... of innovative therapies in sepsis The ACCP/SCCM Consensus Conference Committee American College of Chest Physicians/Society of Critical Care Medicine Chest 1992, 101:1644-1655 Carrigan SD, Scott ... and specificity of C- reactiveprotein (CRP), procalcitonin (PCT) and neutrophil count were computed using the predefined cutoff values of 60 mg/l, 0.25 μg/l and 7.5 × 109 cells/l, respectively ... shown that high concentrations of suPAR portend a poor clinical outcome in diverse infections such as tuberculosis, malaria and pneumococcal bacteraemia [14,15] Finally, the cytokine macrophage...
... test indicating the presence of coronary artery disease (CAD) Lack of ACS was determined by negative diagnostic testing or absence of a cardiac event (death, myocardial infarction, or revascularization) ... of Emergency Medicine 2011, 4:37 http://www.intjem.com/content/4/1/37 0.00 0.25 0.50 - Specificity 0.75 1.00 Area under ROC curve = 0.4969 Figure ROC curve for the diagnostic accuracy of hs-CRP ... (0.47-1.07) hs-CRP mg/l 0.99 (0.98-1.01) CAD, coronary artery disease; ECG, electrocardiogram; hs-CRP, high sensitivity Creactiveprotein Diercks et al International Journal of Emergency Medicine 2011,...
... hepatocyte-stimulating factor Proc Natl Acad Sci USA 2000, 97:10144-10149 Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F: C- reactiveprotein (CRP) induces chemokine secretion via CD11b/ICAM-1 ... the lack of association between replication and viral load or CD4+ cell counts as shown in Fig 2C and 2D, respectively Biological characterization of viral isolates Replication capacity of isolates ... (n = 85) replicated more efficiently in U87 CD4 cells expressing CCR5 than in CXCR4expressing cells, indicating that they are R5 tropic viruses The fold difference of CCR5 over CXCR4 growth was...
... Infectious Diseases concentrations: comparisons in patients with septic shock, Society of America/American Thoracic Society consensus guidelines cardiogenic shock, and bacterial pneumonia Crit Care ... procalcitonin and C- reactiveprotein levels as markers of bacterial B Usefulness of procalcitonin as a marker of systemic infection in infection: a systematic review and meta-analysis Clin Infect ... bacterial community-acquired pneumonia for C- reactiveprotein (CRP) and procalcitonin (PCT) No difference was detected in the discriminative value between CRP and PCT had positive urinary pneumococcal...
... MP C- reactiveprotein in atherosclerosis: A causal factor? Cardiovasc Res 2006; 71: 30-39 24 Yip HK, Sun CK, Chang LT, Chen MC, Liou CW Time course and prognostic value of plasma levels of N-terminal ... ischemic and hemorrhagic stroke without significant differences Ischemic strokes showed higher values of NT-PBNP and lower values of CRP than hemorrhagic strokes without statistical significance ... differences of CRP levels between cardioembolic and atherosclerotic strokes The significance of NT-PBNP elevation in the acute phase of stroke is mostly unknown In 86 consecutive patients with ischemic...
... component [4,18] Furthermore, CRP binds ICs [19] and facilitates the clearance of soluble or particulate ‘debris’ by means of phagocyte Fcγ receptors (FcγRs) [3,20–22] Some of these effects can ... modified C- reactiveprotein J Immunol 1996, 156:4435-4441 Mold C, Baca R, Du Clos TW: Serum amyloid P component and C- reactiveprotein opsonize apoptotic cells for phagocyγ tosis through FcγRs J ... surface of human peripheral blood lymphocytes Characterization of lymphocytes reactive with anti-neo-CRP J Immunol 1988, 140:4271-4278 40 Cocca BA, Cline AM, Radic MZ: Blebs and apoptotic bodies...
... Benedetti Panici P, Foti E, Martucci R, Gadducci A, Perillo A, Facchini V, Peschle C, Mancuso S: Prognostic significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, ... Page of Figure CRP and the characteristics of breast tumour (A) CRP levels according to tumor depth (B) CRP levels according to LN metastasis (C) CRP levels according to distant metastasis (D) CRP ... pre-diagnostic CRP levels are high [7] Cancer invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of...
... osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Arthritis Rheum 1986, 29:1039-1049 Yudkin J, Stehouwer C, Emeis J, Coppack S: C- reactiveprotein ... malignancy or cancer treatment, excluding non-melanotic skin cancer All participants provided a detailed medical history in response to specific questioning and those with an active medical condition ... Parenthesis indicate the sign of regression coefficients statistically significant at the 5% level BMI, body mass index (kg/m2); ln hsCRP, natural log high sensitivity C- reactiveprotein tibiofemoral...
... the IFCC/BCR/ CAP Reference Material (CRM 470) International Federation of Clinical Chemistry Community Bureau of Reference of the Commission of the European Communities College of American Pathologists ... sandwich test channel (❍); direct capture assay test channel (ᮀ); direct sandwich test channel ( ); homogenous sandwich control channel (x); direct capture control channel (+); direct sandwich control ... 7(3):285-289 Schulte TH, Bardell RL, Weigl BH: Microfluidic technologies in clinical diagnostics Clin Chim Acta 2002, 321(1-2):1-10 Cooper MA: Akubio: label-free screening of molecular interactions...
