gene expression profiling in the process of osteochondro inductive events in the spine
Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... model in which activated lymphocytes of arthritic donor BALB/c mice migrate and interact with the intact innate immunity environment in the joints of BALB/cSCID mice The gene expression profiles in ... with genes related to cytoskeleton reorganization such as Rho interacting protein 3, myosin, and β-actin (reviewed in [52,53]) Cluster A genes were at the peak of their expression in the PA joint ... transcription increased as the disease progressed, reaching a peak in the pre-inflamed joint or during inflammation Cluster A included genes that coded for variable parts of the T cell receptor, together...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... according to the formula Cttarget gene - Ctactin; Ct values then were obtained by subtracting the Ct of a reference sample from the Ct of the studied samples Finally, the levels of expression of the ... representative of the globality of the slide The surface staining (S) and the surface of the nuclei (N) were determined for each image, and the area of staining then was normalized by calculating the ratio ... half of the samples and selection of the 8,000 genes that displayed the widest inter-individual variations in the remaining genes Further statistical analyses were performed using Genespringđ software...
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Báo cáo y học: "Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies" doc
... to the disease group, the authors speculated that their gene selection might reflect a genetic trait rather than the disease process Gene expression profiling in lupus was reviewed recently in ... various inflammatory genes to be upregulated in chronic inflammation of periprosthetic membranes of RA and OA patients in the process of prosthetic loosening [16] To overcome the problem of unspecific ... knowledge and investigative capacity of the scientists and is susceptible to misinterpretation In the face of our limited knowledge of the role and function of most of the genes that we discover in our...
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báo cáo khoa học: " Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: Extending MapMan ontology for grapevine" pdf
... Annotation of grapevine Gene Index Annotation of grapevine Gene Index (VvGI version 5) using the MapMan ontology was performed by including information on grapevine genome and plant protein domains, the ... displays the informa- tion about the members of the gene families, the relative gene expression and the name of the enzyme in a single image It is interesting to observe that before véraison the pathway ... doubt the ease and speed of the analysis The visualization of the genes distribution among the phytohormones confirms the large involvement of genes linked to auxins and ethylene and fewer genes involved...
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Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx
... the molecular effects of the treatment in patients with SSc by studying CECs gene expression Page of 15 profiling before and after the treatment Moreover, since digital ulcers are the key clinical ... exclude cells not of interest for the analysis Indeed, the interest of the method reported here lies in the high intra-assay reproducibility and the high precision in the detection of both CECs and ... subsets in the gene expression signatures of scleroderma skin PLoS One 2008, 3:e2696 doi:10.1186/ar3069 Cite this article as: Tinazzi et al.: Gene expression profiling in circulating endothelial...
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Gene expression profiling in a rat model of neurodegeneration
... suggesting neuroprotection These findings not only provide molecular insight into the contribution of chemokines and their receptors in excitotoxic injury involved in stroke and neurodegenerative ... and neurofibrillary tangles are often present in the affected regions of the brain (Tiraboschi et al 2004) PD arises from the loss of dopamine-generating cells in the substantia nigra and the most ... roles in the CNS and increased expression in various CNS diseases, chemokines have become therapeutic targets of interest in neuroinflammatory or neurodegenerative diseases chemokines play in the...
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Báo cáo hóa học: " cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis" ppt
... participated in the expression profiling assays and participated in the ex vivo dosing study DA participated in the expression profiling assays and participated in the ex vivo dosing study HC ... or inability to fully mitigate globin effects There are several examples in the literature of ex vivo gene expression profiling as well as experiments looking at the SAHA-induced expression profiling ... participated in drafting and editing of the manuscript SL completed the analysis of the protocol selection study, participated in the analysis of the SAHA data and participated in the drafting and editing...
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Báo cáo y học: "Early and long-standing rheumatoid arthritis: distinct molecular signatures identified by gene-expression profiling in synovia" pot
... some of their findings converge, pointing to the involvement of stress responses and defense mechanisms in early RA, and are therefore complementary, contributing to a better understanding of the ... opposite gene regulations, suggesting the involvement of different pathophysiological mechanisms during the disease course Moreover, the novel comparison of the gene- expression levels in early ... in PANTHER A P value was determined using the binomial statistic (that is, the probability that the number of genes observed in each category occurred by chance [randomly], as determined by the...
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Orthologous gene-expression profiling in multi-species models: search for candidate genes doc
... driven by these genes Starting from the notion that genes coding for proteins involved in the same biological processes are regulated in coordinated manner, and that expression of members of a given ... searching for candidate genes involved in specific biological processes of interest General trends in the expression of common groups of genes in response to a specific stimulus in diverse species ... (Table 2) Given the pre-eminent importance of the vascular component in ALI pathogenesis, our primary trait in selecting candidate genes was their expression in vascular endothelium The PubMatrix...
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Báo cáo y học: "Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses" ppt
... response during H5N1 infection The differences in the constitution of the internal genes between the subtypes of influenza viruses may possibly play an important role in differential host gene expression ... to that of b-Actin to generate ΔCT, and the difference between the ΔCT value of the sample and that of the reference (uninfected sample) was calculated as ΔΔCT The relative level of gene expression ... GO:0019221~cytokine-mediated signaling pathway down regulated genes at different time point post infection Contrastingly, genes coding for ribosomal proteins and other proteins involved in protein translation...
