20 β2 adrenoceptor agonists and allergic disease the enhancing effect of β2 adrenoceptor agonists on cytokine induced tslp production by human lung tissue cells
Báo cáo y học: " Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats" pps
... migration and the development of pulmonary hypertension Therefore, this is the first study to show that migration inhibition of bone marrow cells by CXCR4 shRNA inhibits development of hypoxia -induced ... regulation of bone marrow cell migration during development of pulmonary hypertension and vascular remodeling induced by hypoxia This finding also demonstrated the involvement of bone marrow cells ... = transplantation of bone marrow cells with CXCR4 shRNA Effect of CXCR4 shRNA delivery on engraftment of bone marrow cells To investigate the effect of CXCR4 shRNA delivery on bone marrow cell...
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Báo cáo y học: " GM-CSF and IL-2 as adjuvant enhance the immune effect of protein vaccine against foot-and-mouth disease" pot
... the contact of DC and T cell in a short time and the binding of receptor and ligand, therefore, enhancing the antigen-presenting ability of APC, subsequently enhancing the level of cell and humoral ... with the salineinoculated group The groups of BoIL-2/BoGM-CSF/ VP1 and BoIL-2/VP1+BoGM-CSF/VP1 showed the highest level of mRNAs of either Th1 or Th2 cytokines Expression of the cytokines in the ... epitopes for the ELISA and T cell proliferation assays Cloning, expression and co-expression of targeted genes After isolation of peripheral blood mononuclear cells (PBMC) from Holstein cow and stimulated...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... conditions, the activity of MMPs is regulated by transcription, activation of the precursor zymogen and by interactions with specific extracellular matrix components In addition, endogenous tissue ... As part of the regulation of MMPs, rate-limiting effects, such as zymogen activation and the availability of TIMPs are important Another control element may be contributed by HS chains of proteoglycans, ... influence the outcome of cell adhesion and migration because their different activation states and clustering on the cell surface result in varying degrees of mechanical force exerted on the extracellular...
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Báo cáo hóa học: " The synergistic effect of IFN-α and IFN-γ against HSV-2 replication in Vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin" pptx
... ii) the effect of CDM on interferons action Results Antiviral effect of IFN-α, IFN-γ and IFNs combination on HSV-2 plaque formation Since there is no published data on the effect of IFNs on HSV-2 ... the early stages of infection by natural killer cells and at later stages by activated T cells [18] The innate immune response to viral infection depends on the integrity of this network of cytokines, ... infection in Vero cells the capacity of human IFNα and/ or IFN-γ to inhibit the replication of HSV-2 strains MS and G was initially performed in a plaque reduction assay The concentration of IFN-α and...
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Báo cáo khoa học: "The combination effect of sodium butyrate and 5-Aza-2''''-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines" pot
... covalent bond to Figure The effect of 5-azaDC and SB on radiation (logarismic scale) The effect of 5-azaDC and SB on radiation (logarismic scale) Histone plays an important role in post-translational ... 0.001) In the RKO cell line, 56.5% of the cells survived after radiation alone, 47% survived with the addition of 5-aza-DC, and a similar percentage (46%) survived with the addition of SB The combination ... demethylating agents, the DNA methylation and histone acetylation becomes inactivated and a synergic effect occurs Also, the combination of SB and 5-aza-DC facilitates the transformation of chromatin...
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Báo cáo y học: " Interleukin-4 receptor α gene variants and allergic disease" potx
... for the development of asthma and atopy both in the Hutterite population and in other outbred populations However, despite a number of clinical studies and functional studies on signalling of the ... that the true susceptibility locus might depend on additional variation outside the coding region of the IL-4Rα gene itself Another possibility worthy of further study is that combinations of variants ... variation; the best example is perhaps the β2 adrenoceptor locus on chromosome 5q31–33, which contains at least 17 SNPs within a region of approx kilobases containing the gene and important 5′ and...
