evaluating oncopathological studies the need to evaluate the internal and external validity of study results
Tài liệu What Lung Cancer Patients Need to Know About Bone Health: A Publication of The Bone and Cancer Foundation pdf
... supply These include the ends of the arms and legs (nearest the torso), the pelvis, the ribs, and the spine When lung cancer spreads to bone, several factors can increase the process of bone ... through the blood stream to a new location, where they grow and multiply Although lung cancer can spread to any part of the skeleton, tumor cells most often affect the bones that have the greatest ... Vertebra: The bony segments that make up the spinal column The mission of The Bone and Cancer Foundation is to: • Provide information to cancer patients and family member on the causes and current...
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The Minimum You Need to Know About Java and xBase potx
... can open the file to do an export. When they track me down via the Web and call my office, they get disappointed finding out I don't have time to drop everything and fly to their location to help them free of charge. Then they say my ... AshtonTate had a lot of sales, a lot of money, a lot of attitude, and a lot of lawyers. This led to them believing they had the rights to all things dBASE. When the cash cow started giving lots of green milk the clone vendors piled into the fray. ... There is a lot of history and folklore surrounding the history of xBASE. You could probably make a movie out of it like they made a movie out of the rise of Microsoft and Apple called “Pirates of Silicon Valley” in 1999. You can piece together part of the history, at least from a...
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from dust to stars studies of the formation and early evolution of stars
... developments and scientific milestones that led to the pursuit of modern star formation studies 2.1.1 From Ptolemy to Newton It took humankind until the dawn of the New Age to put basic pieces together and ... estimate the lifetime of stars by: tlif e = 7.3 × 109 M/M yr L/L (2.2) 2.2 The Quest to Understand the Formation of Stars 21 where M and and L are the mass and luminosity of the Sun and M and L the ... book On the one hand, it is necessary to understand the underlying physics to be able to properly describe the manifold of different processes involved On the other hand there is a story to tell...
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Báo cáo khoa học: "Comparative studies on the pathogenicity and tissue distribution of three virulence variants of classical swine fever virus, two field isolates and one vaccine strain, with special regard to immunohistochemical investigations" ppt
... under the level of the detection capacity of the VI test in quite a number of animals As further tools of direct virus detection, DIF and IHC proved to be complementary methods to the "golden standard" ... design of the study and performed and evaluated the second animal experiment inclusive virus isolation CM participated in the design and performing of the in situ hybridisation study, evaluated the ... restricted to the tonsils and lymph nodes The signals were observed between PIDs to in this group The hybridisation signals were observed in the cytoplasm of the epithelial (Figure 8), mononuclear and...
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Comparing the cultural and linguistic analysis of the English word “meal” and words relating to it in contrast with Vietnamese equivalents.
... bar and the saloon bar The English like showing off when they go out for a drink and whereas the poorest customers go into the public bar, they go into the saloon bar The differences between the ... mentioned The men, especially the husband and the grandfather, sip alcohol and tell their family members what they see and hear or remind them of right or wrong things in life The others also ... difficult The oldest or the husband of the family sits at the head of the table and others sit in descending order according to age or wherever they like The meal starts when everyone has their own...
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Báo cáo khoa học: Ibuprofen binding to secondary sites allosterically modulates the spectroscopic and catalytic properties of human serum heme–albumin doc
... according to Eqn (7) [20]: koff ẳ koff2ị ẵibuprofen=K2 ẵibuprofenị ỵ koff3ị ẵibuprofen=K3 ẵibuprofenịị ỵ kỵ off 7ị where koff(2) and koff(3) indicate values of koff occurring at K2 < [ibuprofen] ... s)1) Ibuprofen binding to tHSAheme-Fe(II)-NO Figure shows the binding isotherm for ibuprofen binding to tHSAheme-Fe(II)-NO Analysis of the dependence of the molar fraction of the ibuprofenbound ... where a and ) a are the relative spectroscopic contributions to the total electronic absorbance change of ibuprofen binding to the high-afnity and low-afnity sites, respectively Effect of ibuprofen...
