17β estradiol inhibits pge2 induced expression of upa and mmp 9 by suppressing activation of jnk1 2
Báo cáo y học: "JNK suppression is essential for 17b-Estradiol inhibits prostaglandin E2-Induced uPA and MMP9 expressions and cell migration in human LoVo colon cancer cells" ppsx
... administration of PGE2 may induce the motility of human colon cancer by inducing the activation of JNK1/ 2 17b -Estradiol Inhibits PGE2- Induced Expression of uPA and MMP- 9 by Suppressing Activation of JNK1/ 2 ... PGE -induced activation of JNK1/ 2 within 30 min, and suppressed PGE2- induced expression of uPA and MMP- 9 within 24 h in human LoVo colon cancer cells (Figure 4B) 17b -Estradiol Inhibits PGE2- Induced ... and expression of uPA and MMP- 9 by suppressing the activation of JNK1/ 2 in LoVo cells The present study suggests that 17b -estradiol presents the properties of anti-cancer by inhibiting PGE2- induced...
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Báo cáo khoa học: Expression of heme oxygenase-1 is repressed by interferon-c and induced by hypoxia in human retinal pigment epithelial cells pot
... feedback regulation of HO-1 expression [47, 59] However, the expression of HO-1 and Bach1 mRNAs was concomitantly induced by the treatment with the combination of TNF-a and IL-1b in ARPE- 19 cells, indicating ... ( 199 9) Role of IFN-c -induced indoleamine 2, 3dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells J Immunol 1 62, 95 7 96 4 ... (20 02) Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene EMBO J 21 , 521 6– 522 4 48 McKay, B.S & Burke, J.M ( 199 4) Separation of phenotypically distinct subpopulations of...
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Báo cáo khoa học: Stage-specific activation of MIG-17⁄ADAMTS controls cell migration in Caenorhabditis elegans docx
... migration, requires removal of FEBS Journal 27 5 (20 08) 4 29 6 –4305 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 4 29 7 Regulated activation of MIG-17 ⁄ ADAMTS S Ihara and K Nishiwaki the prodomain ... 25 6, 173–186 20 Blelloch R & Kimble J ( 199 9) Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans Nature 399 , 586– 590 21 Meighan CM & Schwarzbauer JE (20 07) ... turn of DTCs in mid-L3 This FEBS Journal 27 5 (20 08) 4 29 6 –4305 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 4301 Regulated activation of MIG-17 ⁄ ADAMTS S Ihara and K Nishiwaki timing of MIG-17...
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Báo cáo khoa học: Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing docx
... Cas CasKo Nck2 20 µm 20 µm C 1.5 Relative ratio of active Cdc 42 siRNA Ctrl Nck2 Active Cdc 42 Total Cdc 42 0.5 siRNA Ctrl CrkII Ctrl Nck2 siRNA Active Cdc 42 Total Cdc 42 Cas Nck2 Cdc 42 Polarization ... Cell Biol 144, 123 5– 124 4 Chang F & Peter M (20 03) Yeasts make their mark Nat Cell Biol 5, 29 4 – 29 9 Etienne-Manneville S (20 04) Cdc 42 – the centre of polarity J Cell Sci 117, 1 29 1 –1300 Fukata M, ... migration, invasion and survival [28 , 29 ] The Nck family has two known members, Nck1 and Nck2, and both proteins can associate with phosphorylated Cas [20 ,22 ,24 ] As shown in Fig 6A, Crk and Nck proteins...
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Báo cáo Y học: Bax-induced cell death in yeast depends on mitochondrial lipid oxidation doc
... USA 96 , 4 820 –4 825 Scorrano, L., Petronilli, V & Bernardi, P ( 199 7) On the voltage dependence of the mitochondrial permeability transition pore A critical appraisal J Biol Chem 27 2, 12 29 5 – 12 29 9 ... Clow, A., Camougrand, N & Manon, S ( 199 9) Investigation of bax -induced release of cytochrome c 5450 M Priault et al (Eur J Biochem 2 69) 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 from ... K.U ( 199 9) Oxygen stress: a regulator of ¨ apoptosis in yeast J Cell Biol 145, 747–757 22 Priault, M., Camougrand, N., Chaudhuri, B & Manon, S ( 199 9) Role of the C-terminal domain of Bax and Bcl-XL...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... inhibitor), LY 29 4 0 02 (10 lM; PI3K inhibitor), U73 122 (10 lM; PLC inhibitor) and PD980 59 (25 lM; MAPK/ERK inhibitor), followed by LPA treatment PTX and LY 29 4 0 02 markedly inhibited LPA -induced PAK1 activation, ... L.A ( 199 2) Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein J Biol Chem 26 7, 25 24 25 29 28 Knaus, U.G & Bokoch, G.M ( 199 8) The p21rac/Cdc 42- activated ... LY 29 4 0 02 (10 lM, h), U73 122 (10 lM, 0.5 h), PD980 59 (25 lM, h), genistein (100 lM, h), Y276 32 (100 lM, h) and further incubated with or without lM LPA for min, and PAK1 activity was assessed by...