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Báo cáo khoa học: A functional polymorphism at the transcriptional initiation site in b2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of b2-glycoprotein I docx
... basis of APA is complex and other genetic and/or biological factors are involved in the occurrence of APA The structural organization of the b2GPI gene, including 626 bp sequence in the 5¢ flanking ... levels and the low occurrence of APA Furthermore, this mutation reduces the expression of the luciferase (Luc) reporter gene by twofold and disrupts the binding of nuclear trans-acting factors ... B.F (1987) The superfamily of C3b/C4b-binding proteins Federation Proc 46, 2463–2469 13 Schousboe, I (1985) b2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... instance, miR-373 induces the expression of E-cadherin and CSDC2 by targeting their promoter region and initiate their expression[ 73] Another mechanism is that the engagement of miRNA and their targets ... analysis of these genes also divided the samples into three groups, hES, EB, and adult cells, and divided the genes into major nodes (Figure 4) The node containing 226 genes that were upregulated in ... [21,43], if the function of the miRNA is dominant in leading the mRNA target degradation, however, most animal miRNAs pair to the 3' UTRs of their targets by incomplete base-pairing through their seed...
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báo cáo khoa học: " Expression profiling and integrative analysis of the CESA/CSL superfamily in rice" doc
... among the members in a family although most of them exhibit different expression patterns Expression divergence of OsCESA/CSL genes in duplication We further observed the expression profiling of the ... indicate the preferential expression, while the minus sign indicates lower expression; The asterisks indicate the genes expressed throughout the tissues examined; The numbers in parentheses indicate ... divided into three major groups (Figure 7) In contrast, the expression patterns of the CESA/CSL genes in both species are summarized in Table Clearly, the expression patterns of the genes of the...
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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx
... DNA binding proteins that are crucial to regulating expression of other genes in the nucleus of cells The typical AP haloperidol has been shown to induce DNA methylation changes in the brain and ... shown to increase insulin sensitivity in the liver by attenuating insulin and leptin signaling pathways [55] It is interesting that one of the main side effects of atypical Page 11 of 15 (page number ... chlorpromazine decreases SOD enzyme activity in the brain and in erythrocytes [61], the effects in the liver are not known The interleukin receptor antagonist (IL1RN) gene inhibits the activities of interleukin...
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Báo cáo y học: " 3′-coterminal subgenomic RNAs and putative cis-acting elements of Grapevine leafroll-associated virus 3 reveals ‘unique’ features of gene expression strategy in the genus Ampelovirus" potx
... termini, with the exception of BYV p6 sgRNA that contains a guanylate similar to the 5′ terminus of the genomic RNA [16,17] On the other hand, the 5′terminal nucleotide of the sgRNAs of the crinivirus ... CTV, the cisacting elements that regulate the level of expression of genes in the 3′ half of the genome are located immediately upstream to the transcription start site of their sgRNAs These ... understanding strategies underlying production of the sgRNAs of viruses in the genus Ampelovirus, we mapped the 5′ termini of the four most abundantly expressed genes in relation to the genomic RNA of...
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Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... Lv-shCD36-NC in physiological saline, was instilled into the lungs using a 14-gauge needle inserted into the trachea through the epiglottis of the larynx The site of surgery was sutured and the rats ... determine the silencing effect of CD36 in AMs in the silica+Lv-shCD36 group The results demonstrate that expression of CD36 mRNA in the silica+Lv-shCD36 group was significantly lower than in the ... tiny collagen fibers in the lung of rats in the silica+Lv-shCD36 group Compared to the silica and the silica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the silica+Lv-shCD36...
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Báo cáo y học: " Global gene expression patterns in the post-pneumonectomy lung of adult mice" ppt
... set The networks are ranked depending on the number of significantly expressed genes they contain, based on a Pvalue that indicates the likelihood of the genes in a network being found together ... influence the growth and migration of epithelial and endothelial cells in a paracrine fashion Furthermore there is an increase in expression of "anti-inflammatory" cytokines which may be important in ... further understand the process of lung regeneration Competing interests The authors declare that they have no competing interests Authors' contributions JAP participated in the design of the...
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Báo cáo y học: " Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells" doc
... expression of Cyclin T2a, another Cyclin partner of CDK9, remained largely unchanged by prostratin (Fig 2B), suggesting the presence of Cyclin T2a does not prevent the induced Cyclin T1 from binding ... constitutive gene expression in resting and activated CD4+ T cells, whereas Cyclin T1 may play a larger role in the expression of genes induced by T cell activation Effects of prostratin on the levels of ... Figure induces expression of CD69 without promoting cell cycle progression in resting CD4+ T cells Prostratin Prostratin induces expression of CD69 without promoting cell cycle progression in resting...
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Báo cáo y học: " Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers" pdf
... upregulation of the gene encoding the upstream transcription factor Usf2, which was recently found to be involved in the control of hepcidin expression [23], in the B6 strain Finally, and worthy of note ... database/resource from which the terms originate The Term column indicates enriched terms associated with the gene list The n column indicates the number of genes involved in the term The expression analysis ... non-transferrin-bound iron uptake into cells [27] Of note, Hfe-/- D2 mice also have increased duodenal expression of mucin and spermine synthase Increased binding of Dmt1 to mucin in vesicles near the intestinal...
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Báo cáo y học: "Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex" pps
... diurnal of the Heat map of enriched TFBSs and their corresponding TFs for each of the eight clusters, when both TFBSs and TFs are present in the diurnal genes The columns indicate the TFs in each of ... of the eight clusters, where the rows represent the enriched (P < 0.05) TFBSs in the kb upstream region of genes in each of the eight clusters The color of the cell represents the degree of matching: ... responses or the regulation of these processes For example, genes involved in protein transport and localization are enriched in cluster 1, in which the genes are highly expressed during the rest...
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