in vitro uptake and treatment of mps i

Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt

Ngày tải lên : 20/03/2014, 03:20

... giai đoạn G1 , ức chế tyrosin - kinase, ngăn chặn hoạt tính protein - ras In vitro, quercetin ức chế tyrosin - kinase ng i ung th, ức chế phát triển kh i u, làm tăng th i gian sống sót động vật mang ... chống viêm Curcumin chống oxy hoá mạnh, mạnh vitamin E để ngăn ngừa peroxy hoá lipid in vitro Curcumin ức chế COX LOX, làm giảm tổng hợp PGE2 , LTB4 5-HPETE Nhiều kết nghiên cứu cho thấy curcumin ... chống đợc nhiều tác dụng độc hoá liệu pháp (nh ph i hợp v i bleomycin, cyclophosphamid, cisplatin) Trên ng i, thấy kết rõ rệt b i thuốc mỡ curcumin làm giảm triệu chứng ng i ung th biểu mô có vảy...

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UPDATES IN THE DIAGNOSIS AND TREATMENT OF VASCULITIS pot

Ngày tải lên : 30/03/2014, 00:20

... contain PR3 and MPO in addition to chromatin and LL37 (an antimicrobial peptide with capabilities of activating dendritic cells) [112] In- vivo presence of NETs was shown in tissues (kidney biopsies ... studies, utilizing rodent models of vascu‐ litis Further insights into disease pathogenesis can be gained from clinical trials, includ‐ ing those with negative results Genetic and epigenetic basis ... expression in several autoimmune diseases This is not surprising considering several of these genes encode proteins critical for maintenance of the immune system, including the function of innate immune...

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Updates in the Diagnosis and Treatment of Vasculitis Edited by Lazaros I. Sakkas and Christina Katsiari pptx

Ngày tải lên : 30/03/2014, 18:20

... contain PR3 and MPO in addition to chromatin and LL37 (an antimicrobial peptide with capabilities of activating dendritic cells) [112] In- vivo presence of NETs was shown in tissues (kidney biopsies ... studies, utilizing rodent models of vascu‐ litis Further insights into disease pathogenesis can be gained from clinical trials, includ‐ ing those with negative results Genetic and epigenetic basis ... expression in several autoimmune diseases This is not surprising considering several of these genes encode proteins critical for maintenance of the immune system, including the function of innate immune...

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Báo cáo khoa học: In vitro selection and characterization of a stable subdomain of phosphoribosylanthranilate isomerase potx

Ngày tải lên : 30/03/2014, 20:20

... increasing the likelihood of correct folding in a reducing environment while minimizing the risk of proteolytic degradation The association of plasmid and fusion protein can be maintained on ... Molecular dissection of the folding mechanism of the a subunit of tryptophan synthase: an amino-terminal autonomous folding unit controls several rate-limiting steps in the folding of a single domain ... pWP107His Subcloning trPRAI for expression (without its p50 fusion partner) required the re-introduction of an initiator To facilitate high-yield puriﬁcation, the C-terminal FLAG epitope of trPRAI...

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Báo cáo y học: " New approaches in the diagnosis and treatment of latent tuberculosis infection" pptx

Ngày tải lên : 12/08/2014, 13:22

... in spectrum and severity of TB cases and proportion of HIV-coinfected individuals included in various studies [123,126] In low TB incidence countries, screening for LTBI aims to identify individuals ... be particularly important in high TB incidence countries in which latent infection is widespread and reinfection happens frequently and in immunocompromised individuals (such HIV-seropositive subjects) ... people worldwide are infected with M tuberculosis Complete elimination of tubercle bacilli is achieved in ~10% individuals only while in ~90% of infected individuals, bacterial growth is stopped...

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Tài liệu Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults pdf

Ngày tải lên : 14/02/2014, 09:20

... vi II–20 II–20 II–20 II–21 II–21 II–21 II–22 II–22 II–22 II–22 II–22 II–23 II–23 II–23 II–24 II–24 II–24 II–24 II–25 II–25 II–25 II–25 II–26 II–26 II–27 II–28 II–28 II–28 II–28 II–28 II–29 II–29 ... of emerging risk factors in risk assessment III–1 III–1 III–1 II–57 II–58 II–58 II–58 II–58 II–58 II–59 II–59 II–60 III–1 III–2 III–2 III–6 III–6 III–6 III–7 III–7 III–7 ... history of premature CHD II–1 II–1 II–1 II–2 II–3 II–5 II–5 II–5 II–5 II–6 II–6 II–6 II–6 II–7 II–7 II–7 II–8 II–9 II–9 II–10 II–10 II–11 II–11 II–11 II–11 II–14 II–15...

