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(BQ) Part 1 book Textbook of clinical embryology presents the following contents: Introduction to human embryology, reproductive system, cell division and gametogenesis, fertilization and formation of germ layers, extraembryonic membranes and twinning, integumentary system, skeletal system, muscular system,...
Textbook of Clinical Embryology VS-Prelims.indd i 6/21/2012 3:46:17 PM “This page intentionally left blank" Textbook of Clinical Embryology Vishram Singh, ms Professor & Head, Department of Anatomy, Professor-in-Charge, Medical Education Unit, Additional Senior Superintendent of Examination, Santosh Medical College, Santosh University, Ghaziabad, NCR, Delhi Examiner in National and International Universities; Member, Academic Council, Santosh University; Member, Editorial Board, Indian Journal of Otology; Vice President, Anatomical Society of India; Medicolegal Advisor, ICPS, India; Consulting Editor, ABI, North Carolina, USA Formerly at: GSVM Medical College, Kanpur; King George Medical College, Lucknow; Al-Arab Medical University, Benghazi (Libya); All India Institute of Medical Sciences, New Delhi ELSEVIER A division of Reed Elsevier India Private Limited VS-Prelims.indd iii 6/21/2012 3:46:17 PM Textbook of Clinical Embryology, 1e Vishram Singh ELSEVIER A division of Reed Elsevier India Private Limited Mosby, Saunders, Churchill Livingstone, Butterworth-Heinemann and Hanley & Belfus are the Health Science imprints of Elsevier © 2012 Elsevier All rights are reserved No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission of the publisher ISBN: 978-81-312-3048-0 Medical knowledge is constantly changing As new information becomes available, changes in treatment, procedures, equipment and the use of drugs become necessary The authors, editors, contributors and the publisher have, as far as it is possible, taken care to ensure that the information given in this text is accurate and up-to-date However, readers are strongly advised to confirm that the information, especially with regard to drug dose/usage, complies with current legislation and standards of practice Published by Elsevier, a division of Reed Elsevier India Private Limited Registered Office: 305, Rohit House, 3, Tolstoy Marg, New Delhi 110 001 Corporate Office: 14th Floor, Building No 10B, DLF Cyber City, Phase-II, Gurgaon 122002, Haryana, India Senior Commissioning Editor: Shukti Mukherjee Managing Editor: Shabina Nasim Development Editor: Goldy Bhatnagar Copy Editors: Richa Srivastava and Shrayosee Dutta Manager – Publishing Operations: Sunil Kumar Manager – Production: NC Pant Cover Designer: Raman Kumar Typeset by Olympus Premedia Pvt Ltd ( formerly Olympus Infotech Pvt Ltd.), Chennai, India www.olympus.co.in Printed and bound at Ajanta Offset, New Delhi VS-Prelims.indd iv 6/21/2012 3:46:18 PM Dedicated to the Sacred Memory of My Parents VS-Prelims.indd v 6/21/2012 3:46:18 PM “This page intentionally left blank" Preface Textbook of Clinical Embryology has been carefully planned for the first year medical and dental students It follows the revised anatomy curriculum of the Medical Council of India Following the current trends of clinically oriented study of Anatomy, I have adopted a parallel approach of imparting basic embryological knowledge to students and simultaneously providing them its applied aspects To help students score high in examinations the text is written in simple language It is arranged in easily understandable small sections While embryological details of little clinical relevance, phylogenetic discussions, and comparative analogies have been either omitted or described in brief, all clinically important topics are described in detail Because of increasingly significant role of molecular biology and genetics in embryology and study of birth defects, the basic molecular and genetic principles are discussed throughout the text In addition, a separate chapter on medical genetics has been added The tables and flowcharts given in the book summarize important and complex information into digestible knowledge capsules Multiple choice questions have been given chapter-by-chapter at the end of the book to test the level of understanding and memory recall of the students The numerous simple four-color illustrations and clinical photographs further assist in fast comprehension and retention of complicated information All the illustrations are drawn by the author himself to ensure accuracy Throughout the preparation of this book one thing I have kept in mind is that thorough knowledge of embryology is required by Clinicians, especially Gynecologists, Pediatricians, and Pediatric Surgeons for physical examination, prenatal diagnostic tests, and surgical procedures Therefore, embryological events relevant to prenatal diagnostic and surgical procedures are clinically correlated throughout the text Further, patient-oriented problems and their embryological