cutaneous reactions to drugs
Veterinary Pharmacovigilance Adverse Reactions to Veterinary Medicinal Products docx
... levels Phytotoxicity Invertebrate toxicity Vertebrate toxicity Target Animal Safety: Clinical trials Laboratory studies Tolerance studies Environmental Safety Efficacy: Clinical trials Laboratory ... Adverse drug reactions in dogs – toxic hepatic responses K.N Woodward 423 453 20 Adverse reactions in humans following exposure to veterinary drugs 475 K.N Woodward 21 Medicines used to control ... health care professionals to report serious and unexpected suspected adverse reactions and adverse reactions in humans exposed to veterinary medicinal products to the regulatory authorities In doing...
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THE DIMENSIONS OF AESTHETIC REACTIONS TO MUSIC doc
... preliminary version was applied to the written reactions of 30 junior school-children to 18 short musical extracts in a pilot study (Ashford, 1979), and subsequently modified to produce the following ... ultimately felt to be spuriously detailed for any meaningful analysis to be undertaken.) Results All constructs were classified according to the content analysis system, and the number falling into each ... was subjected to principal components factor analysis, and a Varimax rotation was performed Two factors were extracted by adopting Kaiser's criterion (Harman, 1960); the two factor matrices appear...
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Báo cáo khoa học: "Predicting User Reactions to System Error" ppt
... me the train to New York City from Baltimore on Sunday at eight thirty pm Which city you want to go to? New York City Which city you want to leave from? Baltimore Do you want me to find the trains ... Baltimore to New York City today at anytime now? No How may I help you? Get me the train to New York City from Baltimore on Sunday at eight thirty pm Do you want me to find the trains from Baltimore to ... automatically available features With our new success in identifying aware sites, we acquire another potentially powerful indicator of prior error Using these two indicators together, we hope to...
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An Introduction to Drugs in Sport pptx
... performanceenhancing drugs Dunning and Waddington (2003: 364) have suggested that ‘it may be useful to differentiate between these terms and to apply them to two rather different ways in which drugs may be used to ... ‘determined to see an end to tobacco advertising in motor racing’, Sir Rodney’s primary concern was that the loss of income from tobacco sponsorship would be difficult to Sport, health and drugs 27 ... why does it give rise to demands for such swingeing punishments for those found to be using drugs? The Sport, health and drugs 17 central objective of this chapter is to try to answer these questions,...
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A Perception-Based View of the Employee: A Study of Employees’ Reactions to Change doc
... resistance to change Indicator for active resistance to change Indicator for active resistance to change Indicator for active resistance to change Active support for change Indicator for active ... resistance to change Indicator for passive resistance to change Indicator for passive resistance to change Indicator for passive resistance to change Passive support for change Indicator for passive ... Consequently, it is important to note that a study of employees’ reactions to privatization not only has to deal inclusively with reactions to privatization but also with reactions to a set of changes...
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Misfortunes of War - Press and Public Reactions to Civilian Deaths in Wartime docx
... is at least as important to get the story right as to get the story out Notwithstanding the view that is sometimes heard that it is critical to get one’s story out first, to operate within the media’s ... Organization (NATO) about the incident—many of xxii Misfortunes of War: Press and Public Reactions to Civilian Deaths in Wartime which also soon proved to be in error themselves—seem to have hurt NATO’s ... affairs guidance used to explain specific incidents should touch upon all the issues likely to be of concern to key audiences The provisions of Article 57 (2) of Protocol I to the Geneva xxiv Misfortunes...
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bioinformatics - from genomes to drugs - thomas langauer
... The series editors are grateful to Thomas Lengauer, who accepted the challenging task to organize this volume on bioinformatics, to convince authors to participate in the project and to ®nish their ... bind tightly to the protein Most drugs that are on the market today modify the enzymatic or regulatory action of a protein by strongly binding to it as described above Among these drugs are long-standing, ... metabolic reactions that is not depicted in Figure 1.1: Many reactions involve co-factors A co-factor is an organic molecule, a metal ion, or ± in some cases ± a protein or peptide that has to be...