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Tài liệu The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults pdf

Ngày tải lên : 14/02/2014, 09:20

... markedly influence the validity of BMI for classifying individuals into broad categories of overweight and obesity in order to monitor the weight status of individuals in clinical settings.23 ... manifestations of hypothyroidism In addition, leg edema, cellulitis, acanthosis nigricans (coarse pigmented skin that is a sign of hyperinsulinemia), and intertriginous rashes with signs of skin ... discontinuing it for the nonresponders If weight is lost within the initial months of therapy or if weight is maintained after the initial weight loss phase, the drug may be continued It is important...

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Tài liệu GENETICS IN PREVENTION AND TREATMENT OF CANCER ppt

Ngày tải lên : 15/02/2014, 04:20

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Crop uptake and extractability of cadmium in soils naturally high in metals at different ph levels

Ngày tải lên : 15/03/2014, 23:22

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Báo cáo khoa học: Fatty acid composition of chylomicron remnant-like particles inﬂuences their uptake and induction of lipid accumulation in macrophages pot

Ngày tải lên : 16/03/2014, 12:20

... to behave like the physiological lipoprotein in their clearance from the blood and metabolism in vivo, and in their effects on cultured cells in vitro [28–30] In addition, in earlier work we ... similar to surface remnants of triglyceride-rich lipoproteins Arterioscler Thromb 14, 622–635 Pal S, Semorine K, Watts GF & Mamo J (2003) Identiﬁcation of lipoproteins of intestinal origin in ... obtained In summary, this study shows that the fatty acid composition of chylomicron remnants in uences their uptake and induction of lipid accumulation in macrophages, with those enriched in...

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Báo cáo khoa học: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities pdf

Ngày tải lên : 16/03/2014, 12:20

... analysed inhibition of cdc2, cdk2, erk1, and cdk5 kinases by preincubation of S100 embryo extracts with the cell cycle inhibitor olomoucine Figure shows that no statistically significant inhibition ... a significant decrease in CNBP phosphorylation level, thus, indicating that H-89 inhibition was predominantly on PKA activity In agreement, PKI, a specific PKA inhibitor, significantly impaired CNBP ... embryos were incubated during 15 with different kinase inhibitors at 30 °C and then used to analyse in vitro recombinant CNBP phosphorylation in kinase buffer containing 100 lm ATP and lCi [32P]ATP[cP]...

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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx

Ngày tải lên : 16/03/2014, 23:20

... 3FLAG HindIII) This product was ligated into the NcoI ⁄ HindIII site of pTrcHisA (Invitrogen, Carlsbad, CA, USA) resulting in a plasmid named MC99-3FLAG The following primers were used to amplify ... detection of COS7-SPC99-3FLAG in vitro c-secretase activity While performing control reactions for inhibitor experiments, a two- to ﬁvefold increase in the detection of products arising from in vitro ... domain that binds metal ions such as zinc, copper, and iron and mediates Ab aggregation ([23] reviewed [38]) This is the ﬁrst report suggesting that this metal binding domain is functional within...

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Factors affecting delays in diagnosis and treatment of pulmonary tuberculosis in a tertiary care hospital in Istanbul, Turkey pptx

Ngày tải lên : 22/03/2014, 18:20

... delayed treatment diagnosis interval treatment interval admission to hospital diagnosis initiation of treatment Table shows the distribution of the diagnosis intervals and initiation of treatment intervals ... delay, and delay in the treatment Both patient and institutional delays result in increased infection risk for the population Diagnostic and treatment delays result in increased infection risk for ... day were considered indicative of a delayed treatment [14,18] Clinic delay was defined as the time from admission to initiation of treatment Regarding the diagnosis and treatment intervals, those...

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Báo cáo khoa học: Role of the plasma membrane leaﬂets in drug uptake and multidrug resistance ppt

Ngày tải lên : 29/03/2014, 08:20

... Beit-Haemmek, Israel) The K562 Pgp-overexpressing subline was obtained by sequential exposure of cells to increasing concentrations of doxorubicin and was maintained in the presence of 0.5 lm doxorubicin ... mitochondria had been poisoned reveals that the active uptake of TMRM into the mitochondria interferes with the second phase of TMA-DPH quenching (Fig 2) Initially, there is signiﬁcant inhibition ... therefore bind to acidic groups in proteins and membranes Thus, their movement into the cell can be envisaged as a series of binding and releasing events rather than simple diffusion However, it should...

