drug interactions with benzodiazepines epidemiologic correlates with other cns depressants and in vitro correlates with inhibitors and inducers of cytochrome p450 3a4
Báo cáo khoa học: Surface-enhanced vibrational spectroscopy for probing transient interactions of proteins with biomimetic interfaces: electric field effects on structure, dynamics and function of cytochromec doc
... by choosing excitation lines in resonance with an electronic transition of the cofactor of the protein, to selectively enhance those Raman bands that originate from the chromophoric part of the ... reflect alterations in the coordination sphere, such that these marker bands allow monitoring equilibria and dynamics of the spin, coordination and ligation configuration of cytochrome c [10,27] ... binding domain, composed of Lys72, Lys73, Lys79, Lys86, and Lys87, is associated with a distinctly weaker average electronic coupling of the haem with the electrode than the medium-affinity binding...
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Báo cáo y học: "Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including a-actinin " docx
... a-actinin 4, myosin, and a-tubulin in glomeruli (1) and tubules (2) 1) Although the intensity of immunoreactivity of a-tubulin did not change, that of immunoreactivity of actin, aactinin and myosin ... O-GlcNAcylation of a-actinin and actin may affect the crosslinking to actin and cause the morphological changes seen in the podocyte foot processes in the glomeruli and in the microvilli of tubules a-Actinin ... O-GlcNAcylation of actin may modulate the actin-tropomyosin interaction and be involved in the polymerization of myosin heavy chains [24] High glucose alters protein kinase C-dependent actin assembly in both...
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Tài liệu The Acquisition of Drugs and Biologics for Chemical and Biological Warfare Defense - Department of Defense Interactions with the Food and Drug Administration doc
... of a continuing dependent relationship that involves three types of interactions: licensing CBW drugs and biologics, especially vaccines; using Investigational New Drugs in military combat (and ... comply with the extensive IND recordkeeping regulations: FDA review of information provided to individual recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information ... manufacturing of drugs and biologics FDA has markedly increased scrutiny of manufacturing of both biological and pharmaceutical products in recent years The difficulties of obtaining anthrax vaccine,...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... sequence PXXP in interacting proteins Seven such motifs are present in the proline-rich domain of the longest isoform of tau in the human central nervous system (CNS) Two distinct PXXP motifs in tau, ... Tyr18, one of five tyrosines present on tau [17–19], and tau also interacts with Fyn via its Src homology (SH)3 domain [20,21] The SH3 domain of Fyn binds to proline-rich motifs within the sequence ... we and others have highlighted the importance of tau interactions with the membrane-anchored nonreceptor tyrosine kinase Fyn during Ab-mediated neurodegeneration in cell and animal models of...
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Tài liệu Báo cáo khoa học: Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast doc
... Coq7 in fission yeast [38] Whereas induction of ctt1+ and apt1 occurred in all ubiquinone-deficient strains, induction of gpx1+ was not observed in any of the tested strains (Fig 6) However, in the ... viability during stationary phase PR110, and RM1(Dcoq7), RM2(Dcoq3), RM3(Dcyc1), and JZ858(Dcgs1), were pregrown in liquid YEA at 30 °C and then grown in Pombe minimum with adenine leucine and uracil ... centrifugation, and 500 lL of supernatant was mixed with 0.1 mL of 0.1% dimethylphenylenediamine (in 5.5 m HCl) and 0.1 mL of 23 mm FeCl3 (in 1.2 m HCl) The samples were incubated at 37 °C for min, after...
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Tài liệu Báo cáo khoa học: Agrobacterium tumefaciens type II NADH dehydrogenase Characterization and interactions with bacterial and thylakoid membranes ppt
... proposed to be involved in the interaction with hydrophobic quinones of respiratory chains [11,13] Respective contributions of both hydrophobic domains to membrane and quinone interactions require ... complementation of the mutant was observed in the absence of IPTG, likely indicating significant IPTG-independent expression of the protein Using an antibody raised against the recombinant protein, AtuNDH-2 ... separation and fluorometric analysis of the flavinic cofactor Continuous line, cofactor extracted from purified recombinant AtuNDH-2; dashed black line, FAD standard; dashed grey line, FMN standard...
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Tài liệu An Account of the Foxglove and some of its Medical Uses With Practical Remarks on Dropsy and Other Diseases doc
... it again, and was so much better as to want no other medicine An Account of the Foxglove and some of its by William Withering 21 In the course of the following winter he became hectic, and died ... very large, and she had a total loss of appetite Half a grain of fol Digital, pulv with gr of merc alcalis were ordered night and morning, and an infusion of bark and rhubarb with steel wine to be ... cured infallibly by weak decoction of Foxglove leaves in water, or wine and water, and drank for constant drink Or take of the juice of the herb and flowers, clarify it, and make a fine syrup with...