... antibodies, CRP interacts with cellular Fcγ receptors, thereby facilitating the phagocytic clearance of circulating opsonized material Activation of the classical complement pathway is considered one of ... inflammation, CRP dissociates to mCRP, which may enhance binding of circulating soluble immune complexes to phagocytic Fcγ receptors [12,43] and constitute a vicious circle Conclusions We have ... consuming and requires a deft cer- tified clinician Microscopic examination of a kidney biopsy, with classification and estimation of indices of renal disease activity and chronicity, today offers...
... negative predictive value, and diagnostic accuracy rates were calculated according to standard definitions The accuracy of discriminatory performance was compared by the area under ROC curves The ... BNP alone Table Performance characteristics of various cut off points of BNP or CRP, excluding mixed type edema Cut-off points Sensitivity Specificity PPV NPV Accuracy ≧400 80.3 66.0 76.0 71.4 ... natriuretic peptide; BP: blood pressure; CRP: C- reactive protein; CPE: cardiogenic pulmonary edema; LVEF: left ventricular ejection fraction acquired pneumonia (CAP) cases with a score of or based...
... Age, Chronic Health Evaluation; PCT, procalcitonin; CRP, C- reactive peptide Figure Plasma concentrations of the corresponding C- reactiveprotein (CRP) concentrations of patients within four categories ... groups of increasing categories of the SOFA score are shown in Figs and Median of PCT concentrations significantly increased with increasing SOFA score levels of the patients (Fig 1) In contrast, CRP ... approach is closer to clinical conditions, since in severely ill patients the presence or absence of a significant infection cannot always be specified [11] With increasing categories of the SOFA...
... http://ccforum.com/content/10/1/R1 Figure and C- reactiveprotein maximum concentrations of procalcitonin (PCT) Histogram of the day of( CRP) in multiple-trauma patients and C- reactiveprotein (CRP) ... inflammation, the various stages of sepsis according to American College of Chest Physicians/Society of Critical Care Medicine criteria [13], and the occurrence of organ dysfunction The final data analyzed ... procalcitonin a 21-day trauma, and reactiveprotein (CRP) complications during (PCT) (0–48 hours) the Initial serum concentrations ofhours) after mechanical follow-up and Creactive protein (CRP)...
... prospective study in intensive care units French ICU Group for Severe Sepsis JAMA 1995, 274:968-974 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: ... CRP, temperature and WCC variations, and for ∆CRP The accuracy of these variables was assessed by calculating the area under the curve (AUC) In medical practice, a diagnostic test with an AUC ... Critical Care Vol 10 No Póvoa et al Figure Patterns of C- reactiveprotein (CRP) course before infection diagnosis or intensive care unit discharge Four patterns of CRP course between day discharge...
... predictors could be age, sex, more specifically categorized diagnosis, localization of Available online http://ccforum.com/content/11/3/R70 Figure Model curves Predicted C- reactiveprotein (CRP) ... septic condition and trauma influence CRP blood levels in children Hence, comparison of CRP and other proinflammatory markers such as PCT can be difficult because of their different kinetics and ... increase of CRP in surgical patients indicates that another factor influences CRP production With respect to our findings, traumatic insult or surgical intervention may cause increased CRP production;...
... 0.76 Page of (page number not for citation purposes) Critical Care Vol 11 No Coelho et al Figure C- reactiveprotein levels C- reactiveprotein (CRP) levels on the day of antibiotic prescription ... citation purposes) Critical Care Vol 11 No Coelho et al Figure Maximal daily C- reactiveprotein variation Receiver-operating characteristics curve of the maximal daily C- reactiveprotein variation ... calculation of the area under the curve (AUC), as described elsewhere [14] In medical practice, a diagnostic test with an AUC
... American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee to define a non-specific generalized inflammatory process independently from any causative factor ... transmittance percentage per second (%T/s) Diagnosis of SIRS and sepsis SIRS and sepsis diagnosis were established according to the American College of Chest Physicians/Society of Critical Care Medicine ... American Society of Anesthesiology; BPW = biphasic waveform; CABG = coronary artery bypass grafting; CPB = cardiopulmonary bypass; CRP = C- reactive protein; EuroSCORE = European system for cardiac...
... role of the fibrinolytic system in severe sepsis Abbreviations AUC: area under curve; CFT: clot-formation time; CI: confidence interval; CRP: C- reactive protein; CT: clotting time; MCF: maximum clot ... prospective cohort study Crit Care 2009, 13:R42 Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCM/ ESICM/ACCP/ATS/SIS ... dysfunction syndrome Crit Care Med 2010, 38:S35-S42 Ganter MT, Hofer CK: Coagulation monitoring: current techniques and clinical use of viscoelastic point -of- care coagulation devices Anesth Analg...
... cardiac or noncardiac subgroups according to their primary diagnosis Noncardiac was defined as a patient with a primary noncardiac diagnosis Noncardiac did not preclude a secondary cardiac disease, ... according to primary admission cause Thus patients in the non -cardiac group may also have cardiac disease and cardiac dysfunction However, patients with cardiac diseases as the primary principal ... natriuretic peptide Wang et al Critical Care 2011, 15:R42 http://ccforum.com/content/15/1/R42 Page of Table Independent predictors of ICU mortality by multivariate logistic regression in non-cardiac...