Đăng ký

Đăng nhập

Hãy chọn một cách để đăng nhập

Facebook

Google

Zalo

Hoặc tiếp tục với email

Nhớ mật khẩu

Chưa có tài khoản? Đăng ký

Drug discovery strategies and methods 2004 makriyannis biegel

338 223 0

Đang tải... (xem toàn văn)

Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống

/ 338 trang

Thông tin tài liệu

... Cannabinergics: Old and New Possibilities Andreas Goutopoulos and Alexandros Makriyannis Development of PET and SPECT Radioligands for Cannabinoid Receptors S John Gatley, Andrew N Gifford, Yu-Shin... areas of research and will provide a contemporary picture of the overall field of drug discovery to scientists from diverse disciplines Alexandros Makriyannis Diane Biegel Copyright 2004 by Marcel... structure-based drug design has become an integral part of the modern drug discovery process and has begun to contribute to a significant portion of the current drug discovery portfolio Copyright 2004 by

Ngày đăng: 07/07/2018, 09:36

Xem thêm: Drug discovery strategies and methods 2004 makriyannis biegel , III. THE STRUCTURE-BASED DRUG DESIGN CYCLE, D. MODEL BUILDING AND REFINEMENT, L. DEDICATED MOLECULAR BIOLOGY AND PROTEIN PURIFICATION GROUPS ARE ESSENTIAL, II. SRC TYROSINE KINASE AND OSTEOPOROSIS, III. SH2 DOMAINS AND PHOSPHOPEPTIDE BINDING, V. SOLID-PHASE PARALLEL SYNTHESIS AND NONPEPTIDE PHENYL PHOSPHATE LIBRARIES, VI. STRUCTURE-BASED, SMALL-MOLECULE LIBRARIES TO EXPLORE SRC SH2 BINDING, VII. DISCOVERY OF AN IN VIVO EFFECTIVE SRC SH2 INHIBITOR, II. THE MATRIX METALLOPROTEINASE FAMILY, III. ASSIGNMENT OF THE RESONANCES OF THE INHIBITED CATALYTIC DOMAIN OF STROMELYSIN-1, IV. ASSIGNMENT OF THE RESONANCES OF THE INHIBITOR AND NOES BETWEEN THE PROTEIN AND THE INHIBITOR, VI. STRUCTURE OF INHIBITED STROMELYSIN-1, VII. COMPARISON OF INHIBITED STROMELYSIN TO OTHER MMPS, V. MAJOR CLASSES OF CANNABINERGIC LIGANDS, VI. THERAPEUTIC POTENTIAL OF CANNABINERGIC AGENTS, III. ATTEMPTS TO DEVELOP RADIOLIGANDS, A. STRUCTURE–ACTIVITY STUDIES OF TIP(P) PEPTIDES, A. PROTOTYPES AND STRUCTURE–ACTIVITY RELATIONSHIPS, B. CONFORMATIONAL STUDY OF H-TYR-C[-ORN-2-NAL-DPRO-GLY-], II. RESINS AND LINKERS FOR CARBOXYLIC ACID GENERATION, III. RESINS AND LINKERS FOR GENERATION OF AMIDE FUNCTION, V. RESINS AND LINKERS FOR HYDROXYL AND GENERATION OF AMINO FUNCTION, IX. RESINS AND LINKERS FOR GENERATION OF OTHER FUNCTIONS, B. ALLOSTERIC MODULATION ON THE ADENOSINE RECEPTOR, I. DISEASES WITH PROTEIN MISFOLDING, III. INTERMEDIATES IN FIBRIL FORMATION, VI. CLINICAL TRIALS FOR AD TESTING OF POSSIBLE DISEASE-MODIFYING AGENTS, A. THE NATURE OF THE BINDING SITE, C. MODELING OF CONFORMATIONALLY RESTRICTED ANALOGUES, D. THE DEVELOPMENT OF A CLINICAL CANDIDATE, V. REVERSE TRANSCRIPTASE INHIBITORS INTERACTING WITH THE SUBSTRATE BINDING SITE, VI. REVERSE TRANSCRIPTASE INHIBITORS INTERACTING WITH A NONSUBSTRATE BINDING SITE: NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Từ khóa liên quan

Mục lục

dke151_fm.pdf
- DRUG DISCOVERY STRATEGIES AND METHODS
  - PREFACE
  - CONTENTS
  - CONTRIBUTORS
  - dke151_ch1.pdf
    - DRUG DISCOVERY STRATEGIES & METHODS
      - CHAPTER 1: PROTEIN CRYSTALLOGRAPHY IN STRUCTURE-BASED DRUG DESIGN
        I. INTRODUCTION
        II. THE DRUG DISCOVERY PROCESS
        III. THE STRUCTURE-BASED DRUG DESIGN CYCLE
        IV. PROTEIN CRYSTALLOGRAPHY
        A. CRYSTALLIZATION
        B. X-RAY DIFFRACTION DATA ACQUISITION
        C. PHASING
        D. MODEL BUILDING AND REFINEMENT
        E. UNDERSTANDING STRUCTURAL COORDINATES
        V. IN SILICO LEAD GENERATION
        A. IN SILICO SCREENING OF VIRTUAL COMPOUND LIBRARIES
        B. BUILDING LEADS FROM MOLECULAR FRAGMENTS
        VI. STRUCTURE-BASED LEAD OPTIMIZATION
        VII. EXPERIENCE WITH STRUCTURE-BASED DRUG DESIGN
        A. DESIGN SHOULD BE BASED ON LIGANDED STRUCTURES
        B. DESIGN OF SMALL MOLECULES TO INTERFERE WITH PROTEIN–PROTEIN INTERACTION REQUIRES THE STRUCTURE OF THE COMPLEX
        C. ALLOW FOR FLEXIBILITY IN THE DESIGN OF ENZYME INHIBITORS TO ASSURE OPTIMAL FIT IN AN OFTEN RIGID ACTIVE SITE CAVITY
        D. SYNTHETIC ACCESSIBILITY IS ESSENTIAL
        E. EVERY WATER MOLECULE IS SPECIAL
        F. FILL AVAILABLE SPACE AND MAXIMIZE INTERACTIONS