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Tài liệu Report:"Language Vitality and Development among the Wakhi People of Tajikistan" pptx
... education had full proficiency in Tajik There is a definite correlation between educational level completed and proficiency levels, on one hand, and occupation, on the other hand, among respondents ... Professional Limited Full professional Professional Limited Full professional Professional Limited Full professional Professional Limited As indicated in section 2.2, limited corresponds to ILR ... 10 Professional Full Total 16 24 The number of respondents with limited proficiency, 18 of 40, seems high, especially in light of the fact that none of the respondents in the middle generation...
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Tài liệu The King''''s Post Being a volume of historical facts relating to the Posts, Mail Coaches, Coach Roads, and Railway Mail Services of and connected with the Ancient City of Bristol from 1580 to the present time pdf
... in the resolutions they passed on the occasion and sent to the Post Office It should not therefore be stated to the public his stopping the Norfolk and Suffolk service by his assertion of the ... business of the Bath Post Office,[Pg 46] and of his cross post contracts, and the other on the house in which John Palmer was born Soon after noon on the eventful day, the Bath postmen's band, Mr ... was only a small item in the expenses of the Post Office The Mayor of Bath proposed the toast of "the Visitors," and said that they had amongst them two representatives of the great men they...
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Tài liệu Báo cáo khoa học: Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells doc
... orientation of the primers Bold font represents the sequence of mature miR9* and italic fonts the sequence of mature miR9 (C) RT-PCR analysis of pri-miR9s during the neuronal differentiation of P19 cells ... monitor miR9 can also be usefully applied to study and monitor the biogenesis of other miRs related to neuronal development, differentiation, and neuronal diseases In addition, the in vitro and ... RT-PCR Control Control for for for for for for for for expression of pri-miR9-1 expression of pri-miR9-1 expression of pri-miR9-2 expression of pri-miR9-2 expression of pri-miR9-3 expression of pri-miR9-3...
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Tài liệu Báo cáo khoa học: Ionic strength and magnesium affect the specificity of Escherichia coli and human 8-oxoguanine-DNA glycosylases pdf
... the effects of ionic strength and Mg2+ on the activity and specificity of OGG1, we measured the apparent values of k2 and k3 under conditions of low salt (KPi only) and no Mg2+, low salt and 20 ... strength, Mg2+ concentration and several other factors 3748 Results Effects of ionic strength and divalent cations on the activity and specificity of Fpg and OGG1 The conditions inside a living cell ... Kinetic constant determination The reaction mixtures were as in the standard assay, except that the components specified in the Results were added, and the concentrations of the substrate and enzyme...
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Tài liệu Báo cáo khoa học: Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family docx
... removal of the CUB domains and thereby activation of the growth factor domains PDGF-C and -D contain both the CUB and growth factor domains when they are secreted and proteolytic cleavage is therefore ... indicates the disulfide bridges in PDGF-C to consist of Cys250 and 294, Cys280 and 335, and Cys287 and 337, and the intermonomeric bonds to consist of Cys274 and 286 [57] At present, analysis of PDGF ... vessels by mobilizing the endothelial progenitor cells, promoting the differentiation of bone marrow progenitor cells into mature endothelial cells, and by stimulating the chemotaxis of different...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... [11]), conformation The thiol group of C115 is highlighted in green and the nitrogen atoms of R 120 and K22 in blue The open form of MurA is unliganded (A) and the closed conformation (B) contains ... that R 120 is an important residue in the stabilization of the closed conformation of the protein This hypothesis can be tested by assessing the extent of the conformational change occurring upon ... assists in the assembly of the proper interactions in the active site by stabilizing the closed conformation of the protein In the closed conformation, R 120 moves from an ÔoutsideÕ position into...