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Báo cáo khoa học: Interactions of imidazoline ligands with the active site of purified monoamine oxidase A potx
... Parini A & Lanier SM (1995) Imidazoline ⁄ guanidinium binding domains on monoamine oxidases ) relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ... level of oxidized enzyme available for inhibitor binding with kynuramine and MPTP [29] Difference spectra and binding curves When ligands bind to the active site of MAO-A, the environment of the ... are given in Table Evidence for the proximity of these ligands to the flavin in MAO-A comes from the in uence of the ligand on the redox properties of the flavin Like other inhibitors of MAO-A [23,30],...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc
... (blue) with an atom within 4.0 A of the other protein (= binding region) are indicated KD1 makes contact with all substrate ⁄ inhibitor specificity-determining loops on HGFA (compare with Fig 1B), and ... structure of HGFA (without inhibitor present) reveals an active site in which key elements of the substrate-binding site are changed in a way that is incompatible with substrate binding and catalytic ... domain (B-chain) The subdomains of the A-chain are: fibronectin type I and type II (FNI and FNII), epidermal growth factor (EGF)-like and Kringle (Kr) Cleavage by thrombin (T) and plasma kallikrein...
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Báo cáo khoa học: Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1 doc
... activation of integrins requires talin binding to the cytoplasmic tail of b integrin [13] Talin is an essential integrin-activating protein that connects the cytoplasmic tail of b integrins to the actin ... they can interact with phosphoinositides and membrane proteins [21] The FERM domain of talin interacts with phosphatidylinositol 4,5-P2 (PIP2) and with the cytoplasmic tail of b integrins [14] ... cytoskeleton [14] Integrin cytoplasmic domain associated protein (ICAP)-1 is a partner of the cytoplasmic tail of b1 integrin and has been shown to compete with talin for binding to b1 integrin [15] Consistently,...
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Báo cáo khoa học: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90 doc
... most of the middle and 4132 all of the C-terminal domains, including the postulated Hsp90-binding and dimerization regions [16] Mutants with truncations extending into the N-terminal domain, Cdc37(1–155), ... functions independently of Hsp90 binding and that these roles not require homodimerization of Cdc37 The N-terminal domain of Cdc37 may be involved in chaperone activities independently of other co-chaperones ... points towards Cdc37 carrying out essential functions that are independent of Hsp90-binding and homodimerization A five amino acid in- frame insertion within the middle domain of S pombe Cdc37 abolishes...
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Báo cáo Y học: Domain V of m-calpain shows the potential to form an oblique-orientated a-helix, which may modulate the enzyme’s activity via interactions with anionic lipid potx
... curve fitting was then applied within the original spectra after the subtraction of baselines resulting from neighbouring bands Similar to the deconvolution technique, the bandshapes of the single ... Ca2+-binding domain J Biol Chem 273, 15879–15882 24 Crawford, C., Brown, N.R & Willis, A.C (1990) Investigation of the structural basis of interaction of calpain II with phospholipid and with ... position, band width, and intensity) were evaluated with the original spectra, if necessary after the subtraction of strong water bands In the case of spectra with weak absorption bands, resolution-enhancement...
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Báo cáo khoa học: Hepatocyte nuclear factor-4a interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression pot
... alternation in the binding of HNF-4 or other HNFs would be expected to affect the formation, configuration and stabilization of the multiple protein–protein interactions or recruitment of other cofactors ... containing 10% fetal bovine serum, 100 unitsÆmL)1 penicillin and 100 lgÆmL)1 streptomycin APR in HepG2 cells was stimulated by incubation with a cytokine mixture consisting of ngÆmL)1 of recombinant ... significantly in a cytokine-induced APR model [17], and that changes in HNF-4a and HNF-1a binding can be seen very rapidly in a murine burn injury model [16,18] To determine whether cytokines have...
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Báo cáo khoa học: Deciphering the key residues in Plasmodium falciparum b-ketoacyl acyl carrier protein reductase responsible for interactions with Plasmodium falciparum acyl carrier protein pptx
... 4759 Interactions of PfFabG with PfACP K Karmodiya et al Table Binding constants (Ka) for interaction of wild-type PfACP with mutant PfFabG, in the absence and in the presence of reduced cofactor ... alanines to determine which of the electrostatic interactions are important for promoting the binding to PfACP Interestingly, within the Plasmodium genus, Arg187 is substituted (Fig 1B) with ... by monitoring the change in its intrinsic fluorescence In these studies, we have investigated the interactions between PfFabG and PfACP using a combination of computational, biochemical and biophysical...