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cell migration in inflammation and immunity
... F., and Dejana, E ( 199 2) Cytokine regulation of endothelial cell function FASEB J 6, 2 591 2 599 Ward, P A., Remold, H G., and David, J R ( 197 0) The production by antigenstimulated lymphocytes of ... 92 , 20 7 21 4 21 Falk, W., Goodwin, R H Jr., and Leonard, E J ( 198 0) A 48-well microchemotaxis assembly for rapid and accurate measurement of leukocyte migration J Immunol Methods 33 ,2 39 24 5 22 ... ( 199 1) The signal transduction pathway involved in the migration induced by a monocyte chemotactic cytokine J Immunol 147, 22 15 22 21 23 Wilkinson, P C ( 199 8) Assays of leukocyte locomotion and...
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Báo cáo y học: " Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands" docx
... rat parotid gland Eur J Pharmacol 20 02, 4 39: 27 -33 26 Bank HL: Rapid assessment of islet viability with acridine orange and propidium iodide In Vitro Cell Dev Biol 198 8, 24 :26 6 -27 3 27 Pregi N, Vittori ... submandibular glands and reversed salivary flow decline [22 ] In line with this, in vitro treatment of NOD macrophages with VIP reduced TNF-α, nitric oxide and IL- 12 and increased IL-10 produced by ... funded by the National Agency of Sciences and Technology ANPCyT (PICT 197 1 and 21 65 to CPL and AN), National Research Council CONICET (PIP 5638 to CPL) and University of Buenos Aires (X1 72 to CPL)...
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Báo cáo y học: "Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis" docx
... upregulation of MMP- 2 mRNA was observed in 16/ 19 of RA patients Equally, there was an increase in MMP- 2 protein Median expression of MMP- 2 in normoxic conditions was 524 ng/ml (range 122 to 1 ,2 59 ng/ml), ... 19) 1.31 (0.03 to 18 .90 ) 2. 68 (0.01 to 26 .08) 0.131 TIMP -2 (n = 19) 2. 57 (0. 12 to 20 .97 ) 2. 20 (0 .24 to 18.64) 0.457 Data presented as the median (range) and were analysed by Wilcoxon signed rank ... Gnarra JR, Woude GF Page 10 of 11 (page number not for citation purposes) 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Vande: The von Hippel – Lindau tumor suppressor gene inhibits hepatocyte growth...
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Báo cáo y học: "Tian Xian Liquid (TXL) induces apoptosis in HT-29 colon cancer cell in vitro and inhibits tumor growth in vivo" doc
... caspase-3 and caspase -9 cleavage Protein from HT- 29 which has been treated with 1%TXL for 12, 24 and 48 hours (A) and protein from HT- 29 which has been treated with indicated concentration of TXL ... 12, 24 and 48 hours (A) or indicated concentration of TXL for 48 hours (B) were analyzed by Western blot with specific antibodies against Bax and Bcl -2 Protein from cytosolic fraction of HT- 29 ... (Figure 2B) TXL triggers interaction between Bcl -2 and Bax and releases cytochrome c Low Δψm is regulated by Bcl -2 family proteins [11] We studied the effects of TXL on the expression of Bax and...
