molecular insight and preclinical perspective of thymoquinone as chemopreventive agent and therapeutic adjunct in cancer
Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... growth of breast cancer cells in vitro and in xenografts in mice [48] miRNAs as biomarkers in cancer Their fundamental role in development and differentiation, and their pervasive corruption in lineagedependent ... publication [9] miRNAs as mechanism-based therapeutic targets in cancer The case for miRNAs as tumor suppressors and oncogenes reflects their loss or gain, respectively, as a function of neoplastic transformation, ... miR-21 is overexpressed in many solid tumors, including breast, colon, lung, prostate and stomach, and in endocrine pancreas tumors, glioblastomas and uterine leiomyomas [17,45–47] This miRNA...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... subtypes as there was no association between breastfeeding and borderline serous or mucinous cancer (48) Ovarian cancer was initially divided based on molecular pathways involved in the development and ... significantly associated with breast cancer including SNPs in FGFR2 region in other sets of 950 consecutive breast cancer cases Major associations were replicated in third independent set of 243 breast cancer ... determine the SNPs in breast cancer or any particular diseases in different populations to identify the risk of developing the disease in an individual 5.2 Gene expression profiling in breast cancer...
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Báo cáo khoa hoc:" A review on SNP and other types of molecular markers and their use in animal genetics" ppt
... biased and can be quite misleading For instance, SanCristobal and Chevalet (1997) [71] showed in simulations of assignments of offspring to parents, that the assumption of the absence of typing ... alternative 6.3 Fine QTL mapping, candidate genes and complex traits Several approaches can be taken for fine QTL mapping, such as increasing the number of meiosis events by increasing the size and/ or the ... that interesting to use, due to the fact that they are of the dominant type, the RAPDs and AFLPs have a great advantage in terms of ease of use in the laboratory Indeed, fingerprint types of patterns...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
... in the transition from normal to intraepithelial cancer to invasive disease The understanding of the timing of instability during progression, the rate of instability and the mechanisms leading ... subclasses of adenocarcinomas Selected genes allow the discrimination between primary lung cancer and metastasis of extrapulmonary sites [90] Studies of expression profiles of adenocarcinomas of the ... lung neoplasia antibody reagents and data interpretation need to be developed and standardized A comprehensive and integrated approach linking laboratory findings of IEN of the lung with clinical...
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An Analysis of Cultural Factors in the Textbook English 12 from the Perspective of English as an International Language = Phân tích các yếu tố văn hóa trong sác
... analyzing and tabulating the frequency of occurrence of topics, ideas, opinions and other aspects of the content of written or spoken communication" (Longman Dictionary of Language Teaching and ... wedding and write about the conical leaf hat of Vietnam The meanings of whistling and hand-clapping in Vietnamese culture are discussed in reading lesson of unit Formal school education system and ... in the 1990s and its participation into the WTO; under the pressure of globalization and the demand of intercultural communication, the number of English learners in Vietnam is on vast increase...
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Tài liệu Báo cáo khoa học: Tachykinin-related peptide precursors in two cockroach species Molecular cloning and peptide expression in brain neurons and intestine docx
... brain and intestine in L maderae [14,15] The finding that N-terminally extended TKRPs are predominantly expressed only in the gut and not in the brain are in line with findings of enrichment of ... conformations of the insectatachy kinin ⁄ tachykinin and insect kinin ⁄ Tyr-W-MIF neuropeptide family pairs Ann NY Acad Sci 897, 388–400 Nassel DR (1999) Tachykinin-related peptides in inver¨ tebrates: ... occurrence of the different TKRPs in glomeruli of the tritocerebrum and in cells of the optical lobe Results Cloning of cockroach preprotachykinin cDNAs Using degenerated PCRs and RACE, we obtained...
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Báo cáo khoa học: Molecular structures and functional relationships in clostridial neurotoxins potx
... because of the single chain molecule The position of the binding domain of E could be obtained by rotating the binding domain of A or B about the linker region connecting the translocation and binding ... chimera EA containing the catalytic and translocation domains of type E and the receptor domain of type A (1–844 of E and 871–1296 of A) acts as fast as BoNT ⁄ E, whereas chimera AE containing the catalytic ... domains The HC is made up of two distinct domains, the N-terminal (HN) and C-terminal (HC) domains, of almost equal molecular mass HC consists of two subdomains, the N-terminal half, HCN and...
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Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx
... acquire increased concentration of the motor proteins and the spindle checkpoint proteins [18] The interaction of kinetochores with the microtubules, resulting in the formation of the kinetochore ... reduction in the concentration of the motor proteins and spindle checkpoint proteins [19] This reduction of checkpoint proteins is required for inactivating the spindle checkpoint signal and progression ... K Rathinasamy and D Panda [10] The binding site of benomyl in tubulin is yet to be determined However, it has been suggested that benomyl binds to tubulin at a site that is distinct from...
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báo cáo hóa học: "Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer" pot
... Health and Quality of Life Outcomes 2007, 5:70 clinical trials in oncology are increasingly incorporating generic preference-based measures such as EQ-5D EQ-5D is an indirect measure of utility ... EQ-5D in the overall cancer cohort, and in the subgroup of lung cancer patients, when possible Distribution-based criteria included: 1/2 standard deviation (SD) and the standard error of the measure ... if lung cancer has a different range of MID estimates Thus, the aim of this study was to provide a range of estimates for meaningful difference in EQ-5D scores in cancer and to determine if MIDs...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
... transition of cells through G1/S phase of cell cycle The channels in presence of hypoxia lead to release of HIF1 and VGEF factor leading to increased angiogenesis and subsequent invasion and metastasis ... investigation of HERG channels in cancer invasion and metastasis revealed that, in addition to the high expression of herg gene and HERG protein in colorectal cancers, highest expression is seen in metastatic ... Maintain membrane potential and development of neurons of spinal cord and carotid glomus cells [92,93] GIT Regulate motility of gut [94] Endocrine system Secretion of insulin and modulating epinephrine...
