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garcinol plumbagin and mangiferin in the prevention and therapy of human malignancies mechanisms of anticancer activity

Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

Sức khỏe giới tính

... Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of Tuberculosis and the ... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination ... resurgence in the incidence of TB occurred in the United States and included increases in the number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
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Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt

Thuốc chống viêm ức chế lipooxygenase và cyclooxygenase dùng dự phòng và điều trị ung th- (LOX an COX - inhibitors as adjunctive therapies in the prevention and treatment of cancer) ppt

Báo cáo khoa học

... ung th in vitro, thấy quercetin làm thoái giáng đột biến p53 - protein, làm ngừng chu kỳ tế bào giai đoạn G1 , ức chế tyrosin - kinase, ngăn chặn hoạt tính protein - ras In vitro, quercetin ức ... Curcumin có nhiều ảnh hởng đến sinh lý bệnh học tế bào ung th: in vitro, curcumin làm ngừng chu kỳ tế bào u, thúc đẩy chết theo chơng trình (apoptosis) Tuy nghiên cứu hạn chế, nhng thấy curcumin ... bào khác nhau, thấy quercetin làm tăng hiệu lực điều trị cisplatin, adriamycin, busulfan, cyclophosphamid làm tế bào ung th giảm đề kháng với gemcitabin topotecan Bromelain Là hỗn hợp protease chứa...
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Báo cáo hóa học:

Báo cáo hóa học: " Targeting the inflammation in HCV-associated hepatocellular carcinoma: a role in the prevention and treatment" pptx

Hóa học - Dầu khí

... (TIRdomain-containing adapter-inducing interferon-b) joining the RIG-I/MDA5 pathway In the other pathway, TLR7 senses single-strand HCV RNA and via the MyD88 adaptor protein activates IRAK4/IRAK1 These kinases stimulate ... retinoids Their combination synergistically inhibited the growth of HepG2 cells without affecting the growth of normal human hepatocytes and increased the expression of RARb and p21(CIP1), while inhibiting ... toll-interleukin-1 receptor domain-containing adaptor inducing IFN (TRIF) TRIF is an adaptor protein that is a critical component of the TLR3 signaling pathway By cleaving IPS-1 and inactivating TRIF,...
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Báo cáo hóa học:

Báo cáo hóa học: " Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects" docx

Hóa học - Dầu khí

... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses Study concept and design: CA and OB Acquisition of data: CA and OB Analysis and interpretation ... or occurring during a fall, is due to an abnormality of processing of musculoskeletal mechanisms and of sensorimotor information in the CNS The central question is to determine whether the age-related ... muscles and the nervous system are also target organs of vitamin D Vitamin D and muscles Clinical evidence First of all, several lines of clinical evidence suggest the existence of a link between...
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báo cáo hóa học:

báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx

Hóa học - Dầu khí

... data, interpreted the findings and wrote the manuscript OM was involved in developing the study proposal, supervising the data collection and reviewing the manuscript SGH was involved in developing ... developing the study proposal and reviewing the manuscript MMS was involved in supervising the data collection and reviewing the manuscript KMM was involved in developing the study proposal and reviewing ... two mothers had live birth of twins (Figure 1) Table shows the demographic and obstetric characteristics of the mothers enrolled in the study The median age of the mothers was 25 years and the...
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TOPICS IN THE PREVENTION, TREATMENT AND COMPLICATIONS OF TYPE 2 DIABETES pptx

TOPICS IN THE PREVENTION, TREATMENT AND COMPLICATIONS OF TYPE 2 DIABETES pptx

Sức khỏe giới tính

... cleavage from the protein backbones AGEs involving protein cross-links include: pentosidine, a dimer of arginine and lysine; methylglyoxal-lysine dimer (MOLD), a dimer of two lysine residues; and methylglyoxal-derived ... characterized by insulin resistance, hyperinsulinemia and impaired insulin signaling Insulin resistance is the common link of the components of the much invoked metabolic syndrome (a cluster of high adiposity, ... results Modelling procedure of the structure indicated in Fig has started by observing the available information regarding the prevalence of population activity/ inactivity and obesity as they are...
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Báo cáo khoa học:

