allogenic mesenchymal stem cells in experimental ischaemic stroke translation to the clinic
Báo cáo khoa học: "Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs" pot
... GBCU dna CSM-BCU eht naht serocs yblO rewol yltnacifingis dah G puorg ,revewoH skeew ta spuorg rehto eht morf ecnereffid tnacifingis yna wohs ton did G puorG spuorg PC dna NC eht neewteb dna spuorg ... eht deretsinimda eW yduts siht ni stnega cixototyc yna ot desopxe ton saw puorg GBCU ehT ]63[ sllec mets ot egamad tcerid gnidulcni sllec mets no stceffe esrevda evah yam ,stnega cixototyc fo ... laitnetop cinegnesem H miK ,H naH ,C nhA ,HI gnaY ,WS miK ,HS gnawH ,AJ gnoeJ ,HS gnoH ,JE gnaG 081-171 ,41 ,5002 cotorP seR niarB seR niarB ymotcenimal morf eerf ledom yrujni droc lanips eninac...
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Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
... sites from proinflammatory to anti-inflammatory [55-57] In a murine pulmonary fibrosis model, MSCs inhibited bleomycin-induced inflammation and fibrosis within the lungs This was shown to be due ... used in vivo for enhancing the engraftment of other tissues (for example, hematopoietic stem cells) MSCs can support hematopoiesis through the secretion of cytokines and have the capacity to maintain ... Growth factors that have regulatory effects on MSCs include members of the transforming growth factor-beta (TGF-β) superfamily, the insulin-like growth factors, the fibroblast growth factors, the platelet-derived...
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báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... transplantation into rats, confirming that these cells were seeded into the liver tissue by BMDC and can modify cell phenotype mimicking the one of resident cells in the host tissue Insults trigger the release ... Hematopoietic Cells as Hepatocyte Stem Cells: A Critical Review of the Evidence Hepatology 2006, 43:2-8 49 Jang YY, Collector MI, Baylin SB, et al: Hematopoietic stem cells convert into liver cells ... increase in the cytoplasmic concentrations of b-catenin results in its translocation from the cytoplasm to the nucleus Once in the nucleus, b-catenin acts as a co-activator to stimulate the transcription...
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Báo cáo y học: " Mesenchymal stem cells in autoimmune diseases: hype or hope" ppt
... fresh encouragement to the endeavors to elucidate the immunomodulatory effects of MSCs in rheumatic diseases [1] Given the apparent difficulties in recapitulating the in vitro effects in vivo, however, ... MSC, the first studies in human autoimmune disease are already appearing [10,11] Not unexpectedly, however, the clinical effects are not coherent Concluding remarks The mechanisms underlying the ... of MSCs to modulate immune responses therefore probably depends, in part, on the composition of the starting population Despite our incomplete understanding of the mechanisms underlying these divergent...
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Báo cáo y học: " Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment" pdf
... this inflammatory and catabolic cascade and demonstrated that curcumin (6) has the capacity to block the action of pro-inflammatory cytokines in the joint thus disrupting the inflammatory cycle inhibit ... (1) lead to the production and accumulation of high levels of pro-inflammatory cytokines (2) in the joint These trigger the production of additional pro-inflammatory cytokines which induce genes ... curcumin inhibits IL-1β induced apoptotic and inflammatory signalling pathways, promoting co-culture induced chondrogenesis Curcumin suppresses IL-1β-induced apoptotic and inflammatory responses in...
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Báo cáo y học: "Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis" pps
... performed using the corresponding inhibitors They included 1-MT (1 mM), an inhibitor of IDO enzymatic activity, INDO (5 μM), an inhibitor of PGE2 synthesis, L-NAME (1 mM), a specific inhibitor of ... proinflammatory cytokine IL-6 Interestingly, the UC-MSCs could downregulate the IL-6 production in the transwell but not the cell -to- cell contact system (Figure 3c) both in single time point and in dynamic ... cells in vivo [38] The upregulation of IL-10 is in line with the induction of Tregs in vitro and in vivo in our study Moreover, in our experiments we did not find UC-MSCs in the joint of the CIA...