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The Costs and Financial Benefits of Green Buildings: A Report to California’s Sustainable Building Task Force pptx
... the Kyoto Protocol CO2 targets, CO2 cost will need to be about $30 per ton.158 A 2002 A.D Little (ADL) study for the CEC and the ARB includes a detailed analysis of the value of CO2 This study ... applicable to other types of buildings and for other public and private sector entities A Report to California’s Sustainable Building Task Force – October 2003 v The Costs and Financial Benefits of Green ... other building costs such as the cost of land and infrastructure Therefore, a meaningful assessment of the cost of building green requires a comparison of conventional and green designs for the...
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Báo cáo khoa học: Coordination of three and four Cu(I) to the a- and b-domain of vertebrate Zn-metallothionein-1, respectively, induces significant structural changes doc
... regardless of whether zinc or cadmium is bound to them and also regardless of the existence of the second domain The assigned peaks of the a-domain were integrated and their consistency with the published ... the NOESY and TOCSY (not shown) spectra of the two domains permitted the full sequence-specific assignments, the identification of the spin systems and the assignment of 398 and 252 of the NOESY ... concentration of mm each and incubated for >48 h before the measurement of their 1H NMR spectra The observed NOESY and TOCSY spectra (not shown) consisted of the sum of the respective spectra of the single...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the major and minor conformations of holo-ACP bear close resemblance to ... in the range 15) 60 C The results of the analysis of these curves using the linear extrapolation model (LEM) are shown in Tables and and Fig 4AC There is a slight temperature dependence of the ... interactions, and the blue lines denote CHO hydrogen bonds The 4Â-PP group is linked to the protein by the Ser37 O-c atom Only residues 3138 of the protein make extensive contacts with the cofactor For the...
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Báo cáo khoa học: Mercury(II) binding to metallothioneins Variables governing the formation and structural features of the mammalian Hg-MT species pptx
... Notwithstanding this, there is a minor effect of t and X at the beginning and end of the titration Thus, the addition of the first 4–6 of Hg(II) to apo-MT gives rise to Hg-MT species of comparable stoichiometry ... stereochemistry and degree of folding of the species formed Thus, to understand the reaction pathways followed by Zn-MT and apo-MT species in the presence of Hg(II), the effect of each of the previous ... of all the variables in the Hg-MT system required the performance and analysis of 18 Ó FEBS 2004 titrations and the corresponding duplicates The detailed and comparative analysis of the set of...
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Báo cáo khoa học: Antimicrobial and conformational studies of the active and inactive analogues of the protegrin-1 peptide docx
... at the two spatial tips of the molecule, at the N-terminus with Arg1 and in the turn in the presence of Arg7 and Arg9 (see Figs and 4) The shorter analogue, BM-2, was the most flexible of all the ... of the peptide Two hydrophilic regions were located at the two spatial tips of the molecule, at both termini with Arg1 and Arg17, and in the turn in the presence of Arg8 and Arg10 (see Figs and ... N-terminal parts The conformational differences between the structural families of these peptides applied mainly to the varied structures of the N- and C-termini All the features of the structures...
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Báo cáo khoa học: Expressed as the sole Hsp90 of yeast, the a and b isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90b generates sensitivity to the Hsp90 inhibitor radicicol pdf
... with mutation to Hsp90, with altered cochaperone function and with the loss of plasma membrane drug efflux pumps [35] The results of this study point to the two isoforms of human cytosolic Hsp90 ... deletion of the SLT2 gene in PP30[pHSC82] The LEU2 vectors pH90a (this study) and pH90b [35] were then inserted into this PP30slt2D, and this was followed by 5-fluoroorotic acid curing of the pHSC82 ... expressing both AD- and BD-fusions) were selected on DO lacking histidine and tryptophan Automated measurement of the b-galactosidase activity due to basal and stress-induced expression of the interaction-responsive,...
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Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx
... 50% of the observed amplitude change RESULTS Expression and purification of CaNa and CaNb CaN heterodimers composed of the Ca2+-binding B subunit and either the a or b catalytic subunit isoform ... to find differences in the phosphatase activities between CaNa and CaNb toward the same substrate The results of the kinetic analyses, and inhibition studies are summarized in Table Although the ... spans the length of the central helix of CaM, and led to the proposal that the 11 consecutive Pro residues of CnAb may modulate the interaction of CaM with the CaM-binding domain of CnAb [41] However,...