Tài liệu cùng người dùng

Social aspects of drug discovery, development and commercialization Social aspects of drug discovery, development and commercialization
298 94 0
Burgers medicinal chemistry and drug discovery volume 1 (sixth edition) edited by donald j abraham Burgers medicinal chemistry and drug discovery volume 1 (sixth edition) edited by donald j abraham
946 192 0
A handbook for DNA encoded chemistry theory and applications for exploring chemical space and drug discovery A handbook for DNA encoded chemistry theory and applications for exploring chemical space and drug discovery
497 857 0
Dynamic combinatorial chemistry in drug discovery bioorganic chemistry and materials science Dynamic combinatorial chemistry in drug discovery bioorganic chemistry and materials science
275 103 0
Drug discovery in africa impacts of genomics natural products traditional medicines insights into medicinal chemistry and technology platforms in pursuit of new drugs Drug discovery in africa impacts of genomics natural products traditional medicines insights into medicinal chemistry and technology platforms in pursuit of new drugs
453 203 0
Medicinal chemistry of nucleic acids wiley series in drug discovery and development Medicinal chemistry of nucleic acids wiley series in drug discovery and development
465 260 0

Tài liệu liên quan

Drug discovery strategies and methods 2004 makriyannis biegel Drug discovery strategies and methods 2004 makriyannis biegel
338 223 0
Drug discovery metformin and the control of diabetes Drug discovery metformin and the control of diabetes
3 321 0
drug targeting, strategies, principles, and applications drug targeting, strategies, principles, and applications
299 181 0
computational medicinal chemistry for drug discovery - p. bultinck, et al., (marcel dekker, 2004) computational medicinal chemistry for drug discovery - p. bultinck, et al., (marcel dekker, 2004)
829 1.006 0
Natural Products Drug Discovery and Therapeutic Medicine Natural Products Drug Discovery and Therapeutic Medicine
380 43 0
Burgers medicinal chemistry and drug discovery volume 1 (sixth edition) edited by donald j abraham Burgers medicinal chemistry and drug discovery volume 1 (sixth edition) edited by donald j abraham
946 11 0
Tài liệu Sensors and Methods for Autonomous Mobile Robot Positioning pptx Tài liệu Sensors and Methods for Autonomous Mobile Robot Positioning pptx
210 608 1
Tài liệu Robotics - Sensors and Methods for Autonomous Mobile Robot Positioning doc Tài liệu Robotics - Sensors and Methods for Autonomous Mobile Robot Positioning doc
210 564 1

Drug discovery strategies and methods 2004 makriyannis biegel

Thông tin tài liệu

Từ khóa liên quan

Mục lục

dke151_fm.pdf

DRUG DISCOVERY STRATEGIES AND METHODS

PREFACE

CONTENTS

CONTRIBUTORS

dke151_ch1.pdf

DRUG DISCOVERY STRATEGIES & METHODS

CHAPTER 1: PROTEIN CRYSTALLOGRAPHY IN STRUCTURE-BASED DRUG DESIGN

I. INTRODUCTION

II. THE DRUG DISCOVERY PROCESS

III. THE STRUCTURE-BASED DRUG DESIGN CYCLE

IV. PROTEIN CRYSTALLOGRAPHY

A. CRYSTALLIZATION

B. X-RAY DIFFRACTION DATA ACQUISITION

C. PHASING

D. MODEL BUILDING AND REFINEMENT

E. UNDERSTANDING STRUCTURAL COORDINATES

V. IN SILICO LEAD GENERATION

A. IN SILICO SCREENING OF VIRTUAL COMPOUND LIBRARIES

B. BUILDING LEADS FROM MOLECULAR FRAGMENTS

VI. STRUCTURE-BASED LEAD OPTIMIZATION

VII. EXPERIENCE WITH STRUCTURE-BASED DRUG DESIGN

A. DESIGN SHOULD BE BASED ON LIGANDED STRUCTURES

B. DESIGN OF SMALL MOLECULES TO INTERFERE WITH PROTEIN–PROTEIN INTERACTION REQUIRES THE STRUCTURE OF THE COMPLEX

C. ALLOW FOR FLEXIBILITY IN THE DESIGN OF ENZYME INHIBITORS TO ASSURE OPTIMAL FIT IN AN OFTEN RIGID ACTIVE SITE CAVITY

D. SYNTHETIC ACCESSIBILITY IS ESSENTIAL

E. EVERY WATER MOLECULE IS SPECIAL

F. FILL AVAILABLE SPACE AND MAXIMIZE INTERACTIONS

Tài liệu cùng người dùng

Tài liệu liên quan