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Báo cáo y học: "Directed cell migration in the presence of obstacles" doc
... Chem Eng Sci 198 9, 44 :28 81 -2 897 Keller EF, Segel LA: Model for Chemotaxis J Theor Biol 197 1, 30 :22 5 -23 4 Dickson B: Molecular Mechanisms of Axon Guidance Science 20 02, 29 8 : 195 9- 196 4 Bray D: Cell ... Biology of the Cell New York: Garland Science; 20 02 Page 11 of 12 (page number not for citation purposes) Theoretical Biology and Medical Modelling 20 07, 4 :2 10 11 12 13 14 15 16 17 18 19 20 21 22 ... http://www.tbiomed.com/content/4/1 /2 Armitage JP, Lackie JM: Biology of the Chemotactic Response Cambridge: Cambridge University Press; 199 0 Berg HC, Purcell EM: Physics of Chemoreception Biophys J 197 7, 20 : 193 -2 19 Beyer...
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Genetic analysis of the role of ARP2 3 complex in border cell migration in drosophila melanogaster
... timing of initiation (Bai et al 20 00), adhesion dynamics (Niewiadomska et al 199 9; Geisbrecht and Montell 20 02; Pacquelet and Rorth 20 05) and guidance (Duchek and Rorth 20 01; Duchek et al 20 01), ... al 199 9; Szymanski et al 199 9), again consistent with the important role of Arp2/3 complex in actin dynamics regulation 16 Arp2/3 complex in border cell migration Lu Ruifeng 20 10 Control Arpc2/- ... assembly of actin filament at tail pushes them through cytoplasm (Dramsi and Cossart 199 8) Accumulated evidence showed that viruses (Frischknecht et al 199 9), endosomes (Merrifield et al 199 9) and...
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Cancer cell migration in 3d collagen gel matrix system
... 31 2. 2 General anti-cancer drug assays in 3D 33 2. 2.1 Introduction 33 2. 2 .2 Background: why 2D cell culture is insufficient for anti-cancer drug testing 34 iv 2. 2.3 ... Conclusions and Future Work 122 6.1 Conclusions 122 6 .2 Further modulation of the ECM environment 125 References 127 Appendix A The Time Dependence of Cell ... movement speed and track straightness 91 Table 5.3 Effects of Y276 32 on cell movement speed and track straightness 99 Table 5.4 Effects of CytoD on cell movement speed and track straightness...
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CHARACTERISATION OF DRUG INDUCED CELL DEATH IN MYCOBACTERIUM SMEGMATIS
... concentration that killed 99 % of the exposed bacterial population Antibiotic MIC(µM) MBC 99( µM) Isoniazida 125 25 0 Ethambutol 1 .25 10 Ciprofloxacina,b 0.8 < 0.8 Levofloxacinb 0. 625
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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
... 21 41 13 176 12 92 27 190 0 22 193 1 16 198 1 25 20 57 32 IL-6 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 5* 62 7 1 79 155 25 2 22 3 2 160 325 00 100 5500 27 1 6800 330 3 720 0 20 0 395 00 403 34400 28 3 38700 Fever ... ± ± ± 510* 21 0 100 26 0 90 96 0 26 870 93 860 100 870 2 0.18 1.06 0 .21 0. 32 0.11 0.31 0 .22 1. 19 0.13 1. 12 0.11 1.07 0 .22 1.08 0 .21 0 .25 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 0. 02 0.03 0. 02 0.04 0.06 ... Number of rabbits tested IL-6 ± ± ± ± ± ± ± ± ± ± ± ± 52* 71* 49* 95 * 75* 60* 90 5000 100 26 200 1 02 33600 82 48300 110 70000 108 6 420 0 ± ± ± ± ± ± ± ± ± ± ± ± 100* 12 200* 21 0* 320 * 12 440* 10...