and genetic basis are presented at the end of each chapter for problem-based learning so that the students could use their embryological knowledge in clinical situations Moreover, keeping in mind the relevance of embryological knowledge in day-to-day clinical practice, a separate chapter on developmental events during the entire period of gestation and their application in clinical practice is given at the end of the book I pay my heartfelt tribute to all the authors of various embryology books, especially Developing Human: Clinically Oriented Embryology, 8th edition by Keith L Moore and TVN Persaud, which I have consulted during the preparation of this book From Developing Human and few other books, some photographs have been used in this book after obtaining due permission from concerned authorities (please refer to page 331 for Figure Credits) As a teacher, I have tried my best to make the book easy to understand and interesting to read For further improvement of this book, I would greatly welcome comments and suggestions from the readers All these comments and suggestions can be e-mailed at indiacontact@elsevier.com and drvishramsingh@gmail.com ‘Mind perceives new ideas best only when put to test.’ Vishram Singh VS-Prelims.indd vii 6/21/2012 3:46:18 PM “This page intentionally left blank" Acknowledgments At the outset, I express my gratitude to Dr P Mahalingam, CMD; Dr Sharmila Anand, DMD; and Dr Ashwyn Anand, CEO at Santosh University, Ghaziabad, NCR, Delhi for providing me an appropriate academic atmosphere and encouragement which helped me a lot in preparing this book I am highly grateful to Dr Devkinandan Sharma, Chancellor and Dr VK Arora, Vice Chancellor, Santosh University for appreciating my work I sincerely thank my colleagues in the Anatomy Department, Professor Nisha Kaul, Dr Latika Arora, Dr Ruchira Sethi, and Dr LK Pandey for their cooperation, especially to Dr Ruchira Sethi for seeing the proofs sincerely I highly appreciate the help rendered by my students Miss Radhika Batra and Mr Divyansh Bhatt and their parents Dr Shailly Batra, Senior Gynecologist, Batra Hospital, New Delhi and Dr Arun Bhatt, Chief Medical Superintendent, SGPGIMS Lucknow, respectively, who also happen to be my students and helped in procuring some of the clinical photographs used in this book I gratefully acknowledge the feedback and support of fellow colleagues in anatomy, particularly, ● ● ● ● ● ● ● ● ● ● ● ● ● ● VS-Prelims.indd ix Professors AK Srivastava (HOD), Ashok Sahai, PK Sharma, Mahdi Hasan, MS Siddiqui, and Punita Manik, King George Medical College, Lucknow Professor NC Goel (HOD), Hind Institute of Medical Sciences, Barabanki Professors Shashi Wadhwa (HOD), Raj Mehra, and Ritu Sehgal, AIIMS, New Delhi; Gayatri Rath (HOD), RK Suri, and Dr Hitendra Loh,Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi; Shipra Paul and Shashi Raheja, Lady Harding Medical College, New Delhi; JM Kaul (HOD) and Smita Kakkar, Maulana Azad Medical College, New Delhi; and Veena Bharihoke (HOD), UCMS, Shahadra, Delhi Professor GS Longia (HOD), People’s Dental Academy, Bhopal Professors AK Asthana (Dean) and Satyam Khare (HOD), Subharti Medical College, Meerut and Namita Mehrotra (HOD), Rama Medical College, Hapur, Meerut Professor Vinod Kumar (HOD), UP RIMS & R Safai, Etawah, UP Professors Gajendra Singh (Director) and SK Pandey, Institute of Medical Sciences, BHU, Varanasi Professors RK Srivastava (HOD and Vice Principal), Rama Medical College, Kanpur Professors SL Jethani (HOD), RK Rohtagi, and Dr Deepa Singh, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun Professor SD Joshi (HOD and Dean), Sri Aurobindo Institute of Medical Sciences; Dr VK Pandit, Associate Professor, MGM Medical College; Professor GP Paul (HOD), Modern Dental College and Research Center, Indore (MP) Professor Sudha Chhabra (HOD) and SK Srivastava, Medical College, Rohtak, Haryana Professor S Ghatak (HOD), Adesh Medical College, Bhatinda and Dr Anjali Jain (HOD), CMC, Ludhiana, Punjab Professors TC Singel (HOD), MP Shah Medical College, Jamnagar and R Rathod (HOD), PDUMC, Rajkot, Gujarat Professors P Parchand (HOD and Dean), GMC, Miraj; Ksheersagar Dilip Dattatraya, NKP Salve IMC & RC; Meena Malikchand Meshram, GMC, Nagpur; Vasanti Arole and P Vatsalaswamy, DY Patil Medical College, Pune, Maharashtra 6/21/2012 3:46:18 PM ... System 10 3 10 Pharyngeal Apparatus 11 0 11 Development of Tongue and Thyroid 12 2 12 Development of Face, Nose, and Palate 13 0 13 Digestive Tract 14 0 14 Major Digestive Glands and Spleen 15 8 15 Development... just at the time when embryo enters the uterus 6/ 21/ 2 012 3:43: 41 PM Introduction to Human Embryology 10 Fig 1. 11 James Till 11 12 13 14 15 Fig 1. 12 Ian Wilmut Blastocyst (Gr Blastos = bud, Kystis... of Oral Cavity (Mouth) 16 8 16 Respiratory System 17 6 17 Body Cavities and Diaphragm 18 6 18 Development of Heart 19 6 19 Development of Blood Vessels 212 20 Development of Urinary System 233 21