a randomized double blind placebo controlled phase ii pilot trial
Báo cáo y học: "First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled comparison with celecoxib [NCT00267215]" doc
... pharmacokinetic profile, such that lumiracoxib has a rapid plasma uptake (Tmax hours) and a short mean plasma half-life of approximately hours [16] The pharmacokinetics of lumiracoxib are characterized ... using analysis of covariance (ANCOVA) The statistical fixed-effects model considered treatment and centre as main effects, whereas baseline actual pain was used as a covariate Data from small centres ... screening/ baseline and study end Statistical analysis The primary efficacy variable was the APID between the baseline pain assessment and the mean of the 3-hour and 5-hour actual pain assessments after...
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Báo cáo khoa hoc:" Effectiveness of low-dose doxycycline (LDD) on clinical symptoms of Sjögren''''s Syndrome: a randomized, double-blind, placebo controlled cross-over study" potx
... of the randomized, controlled trial of remicade in primary Sjögren's Syndrome Arthritis Rheum 2004, 50:1270-1276 Azuma M, Aota K, Tamatani T, Motegi K, Yamashita T, Harada K, Hayashi Y, Sato M: ... participate and 22 patients chose to enter the study All the patients were women This was a randomized, double blind, placebo- controlled clinical trial, and the patients were randomized at the baseline ... clinical symptoms of SS in a randomized, double- blinded, placebo- controlled clinical cross-over trial Figure ment Stimulated saliva pH and salivary flow rate during the experiStimulated saliva pH and...
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Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot
... with a reduction of extracellular GABA levels in the amygdala indicative of a reduced GABA release and/or increased GABA uptake from the extracellular space Clinical studies with topiramate suggest ... literature, and 30% of placebo response Statistical Analysis All data will be analyzed by SPSS (version 13.0) The frequencies of nominal variables from all patients will be calculated The data analysis ... show that AMPA antagonists attenuate acoustic startle response when administered into the amygdala For instance, Khan and Liberzon [20] demonstrated that topiramate reduced significantly the acoustic...
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Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc
... nasal cavity, while placebo treatment has no influence on viral replication at all The basis for the statistical analysis and the ct-values are shown in Additional file 2: Table S2 Nasal lavages ... this article as: Eccles et al.: Efficacy and safety of an antiviral IotaCarrageenan nasal spray: a randomized, double- blind, placebocontrolled exploratory study in volunteers with early symptoms ... resolved, no special actions were necessary The small number of AE reports supports in particular the good safety-profile of Iota-Carrageenan as an active agent and Iota-Carrageenan nasal spray components...
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Báo cáo khoa học: "Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia" doc
... investigate the effect of blinding and placebo in a controlled clinical trial of pain treatment in CHD Materials and methods Animals A total of 80 dogs recruited from all parts of Norway, with pain and ... scand vol 46 no 1-2, 2005 animal is receiving a new treatment In contrast, owners that know their animal is on a standard treatment may react unfavorably if they are made aware that other patients ... assigned to one of six different strata Within each strata, dogs were randomly assigned a gold bead implantation or placebo in accordance with a sealed pre-randomization list Another veterinarian...
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Báo cáo khoa học: "Dexamethasone to prevent postextubation airway obstruction in adults: a prospective, randomized, double-blind, placebo-controlled study" ppt
... 13–15 aData are presented as mean ± standard deviation; Physiologic and Chronic Health Evaluation II bdata are presented as number of patients (percentage of patients) APACHE II, Acute dexamethasone ... every two hours and as needed to maintain a patent airway All patients were older than 18 years of age and met all of the following weaning criteria: (a) temperature of less than or equal to 38°C ... this randomized clinical trial to evaluate the effects of prophylactic dexamethasone therapy in preventing laryngeal edema for adult patients with a CLV of less than 110 ml in an adult medical...
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Báo cáo y học: "A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia" pps
... in these analyses First, the data on the eight domains of CANTAB were assessed by repeated two-way analysis of variance (ANOVA) Next, the data of CANTAB in each group were assessed by paired Student ... Tsuyoshi Sasaki (Chiba University), Daiji Sakurai (Kisarazu Hospital), Hiroshi Yamanaka and Makoto Asano (Chiba Psychiatric Medical Center) for recruiting the patients The authors thank Professor ... milnacipran and trazodone in the placebo group One patient had taken valproic acid, and another patient had taken carbamazepine in the tropisetron group None of the patients had taken tricyclic antidepressants...
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Báo cáo y học: " Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: protocol for a randomised, double-blind, placebo controlled trial" ppt
... interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial JAMA 2007, ... baseline dataset will be available for analysis Refer to Table for a list of all outcomes to be assessed Other Outcomes The investigators, analysts, trial manager and all participants will be blinded ... relaxation and physical activity; and HealthWatch, an online active control program The trial consists of a 12-week intervention treatment phase with a 40-week follow-up phase The total trial...