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Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
... NM_ 024 105 NM_004048 NM_0 322 55 NM_018648 NM_0 026 07 2. 625 2. 618 2. 577 2. 5 2. 475 2. 457 2. 451 2. 375 2. 37 2. 32 2. 29 9 2. 2 42 2 .24 2 2. 2 42 2 .23 7 2. 2 32 2 .23 2 2. 2 12 2 .21 2 2. 198 2. 141 2. 1 32 2.1 32 2. 123 2. 1 19 ... 2. 546 2. 524 2. 386 2. 3 82 2.377 2. 371 2. 353 2. 307 2. 277 2. 268 2. 258 2. 2 49 2. 235 2. 222 2. 215 2. 215 2. 188 30 31 32 33 34 35 RAB31 MCM2 RSL1D1 EHD4 C20orf30 SFPQ NM_006868 NM_004 526 NM_0156 59 NM_1 3 92 65 ... PGRMC2 FKBP1A MT1K FRS3 NM_00 121 6 NM_0 093 09 NM_0 025 82 NM_014400 NM_0 022 22 NM_175617 NM_0 022 05 NM_006 3 92 NM_00 29 9 9 NM_080 725 NM_004576 NM_0 022 13 NM_ 024 0 42 NM_006 3 92 NM_18 29 1 7 NM_01 62 19 NM_00 197 5...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
... radiation -induced expressional upregulation of Fas and subsequent activation of the apoptotic cell-death FEBS Journal 27 5 (20 08) 2 096 21 08 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 2 099 Role of ... ( 199 7) Prevention of apoptosis by Bcl -2: release of cytochrome c from mitochondria blocked Science 27 5, 11 29 11 32 10 Liu YZ, Boxer ML & Latchman SD ( 199 9) Activation of the Bcl -2 promoter by ... radiation is induced by activation of Bax and Bak initiated by transcription upregulation of Fas and by phosphorylation ⁄ inactivation of Bcl -2 in a JNK-dependent manner An improved understanding of the...
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Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... 0.04c 0.07c 20 . 59 14. 49 11 .27 13.68 Cu ± ± ± ± 6.61a 1 . 92 a 1.06b 3.09a 13. 42 26.68 11 .99 31.66 Zn ± ± ± ± 0 .28 a 0.60b 0.42a 1 .21 c 99 .46 95 .03 90 .48 20 0 .24 ± ± ± ± 3 .91 a 1.15a 1.87a 8.51b 620 8 M Kondoh ... Mg 1 0 25 25 12 19. 86 1 194 .45 1167. 09 1376.34 Ca ± ± ± ± 30.66a 13.30a 13.16a 57.47b 42. 86 25 .44 23 . 42 20. 82 Mn ± ± ± ± 11.89a 1.70b 4 .96 b 6.60b 2. 32 1.81 1.06 1. 02 Fe ± ± ± ± 0.03a 0.02b 0.04c ... 55, 123 0– 125 4 28 Seger, R & Krebs, E.G ( 199 5) The MAPK signaling cascade FASEB J 9, 726 –735 29 Xia, Z., Dickens, M., Reingeaud, J., Davis, R.J & Greenberg, M.E ( 199 5) Opposing effects of ERK and...
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Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
... domain of human 17 18 19 20 21 22 23 24 topoisomerase I play a direct role in relaxation J Biol Chem 27 6, 20 220 20 227 Kowalska-Loth, B., Bubko, I., Komorowska, B., Szumiel, I & ´ Staron, K ( 199 8) ... Kerrigan, D., Hartman, K.D & Glazer, R.I ( 199 0) Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C J Biol Chem 26 5, 94 18 94 22 ´ ´ Staron, K., Kowalska-Loth, B., Zabek, ... cleavage Effect of SF2/ASF on DNA relaxation Fig Inhibition of kinase activity of htopo I by DNA and camptothecin htopo I (0.16 pmol) and SF2/ASF (1 .25 pmol) were used The concentration of camptothecin...
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Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
... SB -20 3580 MK 591 MK886 Curcumin SP600 125 PD980 59 500 178.4 21 2.5 173.5 168 74 .2 337 p38kinase ± ± ± ± ± ± ± 29 . 5 18.6 78.5 19. 5 22 2. 5 25 MAPK 25 0 34 76 55 43 337 22 5 2 79 38.5 71.5 52. 5 39. 8 199 ... GBP -2 IL-17 IL-6 Prot-Vo BC 028 217 NM-00 191 2 AF050 127 M55543 NM_0 02 190 M 29 1 50 U16306.1 3 0 92 SEB (2 h) )1.73 6.13 2. 3 7.57 2. 2 52. 26 ND ± ± ± ± ± ± SEB (16 h) 0.01 0 .22 0.05 0.08 0.03 1.0 MK 591 (2 ... MK 591 (16 h) )2. 21 4 .9 2. 79 3 .26 4 .97 31.6 )2 1.18 )1.01 1.00 )2. 0 1. 12 ND )2. 45 1. 42 )1 .20 )1.45 )4.80 )4.75 ND )1.65 ± ± ± ± ± ± ± 0.03 0.15 0.03 0.07 0 .23 0 .26 0 .2 ± ± ± ± ± 0.03 0.10 0.02...
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