follow up strategies for the treatment of obesity in primary care settings
Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... contributor for the clearance of NPs, thus the reducing rate of MPS uptake could be considered as the best strategy for prolonging the circulation of NPs (Li & Huang, 2008) Therefore, PA/EPI prepared in ... two groups, each with 10 mice The experimental group received a single intravenous (i.v.) dose of blank PANs (200 mg/kg); the other group was treated with a single i.v dose of normal saline All ... When the standard consists of intravenously administered drug, this is known as relative bioavailability (BAR) The BAR of PA/EPI after administration was calculated using the following formula...
- 7
- 391
- 0
Tài liệu Copper and Fiber Labeling Software and Labeling Sheets docx
... contains labels for the front and back of the hinged label SH ADCLS-TFP2RUA Adhesive label for ADC’s 5RU TFP Fiber Panel Each label sheet contains labels for the front and back of the hinged label ... for ADC’s 1RU TFP Fiber Panel Each label sheet contains labels for the front and back of the hinged label SH ADCLS-TFP1RUA Adhesive label for ADC’s 2RU TFP Fiber Panel Each label sheet contains ... Labeling Sheets Ordering Information Description UOM Catalog Number ADCLS-CL4A SH ADCLS-CL10A Adhesive label for ADC’s patch cords or horizontal cable 1" x 1/4" Each label sheet contains 35 individual...
- 4
- 534
- 0
Tài liệu Stability and Control of Large-Scale Dynamical Systems pptx
... uniformly in xII0 The remainder of the proof involves similar arguments as given above and as in the proof of parts ii) v) of Theorem 2.3 and, hence, is omitted Next, we provide a time-varying ... needed for developing the main results of this monograph In a denition or when a word is dened in the text, the concept dened is italicized Italics in the running text is also used for emphasis The ... collection of interacting subsystems The behavior and properties of the aggregate large-scale system can then be deduced from the behaviors of the individual subsystems and their interconnections Often...
- 389
- 723
- 0
Tài liệu The Decline of Traditional Banking: Implications for Financial Stability and Regulatory Policy doc
... traditional banking Another indicator of the decline in the profitability of traditional banking is the fall in the ratio of market value to book value of bank capital from the mid-1960s to the early ... conducted by the Bank for International Settlements (the “Promisel Report”), the Bank of England, the Group of Thirty, the Of ce of the U.S Comptroller of the Currency, the Commodity Futures Trading Commission, ... banking institutions Indeed, banks’ loan losses in these countries as a fraction of GNP exceeded losses in both the banking and the savings and loans industries in the United States The International...
- 21
- 552
- 0
Tài liệu Báo cáo khoa học: Combinatorial approaches to protein stability and structure pdf
... sequences into a loop of the SH2 domain and screening for binding to the phosphotyrosyl ligand peptide [67] In principle, folded insertions should reduce the entropic penalty for inserting a long ... the B1 domain of IgG-binding protein G [42] Individual clones were examined for expression and grown in the presence of a 15N source, allowing 1H-15N HSQC NMR analysis of crude lysate for well-dispersed ... but the C-terminus of helix has shifted away from the core to accommodate the overpacking (as indicated by the arrow) Interestingly, most of the core residues retained near-ideal rotameric conformations...
- 14
- 584
- 0
Đề tài " Stability and instability of the Cauchy horizon for the spherically symmetric Einstein-Maxwell-scalar field equations " doc
... determines the solution The conditions for predictability are then related to the behavior of the unique solution of the initial value problem on the boundary of this region In the following two ... natural starting point for studying the problem in the nonlinear setting In fact, the method of this paper applies to a much wider class of initial data to be considered in a forthcoming paper We ... to the case where the inequalities (111) are not strict by noting the following continuity principle: Given a fixed metric satisfying the conditions of the theorem, the initial value problem for...
