... each individualcow, indicating that decisions can differ both within andbetween herds.At the farm level, the veterinarians seemed to integratefarm-related information into the decision as to ... generating score data and decision mak-ing inrelationto treatment of metritis and their motiva-tion to produce data. This information was condensedinto a 'model of understanding' ... effect inrelationto production parametersControl of clinical effectHerd statusFarmer's influenceInfluence of strategy in veterinary practiceIdeologyLegislationActa Veterinaria Scandinavica...
... then bind to these adaptors to initiate mul-tiple signalling pathways, including mitogen-activatedprotein kinase, phosphatidylinositol 3-kinase ⁄ AKT andthe signal transducer and activator of ... classified into threegroups (a) ligands that specifically bind to EGFR(including EGF, transforming growth factor-a, amphi-regulin and epigen); (b) those that bind to EGFR andERBB4 (including betacellulin, ... AllERBB proteins have four functional domains: anextracellular ligand-binding domain; a transmembranedomain; an intracellular tyrosine kinase domain; and aC-terminal regulatory domain [2]. The...
... compete with ATP for binding to the tyrosine kinase pocket of the receptor, therebyinhibiting receptor tyrosine kinase activity and EGFRsignaling pathways (Fig. 1). Early clinical studiesshowed ... (2006) Lung adenocarcinomasinduced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibi-tor or to down-regulation of the receptors. Genes Dev20, 1496–1510.25 ... cancer cells undergoing apoptosis.Moreover, EGFR mutations result in repositioning ofcritical residues surrounding the ATP-binding cleft ofthe tyrosine kinase domain of the receptor and therebystabilize...
... erlotinib ineffective inhibitors of EGFRkinase activity, blocks gefitinb-induced up-regulationof Bim and apoptosis [38]. These experiments point to an important role for the induction of Bim in gefitinib-triggered ... are needed to understandthe precise mechanism by which gefitinib inducesapoptosis in a Bax-dependent manner.Inhibitor of apoptosis protein familyInduction of MOMP following apoptotic stimuliresults ... consists of p15INK4b,p16INK4a, p18INK4cand p19INK4d.AG1478, which, like gefitinib and erlotinib, acts as aspecific inhibitor of the EGFR tyrosine kinase, hasbeen shown to result in a dose-dependent...
... Nussinov, R. (2000) Factors enhancingprotein thermostability. Protein Eng. 13, 179–191.39. Turunen, O., Vuorio, M., Fenel, F. & Leisola, M. (2002)Engineering of multiple arginines into ... Ôsticky patchesÕon the protein surface that may lead to protein aggregation[16]. In addition, introduction of a single tyrosine intothe N-terminal region has been reported to improve thethermostability ... in bleaching of pulp to reduce the use of toxic chlorine-containing chemicals [1] or to improve the quality of animalfeed [2]. In addition, there are applications in the food andbeverage industry...
... and in charcoal-making. To compare the performance of rubber trees in a marginal area in terms ofwood production potential, it was essential to pay attention mainly to the productivity ofindustrially ... does not seem interesting, from an economical point of view, to delay theopening age for tapping and accept a reduction in latex production in order to improve rubberwood production. In the present ... integratedtimber trees to traditional monoculture plantations in terms of income in both smallholdingsand large estates. For the smallholdings, projected income from integrated timber speciesseemed...
... Motor Vehicle Electrical and Electronic Equip. Plastics Processing Machine Operators 3336360 9422 Motor Vehicle Seating and Interior Trim Mfr Plastics Processing Machine Operators 3Minor sectors: ... to canningprocesses involving lead (historically) and coatingemissions. Can ning processing has been found to sig-nificantly reduce levels of residual pesticide [59]through washing, boiling, ... Motor Vehicle Plastics Parts Manufacturing Sewing Machine Operators 3326193 9482 Motor Vehicle Plastics Parts Manufacturing Motor Vehicle Assemblers, Inspectors and Testers 3326193 9495 Motor...
... dietary intakefor Cd was estimated at about 23 mg Cd dayy1 in Ž.France Table 1 ; in comparison, the increase in Cd in cereals and potato tubers alone may lead to anincrease in the range of 41% to ... concentra-tion in wheat grain were generally too inconsistent to allow conclusions to be drawn. However, higher CdŽ.concentrations were found in wheat grain ) 30%grown was found in a continuous wheat ... changes in soil pH are not easy to investigatebecause of soil variability. The significance ofchanges in Cd concentration in edible plant parts,and especially in cereal grain inrelationto nitrogenfertilization,...
... pair bound to L1 and L2.Turning a gene into an active state from a state ofinactivation often involves binding of a single activatormolecule to its site in a repressive chromatin structure[37]. ... denoting anincrease in the linking number of the DNA. As chloro-quin introduces positive supercoils into the DNA, thisshift confirms that with increasing salt concentration,there is a change in ... thenucleosome-spacing effects on the bulk chromatin.The distance between protein-binding sitesdecides nucleosome positioningPositioning of five nucleosomes in a single register as aresult of the binding...
... being either sought out or roped into peculiarcircumstances is a common one in heroic tales; frequently, the would-be hero is swept up intosomething that he initially appears to have nothing ... Neo is told that he'sright to think that the world is not what it seems. However, something always happens to convincethe hero to change his mind. In The Matrix, Neo goes back to work ... finds himself edgingaround a window ledge at the direction of a mysterious voice on a cell phone. Unable to take therisk of plunging to his death, he instead allows himself to be taken into...
... associations inrelationto transgressionandregressionphaseandtectonicmovements: fluvial and marine terraces in mainland and in continental shelf that aredistributed in different ... hofaciesassociationofsandybarriersandlagoonalfaciesisthemainfeature in CentralcoastalplainfromQuang Binh Province to Mui Ne‐Phan Thiet,BinhThuanProvince.The secondsedimentary cycle from Middle‐ Late Pleistocene ... Middle‐LatePleistocenearedominatedbyinnerbarriers.TheTranNghietal./VNUJournalofScience,EarthSciences23(2007)235‐243241Fig.9.Lateritegravel in bottomsediment in SWEasternSea.Fig.10.Foraminifera,diatomea,quaczitefragmentsandfragmentsofdaciterock in bottomsediments in SWofEasternSea.Fig.11.Weatheringspottedclay in LatePleistocenesediment in SWofEasternSea.6.Quaternaryshorelines in bottomofcontin...
... place after binding to proteins such aslipopolysaccharide-binding protein (LBP) and CD14[8,9], which finally transport the compounds to integralmembrane proteins such as Toll-like receptor 4(TLR4) ... ngÆmL)1macrophagecolony-stimulating factor (M-CSF)14 in RPMI 1640 medium(endotoxin < 0.01 endotoxin units (EU)ÆmL)1 in Limulustest; Biochrom, Berlin, Germany) containing 2 mml-gluta-mine, 100 UÆmL)1penicillin, and ... the culture plates for 10 min at 400 g and stored at )20 °C until deter-mination of cytokine content (see above).Determination of endotoxin activity by thechromogenic Limulus testEndotoxin...
... predicted to be larger in the mating season than in the post-mating season (Sandell 1989). However, few studies haveanalysed seasonal variation in range size inrelation to mating behaviour.How mating ... notlarge enough to explain the increase (74–177%) in range size from the mating to the post-mating season in females with cubs. Although range size of individualbears is probably in uenced by food ... selected infanticide seem to in uence range size in females, selecting for large mat-ing season ranges and multiple mating in oestrousfemales to hide paternity and for restricted mating sea-son...