... collection ofoperatingsystem primitives defined such that a programmer has the option of choosing to use either shared memory or message-based communication as the basis for the implementation of amultithreaded ... may be located on either ofthe clients’ hosts, or on yetanother host.In the second frame, each client takes a read fault on the same page ofthe shared memory region. The same pagemay be ... tasks.Many other operating systems have met with this problem. Often these systems solve the problem by using insideknowledge ofthe algorithms used to manage secondary storage. Unfortunately, the Mach...
... and Professor of Economics at the Wharton School ofthe University of PennsylvaniaThorsten Beck Professor of Economics and Chairman ofthe European Banking Center, Tilburg University, NetherlandsCharles ... transmission of information in the price, and greater effi-ciency ofthe market. In the bond market, the most commonly used variable is the tightness of the bid-ask spread (with the U.S. and ... development and theroleof the state in finance.Despite the crisis experience, 90 percent ofthe country officials and experts surveyed in the poll perceive that positive effects of finance (in...
... must still be determined whetherits absence in the V79-G18 mutant is the result ofthe missingESSS subunit alone, or whether the absence of ESSS causes the f ailure of other integral membrane subunits ... as a nother identification of the complex at the position o f the histochemical stain in the left panel. Antisera against the SDHC subunit of complex IIand against the Rieske protein of complex ... and the effect of the absence of intact complex I, but the results are toopreliminary in this regard.Heterologous expression ofthe ESSS-HA subunit The localization ofthe ESSS subunit in the...
... ducts is of considerable significance in the pathology of a number of diseases including cystic fibrosis and cancer.Equally important is the fate ofthe cytoplasmic tail of the mucins once the extracellular ... required for efficientcleavage [11]. The solution structure ofthe SEA domain of the mouse homologue of MUC16 (which in the humanencodes the core protein ofthe ovarian cancer antigenCA125) was ... contained in a surface-exposed loop. To furtherinvestigate theroleofthe SEA domain in cleavage of membrane-tethered mucins we carried out site-directedmutagenesis ofthe FRPG ⁄ SVVV site and...
... binding of GTP to the allosteric site promotes coordination of the phosphorylation of UTP and hydrolysis of glutamine foroptimal efficiency in CTP synthesis rather than just acting toincrease the ... ATP-cS. On the basis of these results, ATP-cSwas chosen as a binding analog of ATP. CTP synthesisrequires the presence of both the nucleotide substrates ATPand UTP. When phosphorylation of UTP ... locks the enzyme in the active form for CTP synthesis andthereby stimulates the kcat of the reaction. Since GTP actually willactivate the uncoupled glutaminase reaction the structure of the monomer...
... sense of group identity, in the eyes of its members and those outside the group. What is theroleofthe facilitator? The roleofthe facilitator is to make it easier for groups to work together ... 1. TheRoleofthe Facilitator – page 6What is theroleofthe facilitator?How do facilitators help groups achieve their goals?They do it by • Clarifying and reinforcing the purpose ofthe ... Facilitation - 1. TheRoleofthe Facilitator – page 11Group dynamicsFacilitators need to be aware both ofthe communication styles ofthe individuals who make up the group, and ofthe way the group...
... examine the dynamics of tobacco-related media interventions at each of these levels, within a systemic framework. The relationships among these levels and stakeholders on either side ofthe tobacco ... provide the advantage of internal validity and are helpful in confirming causal relationships. These experiments, however, are often limited in terms ofthe rather forced nature of exposure, ... nature of several tobacco promotional campaigns; (3) the unavoidable exposure of youth to these campaigns; (4) theroleof tobacco advertising and promotion in increasing tobacco use in the...
... For the purposes of this analysis however we have chosen the boundaries ofthe situational analysis to reflect those ofthe ‘political’ region of South East Queensland (see Figure 1b). The ... health ofthe aquatic ecosystem. There are several measures ofthe level of nitrogen present in a water body, these include TKN, ammonia, nitrate and nitrite concentrations. The quantity of phosphorus ... et al 2008). One ofthe key positive unintended outcomes ofthe EHMP was the building of momentum leading to the establishment ofthe Partnership. The EHMP began in 1999, and the Partnership...
