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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... in the stearic acid incorporation after the de novo synthesis of this lipid (i.e the second hypothesis) According to this hypothesis, previously raised for mammals [34–36], the decrease in the ... centrifugation, the organic phase was isolated and the remaining lipids were further extracted by the addition of mL of chloroform to the aqueous phase and by shaking (in the presence of the glass beads) The ... observe any differences in the distribution of the label into the various phospholipids (including PI) in wild-type and mutant cells (Fig S2) Taken together, these results suggest that the mutation...
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LUẬN MẪU LỚP 12 Discuss the view that tolerance is essential for peace and harmony in any community or country
... and it is in such moments that men also discover their own physical strength, and other advantages of resistance For instance, a man who is attacked by an animal will fiercely in an effort to avert ... in the midst of wild animals but also began to domesticate many of them for his own advantage Soon, even the most ferocious and largest of animals learnt to respect his courage They began to ... to prevent wars in the future Their leaders have met at various times, in the course of history, to discuss peace and to find a way of removing the causes of war It is this urge that led to the...
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Tài liệu Báo cáo Y học: The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex potx
... characteristics when overexpressed in human 293-cells The main objective of the present work was to find an explanation for this phenomenon It is demonstrated that the formation of the active complex is ... region within the catalytic domain This is the first evidence that this region is involved in the formation of the active complex MATERIALS AND METHODS transfected with the pcDNA3 vector alone were ... constructed by use of the EcoRV and SacI sites in the cDNA and were then used to transform 293-cells The region responsible for the different degree of association of the human and murine enzyme...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... co-localize and interact with the type transferrin receptor (TfR1) [5,18] TfR1 mediates the endocytosis of iron-loaded transferrin into acidic endosomes where the iron is released and transported into the ... with that of the HFE-C282Y protein that is known to misfold and induce a cellular unfolded protein response We propose that glycosylation is important for the folding of HFE and is essential for ... WT-Tunica) This suggested that both the single and double mutants were still partially glycosylated To test this, we transfected HEK293T cells to express either the wild-type or mutant proteins, and incubated...
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Báo cáo khoa học: YidC is required for the assembly of the MscL homopentameric pore potx
... membranes is equal to that of the non-depleted IMVs This indicates that YidC is required for assembly of the MscL complex (Fig 5) To investigate the role of the Sec translocon in formation of the ... Based on the structure of the Mycobacterium tuberculosis MscL homologue, this position is expected to be exposed and relatively distant from the membrane, and should therefore be accessible to externally ... the earlier study [13], is located adjacent to the centre of the pore-forming TM1 It is therefore conceivable that even a slight perturbation of the conformation of MscL, for example due to the...
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Book on Life Life - answers that everyone is looking for Rev. 2 pptx
... precise, simple to understand, makes sense and is freely available to anyone. A straight to the point book. This is the effort of many years, boiled, purified and refined to the very basic principles There are too many people to thank for, far too many to even list them ... Once a man has a high paying job, he wants a bigger house, then a car, then good clothes, then new furniture to match the status of his life, then more money is needed, then he wants to join club houses, then he wants another house, then some more money, then more ... Chapter 8 : BRAIN IS JUST A TOOL Brain of man is just a tool that is provided for survival and creation But a man uses his brain to : • Making plans to fulfill his selfish desires • Find loopholes in the system for his own exploitation and gains...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... possible explanation for this is that, in the case of CPT1B, the docking of the N-terminal fragment might differ from that of the established model A further explanation for our data might be that Asp17 ... carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison between mutants) In this article, we show that Glu17 ... 3C and Table show that the IC50 values of these two single mutants were similar and that they lay between the IC50 values of the human and pig CPT1B wild-type enzymes These results indicate that...
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Báo cáo khoa học: Knock-out of the chloroplast-encoded PSI-J subunit of photosystem I in Nicotiana tabacum PSI-J is required for efficient electron transfer and stable accumulation of photosystem I pot
... stained and the right hand side the actual Northern blot) (D) Immunoblot analysis of PSI complexes from wild-type and DpsaJ plants The panel on the left is the stained gel, and the panel on the right ... of the J subunit of PSI 10 11 12 Acknowledgements We wish to thank Ingrid Duschanek and Elli Gerick for excellent technical assistance, and Steen Malmmose for assistance with growing plants The ... Pc and Cyt c6 to PSI [20] To determine the role of PSI-J in plants, we generated homoplastomic psaJ knock-outs in tobacco Transplastomic transformants were obtained and analyzed for differences...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... (up to 200 lM) are shown in the upper panels Numbers on the top of each lane indicate the concentration of His6-CIII or CIIIC (in lM) Lane C indicates the control lane showing undigested r32 The ... show that both CIII and CIIIC inhibit the HflB-mediated proteolysis of r32 in vitro, and that CIIIC is a more effective inhibitor We also found that there is no interaction between CIII and r32 ... bound to glutathione-Sepharose beads followed by the addition of r32 The proteins were analyzed on an 11% SDS ⁄ PAGE and visualized by western blotting with anti-his as the primary antibody The...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
... between the reaction rates for Dopa and 4-t-butylcatechol [22] These results are explained by the requirement for the monophenols to rearrange from the axial to equatorial position in the binuclear ... appears that the size of the side substituent is not the primary factor It has been demonstrated recently that the carboxyl group plays an important role in substrate recognition by the mammalian ... difference in the kinetic parameters for the H389L mutant indicated that histidine 389 is likely to be involved in interactions of the mammalian enzyme with the carboxylate group of the diphenolic...