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Applying macromolecular crowding to promote the expansion and adipogenic differentiation of human mesenchymal stem cells in vitro; an effect of matrix reciprocity
... 2001;Function and interactions of integrins Cell Tissue Res (3):285-298 41 Mould AP, Askari JA, Aota SI, et al 1997;Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory ... bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts J Bone Miner Res (12):1943-1956 64 Akino K, Mineta T, Fukui ... expansion Cytotherapy 75 Du F, Zhou Z, Mo ZY, et al 2006;Mixed macromolecular crowding accelerates the refolding of rabbit muscle creatine kinase: implications for protein folding in physiological...
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Báo cáo y học: "Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study" pptx
... H.O., and T.N.) independently made a diagnosis using the μm sections stained with haematoxylin and 2 Immunohistochemical Staining The neuroendocrine nature of tumors was confirmed with the three representative ... those in SCLC in the region (y>3.84, z>3.84) on the y-z plane and those in LCC in the region (x>3.84, y>3.84) Nomura et al Journal of Clinical Bioinformatics 2011, 1:23 http://www.jclinbioinformatics.com/content/1/1/23 ... search settings used, we identified significant proteins as follows: LCNEC contained a total of 1,124 proteins including 410 unique, 168 in the overlap only between LCNEC and SCLC, 93 in the overlap...
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Báo cáo sinh học: " Effects of transplantation with bone marrowderived mesenchymal stem cells modified by Survivin on experimental stroke in rats" potx
... infarction in each brain slice was measured using Image J analysis software (version 1.6 NIH) The infarct volume was indirectly determined by subtracting the volume of intact tissue in the ipsilateral ... many inflammation cytokines and chemokines were released into peripheral blood including vascular cell adhesion molecule 1, p-selectin, CXCR4 and SDF-1, which promote the adhesion of MSCs to the ... the endothelium or induce the migration of MSCs to the ischemic tissue in the brain [20-22] However, in previous studies, it has been demonstrated that the transplanted cells may be detained by...
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o cáo hóa học:" Effects of transplantation with bone marrowderived mesenchymal stem cells modified by Survivin on experimental stroke in rats" docx
... infarction in each brain slice was measured using Image J analysis software (version 1.6 NIH) The infarct volume was indirectly determined by subtracting the volume of intact tissue in the ipsilateral ... many inflammation cytokines and chemokines were released into peripheral blood including vascular cell adhesion molecule 1, p-selectin, CXCR4 and SDF-1, which promote the adhesion of MSCs to the ... the endothelium or induce the migration of MSCs to the ischemic tissue in the brain [20-22] However, in previous studies, it has been demonstrated that the transplanted cells may be detained by...
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Báo cáo khoa học: A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells doc
... growth factor combination [HGF and fibroblast growth factors and (FGF1 and FGF4)] to induce mouse ES cells to develop into functional hepatocytes These factors, named HIFC (hepatic induction factor ... compared with the expression level in human hepatocytes (reference sample) Mesenchymal- to- epithelial transition in AT-MSC-Hepa Although AT-MSCs indeed differentiate into hepatocyte-like cells in vitro, ... apolipoprotein A-I apolipoprotein A-II apolipoprotein B apolipoprotein C-I apolipoprotein C-II apolipoprotein D apolipoprotein E apolipoprotein F apolipoprotein H fatty acid binding protein 1, liver...
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báo cáo hóa học:" Human fallopian tube: a new source of multipotent adult mesenchymal stem cells discarded in surgical procedures" potx
... share the same embryologic origin as the uterus They have the capacity to undergo dynamic endocrine-induced changes during the menstrual cycle, including cell growth and regeneration, in order to ... cells induced for myogenic differentiation 1A) Dystrophin expression in muscle control and in the induced hFTs cells 1B) Skeletal myosin expression in muscle control and in the induced hFTs cells ... 200) Discussion The possibility of using stem cells for regenerative medicine has opened a new field of investigation to find the best sources for obtaining multipotent stem cells, in particular...
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Báo cáo hóa học: " Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats" pptx
... transplanted cells into the host tissue [3] Interestingly, while stem cell therapy, including bone marrow-derived mesenchymal stem cells [15-17], embryonic stem cells [14] and endothelial progenitor cells ... extensively investigated in the treatment of stroke in experimental studies and, to a lesser extent, in humankind, the use of adipose-derived mesenchymal stem cells (ADMSCs) for the treatment of stroke ... tested the hypothesis that ADMSC therapy is safe and effective in limiting the size of brain infarct and improving neurological function in a rat model of acute IS We further investigated whether intravenous...