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market reactions to the credit risk announcements
... is more likely to occur on lower rated bonds, causing dealer inventory imbalance The stock market has strived to improve transparency To enhance the ability of market participants to observe information ... more actions to improve liquidity are needed in the corporate bond market to be comparable to the stock market It would be interesting to test directly how adverse selection and inventory models ... pay higher coupon rates to attract investors to invest in risky bonds Time to maturity (avg = 12 years) 12 is calculated by subtracting bond issue date from maturity date To examine debt seniority,...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 1) pps
... spectra The cutoff at the short end of the UV is at ~290 nm; this is due primarily to stratospheric ozone formed by highly energetic ionizing radiation, thereby preventing penetration to the earth's ... Photosensitivity occurs when a photon-absorbing chemical (chromophore) present in the skin absorbs incident energy, becomes excited, and transfers the absorbed energy to various structures or to ... about destruction of the ozone layer by chlorofluorocarbons released into the atmosphere has led to international agreements to reduce production of these chemicals Measurements of solar flux indicate...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 2) pps
... of vasoactive mediator(s), or cytokines, that diffuse to the dermal vasculature to evoke vasodilatation The action spectrum for sunburn erythema includes the UV-B and UV-A Photons in the UV-B are ... nuclear factor-κB (NF-κB)-dependent gene transactivation can augment release of several proinflammatory cytokines including interleukin (IL) 1B, 1L-6, IL-8, vascular endothelial growth factor, prostaglandin ... factor α Local accumulation of these cytokines occurs in sunburned skin, providing chemotactic factors that attract neutrophils and macrophages It is of interest that nonsteroidal anti-inflammatory...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 5) pps
... weeks prior to initial sun exposure Phototoxicity and Photoallergy These photosensitivity disorders are related to the topical or systemic administration of drugs and other chemicals Both reactions ... excited-state photosensitizer that can transfer its absorbed energy to a bystander molecule or to molecular oxygen, thereby generating tissue-destructive chemical species, including ROS Phototoxicity ... manifestations typically differ from those of phototoxicity in that an intensely pruritic eczematous dermatitis tends to predominate and evolves into lichenified, thickened, "leathery" changes in...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 6) ppsx
... sensitive to UV-B, UV-A, and visible wavelengths Diagnostic confirmation of phototoxicity and photoallergy can often be obtained using phototest procedures In patients with suspected phototoxicity, ... drug photosensitivity involves first and foremost the elimination of exposure to the chemical agents responsible for the reaction and minimization of sun exposure The acute symptoms of phototoxicity ... photosensitizing porphyrins The porphyrins circulate in the bloodstream and diffuse into the skin, where they absorb solar energy, become photoexcited, generate ROS, and evoke cutaneous photosensitivity...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 7) docx
... appears to be an independent risk factor for PCT Treatment of PCT consists of repeated phlebotomies to diminish the excessive hepatic iron stores and/or intermittent low doses of the antimalarial drugs ... eliminates exposure to porphyrinogenic agents Erythropoietic protoporphyria originates in the bone marrow and is due to a decrease in the mitochondrial enzyme ferrochelatase secondary to numerous gene ... erythrocyte protoporphyrin Detection of increased plasma protoporphyrin helps to differentiate lead poisoning and iron-deficiency anemia, in both of which elevated erythrocyte protoporphyrin levels...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 8) pot
... thought to decrease DNA synthesis and relate to the improvement that occurs in psoriasis The reason that PUVA photochemotherapy is effective in cutaneous T cell lymphoma is not clear In addition to ... administration of UV-B alone or in combination with topically applied agents can induce remissions of psoriasis and atopic dermatitis Photochemotherapy in which topically applied or systemically administered ... psoriasis and in the early stages of cutaneous T cell lymphoma and vitiligo Psoralens are tricyclic furocoumarins that, when intercalated into DNA and exposed to UV-A, form adducts with pyrimidine...