... 0.8%. A possibleinterpretation ofthe data suggests that the indicatedbasic region of ic3 ofthe D2receptor and acidic region of the C-tail ofthe D1receptor might be involved in the interactions ... localization of these proteins in the cell rather thanfrom the possible roleofthe D2R basic domain in the mechanism of D1–D2receptor heterodimerization. However, we find that the acidicepitope ... efficiency in the trafficking ofthe wild-type D2receptor [61]. The construction of genetic variants ofthe studieddopamine receptors, which were supposed to prove the contribution ofthe indicated...
... sequence contacts the c-phosphate ofthe bound nucleotide across the dimer [15] and the aromatic residue ofthe A-loopstacks against the adenine moiety of boundnucleotide and provides further stabilization ... cleavage ofthe c-phosphate does occur in the NBD with the mutation at the IC [36,38,39]. More-over, these and other studies suggest that the ICresidues are involved in the formation ofthe NBDdimer, ... activates the attackingwater molecule that cleaves the terminal phosphate of bound ATP. In the latter model, the IC is part of acatalytic dyad, along with the histidine residue of the H-loop, and positions...
... hasbeen proposed that metabolic channeling of (E)-cin-namic acid requires the close association of specificforms of PAL with C4H on microsomal membranes[63]. The site of phosphorylation of French ... study the behavior ofthe Tyr110-loop in PAL in moredetail.Results and discussionModeling the active conformation of the essential Tyr110-loop of parsley PALBecause ofthe uncertainty ofthe ... the biosynthesis ofthe photoactive yellow proteinchromophore of these bacteria. The two recently discovered aminomutases, the phe-nylalanine 2,3-aminomutase (PAM) involved in taxolbiosynthesis...
... family. One ofthe women told that she had been at the offices of the company and an officer showed her the papers related to the purchase of lands ofthe family. According to him, they had just ... from the existence of swamps. The Pampa ofthe South of Brazil, in the State of Rio Grande do Sul (RS) borders another two countries ofthe Pampa: Uruguay and Argentina. Due to a number of ... meet the needs ofthe communities. On the contrary, they were designed on the basis of an agro-export model geared to the countries ofthe North – and the European Union specifically in the...
... upstream of the GAF domain are the potential ligands of the Fe-S cluster. Consequently, the binding ofthe ATPanalog and the subsequent rearrangement ofthe inter-domain interaction affects the ... electronic condition of the Fe-S cluster through the protein scaffold, resultingin an alteration ofthe signal rhombicity ofthe EPRspectrum. The divergence ofthe g-value from that of the whole cell ... level ofthe lacZ gene immediately after the addition of o-phen to minimize the effect ofthe growthinhibition by o-phen on the transcriptional activity of VnfA. Figure 5 shows the time course of...
... discrepancies within the nursing profession with regard to specialist/advanced nursing titles, differing roles and the educational needs of these nurses.In the United Kingdom, the idea of advanced ... ongoing professional development, rather than a requirement of their job description. The implementation within the NHS ofthe Agenda for Change in 2005 aimed to evaluate nursing roles based ... participation in the research process. If the aim of clinical nurse specialists is to enhance patient care, then research must be part oftherole (Armstrong 1999). It will involve their awareness of current...
... thereby revealing the close network of interactions that hold the terminal glucose ofthe b-glucan substrate in the )1 subsite at the bottom of the active site pocket [20]. The entrance to the ... 3N9KaBGC1 is the glucose residue from the nonreducing end of laminaripentose (L5) bound to the exterior ofthe protein.bBGC2 is the weaklybound glucose residue of L5 bound in the Phe-Phe clamp.cL3-1 ... implementedto help explain their importance to the specificity andcatalytic efficiency ofthe enzyme. The roleofthe Phe-Phe entranceway The fortuitous discovery of an unreacted molecule of the mechanism-based...