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Tài liệu Báo cáo khoa học: Unfolding and aggregation during the thermal denaturation of streptokinase pptx
... aggregation processes has a profound effect on the DSC curves and precludes their analysis by standard equilibrium deconvolution methods The results presented here on the thermal denaturation of SK and ... simplifications, the model is consistent with the effect of concentration on the shape and Tm of the first transition occurring at % 50 °C Good descriptions of the DSC curves are obtained when the n ... denaturation processes concomitant with the thermal unfolding of SK occur at pH 7.0 and high sample concentrations and at pH 6.0 at all concentrations The effect of the temperature scan rate on the...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... dimethylsulfoxide and various concentrations of fatty acids (10–250 lm) The reactions were stopped by the addition of 7.5 lL acetic acid The conversion rate of holo-DptF into fatty acyl S-DptF was analysed by ... absorbance of 0.3 at 30 °C The cultures were cooled to 18 °C and protein production was induced by the addition of IPTG to a final concentration of 0.1 mm The cultures were incubated for a further 18 ... Determination of the kinetic parameters of DptF lipidation by DptE To determine the kinetic parameters for holo-DtpF lipidation by DptE, we performed the reactions under ACP saturation and varied the...
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Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc
... However, the development of effective and safe agents for the prevention and treatment of cancer remains inefficient and costly, and falls short of the requirements for primary prevention among the ... those containing monomers Cell cycle analysis To examine the effects of grape and pine fractions on the cell cycle pattern at concentrations equal to their IC50 and IC80 values (Table 1), HT29 cells ... B= IC80 Fig Induction of apoptosis by grape fractions VIIIG and IVG in HT29 cells (A) Nuclear condensation of HT29 cells Arrows indicate the apoptotic cells with condensed and fragmented nuclei...
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Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39] Moreover, these and other studies suggest that the IC residues are involved in the formation of the NBD ... H-loop, and positions the ‘linchpin’ histidine in the correct orientation such that all atoms are then in position to favor abstraction of a proton from the attacking water molecule by the bound ... reproducibility of our current assay; and would represent < 1% of the activity of the wild-type enzyme We then determined, by photoaffinity labeling, whether any of the mutations altered the apparent...
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Trends in the European Investment Fund Industry in the Second Quarter of 2011 and Results for the First Half of 2011 potx
... excess of EUR billion (Ireland EUR 26 billion, Luxembourg EUR billion, United Kingdom EUR billion, Switzerland EUR billion, the Netherlands EUR billion, Sweden EUR billion and Denmark EUR billion) ... EUR 48 billion during the first half of 201 1, slightly behind the EUR 55 billion recorded in the first half of 201 0 Long-term UCITS attracted EUR 87 billion during the first half of the year, down ... inflows of EUR 44 billion, albeit down from net inflows of EUR 62 billion in the first half of 201 0 Table Breakdow n of Non-UCITS Assets and Num ber by Category 30/6 /201 1 31/12 /201 0 31/3 /201 1 %...
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Trends in the European Investment Fund Industry in the Second Quarter of 2012 and Results for the First Half of 2012 pdf
... inflows of EUR 52 billion in the first half of 201 2, up from EUR 47 billion in the first half of 201 1 Table Breakdow n of Non-UCITS Assets and Num ber by Category 31/3 /201 2 30/06 /201 2 31/12 /201 1 ... during the second quarter This can be seen from the trends in monthly net sales for UCITS Equity funds continued to suffer on account of the poor economic outlook On the other hand, bond funds ... Luxembourg (EUR billion) Luxembourg and Ireland attracted net inflows of EUR 22 billion and EUR 17 billion, respectively, into bond funds during the quarter On the other hand, money market funds...
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Báo cáo khoa học: "Some Comments on Algorithm and Grammar in the Automatic Parsing of Natural Languages" ppt
... difference in the adequacy of the parsings of natural-language sentences will be alterations of the format itself in terms of increasing the degree of context-sensitivity This in effect means that the ... If, on the other hand, the question of processing is to be ignored in deciding what is to be viewed as input data, then another consideration must be taken into account It is the following: the ... satisfactory is the well-known one of structuring the parsing program as an executive main routine with appropriate subroutines This raises the further question of the functions and design of the executive...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25