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intro to the math. and stat. foundations of econometrics - h. bierens
... variety of mathematical topics and concepts that are used throughout the main text, and Appendix III reviews the basics of complex analysis which is needed to understand and derive the properties of ... by hand, using the Triangle of Pascal: 1 1 1 þ 1 10 þ 10 þ (1.3) þ þ Except for the 1's on the legs and top of the triangle in (1.3), the entries are the sums of the adjacent numbers on the previous ... common: their intersections are the empty set The conditions (1.8) and (1.9) are clearly satisfied for the case of the Texas lotto On the other hand, in the case under review the collection ö of events...
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reasons of identity a normative guide to the political and legal assessment of identity claims nov 2009
... practices often invoke a test to establish the sincerity of claimants both in the sense of whether they present themselves as sincere to the court and in relation to their past history and practices.22 ... 23) Or they make of these scripts what they wish and bind themselves to groups in ways that are, at the same time, of their own making and diYcult to change without causing real damage to themselves ... ubiquitous in the public sphere and so a pragmatic need arises to develop institutions able to respond to them fairly This chapter elaborates on these reasons and then provides an overview of the theoretical...
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Introduction to the Mathematical and Statistical Foundations of Econometrics pps
... variety of mathematical topics and concepts that are used throughout the main text, and Appendix III reviews the basics of complex analysis which is needed to understand and derive the properties of ... by hand, using the Triangle of Pascal: 1 1 1 þ 1 10 þ 10 þ (1.3) þ þ Except for the 1's on the legs and top of the triangle in (1.3), the entries are the sums of the adjacent numbers on the previous ... common: their intersections are the empty set The conditions (1.8) and (1.9) are clearly satisfied for the case of the Texas lotto On the other hand, in the case under review the collection ö of events...
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Báo cáo y học: "Variety of transversus thoracis muscle in relation to the internal thoracic artery: an autopsy study of 120 subjects" docx
... the anterior axillary line and the chest plate containing the sternum, the medial part of the upper eight to nine ribs and the surrounding soft tissues was removed from the body Afterwards, the ... in the autopsy material, the slip to the fifth rib on both sides always existed The slips to the fourth and sixth ribs were presented in most of cases (Figure 2D) The number of slips forming the ... Department of Anatomy, Histology and Embryology, Medical University of Sofia, blvd Sv Georgi Sofiiski 1, 1431 Sofia, Bulgaria 2Department of Forensic Medicine and Deontology, Medical University of Sofia,...
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báo cáo khoa học: " Defining the effect and mediators of two knowledge translation strategies designed to alter knowledge, intent and clinical utilization of rehabilitation outcome measures: a study protocol [NCT00298727]" docx
... consistent with the Transtheoretical Model of (Readiness to) Change; and To determine the relative importance of potential predictors of change, including characteristics of clinicians (years of practice, ... the extent to which programs change the behavior of the clinician within their practice and requires chart audits and observations Stage focuses on the client and requires evaluation of the efficiency, ... current state of practice and knowledge, we propose to evaluate two KT approaches to implanting knowledge on outcome measures Purpose Primary objective of the study This study will evaluate the effectiveness...
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Báo cáo y học: "The personal and national costs of mental health conditions: impacts on income, taxes, government support payments due to lost labour force participation" pot
... areas of income, mental health and wealth EC contributed to the generation of results, and drafted the manuscript All authors contributed to the interpretation of the results, and edited the final ... considered to be out of the labour force due to depression Those who reported being out of the labour force due to their illness and listed one of the other mental health conditions as their main condition ... retirement The UK Department of Health has support the prevention and early treatment of mental health conditions in recognition of the potential to avoid the large financial burden of the disease on the...
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Báo cáo y học: " A validity-driven approach to the understanding of the personal and societal burden of low back pain: development of a conceptual and measurement model" doc
... reactions of others and the person’s psychological state, seen in the top right hand corner; 2) the variety of statements related to the effort of living, down the right hand side of the map These ... hampered by the lack of an organized understanding of what aspects of a person’s life are affected, and comprehensive measures of these effects The aim of this study was to develop a conceptual and measurement ... of treatment and health states) The maps produced by the other groups had a similar range of concepts and a similar emphasis on issues associated with the reactions of others and the effort of...
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