- inducedgrowth changes in D. discoideumPARP inhibition conferred protection against ... 3B). Oxidative stress induces PARP activationPARP activity in D. discoideum was assayed at varioustime points (5, 10, 20 and 60 min and 4 h) after HA stress. PARP activity was increased initially, and...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
... on both hands, mild rigidity and bradykinesia in the upper limbs,gait slowness, and mild postural instability. He cried during the interview, and worriedabout being unable to continue his work ... pallidotomyIndicationsAdvanced disease with rigidity and bradykinesia, and a poor response to antiparkinsonianmedicationsDisabling dyskinesiasSevere motor XuctuationsPainful cramps and severe dystoniasSerious ... the cognitive and emotional side-eVects ofspeciWc antiparkinsonian drugs, such as l-dopa, dopaminergic agonists,amantadine, selegiline, and anticholinergic drugs. In the eighth, and last, chapter...
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Báo cáo khoa học: The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells doc
... depletioninduced no major changes in cell cycle and in mito-chondria aspect and network, and suggest that ADFcells possess alternative mechanisms for providingmitochondria with ATP and maintaining ... rup-ture and were also negative to propidium iodide stain-ing (data not shown), indicating that the plasmamembrane is maintained intact, allowing us to excludeprimary necrosis as the principal ... isoforms in astrocytes and astrocytic tumors. Ithas been reported that ANT1 levels are increased in reactive astrocytes [28] and that ANT2 levels areincreased in glial cells and neurons during hypertonic-ity...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... harboring the zooxanthellae (Fig. 6B).Effect of heat stress on antioxidant defenses and bleaching in animal tissue of A. viridisThe occurrence of oxidative stress in the animal tissue(ectoderm and ... equations for determining chlorophylls a, b, c1 and c2 in higher plants, algae and natural phytoplank-ton. Biochem Physiol Pflanzen 167, 191–194.Apoptosis and oxidative stress in bleaching S. Richier ... mitochondria and chloroplasts and can directly and ⁄ or indirectly cause caspase activa-tion (reviewed in [25,27,49]). The delay observed in our study between the antioxidant induction and thecaspase-like...
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Tài liệu IMPLANT AND REGENERATIVE THERAPY IN DENTISTRY A GUIDE TO DECISION MAKING docx
... separate sinus augmentation procedure, and to have a thorough understanding of the capa-bilities of implants of various lengths in replacingsingle missing maxillary posterior teeth.Eliminating less ... willreceive or are receiving intravenous BIS ther-apy include:Before initiating intravenous BIS therapy: Due to the recognized high level of co-morbidity of dental diseases with BIS therapy (84% of ... thus reducing thebuccolingual osseous ledging and eliminating re-verse architecture, as well as forming an interprox-imal osseous peak, had the greatest effect on colFigure 1.4 As the in ammatory...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... orunfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies ... M & Vierling E (2001) Theexpanding family of Arabidopsis thaliana small heat stress proteins and a new family of proteins containinga-crystallin domains (Acd proteins). Cell Stress Chap-erones ... deficient in desmin, again demonstrating inclusion body construc-tion independent of intermediate fialments [62]. Inter-estingly, inclusion body formation is slowed byaB-crystallin, Hsp27 and HspB8,...
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Báo cáo khoa học: Exogenous oxidative stress induces Ca2+ release in the yeast Saccharomyces cerevisiae potx
... Ca2+sensor protein calmodulin, which can bind and activate calcineurin; this inhibits, at the post-tran-scriptional level, the function of Vcx1p [11,15,16] and induces the expression of PMC1 and PMR1 ... cell lines for studying theeffect of oxidative stress on the eukaryotic cells and also an interesting model for studying antioxidants in vivo [21–28]. Living in an oxidant-rich mediumunder natural ... encodingthe regulatory subunit of calcineurin) under oxidative stress was tested. It was noted that CNB1 deletionresulted in an increase of tolerance to H2O2(Fig. 3B), Oxidative stress and...
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gene therapy in cardiovascular disease
... CARDIOVASCULAR DISEASE CHAPTER 8Gene Therapy in Cardiovascular Disease VICTOR J. DZAU, M.D., AFSHIN EHSAN, M.D., and MICHAEL J. MANN, M.D.INTRODUCTIONThe explosive growth in understanding the changes in ... retention in vitro and in vivo. Circulation 93:1439–1446, 1996.George SJ, Baker AH, Angelini GD. Gene transfer of tissue inhibitor of metalloproteinase-2 inhibits metalloproteinase activity and neointima ... transfer into vein grafts using viral vectors.The vast majority of vein graft failures that have been linked to the neointimal disease is part of graft remodeling after surgery. Although neointimal...
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