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As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke. Because the potential protective effects of UA in traumatic brain injury (TBI) remain largely unknown, this study investigated the role of UA in TBI in both clinical patients and experimental animals.
Int J Med Sci 2018, Vol 15 Ivyspring International Publisher 1072 International Journal of Medical Sciences 2018; 15(10): 1072-1082 doi: 10.7150/ijms.25799 Research Paper Clinical and Basic Evaluation of the Prognostic Value of Uric Acid in Traumatic Brain Injury Han Liu, Junchi He, Jianjun Zhong, Hongrong Zhang, Zhaosi Zhang, Liu Liu, Zhijian Huang, Yue Wu, Li Jiang, Zongduo Guo, Rui Xu, Weina Chai, Gang Huo, Xiaochuan Sun and Chongjie Cheng Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Corresponding author: Xiaochuan Sun, Phone: 13883022455; E-mail: sunxch1445@qq.com and Chongjie Cheng, Phone: 15334587556; E-mail: 358187887@qq.com © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/) See http://ivyspring.com/terms for full terms and conditions Received: 2018.02.28; Accepted: 2018.06.08; Published: 2018.06.23 Abstract Background: As a major antioxidant in serum, uric acid (UA) was once considered only as the leading cause of gout; however, recent studies have validated its neuroprotective role in ischemic stroke Because the potential protective effects of UA in traumatic brain injury (TBI) remain largely unknown, this study investigated the role of UA in TBI in both clinical patients and experimental animals Methods: In TBI patients, serum UA concentrations were measured within days after injury Clinical outcomes at discharge were classified according to the Glasgow Outcome Scale: good outcome (4–5) and poor outcome (1–3) Risk factors for good outcome were identified via backward logistic regression analysis For the animal study, a controlled cortical impact (CCI) injury model was established in mice These mice were given UA at different doses intraperitoneally, and subsequent UA concentrations in mouse serum and brain tissue were determined Neurological function, oxidative stress, inflammatory response, neuronal maintenance, cerebral blood flow, and lesion size were also assessed Results: The serum UA level was significantly lower in TBI patients who had a good outcome (P