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Báo cáo y học: "Phytalgic®, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial" potx
... manifestations of OA: unilateral or bilateral osteoarthritis of the knee and/or hip, which is an advantage and a drawback: an advantage because it can be seen as a real-life population, increasing ... relevant authorities Statistical analysis All analyses were done in intention to treat (ITT), using all available data at each time point and baseline observation carried forward (BOCF) approach for ... function Materials and methods Study design and participants This was a double- blind, randomized, placebo- controlled, parallel-arms clinical trial It was approved by the Regional Bordeaux B Committee...
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Báo cáo y học: "The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study" pot
... female Diagnosis medical:3 surgical APACHE II (admission) Mean 18 APACHE II (study) Mean 17 Days in intensive care unit Mean days Serum creatinine (μmol/l) Mean 73 μmol Plasma albumin(g/l) Mean ... Adelaide/Royal Adelaide Hospital Co-funded Dawes Scholarship This study was supported by a research grant from the Australian New Zealand Collage of Anaesthetists The authors are grateful for the assistance ... Medical Solution Diagnostics, Berkeley, California, USA) concentrations were measured by radioimmunoassay, with a CV of 9.2% and 12%, respectively Statistical analysis Data are presented as mean...
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Long-Term Safety and Impact on Infection Rates of Postnatal Probiotic and Prebiotic (Synbiotic) Treatment: Randomized, Double-Blind Placebo-Controlled
... (Synbiotic) Treatment: Randomized, Double- Blind, Placebo- Controlled Trial Kaarina Kukkonen, Erkki Savilahti, Tari Haahtela, Kaisu Juntunen-Backman, Riitta Korpela, Tuija Poussa, Tuula Tuure and Mikael Kuitunen ... Erkki Savilahti, MD, PhDb, Tari Haahtela, MD, PhDa, Kaisu Juntunen-Backman, MD, PhDa, Riitta Korpela, PhDc, Tuija Poussa, MScd, Tuula Tuure, PhDe, Mikael Kuitunen, MD, PhDa aDepartment of Pediatrics, ... ARTICLE Long-Term Safety and Impact on Infection Rates of Postnatal Probiotic and Prebiotic (Synbiotic) Treatment: Randomized, Double- Blind, Placebo- Controlled Trial Kaarina Kukkonen, MDa,...
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Báo cáo y học: " Effects of carbohydrates-BCAAs-caffeine ingestion on performance and neuromuscular function during a 2-h treadmill run: a randomized, double-blind, cross-over placebo-controlled study." ppsx
... their plasma concentration decreases Decreased plasma BCAAs levels may lead to an increased plasma free tryptophan/BCAAs ratio, thus favoring the transport of tryptophan into the brain and consequently ... of fatigue Because BCAAs are transported into the brain by the same carrier system as tryptophan, increasing BCAAs plasma concentration may decrease the uptake of tryptophan in the brain, and ... also carried out the statistical analysis of theses specific variables For other measures of fatigue, SLP was responsible for the statistical analysis All authors have read and approved the final...
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Báo cáo y học: " Evaluation of Lumbar Facet Joint Nerve Blocks in Managing Chronic Low Back Pain: A Randomized, Double-Blind, Controlled Trial with a 2-Year Follow-U"
... Manchukonda R, et al Evaluation of lumbar facet joint nerve blocks in the management of chronic low back pain: A preliminary report of a randomized, double- blind controlled trial Clinical Trial ... C-fibres Acta Anaesthesiol Scand 1990; 34: 335-8 69 Pasqualucci A, Varrassi G, Braschi A, et al Epidural local anesthetic plus corticosteroid for the treatment of cervical brachial radicular pain: ... bupivacaine with or without Sarapin Group II = bupivacaine and steroids with or without Sarapin WC = Workers compensation MVA = Motor vehicle injury Analysis of Data Numbers Analyzed Data were analyzed...
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báo cáo hóa học: " Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" ppt
... Meguro T, Kitamori S, Nakagawa S, Shimizu Y, Takeda H, Asaka M: Randomized, double- blind, placebo- controlled crossover trial of famotidine in patients with functional dyspepsia Aliment Pharmacol Ther ... collaborative care for treating post-CABG depression: a randomized controlled trial JAMA 2009, 302:2095-103 36 Rey E, Alvarez-Sánchez A, Rodríguez-Artalejo F, Moreno Elola-Olaso C, Almansa C, Díaz-Rubio ... investigation phase, as in the randomized double- blind, placebo- controlled, parallel study design To compare the demographic and clinical data presented in Table Fisher’s exact test (for multiway tables)...