- 55
- 318
- 0
Báo cáo khoa học: Purine nucleoside phosphorylases from hyperthermophilic Archaea require a CXC motif for stability and folding pot
... with serines significantly affects both their thermodynamic and kinetic stability [10,12], suggesting the involvement of the cysteine pair in the thermal stabilization of both enzymes In the present ... damage of the other disulfide bonds of the protein To demonstrate the active role of CXC motif in the oxidative folding process, we carried out the unfolding of SsMTAPII, PfPNP and their CXClacking ... mutants by incubation for 22 h at 25 °C with m GdnCl in 20 mm Tris ⁄ HCl (pH 7.4), containing 30 mm dithiothreitol The reversibility of the GdnClinduced unfolding was then examined by assaying the catalytic...
- 7
- 496
- 0
Báo cáo khoa học: Effect of flanking bases on quadruplex stability and Watson–Crick duplex competition pptx
... study the inuence of anking regions on the existence of quadruplexes, their stability and quadruplex duplex competition in the presence of the complementary strand As the quadruplex-forming region ... equilibrium In the current study, we have explored the inuence of anking sequences in the quadruplex-forming region of the c-kit proto-oncogene promoter [16] Conformational analysis of preformed quadruplexes ... 107 106 the binding enthalpy for duplex formation, which increased with the increase in the number of anking bases from to 6, and deviation from the increasing DHITC trend was observed for c-kitG8...
- 13
- 638
- 0
Báo cáo khoa học: Thermodynamic stability and folding of proteins from hyperthermophilic organisms doc
... finding supports that charged interactions are of importance for governing TkMGMT hyperthermostability Other proteins In addition to the described groups of proteins, only a few other hyperthermostable ... combination of the two (Fig 1A) In vitro folding ⁄ unfolding experiments in solution often involve chemical (i.e urea or guanidine hydrochloride, GuHCl) or thermal perturbations of the protein; the ... Comparisons of the thermodynamics and kinetics of the folding of proteins from mesophilic and thermophilic ⁄ hyperthermophilic organisms can provide an insight into the mechanisms of stabilization...
- 11
- 507
- 0
Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf
... those of the WT form In other words, in the mutant thrombin the binding of sodium is not intrinsically perturbed, but should be uncoupled from the specific conformational transitions occurring in the ... simulation of DK9 thrombin in explicit water solvent supports the role of the A-chain in affecting the conformation and catalytic properties of the B-chain, particularly in some insertion loops of the ... sodium binding X-ray structures of human thrombin show that the A-chain closely follows the contour of the catalytic B-chain, hinging the two interacting six-stranded barrel-like domains of the B-chain...
- 11
- 553
- 0
Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... and formation of a compact transition state The temperature-dependence of the refolding rate provides thermodynamic insights into the nature of the TSE for folding Curvature in the plot of 1/T ... determined protein stability, and their involvement in the folding pathway from studies of refolding/unfolding kinetics While the single point mutation P37A is destabilizing by 4.5 kJÆmol)1, in ... WT* The single point S19P mutation leads to a F ¼ 0.37, which points to the stabilizing effect of this mutation not being realized in the folding TSE, indicative of the loop between the N-terminal...
- 11
- 549
- 0
Báo cáo Y học: Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes pptx
... in vivo with the intramolecular route dominating during periods of minimum synthesis and secretion of the cysteine protease The role of a heterologous intermolecular mechanism in the processing ... transition remained unaffected (Fig 5C) Reduction of the intrinsic stability of the protein in the presence of EDTA and the absence of detectable stabilization effect in the presence of mM Ca2+ indicate ... Monitoring of the ellipticity at 205 nm during heating produced a sigmoidal biphasic transition curve indicative of cooperative unfolding for a multidomain protein (Fig 5D) Again, the midpoints for...
