... administration ofPGE2 may induce the motility of human colon cancer by inducing the activationof JNK1/ 2 17b -Estradiol Inhibits PGE2- InducedExpressionofuPAand MMP- 9bySuppressingActivationof JNK1/ 2 ... PGE -induced activationof JNK1/ 2 within 30 min, and suppressed PGE2- inducedexpressionofuPAand MMP- 9 within 24 h in human LoVo colon cancer cells (Figure 4B) 17b -Estradiol Inhibits PGE2- Induced ... andexpressionofuPAand MMP- 9bysuppressing the activationof JNK1/ 2 in LoVo cells The present study suggests that 17b -estradiol presents the properties of anti-cancer by inhibiting PGE2- induced...
... feedback regulation of HO-1 expression [47, 59] However, the expressionof HO-1 and Bach1 mRNAs was concomitantly inducedby the treatment with the combination of TNF-a and IL-1b in ARPE- 19 cells, indicating ... ( 199 9) Role of IFN-c -induced indoleamine 2, 3dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells J Immunol 1 62, 95 7 96 4 ... (20 02) Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene EMBO J 21 , 521 6– 522 4 48 McKay, B.S & Burke, J.M ( 199 4) Separation of phenotypically distinct subpopulations of...
... Cas CasKo Nck2 20 µm 20 µm C 1.5 Relative ratio of active Cdc 42 siRNA Ctrl Nck2 Active Cdc 42 Total Cdc 42 0.5 siRNA Ctrl CrkII Ctrl Nck2 siRNA Active Cdc 42 Total Cdc 42 Cas Nck2 Cdc 42 Polarization ... Cell Biol 144, 123 5– 124 4 Chang F & Peter M (20 03) Yeasts make their mark Nat Cell Biol 5, 29 4 – 29 9 Etienne-Manneville S (20 04) Cdc 42 – the centre of polarity J Cell Sci 117, 1 29 1 –1300 Fukata M, ... migration, invasion and survival [28 , 29 ] The Nck family has two known members, Nck1 and Nck2, and both proteins can associate with phosphorylated Cas [20 ,22 ,24 ] As shown in Fig 6A, Crk and Nck proteins...
... USA 96 , 4 820 –4 825 Scorrano, L., Petronilli, V & Bernardi, P ( 199 7) On the voltage dependence of the mitochondrial permeability transition pore A critical appraisal J Biol Chem 27 2, 12 29 5 – 12 29 9 ... Clow, A., Camougrand, N & Manon, S ( 199 9) Investigation of bax -induced release of cytochrome c 5450 M Priault et al (Eur J Biochem 2 69) 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 from ... K.U ( 199 9) Oxygen stress: a regulator of ¨ apoptosis in yeast J Cell Biol 145, 747–757 22 Priault, M., Camougrand, N., Chaudhuri, B & Manon, S ( 199 9) Role of the C-terminal domain of Bax and Bcl-XL...
... F., and Dejana, E ( 199 2) Cytokine regulation of endothelial cell function FASEB J 6, 2 591 2 599 Ward, P A., Remold, H G., and David, J R ( 197 0) The production by antigenstimulated lymphocytes of ... 92 , 20 7 21 4 21 Falk, W., Goodwin, R H Jr., and Leonard, E J ( 198 0) A 48-well microchemotaxis assembly for rapid and accurate measurement of leukocyte migration J Immunol Methods 33 ,2 39 24 5 22 ... ( 199 1) The signal transduction pathway involved in the migration inducedby a monocyte chemotactic cytokine J Immunol 147, 22 15 22 21 23 Wilkinson, P C ( 199 8) Assays of leukocyte locomotion and...
... rat parotid gland Eur J Pharmacol 20 02, 4 39: 27 -33 26 Bank HL: Rapid assessment of islet viability with acridine orange and propidium iodide In Vitro Cell Dev Biol 198 8, 24 :26 6 -27 3 27 Pregi N, Vittori ... submandibular glands and reversed salivary flow decline [22 ] In line with this, in vitro treatment of NOD macrophages with VIP reduced TNF-α, nitric oxide and IL- 12 and increased IL-10 produced by ... funded by the National Agency of Sciences and Technology ANPCyT (PICT 197 1 and 21 65 to CPL and AN), National Research Council CONICET (PIP 5638 to CPL) and University of Buenos Aires (X1 72 to CPL)...