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Báo cáo y học: ":Evaluation of the Patient Acceptable Symptom State in a pooled analysis of two multicentre, randomised, double-blind, placebo-controlled studies evaluating lumiracoxib and celecoxib in patients with osteoarthritis" pptx
... and on patient achievement of sustained satisfaction by PASS Materials and methods A pooled analysis of data taken from two international, multicentre, double- blind, double- dummy, placebo- controlled, ... great relevance to clinicians and is a useful assessment variable in clinical trials Finally, such presentation facilitates the evaluation of the reported placebo- controlled trials In the case ... study and baseline values as covariates Figure Patient flow diagram diagram Page of 11 (page number not for citation purposes) Arthritis Research & Therapy Vol No Dougados et al Table OA pain intensity...
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Báo cáo y học: "Safety and Effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dosedependent, phase IV clinical trial." pdf
... Canarias Ofra s/n, La Cuesta 38320-La Laguna Espa a 4Hematology Laboratory Hospital Universitario de Canarias Ofra s/n, La Cuesta 38320-La Laguna Espa a 5Biochemical laboratory Hospital Universitario ... de Canarias Ofra s/n, La Cuesta 38320-La Laguna Espa a Cardiac Surgery Department Hospital Universitario de Canarias Ofra s/n, La Cuesta 38320-La Laguna Tenerife Espa a Jiménez et al Journal ... Universitario de Canarias Ofra s/n, La Cuesta 38320-La Laguna Espa a 2Nephrology Department Hospital Universitario Carlos Haya, 29010-Málaga Espa a 3Mixed Research Unit Hospital Universitario de Canarias...
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báo cáo khoa học:" Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey" docx
... Meguro T, Kitamori S, Nakagawa S, Shimizu Y, Takeda H, Asaka M: Randomized, double- blind, placebo- controlled crossover trial of famotidine in patients with functional dyspepsia Aliment Pharmacol Ther ... collaborative care for treating post-CABG depression: a randomized controlled trial JAMA 2009, 302:2095-103 36 Rey E, Alvarez-Sánchez A, Rodríguez-Artalejo F, Moreno Elola-Olaso C, Almansa C, Díaz-Rubio ... investigation phase, as in the randomized double- blind, placebo- controlled, parallel study design To compare the demographic and clinical data presented in Table Fisher’s exact test (for multiway tables)...
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Báo cáo y học: " Onset of relief of dyspnoea with budesonide/formoterol or salbutamol following methacholine-induced severe bronchoconstriction in adults with asthma: a double-blind, placebo-controlled study" pptx
... Grembiale RD, Pelaia G, Naty S, Vatrella A, Tranfa CM, Marsico SA: Comparison of the bronchodilating effects of inhaled formoterol, salmeterol and salbutamol in asthmatic patients Pulm Pharmacol ... and, particularly, formoterol/budesonide used as both maintenance and reliever therapy may have additional advantages over salbutamol These advantages include improved asthma control through a longer ... Respiratory Research 2006, 7:141 Background For many years, short-acting β2-agonists (SABA), such as salbutamol and terbutaline, have played an important role in the treatment of asthma; the...
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Báo cáo y học: "nfluence of atorvastatin on coronary calcifications and myocardial perfusion defects in systemic lupus erythematosus patients: a prospective, randomized, double-masked, placebo-controlled study" docx
... statin Table Biochemical data and SLEDAI score in SLE patients from atorvastatin group and from placebo group at randomization and after one year of treatment At randomization After one year ... Thrombosis and Haemostasis [23] Statistical analysis was performed using Statistica Six Sigma software (StatSoft, Krakow, Poland) All numerical data were expressed as mean values ± standard deviations, ... anticardiolipin antibodies; ANA: antinuclear antibodies; ALT: alanine aminotransferase; APS: antiphospholipid syndrome; AST: aspartate aminotransferase; CPK: creatine phosphokinase; CRP: C-reactive...
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Báo cáo khoa học: "Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial [ISRCTN43755713]" ppsx
... S, Illievich UM, Maas A, Upadhyaya BK: A remifentanil-based technique for analgesia and sedation in ICU patients with neurotrauma: preliminary data [abstract A5 49] Intensive Care Med 2001, Suppl ... the addition of propofol to achieve and maintain optimal sedation and analgesia This was to allow assessment of the efficacy of remifentanil as initial treatment while administering a clinically ... the maintenance phase, the extubation phase, the post-extubation phase and the post-treatment period were calculated for each patient and summarized by treatment group For each time interval, a...
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- a brand new treatment method of lasting wounds a multi centre randomized double blind study on effectiveness of polyhexanide and betaine in ulcers apos healing with venous origin
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- 2006 multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women a randomized controlled trial int j obes 30 10 pp 1545 1556
- 2008 effect of herbal ephedra sinica and evodia rutaecarpa on body composition and resting metabolic rate a randomized double blind clinical trial in korean premenopausal women j acupunct stud 1 2 pp 128 138
- a multicentre double blind randomized clinical trial of intravesical bacillus calmette guérin and interferon alpha 2b in the treatment of superficial bladder cancer
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