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Báo cáo sinh học: " Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases" doc

Ngày tải lên : 18/06/2014, 22:20

... parvovirus Respiratory Syncytial Virus Respiratory Syncytial Virus Rhinovirus (common cold) II Market II I I/II Preclinical Preclinical I I/II I Market I/ II III Preclinical I Approved in 1998 ... complementary pair with specific viral mRNA targets AS-ONs inhibit viral protein production by both blocking viral mRNA translation and triggering its degradation Since the discovery of viral inhibition ... Pharmaceuticals Genital Warts HPV Hepatitis B Hepatitis B Hepatitis C Hepatitis C Hepatitis C, HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS Herpes Simplex Virus type...

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Báo cáo hóa học: "Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation" pptx

Ngày tải lên : 20/06/2014, 00:20

... and inhibits incorporation of iron into the protoporphyrin ring respectively This results in reduced heme synthesis and elevated levels of the precursor δ-aminolevulinic acid (ALA), which is a ... Conclusion Detailed clinical investigation is of prime importance for identifying lead poisoning cases and while treating the lead poisoning cases the chelation therapy must be accompanied by ... aggressive environmental intervention The potential health hazards of lead poisoning still exist and are rising due to the lack of education regarding the dangers of working with lead In a developing...

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báo cáo hóa học:" Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases" pdf

Ngày tải lên : 20/06/2014, 04:20

... parvovirus Respiratory Syncytial Virus Respiratory Syncytial Virus Rhinovirus (common cold) II Market II I I/II Preclinical Preclinical I I/II I Market I/ II III Preclinical I Approved in 1998 ... complementary pair with specific viral mRNA targets AS-ONs inhibit viral protein production by both blocking viral mRNA translation and triggering its degradation Since the discovery of viral inhibition ... Pharmaceuticals Genital Warts HPV Hepatitis B Hepatitis B Hepatitis C Hepatitis C Hepatitis C, HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS HIV/AIDS Herpes Simplex Virus type...

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báo cáo hóa học:" Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer" pdf

Ngày tải lên : 20/06/2014, 07:20

... distinctly distinguish between tissue types This finding is extremely significant because it points to the possibility that miRNAs may have oncogenic or tumor suppressing activities In addition ... resulted in suppressed glucose-stimulated insulin secretion and its inhibition resulted in enhanced insulin secretion Myotrophin, a protein that has a role in exocytosis, was identified as one of the ... biosysnthesis and trafficking to cytoplasm Systematic miRNA biosysnthesis and trafficking to cytoplasm Using RNA immunoprecipitation 3'-end labeling and miRNA cloning, Dostie and colleagues [13] identified...

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Báo cáo toán học: " Influence of different flow conditions on the occurrence and behavior of potentially hazardous organic xenobiotics in the influent and effluent of a municipal sewage treatment plant in Germany: an effect-directed approach" pot

Ngày tải lên : 20/06/2014, 20:20

... precipitation events, a significant decrease in the overall toxicity of the organic xenobiotics - determined after recombination of the individual fractions - and in particular in the toxic effects ... decrease in the overall toxicity of the organic xenobiotics with rising wastewater flow was primarily attributed to a dilution effect This finding could indicate a dominant influence of wastewater ... could approximately be ascertained by testing the recombinant fractions (Figure 5) Inhibitions of the recombinant fractions in the influent of the STP Trier were significantly toxic (median 36.9%)...

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Báo cáo hóa học: " In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics" doc

Ngày tải lên : 22/06/2014, 06:20

... avoided the interference of such functionalizing agent in determining the bactericidal activity of the antibiotics Using the combined reducing property of antibiotics and borohydride, antibiotics ... the antibiotics Ampicillin inhibits the cell wall biosynthesis by inhibiting the cross-linking reaction mediated by transpeptidase, while both streptomycin and kanamycin bind with ribosome and block ... bacterial strain Name of antibiotics Inhibitory zone in sq diameter (cm2) Free antibiotics E coli DH5a (Gram -Ve) Ampicillin 3.085 ± 0.146 % Change in inhibitory sq diameter Gnps-conjugated antibiotics...

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