Báo cáo khoa học: " A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients" pdf

Báo cáo khoa học

... to the affected area with the bare hand Application of the cream was accomplished with the ventral surface of the fingers using a rotary motion of the fingers with light pressure to the skin The ... administered in the same manner and on the skin of the same patient, we removed the individual effects by analyzing the difference of the two scores (i.e., gel score – cream score) rather than the ... at reducing the drying effect of radiation on the skin and involves instructing patients to avoid irritating the irradiated region Dryness due to RT leads to desquamation and loss of the superficial...
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Báo cáo y học:

Báo cáo y học: " Recently published papers: A review of novel strategies in the prevention of hospital-acquired infections, the ability of intensivists to perform echocardiography, and the benefit of polymyxin B haemoperfusion in abdominal sepsis" pot

Báo cáo khoa học

... occupational therapy) In their group of 104 patients, early physical and occupational therapy significantly increased the number of patients who had returned to independent functional status by the point ... using transthoracic ultrasound [11] They trained a group of intensivists with hours of didactic teaching and hours of practical teaching, and provided a range of pre-recorded examinations for the ... findings Effect of polymyxin B haemoperfusion on patients with abdominal sepsis The EUPHAS randomised controlled trial examined the effect of polymyxin B fibre haemoperfusion on the outcome of...
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Tài liệu CONSUMER PREFERENCE AND CONSUMPTION OF ORGANIC PRODUCTS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA docx

Tài liệu CONSUMER PREFERENCE AND CONSUMPTION OF ORGANIC PRODUCTS IN THE EASTERN CAPE PROVINCE OF SOUTH AFRICA docx

Hóa học - Dầu khí

... are marked increases in the future demand of all organic products This augurs well for the growth of the organic industry in the Eastern Cape and in South Africa in general The findings of this ... group of people as part of its ways, aids in the cohesion of this group, helps that particular group maintain its identity in the face of others, and therefore creates a feeling of "belonging" ... a long way in influencing the target market and marketing approach to drive the demand of organics The second LDF identified the person responsible for shopping and the location of the consumer...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx

Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx

Báo cáo khoa học

... resulting in the accumulation of both unmodified cholesteryl esters and glycated apoB in the cells The rate of removal of the latter species is slow, with only 20–30% of the glycated protein being ... SR-A and CD36 The accumulation of lipid in these macrophages is accompanied by increased endocytosis and degradation of apoB, with the difference in the rates of the latter two processes resulting ... that it may be the nature of the products arising from glycation, rather than purely the loss of the parent amino acid, which is the key factor in terms of receptor recognition [29] There are no...
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Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitrificans pptx

Báo cáo khoa học

... represents the ionization of Asp128b This being the case, the effect of substrate binding would be to lower the pKa of this group to 6.0 (i.e the value measured in the plot of klim vs pH; Fig 4C) The ... limiting with ‘fast’ substrates The lack of inhibition observed with benzylamine (Fig 5A) in comparison to the inhibition observed with tryptamine (Fig 5B) suggests differences in binding of the ... by placing aauBEDA and orf-2 (directly downstream of aauA; Fig 9) under the control of the mauF promoter and introducing these genes into P denitrificans using a broad-host-range vector The successful...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

Báo cáo khoa học

... unusual in having two histidine residues (rather than the His-Asn pair seen in OYE, MR and some of the other member proteins; Fig 1B) in the active site for ligand and substrate binding For those ... productive binding of steroid substrates: in the first, a (small) sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive ... 1A) and 2-cyclohexen-1-one indicate that these ligands bind above the si face of the FMN isoalloxazine ring and are held in position by hydrogen bond interactions with His181 and His184 [2] These...
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HEALTH AND NUTRITIONAL STATUS OF THE ELDERLY IN THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA pot

HEALTH AND NUTRITIONAL STATUS OF THE ELDERLY IN THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA pot