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Báo cáo y học: "Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis" potx
... new therapeutics in lupus and has made a considerable investment in bringing new candidates to the clinic The result of this investment is that there are at least 15 compounds currently in clinical ... patients each) and the association with lupus disease activity indices or other clinical features was determined High IFN scores were positively associated with increased disease activity as indicated ... levels of IP-10, MCP-1, and MIP-3β in a longitudinal study of 222 patients over year (~1,300 visits) Detailed clinical and laboratory measurements indicated that measurements of serum chemokine...
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Báo cáo y học: "Oesophageal Perforation: A diagnostic and therapeutic challenge in a resource limited setting. A report of three cases." ppsx
... smelling sputum, dysphagia, and odynophagia since the incident which was 15 days ago There was an associated swinging fever, malaise and anorexia On examination, he was wasted very ill looking and ... contained if diagnosis delayed Leak contained within neck or mediastinum, or between the mediastinum and visceral lung pleura; Drainage into oesophageal lumen as evidenced by contrast imaging; Injury ... healing was confirmed Oral feeding was instituted and after another two days of observation, the chest tube and feeding gastrostomy tube were removed He was discharged and sent home feeding orally...
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Báo cáo y học: "The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer" pptx
... of disintegrins to integrins has been carried out in vitro using recombinant disintegrin domains [8] The biological relevance of these findings are thus unclear The function(s) of the remaining ... for breast cancer are increased in patients with early disease and are thus of little value in identifying women at increased risk of developing this malignancy [55] As well as breast cancer, ... heparin -binding-EGF, IGFBP3; insulin-like growth factor-binding protein 3, IL-18; interleukin-18 Structure of ADAM Proteins The generalised structure of an ADAM protein contains distinct domains...
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Báo cáo y học: "nstitute for Molecular Bioscience and ARC Centre in Bioinformatics" pptx
... Ligand binding ectodomain Ptpre U36758 + Ligand binding ectodomain Ptprg AK144283 + Ligand binding ectodomain Ptprs AK159320 + Ligand binding ectodomain Ptpro U37466 + Ligand binding ectodomain Rps6kc1 ... serine/threonine phosphatase 2C, C-terminal Prkx AK039088 + Protein kinase c terminal domain(IPR000961) Ptpn21 D83072 + Band4.1/Ferm Ptprb AF157628 + Ligand binding ectodomain Ptprd BC025145 + Ligand binding ... expression of nine novel isoforms: seven secreted forms (Epha1 in bladder, Epha7 in brain, Flt3 in spinal cord, Ptprd in hypothalamus, Ptprg in brain, eye, white fat, and lung, Ptpro in brain, and Ptprs...
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Pharmacokinetics of caroverine and its protective and therapeutic roles in noise induced hearing loss following round window administration in the guinea pig
... PHARMACOKINETICS OF CAROVERINE AND ITS PROTECTIVE AND THERAPEUTIC ROLES IN NOISEINDUCED HEARING LOSS FOLLOWING ROUND WINDOW ADMINISTRATION IN THE GUINEA PIG ZHIQIANG CHEN (Bachelor of Medicine) A ... swelling and distortion of the organ of Corti, as was seen earlier, was also seen at week-4 point, suggesting active processes of both degeneration and repair In the findings of Hamernik and Henderson, ... induced the increases in the levels of glutamate and aspartate Furthermore, they found significant increase of glutamate and aspartate in the scala tympani of guinea pig cochlea by using in vivo...
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Molecular diagnosis and mutation characterization in thalassemias
... of PTC-containing β-globin gene in cytoplasm and nucleus in the global presence of translation 111 Figure 4-11 The relative expression level of PTC-containing β-globin gene in cytoplasm and ... accuracy of isoelectric focusing (IEF) in classifying hemoglobin H disease A robust and accurate α-globin gene sequencing protocol was also included in this study In addition, a few β-thalassemia ... globin chain, changing the physical properties and producing the clinical abnormalities Thalassemias arise with the reduced rate of production of one or more of the globin chains Another group of...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... pancreas, and gastric cancers [146,147] It is also detected in normal lung as well as lung cancer tissue, and is increased primarily in adenocarcinomas [148] Treatment of pancreatic cell lines ... Prostate cancer Co-expression of RAGE and HMGB1 has been found in a majority of metastatic cases, in tumor cells and associated stromal cells Pancreatic cancer Enhanced expression of RAGE and HMGB1 in ... propagates inflammatory responses and is a significant RAGE ligand in the setting of sepsis and acute inflammation HMGB1 is an apparent autocrine/paracrine regulator of monocyte invasion, involving...
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Báo cáo khoa học: Molecular cloning and characterization of two soybean protein disulfide isomerases as molecular chaperones for seed storage proteins doc
... GmPDIL-2 and proglycinin or b-conglycinin during the course of the folding process of these proteins Results Cloning and expression of GmPDIL-1 and GmPDIL-2 To clone the soybean ortholog of Arabidopsis ... GmPDIL-1 and GmPDIL-2 were immunoprecipitated irrespective of crosslinking treatment Following metabolic labeling of nascent proteins with [35S]methionine and [35S]cysteine, glycinin was immunoprecipitated ... was performed with the cotyledons treated with tunicamycin Tunicamycin may increase unfolded b-conglycinin a¢-subunit in the ER, as the folding efficiency of glycoproteins such as b-conglycinin...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008