... number of variables, which were possibly relevant forthe quality of patient ratings of HRQoL, were measured forthe purpose of describing the sample of patients, as well as for assessing the quality ... and standard deviations forthe QLQ-C30 scales, as well as forthe characteristics ofthe patients were calculated The internal consistency ofthe multiitem scales ofthe QLQ-C30 was assessed ... and the EORTC QLQ-C30 questionnaire data collected during the previous (in-clinic) measurement wave at T2 Procedure To assess the impact of different MOA’s on themeasurement performance of the...
... achieved by calculation ofthe portion ofthe total area under the curve occupied by the dimers peak The obtained value was divided by two MALDI-TOF MS was performed at The Institute of Nuclear Physics, ... compared to the 90% loss of Trp after the completion of this reaction We confirm that the process is nonstoichiometric and that the amount of LRET depends on the primary structure ofthe protein ... 2) The yields of fragmentation (Table 2) vary for these proteins Discussion In this work, we performed a comparative study ofthe oneelectron oxidation of six proteins from the c-type family of...
... not in the highest risk category The limitations of these studies notwithstanding, the weight of current evidence suggests that routine use ofthe PAC is not useful forthe vast majority of patients ... outcome, therapy, clinician behaviour The majority ofevidence to support the use of Presep ScvO2 catheters comes from the work of Rivers and coworkers [6], but there are also a number of optimization ... assess theadequacyof perfusion is an extremely attractive concept As a consequence ofthe stoichiometry ofthe reactions responsible forthe substrate level phosphorylation of ADP to form ATP,...
... use evaluation often takes place before the course starts with the aim to select the appropriate materials most appropriate forthe particular group of learners and forthe aims ofthe course Formative ... designers Therefore, they can provide the most valid information in theevaluation process Also, their understanding of cultural and political factors ofthe institution in which theevaluation ... seeks their opinions about the content ofthe material Part C asks for their opinions about the methodology Part D requires them to offer suggestions forthe material’s further improvement The...
... Another major factor was the reduction of water use in the factory through the utilization of WWR and water conservation efforts mainly due to their cost consciousness after the introduction of ... calls for water conservation They also continuously make efforts to promote the utilization of SWT devices including the distribution of free SWT-tap developed by them as shown in Fig.7 On the other ... parties during the time regarding the charging system The debate fortheadequacyof such system was between the capitalist party and socialist party The capitalist party opposed it, since the system...
... validity The experts pointed out their level of accordance with the relevance ofthe items, ease of understanding and adequacy as an instrument to characterise the management models ofthe PA programmes ... on the reasons forthe use of quality schemes and pointed out the advantages of their implementation in improving services [24,55,56] On the other hand, Ritchie and Dale suggest the existence of ... this criterion, most ofthe leaders of our study reported that everybody had full access to the information about the mission and objectives ofthe PA programme In the field of Higher Education,...
... on the preliminary conformation ofthe protein and the coordination propertiesofthe incoming metal ions Metallation of apo-a-rhMT-1a with Cd2+ was carried out at pH 7.3 by raising the pH ofthe ... Sequence ofthe a domain of rhMT-1a, showing the connectivities ofthe four divalent metal cations to the 11 cysteinyl sulfurs The numbering ofthe cysteines (1–11 starting from the N-terminus) and the ... binding for M2+ (M ¼ Zn, Cd) initially to the a domain, thereby leading to formation ofthe M4a cluster prior to formation ofthe M3b cluster, demonstrating that the individual binding constants of...
... in the presence of substrate and a proton motive force [23] On the basis of these studies, it has been proposed that binding of substrate to the TatBC subunits triggers the recruitment ofthe ... ofthe mutants exhibited unexpected properties when compared with previous findings The effects ofthe mutations were analyzed using two types of export assay The first involves expression ofthe ... rearrangements ofthe TM spans of these subunits It has not been established whether these TM spans simply anchor the amphipathic regions and cytosolic 2272 domains to the membrane, or whether they serve...
... qualitative evaluationof lexical association measures, mainly forthe following reasons: the instability of precision values obtained from the rst few percent ofthe data in the SLs; the lack of signicant ... precision values above 50% forthe rst 10% ofthe list, but is outperformed by the t-test afterwards Looking at the rst 40% ofthe data, there is a big gap between the good measures (t-test, ... will often produce misleading results For instance, if we just look at the rst ofthe SLs forthe PNV data, we might conclude that the t-test and frequency measures are equally well suited for the...