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Báo cáo hóa học: "Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy" doc
... embryonic stems cells and bone marrow-derived mesenchymal stem cells, adiposederived mesenchymal stem cells (ADMSCs) have the distinct advantages of being abundant, easy to obtain with minimal invasiveness, ... preservation of heart function in DCM rats Accordingly, our finding strengthens the finding of previous study [20] Another important finding in the current study is that combined therapy with ADMSCs and ... Stress To determine whether inflammatory cells were up-regulated in LV myocardium on day 90 following DCM induction, immunohistochemical staining for detection of CD40-positively stained cells...
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Báo cáo sinh học: "Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model" potx
... lung injury through up-regulation of Page 10 of 13 anti-inflammatory cytokine IL-10 [25] Accordingly, in addition to reinforcing the findings of previous studies [17,25,28,32], the results of the ... (Figure 1A) On the other hand, RVSBP was notably lower in groups and than in group 2, and remarkably higher in group than in group (Figure 1B) These findings indicate that IR injury in the experimental ... staining identified substantially higher number of infiltrated CD68+ cells (inflammatory cells of macrophages) in injured lung parenchyma in IR group than in normal control Our findings, therefore,...
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Báo cáo khoa học: "In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood" ppt
... lacipyt a si hcihw ,ygolohprom ladiobuc wohs ton did sCSM BCU eht ,sCSM worram enob ekilnu ,revewoH )4 giF( )gniniats assoK-noV yb deifitnedi( laitnetop cinegoetso evah sCSM taht gnitseggus ,etitapayxordyh ... ,etahpsohp lorecylg -β fo detsisnoc taht muidem noitcudni cinegoetso na desu ew ,sCSM eht morf noitaitnereffid cinegoetso ecudni oT laitnetop cinegoetso tibihxe sCSM doolb droC )A2 giF( nitnemiv dna ... morf ,doolb droc aiv ,gnilevart era srotinegorp lamyhcnesem dna citeiopotameh htob taht dezisehtopyh eb nac ti esuaceb lanoitar si doolb droc ni sllec rotinegorp lamyhcnesem fo ecneserp ehT ]12,5[...
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Báo cáo khoa học: "Enhanced tyrosine hydroxylase expression in PC12 cells co-cultured with feline mesenchymal stem cells" pps
... antibodies were then added to the resuspended cells for 30 at 4°C in the dark Positive cells were then detected on flow cytometers Immunocytochemistry of MSCs and TH expression in PC12 cells To identify ... co-culture of PC12 cells and MSCs In the MSCs alone, the cells showed an elongated fibroblast shape (Fig 3A) In the PC12 cells alone, the cells showed modest growth and tended to grow in small clusters ... cell group, and the combined MSC + PC12 cell group The 5 cells were seeded at 1.5 × 10 cells of each cell type (3 × 10 total in the combined group) onto 60 mm dishes and grown in DMEM supplemented...
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Báo cáo khoa học: "Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs" ppsx
... attributable to the introduced canine UCB-MSCs or to an endochondral sequence, the injected canine UCB-MSCs injected might play a role in osteoconduction in the graft site The results of the present ... progresses toward the center of the graft Remodeling of the graft takes months to years, depending on the length, and might never be complete [24] In the present clinical case, bone lysis and instability ... osteoprogenitor cells, bone remodeling and graft resorption that occur together with host bone ingrowth into and onto the porous coralline microstructure or voids left behind during resorption...
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Báo cáo khoa học: "Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury" potx
... during in vitro culture [4] These findings suggested the presence of mesenchymal stem cell-like cells according to the standard criteria for MSCs from the International Society for Cellular Therapy ... cells For group V, the injured site was exposed by dorsal laminectomy and 150 μL of PBS was injected into the spinal cord at locations to depths of mm using a 30 gauge needle (middle of the injury ... effective in canine SCI model, there was little histological evidence of spinal cord tissue regeneration [22] In this study, we examined whether canine ASCs could survive and integrate into neural cells...
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