assessment of qtc interval prolongation in a phase i study using monte carlo simulation
báo cáo sinh học:" Knowledge and communication needs assessment of community health workers in a developing country: a qualitative study" docx
... educating people to reduce health risks in their lives [3] Highly challenging and innovative ideas such as serving 70% of a population of 190 million in Brazil, skin-to-skin care for newborns in ... communication capability of the LHW; adequacy of their knowledge; effectiveness of the imagebuilding activities involving mass media; and mechanisms for continued education Methods The Ministry of ... SES face more difficulty Response Talking about child & family's future, using religion, using local leaders By talking about child's future, using religious teachings, using help of influentials...
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Báo cáo y học: "Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase" potx
... 011, and of of case, course plasma uricase activity, in IgG elimination' subjects 002, Time and 013 appearance of IgM and 'earlyantibodies against PEG-uricase, and of plasma uricase activity, in ... of antibodies against uricase, which is a foreign protein in humans Antibodies against PEG have been generated in rabbits and mice immunized with PEGylated proteins, including uricase from Candida ... antibodies against ADA protein [26,27] Antibodies against L-asparaginase, and against interferons α- 2a and α-2b, have been observed in a relatively small percentage of patients treated with their...
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Báo cáo khoa học: " Combination of celecoxib with percutaneous radiotherapy in patients with localised prostate cancer – a phase I study" ppt
... proportion of grade toxicities (gastrointestinal and genitourinary) This finding may simply reflect a certain lack of precision for the definition of grade effects using the RTOG criteria, allowing ... application of celecoxib in patients was associated with some partial PSA responses [62] Likewise in patients with biochemical relapse after definitive therapy a significant inhibition of serum PSA ... testing is required for efficacy testing IGF-R Insulin-like growth factor receptor mg Milligram MRI Magnetic resonance imaging Abbreviations AP Alkaline phosphatase NSAID Non steroidal anti-inflammatory...
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Báo cáo sinh học: "Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation–a phase I study (MISOT-I)" doc
... clinical investigations in addition to standard pre-transplant work-up Standardof-care examinations for patients on the Liver Transplant Waiting List will be performed, including baseline clinical ... disease models or in phase I and II clinical studies in humans Thus, we believe that the potential benefit of administering MAPCs to patients after allogeneic liver transplantation is significant ... immunosuppression can achieve good survival of patients and liver grafts [1,2,12] This success of interdisciplinary transplant medicine has made liver transplantation a standard -of- care clinical therapy...
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báo cáo hóa học:" Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation–a phase I study (MISOT-I)" pptx
... clinical investigations in addition to standard pre-transplant work-up Standardof-care examinations for patients on the Liver Transplant Waiting List will be performed, including baseline clinical ... disease models or in phase I and II clinical studies in humans Thus, we believe that the potential benefit of administering MAPCs to patients after allogeneic liver transplantation is significant ... immunosuppression can achieve good survival of patients and liver grafts [1,2,12] This success of interdisciplinary transplant medicine has made liver transplantation a standard -of- care clinical therapy...
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báo cáo khoa học: "The management of advanced oral cancer in a Jehovah''''s Witness using the Ultracision Harmonic Scalpel" docx
... premedicated with a statim dose of gram tranexamic acid and anaestethseia was induced with a combination of propofol (120mg), fentanyl (100mcg) and vecuronium (8mg) Anaesthesia was maintained using ... use of aprotinin and tranxemic acid have also been employed to reduce intraoperative bleeding[12] Previous surgery in JW have used aprotinin, a bovine derived inhibitor of trypsin and plasmin ... We decided against the use of EPO in this case The use of recombinant clotting factors and DDAVP was also thought inappropriate in a patient with a physiologically normal clotting profile With...
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Health related quality of life among the elderly: a population-based study using SF-36 survey pdf
... translated and validated by Ciconelli et al 11 in a study involving individuals with rheumatoid arthritis It was considered suitable for administration under the socioeconomic and cultural conditions of ... worst mean scores in the general health, role-emotional and vitality domains In a sample of 3,802 individuals aged 15 years or more, Wyss et al 13 observed in Tanzania, in individuals aged 65 and ... Multi-Center Intervention Study on Suicide Behavior (SUPRE-MISS) in Brazil 30,31 found associations between religious affiliation and suicidal behavior as well as between religious affiliation and...
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A meta analysis and risk assessment of heavy metal uptake in common garden vegestable
... complexing ligands, and the concentration of the metal in the soil As pH increases, there is an increase in negatively charged binding sites on soil particles, which facilitates the adsorption of zinc ... for articles pertaining to heavy metal contamination of soils and uptake by plants with no limitation on publication date Certain criteria have been set for inclusion into this study Each study ... organic arsenic are monomethyl arsonic acid (MMA) and dimethyl arsinic acid (DMA) MMA and DMA are primarily used as agricultural pesticides Data about the toxicity of organic forms of arsenic are limited;...
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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... glyoxalase pathway in Leishmania infantum Table Glyoxalase I kinetic parameters in Leishmania infantum and other cells Initial rate analysis Glx I Substrate Km (mM) Leishmania infantum GSH T(SH)2 GSH ... methylglyoxal input (A) , initial trypanothione concentration and glyoxalase I activity (B), glyoxalase II activity and glyoxalase I activity (C), methylglyoxal input and glyoxalase I activity (D) ... for glyoxalase I and II were determined using two different approaches, initial rate analysis and time course analysis Initial rate data were tted to irreversible single substrate MichaelisMenten...