... followed their own customs and traditions in using the forest and land as they had done since the time of their ancestors The National Forest Meeting in 1989 raised the importance ofthe forest forthe ... on the Management of Forest and Forest Land in 19892 certified the change in objectives forthe use ofthe forest and forest land so that it can be used forthe development ofthe economy, including ... Ministers on the protection ofthe Forest, 74, on 17 July 1979, (Forestry Strategy of Lao PDR 2020, 2005: 3) Decree ofthe Assembly of Ministers on the management and use ofthe forest and forest land...
... understanding ofthe function and organization ofthe enzyme complex, the analysis of mutant alleles ofthe genes involved in the biosynthetic pathway can certainly provide valuable information In ... to the loss of a functional myristoylation site could determine the alteration ofthe local molecular environment conditions required forthe association ofthe different enzyme monomers or for ... sequence analysis ofthe carB mutant alleles To check if strain A486 was altered in the carB gene, and in order to get further insights into the nature ofthe mutations ofthe carB gene in strains...
... have the ability to convert the major circulating form of vitamin D, 25(OH)D, into the active hormonal form, 1,25(OH)2D So, there is a local mechanism in many tissues ofthe body for converting the ... urinary secretion of isothiocyanates, was inversely related to the risk of breast cancer; the quartile with the highest intake only had 50% ofthe risk ofthe lowest intake group [89] In the Nurses' ... protein) in the methylenetetrahydrofolate reductase and the methionine synthase genes which increase the relative amount of folate available for DNA synthesis and repair also reduces the risk of colon...
... addition, the majority ofthe lesions examined appear to be ofthe Class I type, rather than Class II lesions for which the technology would have the greatest potential benefit Finally, since 1/3 ofthe ... appropriate to the purpose ofthe test? Use examiners representative ofthe target or primary clinical providers ofthe test? Show evidence that the test can distinguish cancer/precancer from other conditions ... Critical evaluationof diagnostic aids forthe , Oral Oncol (2007), doi:10.1016/j.oraloncology.2007.06.011 ARTICLE IN PRESS Critical evaluationof diagnostic aids forthe detection of oral cancer then...
... coupling constant ofthe spectrum ofthe turnover form ofthe T2Cu center are slightly different from that ofthe as-puried form (cf Table 2) which suggests the existence of modications in the catalytic ... catalytic center ofthe enzyme These modications may be attributed to either the presence ofthe substrate and/or a product in the vicinity ofthe T2Cu active center rather than to disruption of this ... surface area of 0.018 cm2 Before each measurement, both the cell and the sample (70100 lL) were ushed with argon for 15 During the measurements the solution was kept under a ow of argon The voltammetric...
... clarify the binding propertiesof each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos ... and XI ofthe receptor serine ⁄ threonine kinase domain [22] Another striking point is the phase conservation ofthe intron– exon boundaries that lie either side ofthe exon encoding the extracellular ... end and C2 defines the domain closest to the cell membrane A comparison ofthe inferred amino acid sequence ofthe C1 and C2 domains reveals that only the approximate spacing ofthe 10 cysteine...
... disposition ofthe proximal His and Asp residues, affecting the imidazolate character ofthe His, but also by the formation of a LS species The latter indicating the probable binding of His42 to the ... consistent with the very subtle nature ofthe mutation, i.e the loss of a single methyl group, depicted in green in Fig In marked contrast, forthe reduced state comparison ofthe RR spectra ofthe Thr171Ser ... impact on thepropertiesof His170 The strength ofthe hydrogen bond between the proximal His and Asp residues, and thus the imidazolate character ofthe His is expected to modulate not only the strength...
... that the presence ofthe C-terminal domain is crucial forthe acquisition ofthe correct enzyme fold Analysis ofthe interactions between the two domains led us to presume that expression ofthe ... or in the absence of chelators (90.94 ± 7.85 UÆmg)1) These results suggest that the presence of calcium is important forthe optimal activity of BsArb43B Furthermore, to determine whether the role ... Together, these results confirm that the atom in the cluster is calcium To determine whether the calcium ion has a specific role in the activity of BsArb43B, assays were performed in the presence of...
... 2B) These results show that Mpl partially lost the cytochrome c; the densitometric analysis ofthe immunodecoration show a decrease of approximately 50% in the Mpl proteins On the other hand, the ... activation ofthe iron transport systems [37] Therefore, they are crucial in controlling iron storage and homeostasis in the plant cells Other functions of plant ferritins are, on the other hand, ... Table The theoric molecular mass, 23.6 kDa, calculated from the database sequence after removal ofthe N-terminus signal peptide, is in agreement with the value of 25–26 kDa estimated from the...