... upregulation of MMP- 2 mRNA was observed in 16/ 19 of RA patients Equally, there was an increase in MMP- 2 protein Median expressionof MMP- 2 in normoxic conditions was 524 ng/ml (range 122 to 1 ,2 59 ng/ml), ... 19) 1.31 (0.03 to 18 .90 ) 2. 68 (0.01 to 26 .08) 0.131 TIMP -2 (n = 19) 2. 57 (0. 12 to 20 .97 ) 2. 20 (0 .24 to 18.64) 0.457 Data presented as the median (range) and were analysed by Wilcoxon signed rank ... Gnarra JR, Woude GF Page 10 of 11 (page number not for citation purposes) 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 Vande: The von Hippel – Lindau tumor suppressor gene inhibits hepatocyte growth...
... caspase-3 and caspase -9 cleavage Protein from HT- 29 which has been treated with 1%TXL for 12, 24 and 48 hours (A) and protein from HT- 29 which has been treated with indicated concentration of TXL ... 12, 24 and 48 hours (A) or indicated concentration of TXL for 48 hours (B) were analyzed by Western blot with specific antibodies against Bax and Bcl -2 Protein from cytosolic fraction of HT- 29 ... (Figure 2B) TXL triggers interaction between Bcl -2 and Bax and releases cytochrome c Low Δψm is regulated by Bcl -2 family proteins [11] We studied the effects of TXL on the expressionof Bax and...
... timing of initiation (Bai et al 20 00), adhesion dynamics (Niewiadomska et al 199 9; Geisbrecht and Montell 20 02; Pacquelet and Rorth 20 05) and guidance (Duchek and Rorth 20 01; Duchek et al 20 01), ... al 199 9; Szymanski et al 199 9), again consistent with the important role of Arp2/3 complex in actin dynamics regulation 16 Arp2/3 complex in border cell migration Lu Ruifeng 20 10 Control Arpc2/- ... assembly of actin filament at tail pushes them through cytoplasm (Dramsi and Cossart 199 8) Accumulated evidence showed that viruses (Frischknecht et al 199 9), endosomes (Merrifield et al 199 9) and...
... 31 2.2 General anti-cancer drug assays in 3D 33 2. 2.1 Introduction 33 2.2 .2 Background: why 2D cell culture is insufficient for anti-cancer drug testing 34 iv 2. 2.3 ... Conclusions and Future Work 122 6.1 Conclusions 122 6 .2 Further modulation of the ECM environment 125 References 127 Appendix A The Time Dependence of Cell ... movement speed and track straightness 91 Table 5.3 Effects of Y276 32 on cell movement speed and track straightness 99 Table 5.4 Effects of CytoD on cell movement speed and track straightness...
... radiation -induced expressional upregulation of Fas and subsequent activationof the apoptotic cell-death FEBS Journal 27 5 (20 08) 2 096 21 08 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 2 099 Role of ... ( 199 7) Prevention of apoptosis by Bcl -2: release of cytochrome c from mitochondria blocked Science 27 5, 11 29 11 32 10 Liu YZ, Boxer ML & Latchman SD ( 199 9) Activationof the Bcl -2 promoter by ... radiation is inducedbyactivationof Bax and Bak initiated by transcription upregulation of Fas andby phosphorylation ⁄ inactivation of Bcl -2 in a JNK-dependent manner An improved understanding of the...
... domain of human 17 18 19 20 21 22 23 24 topoisomerase I play a direct role in relaxation J Biol Chem 27 6, 20 220 20 227 Kowalska-Loth, B., Bubko, I., Komorowska, B., Szumiel, I & ´ Staron, K ( 199 8) ... Kerrigan, D., Hartman, K.D & Glazer, R.I ( 199 0) Phosphorylation of mammalian DNA topoisomerase I andactivationby protein kinase C J Biol Chem 26 5, 94 18 94 22 ´ ´ Staron, K., Kowalska-Loth, B., Zabek, ... cleavage Effect of SF2/ASF on DNA relaxation Fig Inhibition of kinase activity of htopo I by DNA and camptothecin htopo I (0.16 pmol) and SF2/ASF (1 .25 pmol) were used The concentration of camptothecin...