- 13
- 487
- 0
FINANCIAL LIBERALIZATION, MACROECONOMIC (IN)-STABILITY, AND PATTERNS OF DISTRIBUTION pptx
... authority can independently target either the nominal exchange rate or the interest rate, leaving the determination of the other to the interplay of the market forces The overwhelming evidence ... saving performance of 25 the public sector, and the abrupt financing demands of the government increases uncertainty and risk in the financial markets It also increases the volatility of the money ... empirical findings for developing countries as a whole or for the sub-group of “emerging markets” have shown that cumulative sums of each of the foregoing items for a few years or for the full financial...
- 73
- 449
- 0
Báo cáo khoa học: Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein potx
... proteins [38–40] These include tighter hydrophobic packing of the protein core [41–43], increased electrostatic interactions on the surface of the protein [44,45], more prolines and alanines ... by the SDS ⁄ BME treatment, and remain either in a monomeric or a tetrameric state, depending on the pH of the protein buffer In contrast, SDS ⁄ b-ME treatment alone dissociates a fraction of the ... within the TTR family in dark and light blue, and those within the TLP subgroup in dark and light gray The secondary structure elements are based on hTTR [12] Residues lining the substrate-binding...
- 13
- 419
- 0
Báo cáo khoa học: Crystal and solution structure, stability and post-translational modifications of collapsin response mediator protein 2 pdf
... Kd values for the binding of the cations onto the CRMP-2 protein surface are 15–20 mm for the divalent cations and > 100 mm for potassium The detection of several isoforms of CRMP-2 in rat hippocampus ... in the 3D structure of CRMP2 (Fig 6) The first concerns the main deamidation site and four of the main oxidation sites The second one contains the remaining two main oxidation sites and two minor ... identified in the brain Our data, including the mapping of post-translational modifications onto the structure of CRMP-2, open up new possibilities for studying the function and interactions of CRMP-2,...
- 14
- 431
- 0
power system stability and control chuong (1)
... the reaction of the current during the sag can help determine the source of the sag If the current doubles when the voltage sags 10%, then the cause of the sag is on the load side of the current ... capture the waveform if there is a significant deviation in any portion of the waveform Others capture waveforms if there is a significant change in the rms value of successive waveforms Another method ... the current monitor point If the current increases or decreases 10–20% during a 10% voltage sag, then the cause of the sag is on the source side of the current monitoring point Sensitive equipment...
- 8
- 522
- 3
power system stability and control chuong (2)
... all of the many topics encompassed by the field The chapters are written primarily for the electric power engineering professional who is seeking factual information, and secondarily for the professional ... particular topic of interest is not included in this list, please refer to the list of companion volumes seen at the beginning of this book In reading the individual chapters of this handbook, ... Outstanding Engineering Educator Award, the 1996 Birdsong Superior Teaching Award at Auburn University, and the IEEE Power Engineering Society Outstanding Power Engineering Educator Award in 2003 Professor...
- 14
- 498
- 5
power system stability and control chuong (3)
... decrease the fuel supply to bring generation into equilibrium with load In this case, storage is in the form of coal in the pile or natural gas in the well An excellent form of storage is water in ... They therefore must cut back part of the time because of the lack of water A combination hydro and wind plant can conserve water when the wind is blowing, and use the water later, when the wind ... justify a wind turbine, and had the effect of killing the small wind turbine business 1.1.3 Large, Non-Grid Connected These machines would be installed on islands or in native villages in the far...
- 10
- 611
- 3
power system stability and control chuong (4)
... ratio are in uenced by the utility’s load curve, and the price of off-peak power For example, the CAES plant in Germany requires h of compression per hour of generation On the other hand, the Alabama ... better candidate for combined cycle applications whereby the fuel cell exhaust can be used as input to the intake of a gas turbine or the boiler of a steam turbine The total thermal efficiency ... until early in the 21st century 2.1.4.7 Zinc and Aluminum Air Batteries Zinc air batteries are currently being tested in postal trucks in Germany These batteries use either aluminum or zinc as a...
- 8
- 328
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008