Sức khỏe người cao tuổi

... boundary of the map, with at least two points in the middle of the map Link points to a landmark so they can be identified Randomly choose one of the numbers, and make that your starting point Option ... of 1:2 Taking into account the demographic profile, a continuing increase in the number of elderly people is to be expected The importance of aging in public health On a global scale, while the ... increase in the elderly population will be of the order of 30–140% in the next 30 years, depending on the country Elderly people themselves are growing older, increasing the numbers and proportions of...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt

Báo cáo khoa học

... contained a 30 bp insertion in the ¨ ORF, beginning at nucleotide 516 This resulted in insertion of a 10 amino acid segment (TREIDYPETI) and one substitution (Ser fi Gly) at the C-terminal end of the ... ortho¨ log of the product of this gene In the clade including Spatzle-1, the branch lengths are noticeably longer and ¨ the bootstrap values are lower than in the other clades containing Spatzle-2 ... reported in other genes, such as human and Drosophila Gsa (the a-subunit of the guanine nucleotide-binding protein) isoforms [41,42] ProSpatzle-1 mRNA was detected in hemocytes and ¨ fat bodies of...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx

Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx

Báo cáo khoa học

... Frequency of amino acid residues in the flexible region of the C-terminal extensions of human and murine sHsps Residues present in the flexible region of the C-terminal extension of each of the eight human ... demonstrates the importance of each of the negatively charged residues in the C-terminal extension in maintaining the solubility of the Hsp25 oligomer Similarly, the introduction of hydrophobicity into the ... that the structure of the N-terminal domain is maintained, at least in the vicinity of the tryptophan residues The increase in exposed clustered hydrophobicity observed for the mutants is therefore...
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Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf

Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf

Báo cáo khoa học

... h in either the absence or presence of p26, and then enzyme activity was determined p26 concentrations are indicated and the p26 variants are in the same order in each histogram group The standard ... domain The interface between monomers of a dimer involves interaction between strands b2 and b6 of neighboring monomers The p26 modifications examined in this study are not located in either of these ... contact of b-strand 10 from the C-terminal extensions of monomers A and D with b-strands and in the a-crystallin domain of monomers C and B, respectively (Fig 8) A more prominent dimer–dimer interface...
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Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt

Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt

Báo cáo khoa học

... binding ligand Sodium ions may still bind to the N373L mutant through coordination to the other ligands of the binding site (center I), but the binding becomes much weaker as emphasized by the ... feature in the proposed mechanism is the binding of Na+ ions from the cytoplasm at D203 and S382 including sites and their delivery into the periplasm as a proton enters the channel from this site and ... group of Y229 In (D), the Na+ binding sites are empty and exposed towards the periplasm and the biotin prosthetic group is not modified (B-H) Upon carboxylation of the biotin, the protein switches...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

Báo cáo khoa học

... the N-terminus of the RT domain is required for protein interactions with the high-affinity binding site in subdomain DIVa of the intron, whereas other regions of the RT and domain X interact with ... motif, in which the Y354 and Y355 amino acids were replaced by alanine residues, and the 2.5· mutant [27], in which the IEP was truncated in the RT domain Therefore, the pattern of inhibition for the ... extension In the present study, we investigated the C-terminal region of the RmInt1 IEP up to the maturase domain and the C-tail We found that the C-tail and upstream amino acid residues, located in...
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Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

Báo cáo khoa học: Post-translational modifications in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

Báo cáo khoa học

... described for the sulfuration of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molybdopterin biosynthesis, respectively, and for the sulfuration of uridine in tRNA ... strength of coenzyme B binding A more important function of the methyl group may involved improved orientation of the histidine inside the coenzyme B-binding site With the methylation, the histidine ... S-adenosylmethionine-dependent protein methylases [9] How the sulfur is transferred into the carboxamide group of glycine in the peptide chain remains to be shown Neither the functions of the five modifications...
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Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf

Báo cáo khoa học: FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis pdf

Báo cáo khoa học

... GM-CSF is involved in the proliferation of primary RA FLSs [7] In the present study, we investigated cell proliferation and MLN51 expression using an RA FLS cell line, MH7A, in the presence of GM-CSF ... upregulated in the FLSs of RA patients, and is enhanced days after GM-CSF treatment [7] In the present experiments, we assessed the dose and time kinetics of the effects of GM-CSF on MLN51 expression in ... localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells...
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