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Chapter 057. Photosensitivity and Other Reactions to Light (Part 3) doc
... due to failure to control for confounding factors such as sunscreen stability and frequency of application Since no prospective studies are available to address this issue, it seems reasonable to ... tumorigenic process Exposure to a tumor initiator such as UV-B is believed to be a necessary but not sufficient step in the malignant process, since initiated skin cells not exposed to tumor promoters ... human skin to photocatalytically produce vitamin D3, the widespread use of sunscreens that filter out UV-B has led to concern that vitamin D deficiency may become...
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Báo cáo y học: "Nonimmunoglobulin E–Mediated Immune Reactions to Foods" pptx
... E–Mediated Immune Reactions to Foods — Spergel 79 Table Disorder Symptoms Diagnostic Testing Food Involved Cutaneous Atopic dermatitis Chronic relapsing pruritic rash Skin testing and atopy patch testing ... any IgE-mediated symptoms or immediate reactions to foods, which suggests a role for non–IgE-mediated food reactions Orenstein and colleagues27 tried to link food allergies to EE more definitively ... history is more difficult in the case of non–IgE-mediated reactions as compared to IgE-mediated reactions because of the delay in the onset of symptoms after ingestion of the food IgE-mediated reactions...
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Báo cáo khoa học: "Late cutaneous metastases to the face from malignant pleural mesothelioma: A case report and review of the literature" docx
... Histologically, Mesothelioma is divided into epithelial, sarcomatous and mixed or biphasic subtypes In several series epithelial type has a significantly improved prognosis compared to sarcomatous ... related to asbestos exposure [2] Its incidence has been rising steadily over the past few decades [1] Approximately 1000 people die of mesothelioma each year in the UK, and it is predicted to rise to ... microscopic examination showed sarcomatous atypical spindle cell proliferation within the dermis extending into the subcutaneous adipose tissue (Fig 3) Mitotic figures including atypical forms...
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báo cáo khoa học: "Hypersensitivity reactions to anticancer agents: Data mining of the public version of the FDA adverse event reporting system, AERS" ppsx
... August 2011 Accepted: October 2011 Published: October 2011 17 References Pagani M: The complex clinical picture of presumably allergic side effects to cytostatic drugs: symptoms, pathomechanism, ... asparaginase, teniposide, and etoposide, in order to more clarify the critical factors to reproduce the clinical observations on HSRs Additionally, agents thought to be associated with HSRs were ... and epipodophyllotoxins are thought to increase the susceptibility to such reactions [1-5] Previously [7], and in this study, pharmacoepidemiological analyses were performed to confirm the HSRs...
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báo cáo khoa học: " US smokers’ reactions to a brief trial of oral nicotine products" pps
... through partnership or acquisition, moved into the smokeless tobacco business This has allowed tobacco manufacturers to introduce smokers to new smokeless tobacco products for use in situations where ... believe about products, and their reactions to those products, are recognized to be important to understanding how smokeless tobacco and medicinal nicotine are likely to be used and thus their potential ... and failed to suppress tobacco abstinence symptoms as effectively as cigarettes Overall, the literature suggests that it is important to try to assess smokers’ reactions to proposed cigarette...
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Báo cáo y học: "Severe allergic reactions to guinea pig" docx
... exposed to guinea pigs In contrast to domestic settings, laboratory animal allergy (LAA) is well documented [1-5] Approximately one third of laboratory animal workers have occupational allergy to ... Case Two Percutaneous skin testing was positive (equivalent to histamine control with negative saline control) to guinea pig epithelium extract Skin reactivity was also detected to cat dander ... those related to EIA She reported previous casual exposure to guinea pigs without adverse reaction, but had not kept any rodents as pets She denied symptoms on previous exposures to dogs, cats,...
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