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beer is proof god loves us reaching for the soul of beer and brewing
... from the main board to the janitor as equally deserving of respect and regard for their contribution to the whole—and that esteem and goodwill extended to suppliers on the one hand and to the ... provenance than would have been the case prior to the acquisition With what irony, then, was the brand restored to the InBev portfolio with the acquisition by the latter of AnheuserBusch And so ... Brazilian business *** If the Brazilian beer market is not much more than two centuries old, that in Belgium is rather more long-standing The Artois brewery, which lends its name to the historic and...
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What qualities and skills are needed for the managers to manage people? • What is the importance of good human resources management
... able to face these changes 5 Dealing with changes Dealing with changes Each manager need to make the correct and flexibility decision for their work They need to keep their confidence and assertiveness ... working Good organization • • A manager must be able to plan, direct, coordinate, and organize through out the day 1 Good organization Summary, organization is an important management quality ... leader you need to know listen openly to others, provide and accept the offer constructive employee, encourage members to exchange ideas The ability to listen well is a cornerstone of good leadership...
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Báo cáo y học: "Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis" pdf
... prepared the arthritis model, and performed the ELISAs and apoptosis assays JH performed all flow cytometry work EB assisted with all measurements for arthritis GKH was the pathologist who analyzed the ... pro-inflammatory factors is similar in Wt and Bid-/- mice following serum transfer The cytokine and chemokine milieu of the joint is necessary for the initiation and the perpetuation of inflammatory ... Bid-/- mice may be due to an inability to delete the autoreactive cells in the joint Discussion Over the past years the notion that a lack of apoptosis contributes to the increase in synovial...
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báo cáo khoa học: " Sgt1, but not Rar1, is essential for the RB-mediated broad-spectrum resistance to potato late blight" pptx
... provides an excellent model to study the mechanism of broad-spectrum and rate-limiting disease resistances An understanding of the underlying mechanism of this type of resistance is important for ... S: An ancient R gene from the wild potato species Solanum bulbocastanum confers broad-spectrum resistance to Phytophthora infestans in cultivated potato and tomato Plant J 2003, 36:867-882 van ... resistance, but the same plants still held the Mi-1-mediated root-knot nematode resistance These results support the hypothesis that plant R proteins differ in the amounts of SGT1 needed to trigger...
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Báo cáo y học: "Percutaneous dilatation tracheostomy: which technique is the best for the critically ill patient, and how can we gather further scientific evidence" pptx
... safe and easy to perform, similar to their findings presented in this issue Fikkers and coworkers indeed address a very important issue, because they analyze two different techniques for percutaneous ... placement of the tracheal cannula It remains unclear whether this was related to the level of procedural experience in the individuals performing the procedures or due to other factors These observations ... methods to be equally safe and effective However, because they recognise the limitations of a retrospective analysis, they plan to conduct a prospective, randomized study to compare GWDF and conic...
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Báo cáo y học: " Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2" ppsx
... podoplanin-specific antibody and the apoptosis marker annexin V or the necrosis marker 7-AAD, and staining analyzed by flow cytometry including both, live and dead cells Black filled histogram: ... by the arrows in the scatter plot) Alternatively, the cells were co-stained with podoplaninspecific antibody and the apoptosis marker annexin V or the necrosis marker 7-AAD, and staining analyzed ... protein) is present within CEM×174 cells and other cell types, and that the protein becomes accessible to antibody staining only upon induction of apoptosis If the latter process is due to specific...
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Báo cáo y học: " Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs" pptx
... constructed and characterized the HIV-1 viruses and lentiviral vectors used in the study CS performed the analysis of DNA microarray data and performed the statistical analysis AR conceived of the study, ... tabulated and is shown on the Y axis A histogram was generated based on the frequencies in each corresponding bin, representing the distribution of the fold-changes for those probe sets The black ... (FDR) value for the comparison was less than 0.05 Finally, the genes identified in the various lists were subjected to gene ontology (GO) content analysis[38] GO content analysis was performed by...
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Báo cáo y học: " PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line" ppsx
... the manuscript Acknowledgements We thank William W Hall for donating the Tax2B plasmid and the antibody against Tax2B We thank the Takeda pharmaceutical company for providing recombinant human ... Tax1, Tax2B and their mutant proteins Structure of Tax1, Tax2B and their mutant proteins The amino acid sequence of PBM and its mutants are indicated The tax1, tax2B genes and their mutant genes ... it is unclear whether these two activities utilize the same mechanism Both the number and size of the transformed colonies of Rat-1/Tax1 cells were greater than those of Rat1/Tax2B cells, but the...
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Báo cáo y học: " Number of active transcription factor binding sites is essential for the Hes7 oscillator" pptx
... site for Hes7 dimers On the other hand, Bessho et al [4] showed that Hes7 has one N box and two E boxes as regulatory elements in the promoter region By transcription analysis they demonstrated that ... Kageyama for informative discussion S Z and H T were supported by the BFAM project (Bioinformatics for the Functional Analysis of Mammalian Genomes) of the German BMBF yours — you keep the copyright ... describes the negative feedback of Hes7 protein on Hes7 mRNA synthesis The entries k and a are the basal transcription rate in the absence of inhibitory proteins, and the rate constant of translation,...
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A study on the techniques for the improvement to the teaching of oral skills in light of communicative english language teaching for junior high school teachers in quang ngai province part 1
... students to listen for details in the text Some of the information has already been filled in to guide their listening Students listen and fill in the rest in note form Example: Listen to the weather ... There aren’t any rivers, but there is a big lake 3.1.3.4 Interview The teacher asks students to ask and answer about a certain topic in pairs One student is the interviewer and the other is the ... the students to listen and then start the cassette While-listening: This stage is to help the students understand the text/dialogue The teacher should not expect them to understand every word...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25