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Báo cáo sinh học: "Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety" ppt
... Sakiyama O, Takahashi K, Miyazaki H, Hashimoto S, Daikukhara Y: Purification and partial characterization of hepatocyte growth factor from plasma of patients with fulminant hepatic failure J Clin Invest ... renal toxicity induced by repeated rh-HGF dosing, including an increase in urinary excretion of albumin, were potential adverse events in a human study In the phase I/ II study of patients Table ... (day 14) and the observation period (day 28) to evaluate renal involvement, including serum creatinine and histological findings A phase I/ II clinical trial for patients with acute liver failure...
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Báo cáo khoa học: "A phase I radiation dose-escalation study to determine the maximal dose of radiotherapy in combination with weekly gemcitabine in patients with locally advanced pancreatic adenocarcinoma" doc
... indication of anti-tumour activity [13,15,16] In a phase I study by McGinn et al to find the MTD of gemcitabine in association with RT to 50.4 Gy in 1.8 Gy daily fractions in patients with locally ... participated in the patient evaluation DB participated in the patient evaluation DVB participated in the patient evaluation LG participated in the study design and patient follow up during RT CV participated ... radiosensitization Semin Oncol 1997, 24:S7 Mason KA, Milas L, Hunter NR, Elshaikh M, Buchmiller L, Kishi K, et al.: Maximizing therapeutic gain with gemcitabine and fractionated radiation Int J Radiat...
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Báo cáo y học: "Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure" potx
... sampling analysis after this point would lead to an insignificant gain in the estimate of Available online http://arthritis-research.com/content/9/5/R101 Figure Evaluation of the minimum area ... cellular infiltration within the synovium Macrophage infiltration is currently regarded as the main histopathological marker of activity and severity in RA [6,28,29] In addition, despite the rapidly ... biopsies Qualitative histological examination of H & E-stained specimens showed that good quality synovial tissue was available in all cases of US-guided biopsy A representative synovial sample...
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Báo cáo y học: "Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus" potx
... and was safely administered to patients with SLE These findings supported the initiation of phase II studies investigating the safety and clinical activity of belimumab in patients with SLE and ... history of drug-induced urticaria during the administration of a 20 mg/kg single dose The infusion was discontinued approximately 40 minutes after initiation, and the urticaria and chest pain resolved ... concentrations declined in a bi-exponential manner, with a mean distribution phase half-life of 1.0 to 2.2 days and a mean terminal elimination half-life of 8.5 to 14.1 days (Table and Figure 1) Belimumab...
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Báo cáo y học: "Parents'''' assessment of parent-child interaction interventions – a longitudinal study in 101 families" docx
... Interview Schedule for Social Interaction;(AVAT) Availability of attachment; (ADAT) Adequacy of attachment; (AVSI) Availability of social integration; (ADSI) Adequacy of social integration High ... attachment and social interaction and is divided into four subscales The maximum obtainable scores are: for Availability of Social Integration (AVSI) points, Adequacy of Social Integration (ADSI) ... home Information missing Initiating contact (≥ per case; 124 contact initiators in 101 families) Social services Parents Adult psychiatry Child health service Paediatric clinic Preschool Child...
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Báo cáo y học: "Release of extraction-resistant mRNA in stationary phase Saccharomyces cerevisiae produces a massive increase in transcript abundance in response to stress" ppt
... evaluated using a Bioanalyzer 2100 (Agilent) Array printing and slide treatment UltraGAPS slides (Corning, Corning, NY, USA) were printed using an OmniGrid 100 Arrayer (GeneMachines, San Carlos, ... to a final oligonucleotide concentration of 40 µM, and used to print the slides During printing, the relative humidity was maintained between 50% and 52% and the ambient temperature was maintained ... experimental information to be analyzed in relationship to the same reference, allowing better normalization [51] For within-slide normalization, 10 ng of Arabidopsis thaliana CAB mRNA (Stratagene) was added...
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Báo cáo y học: "Utility of routine chest radiographs in a medical–surgical intensive care unit: a quality assurance survey"
... Post-partum complications 10 Cardiovascular (congestive heart failure, cardiac arrest) Gastrointestinal complications* Other Sepsis Cardiovascular Gastrointestinal Gastrointestinal bleeding Liver ... elimination of routine chest radiographs in a pediatric intensive care unit Crit Care Med 1999, 27:1588-1593 Hall JB, White SR, Karrison T: Efficacy of daily routine chest radiographs in intubated, ... determination of ETT or PA catheter position [9] In contrast, Gladwin et al found that the sensitivity of a clinical decision protocol for detecting complications and malpositions of IJ catheter insertion...
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Báo cáo y học: "Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma"
... head and neck cancer in vivo Anticancer Res 2006; 26: 989-94 Yamashita H, Nakagawa K, Tago M, et al Radiation therapy combined with cis-diammine-glycolatoplatinum (nedaplatin) and 5-fluorouracil ... 5-FU/CDDP-based CRT is associated with acute toxicities, predominantly leucopenia, stomatitis, and cheilitis [5-9,18] Toxicity was evaluated using criteria defined by the Japan Clinical Oncology ... characteristics of 56 ESCC patients are summarized in Table The ratio of T1/T2/T3/T4 was 17/6/21/12, that of N0/N1 was 23/33, and that of M0/M 1a was 45/11, resulting in a stage I/ II/III/IVa ratio...
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Quantification of Microcystin-degrading Bacteria in a Biofilm from a Practical Biological Treatment Facility by Real-time PCR
... microcystin-degrading bacteria in a biofilm from a practical biological treatment facility by real-time PCR using the newly designed primer set and a TaqMan probe The specificity of new primers was investigated ... cultivation Table shows the strains examined in this study MD-1 strain was isolated from Lake Kasumigaura in Japan (Saito et al., 200 3a) MD-1 strain can degrade the microcystin analogs, microcystin-RR, ... quantification of microcystin-degrading bacteria, including bacteria without mlrA gene are required Moreover, an increase in the cell number of microcystin-degrading bacteria was observed in the...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25