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Báo cáo Y học: ER–resident chaperone interactions with recombinant antibodies in transgenic plants potx
... with nontransgenic plants The results are consistent with the putative role of BiP in binding to and retaining unassembled subunit proteins [9,49] and in folding and assembly of immunoglobulin ... that the BiP–Ig chain interaction in plants is not artefactual and is consistent with the model of BiP binding transiently in the ER to Ig chains during protein folding and processing The immunoblot ... studied the involvement of BiP and calreticulin in the folding and assembly of recombinant immunoglobulin heavy and light chains in transgenic plants that express the assembled form of an IgG monoclonal...
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báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions" pptx
... nostaining was found in normal-appearing white matter of brain and spinal cord IL-16 immunoreactivity was readily observed in CD3+ T cells in perivenular infiltrates (Fig 6A) Within the pool of infiltrating ... lesions in brain, (Fig 3A) and in acute spinal cord lesions (Fig 3B), corresponding to increases in IL-16 Levels of T-bet in spinal cord were greatest in acute lesions, and gradually decreased in ... immunopathology of MS is initiated by infiltration of macrophages and lymphocytes into brain and spinal cord [3] In patients with MS, magnetic resonance imaging (MRI) has confirmed that intrathecal infiltration...
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báo cáo hóa học: " Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed avb3 and avb5 integrins" pptx
... Page of 10 Figure Evaluating the role of the avb3 and avb5 integrins in promoting microglial activation state in response to vitronectin Wildtype, b3 integrin KO, b5 integrin KO and b3/b5 integrin ... comparison of the effect of Page of 10 Figure Examination of the role of b1 integrins in mediating microglial adhesion to vitronectin or fibronectin A Adhesion to vitronectin or fibronectin of microglia ... Examination of the role of the avb3 and avb5 integrins in mediating vitronectin induction of microglial activation Wild-type, b3 integrin KO, b5 integrin KO and b3/b5 integrin DKO microglia were purified...
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báo cáo hóa học:" Ilizarov treatment of humeral shaft nonunion in an antiepileptic drug patient with uncontrolled generalized tonic-clonic seizure activity" ppt
... both CYP450 inducers and inhibitors through stimulation of vitamin D catabolism and inhibition of 25-hydroxylation of vitamin D [16] The effect of antiepileptic drugs on bone mineral density is ... added in the anticonvulsant therapy The patient was instructed in pin care cleaning and hygiene and discharged from the hospital days after surgery Pin-tract infection was noticed in two skin/pin ... bone healing, and minimize the fixation time Ilizarov technique may involve the risk of pin-tract infections most of which can be treated by administration of antibiotics, as in our case Other disadvantages...
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Báo cáo toán học: " Case report: successful lipid resuscitation in multi-drug overdose with predominant tricyclic antidepressant toxidrome" ppt
... bupivacaine with reducing pH [10], and the findings of Mazoit et al purporting a lowered bupivacaine-lipid binding capacity with acidosis [11] In the present case, bicarbonate infusion prior to ILE injection ... assayed amitriptyline elevation and induced hypertriglyceridaemia Amitriptyline levels may have increased regardless of ILE therapy because of ongoing gastrointestinal absorption of toxin Furthermore, ... tricyclic antidepressant intoxication following self-poisoning with multiple pharmaceuticals including amitriptyline in excess of 43 mg/kg, in a 51-year-old male Institution of mechanical ventilation,...
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báo cáo hóa học:" Case report: successful lipid resuscitation in multi-drug overdose with predominant tricyclic antidepressant toxidrome" docx
... bupivacaine with reducing pH [10], and the findings of Mazoit et al purporting a lowered bupivacaine-lipid binding capacity with acidosis [11] In the present case, bicarbonate infusion prior to ILE injection ... assayed amitriptyline elevation and induced hypertriglyceridaemia Amitriptyline levels may have increased regardless of ILE therapy because of ongoing gastrointestinal absorption of toxin Furthermore, ... tricyclic antidepressant intoxication following self-poisoning with multiple pharmaceuticals including amitriptyline in excess of 43 mg/kg, in a 51-year-old male Institution of mechanical ventilation,...
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Tìm thêm: khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25